Active rTMS compared to sham rTMS will result in a larger reduction of depressive symptoms. Objective: To determine if rTMS is effective in patients with bipolar depression who did not respond to two or more adequately dosed medication trials Study design: This study comprises a pragmatic multicentre, two-phase, randomized clinical trial. Phase 1 comprises a randomized, sham-controlled rTMS trial. In Phase 1, participants will be assigned to one of the two treatment groups, and will receive active or sham rTMS, for 25 rTMS sessions, i.e. 5 weeks. Phase 2 comprises of two follow-up measurements, one at 04 weeks and one at 12-weeks after treatment with active or sham