Amsterdam Neuroscience - Cellular and Molecular Mechanisms

Research Output

2017

Genome-wide association meta- A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Sniekers, S., Stringer, S., Watanabe, K., Jansen, P. R., Coleman, J. R. I., Krapohl, E., Taskesen, E., Hammerschlag, A. R., Okbay, A., Zabaneh, D., Amin, N., Breen, G., Cesarini, D., Chabris, C. F., Iacono, W. G., Ikram, M. A., Johannesson, M., Koellinger, P., Lee, J. J., Magnusson, P. K. E. & 10 others, McGue, M., Miller, M. B., Ollier, W. E. R., Payton, A., Pendleton, N., Plomin, R., Rietveld, C. A., Tiemeier, H., Van Duijn, C. M. & Posthuma, D., 1 Jul 2017, In : Nature Genetics. 49, 7, p. 1107-1112 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genotype-phenotype correlation in ATAD3A deletions: Not just of scientific relevance

Peeters-Scholte, C. M. P. C. D., Adama Van Scheltema, P. N., Klumper, F. J. C. M., Everwijn, S. M. P., Koopmans, M., Hoffer, M. J. V., Koopmann, T. T., Ruivenkamp, C. A. L., Steggerda, S. J., Van Der Knaap, M. S. & Santen, G. W. E., 1 Nov 2017, In : Brain. 140, 11, p. e66

Research output: Contribution to journalLetterAcademicpeer-review

Guanidinoacetate Methyltransferase Activity in Lymphocytes, for a Fast Diagnosis

Berends, L. M., Struys, E. A., Roos, B., Holwerda, U., Jansen, E. E. W., Salomons, G. S. & Wamelink, M. M. C., 2017, In : JIMD Reports. 37, p. 13-17 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Heat Shock Proteins: Old and Novel Roles in Neurodegenerative Diseases in the Central Nervous System

van Noort, J. M., Bugiani, M. & Amor, S., 2017, In : CNS and Neurological Disorders. Drug Targets. 16, 3, p. 244-256 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

HHV8/KSHV-Positive Lymphoproliferative Disorders and the Spectrum of Plasmablastic and Plasma Cell Neoplasms: 2015 SH/EAHP Workshop Report-Part 3

Chadburn, A., Said, J., Gratzinger, D., Chan, J. K. C., de Jong, D., Jaffe, E. S., Natkunam, Y. & Goodlad, J. R., 1 Feb 2017, In : American Journal of Clinical Pathology. 147, 2, p. 171-187 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hirayama disease; an atypical clinical manifestation of a cervical myelopathy with typical MRI features

Salome, M., Barkhof, F. & Visser, L., 2017, In : BMJ Case Reports. 2017, e217780.

Research output: Contribution to journalComment/Letter to the editorAcademic

Identification of 3 Novel Patients with CLCN2-Related Leukoencephalopathy due to CLCN2 Mutations

Zeydan, B., Uygunoglu, U., Altintas, A., Saip, S., Siva, A., Abbink, T. E. M., Van Der Knaap, M. S. & Yalcinkaya, C., 1 Sep 2017, In : European Neurology. 78, 3-4, p. 125-127 3 p.

Research output: Contribution to journalLetterAcademicpeer-review

Immunodeficiency and Dysregulation: Report of the 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology

Natkunam, Y., Gratzinger, D., de Jong, D., Chadburn, A., Goodlad, J. R., Chan, J. K. C., Said, J. & Jaffe, E. S., 1 Feb 2017, In : American Journal of Clinical Pathology. 147, 2, p. 124-128 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

ImmunoPET imaging to assess target engagement: Experience from Zr-89-anti-HER3 mAb (GSK2849330) in patients with solid tumors

Mcgeoch, A., van Oordt, C. M. D. H., Bergstrom, M., McSherry, I., Smith, D., Cleveland, M., Hoekstra, O., Vugts, D., Weber, A., Freedman, I., Huisman, M., Matheny, C., van Dongen, G. & Zhang, S., Oct 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, p. S314-S315

Research output: Contribution to journalMeeting AbstractAcademic

Impact of removing facial features from MR images of MS patients on automatic lesion and atrophy metrics

de Sitter, A., Visser, M., Brouwer, I., van Schijndel, R. A., Uitdehaag, B. M. J., Barkhof, F. & Vrenken, H., Oct 2017, In : Multiple Sclerosis Journal. 23, p. 226-226

Research output: Contribution to journalMeeting AbstractAcademic

Improved high-dimensional prediction with Random Forests by the use of co-data

te Beest, D. E., Mes, S. W., Wilting, S. M., Brakenhoff, R. H. & van de Wiel, M. A., 28 Dec 2017, In : BMC Bioinformatics. 18, 1, 584.

Research output: Contribution to journalArticleAcademicpeer-review

Individualized versus standard FSH dosing in women starting IVF/ICSI: an RCT. Part 2: The predicted hyper responder

Oudshoorn, S. C., van Tilborg, T. C., Eijkemans, M. J. C., Oosterhuis, G. J. E., Friederich, J., van Hooff, M. H. A., van Santbrink, E. J. P., Brinkhuis, E. A., Smeenk, J. M. J., Kwee, J., de Koning, C. H., Groen, H., Lambalk, C. B., Mol, B. W. J., Broekmans, F. J. M., Torrance, H. L. & OPTIMIST study group, 1 Dec 2017, In : Human Reproduction. 32, 12, p. 2506-2514 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation: a denominating factor in coronary artery disease and venous bypass graft failure

Kupreishvili, K., 2017, 158 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University Amsterdam

Open Access

Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation

van der Harg, J. M., Eggels, L., Bangel, F. N., Ruigrok, S. R., Zwart, R., Hoozemans, J. J. M., la Fleur, S. E. & Scheper, W., Jul 2017, In : Neurobiology of Disease. 103, p. 163-173 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

Nguyen, H. T., Bryois, J., Kim, A., Dobbyn, A., Huckins, L. M., Munoz-Manchado, A. B., Ruderfer, D. M., Genovese, G., Fromer, M., Xu, X., Pinto, D., Linnarsson, S., Verhage, M., Smit, A. B., Hjerling-Leffler, J., Buxbaum, J. D., Hultman, C., Sklar, P., Purcell, S. M., Lage, K. & 3 others, He, X., Sullivan, P. F. & Stahl, E. A., 20 Dec 2017, In : Genome Medicine. 9, 1, 114.

Research output: Contribution to journalArticleAcademicpeer-review

Interaction of Vascular Damage and Alzheimer Dementia: Focal Damage and Disconnection

Haller, S. & Barkhof, F., Feb 2017, In : Radiology. 282, 2, p. 311-313 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation

Albers-Wolthers, C. H. J., de Gier, J., Walen, M., van Kooten, P. J. S., Lambalk, C. B., Leegwater, P. A. J., Roelen, B. A. J., Schaefers-Okkens, A. C., Rutten, V. P. M. G., Millar, R. P. M. & Kooistra, H. S., 2017, In : PLoS ONE. 12, 6, p. e0179156

Research output: Contribution to journalArticleAcademicpeer-review

In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells

Vogel, K. R., Ainslie, G. R., Jansen, E. E., Salomons, G. S., Roullet, J. B. & Gibson, K. M., 1 Oct 2017, In : PLoS ONE. 12, 10, e0186919.

Research output: Contribution to journalArticleAcademicpeer-review

IRE1 signaling exacerbates Alzheimer's disease pathogenesis

Duran-Aniotz, C., Cornejo, V. H., Espinoza, S., Ardiles, Á. O., Medinas, D. B., Salazar, C., Foley, A., Gajardo, I., Thielen, P., Iwawaki, T., Scheper, W., Soto, C., Palacios, A. G., Hoozemans, J. J. M. & Hetz, C., 1 Sep 2017, In : Acta Neuropathologica. 134, 3, p. 489-506 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Laboratory diagnosis of creatine deficiency syndromes: A technical standard and guideline of the American College of Medical Genetics and Genomics

Daniel Sharer, J., Bodamer, O., Longo, N., Tortorelli, S., Wamelink, M. M. C. & Young, S., 1 Feb 2017, In : Genetics in Medicine. 19, 2, p. 256-263 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Less cortical folding in adult patients with longstanding type 1 diabetes is related to cognition and diabetes duration

IJzerman, R. G., Steenwijk, M. D., Landeira-Fernandez, J., Klein, M., Barkhof, F., Moll, A. C., Diamant, M., Snoek, F. J. & van Duinkerken, E., Sep 2017, In : Diabetologia. 60, p. S552-S552

Research output: Contribution to journalMeeting AbstractAcademic

Less Cortical Folding in Adult Patients with Long-Standing Type 1 Diabetes Is Related to Cognition and Diabetes Duration

Van Duinkerken, E., Steenwijk, M. D., Landeira-Fernandez, J., Klein, M., Barkhof, F., Moll, A. C., Diamant, M., Snoek, F. J. & Ijzerman, R. G., 1 Jun 2017, In : Diabetes. 66, p. A223-A223

Research output: Contribution to journalMeeting AbstractAcademic

Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms

van der Knaap, M. S. & Bugiani, M., 1 Sep 2017, In : Acta Neuropathologica. 134, 3, p. 351-382 32 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer’s disease

Benedictus, M. R., Leeuwis, A. E., Binnewijzend, M. A. A., Kuijer, J. P. A., Scheltens, P., Barkhof, F., van der Flier, W. M. & Prins, N. D., 1 Mar 2017, In : European Radiology. 27, 3, p. 1169-1175 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease

Leeuwis, A. E., Benedictus, M. R., Kuijer, J. P. A., Binnewijzend, M. A. A., Hooghiemstra, A. M., Verfaillie, S. C. J., Koene, T., Scheltens, P., Barkhof, F., Prins, N. D. & van der Flier, W. M., 1 May 2017, In : Alzheimer's and Dementia. 13, 5, p. 531-540 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Megalencephalic leukoencephalopathy with cysts: the Glialcam-null mouse model

Bugiani, M., Dubey, M., Breur, M., Postma, N. L., Dekker, M. P., Ter Braak, T., Boschert, U., Abbink, T. E. M., Mansvelder, H. D., Min, R., van Weering, J. R. T. & van der Knaap, M. S., Jul 2017, In : Annals of Clinical and Translational Neurology. 4, 7, p. 450-465 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Methodological Guidelines to Study Extracellular Vesicles

Coumans, F. A. W., Brisson, A. R., Buzas, E. I., Dignat-George, F., Drees, E. E. E., El-Andaloussi, S., Emanueli, C., Gasecka, A., Hendrix, A., Hill, A. F., Lacroix, R., Lee, Y., van Leeuwen, T. G., Mackman, N., Mäger, I., Nolan, J. P., van der Pol, E., Pegtel, D. M., Sahoo, S., Siljander, P. R. M. & 3 others, Sturk, G., de Wever, O. & Nieuwland, R., 12 May 2017, In : Circulation Research. 120, 10, p. 1632-1648 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Molecular profiling for risk assessment of pre-invasive endobronchial lesions

van Boerdonk, RAA., 2017, 153 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University Amsterdam

Open Access

MRI-BASED CLASSIFICATION ACCURACY OF DEMENTIA TYPE IS DETERMINED BY MRI MODALITY

Bouts, M. J. R. J., Möller, C., Hafkemeijer, A., van Swieten, J. C., Dopper, E. G. P., van der Flier, W. M., Vrenken, H., Wink, A. M., Pijnenburg, Y. A. L., Scheltens, P., Barkhof, F., van der Grond, J., de Rooij, M. & Rombouts, S. A. R. B., Jul 2017, In : Alzheimers & Dementia. 13, 7, p. P98-P99

Research output: Contribution to journalArticleAcademicpeer-review

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

Nadadhur, A. G., Melero, J. E., Meijer, M., Schut, D., Jacobs, G., Wan Li, K., Hjorth, J. J. J., Meredith, R. M., Toonen, R. F., Van Kesteren, R. E., Smit, A. B., Verhage, M. & Heine, V. M., 1 Jun 2017, In : PLoS ONE. 12, 6, 0178533.

Research output: Contribution to journalArticleAcademicpeer-review

Multisite assessment of aging-related tau astrogliopathy (ARTAG)

ARTAG group, 1 Jan 2017, In : Journal of Neuropathology and Experimental Neurology. 76, 7, p. 605-619 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

He, E., Wierda, K., Van Westen, R., Broeke, J. H., Toonen, R. F., Cornelisse, L. N. & Verhage, M., 21 Jun 2017, In : Nature Communications. 8, 15915.

Research output: Contribution to journalArticleAcademicpeer-review

Neonatal detection of Aicardi Goutières Syndrome by increased C26: 0 lysophosphatidylcholine and interferon signature on newborn screening blood spots

Armangue, T., Orsini, J. J., Takanohashi, A., Gavazzi, F., Conant, A., Ulrick, N., Morrissey, M. A., Nahhas, N., Helman, G., Gordish-Dressman, H., Orcesi, S., Tonduti, D., Stutterd, C., van Haren, K., Toro, C., Iglesias, A. D., van der Knaap, M. S., Goldbach Mansky, R., Moser, A. B., Jones, R. O. & 1 others, Vanderver, A., 1 Nov 2017, In : Molecular Genetics and Metabolism. 122, 3, p. 134-139 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Neuropathological assessment of cognitively healthy centenarians - The 100-Plus Study

Ganz, A. B., de Reus, M. A., Smit, A. B., Scheltens, P., Rozemuller, A., Hoozemans, J. J. M. & Holstege, H., Feb 2017, In : Neuropathology and Applied Neurobiology. 43, p. 14-15

Research output: Contribution to journalMeeting AbstractAcademic

NGS panel analysis in 24 ectopia lentis patients; a clinically relevant test with a high diagnostic yield

Overwater, E., Floor, K., van Beek, D., de Boer, K., van Dijk, T., Hilhorst-Hofstee, Y., Hoogeboom, A. J. M., van Kaam, K. J., van de Kamp, J. M., Kempers, M., Krapels, I. P. C., Kroes, H. Y., Loeys, B., Salemink, S., Stumpel, C. T. R. M., Verhoeven, V. J. M., Wijnands-van den Berg, E., Cobben, J. M., van Tintelen, J. P., Weiss, M. M. & 2 others, Houweling, A. C. & Maugeri, A., 1 Sep 2017, In : European Journal of Medical Genetics. 60, 9, p. 465-473 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Non-motor symptoms and quality of life in dopa-responsive dystonia patients

Timmers, E. R., Kuiper, A., Smit, M., Bartels, A. L., Kamphuis, D. J., Wolf, N. I., Poll-The, B. T., Wassenberg, T., Peeters, E. A. J., de Koning, T. J. & Tijssen, M. A. J., Dec 2017, In : Parkinsonism and Related Disorders. 45, p. 57-62

Research output: Contribution to journalArticleAcademicpeer-review

No relationship between vertebral column shifts and limb fluctuating asymmetry in human foetuses

ten Broek, C. M. A., Bots, J., Bugiani, M., Galis, F. & Van Dongen, S., 2017, In : PeerJ. 2017, 6, e3359.

Research output: Contribution to journalArticleAcademicpeer-review

Novel biomarkers for cervical screening and surveillance of women treated for cervical precancer

Uijterwaal, MH., 2017, 183 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University Amsterdam

Open Access

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper

Mateescu, B., Kowal, E. J. K., van Balkom, B. W. M., Bartel, S., Bhattacharyya, S. N., Buzás, E. I., Buck, A. H., de Candia, P., Chow, F. W. N., Das, S., Driedonks, T. A. P., Fernández-Messina, L., Haderk, F., Hill, A. F., Jones, J. C., Van Keuren-Jensen, K. R., Lai, C. P., Lässer, C., Liegro, I. D., Lunavat, T. R. & 16 others, Lorenowicz, M. J., Maas, S. L. N., Mäger, I., Mittelbrunn, M., Momma, S., Mukherjee, K., Nawaz, M., Pegtel, D. M., Pfaffl, M. W., Schiffelers, R. M., Tahara, H., Théry, C., Tosar, J. P., Wauben, M. H. M., Witwer, K. W. & Nolte-'t Hoen, E. N. M., 2017, In : Journal of Extracellular Vesicles. 6, 1, p. 1286095

Research output: Contribution to journalArticleAcademicpeer-review

Olig1 is required for noggin-induced neonatal myelin repair

Sabo, J. K., Heine, V., Silbereis, J. C., Schirmer, L., Levison, S. W. & Rowitch, D. H., 1 Apr 2017, In : Annals of Neurology. 81, 4, p. 560-571 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

On the mean squared error of the ridge estimator of the covariance and precision matrix

van Wieringen, W. N., 1 Apr 2017, In : Statistics and Probability Letters. 123, p. 88-92 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

P18.02 Comparing quality of glioblastoma resections between care teams

Müller, D. M. J., Robe, P. A. J., Barkhof, F., Vandertop, W. P. & de Witt Hamer, P. C., 3 Feb 2017, In : Neuro-Oncology. 18, suppl_4, p. iv78-iv79

Research output: Contribution to journalArticleAcademicpeer-review

Performance of five research-domain automated WM lesion segmentation methods in a multi-center MS study

de Sitter, A., Steenwijk, M. D., Ruet, A., Versteeg, A., Liu, Y., van Schijndel, R. A., Pouwels, P. J. W., Kilsdonk, I. D., Cover, K. S., van Dijk, B. W., Ropele, S., Rocca, M. A., Yiannakas, M., Wattjes, M. P., Damangir, S., Frisoni, G. B., Sastre-Garriga, J., Rovira, A., Enzinger, C., Filippi, M. & 7 others, Frederiksen, J. L., Ciccarelli, O., Kappos, L., Barkhof, F., Vrenken, H., MAGNIMS Study Group & neuGRID, 1 Dec 2017, In : NeuroImage. 163, p. 106-114 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy

Al Teneiji, A., Bruun, T. U. J., Cordeiro, D., Patel, J., Inbar-Feigenberg, M., Weiss, S., Struys, E. & Mercimek-Mahmutoglu, S., Apr 2017, In : METABOLIC BRAIN DISEASE. 32, 2, p. 443-451 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Postmortem Whole Exome Sequencing Identifies Novel EIF2B3 Mutation with Prenatal Phenotype in 2 Siblings

Song, H., Haeri, S., Vogel, H., Van Der Knaap, M. & Van Haren, K., 1 Sep 2017, In : Journal of Child Neurology. 32, 10, p. 867-870 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Predicting clinical progression in multiple sclerosis six and twelve years after onset

Dekker, I., Eijlers, A. J. C., Popescu, V., Balk, L. J., Vrenken, H., Wattjes, M. P., Uitdehaag, B. M. J., Killestein, J., Geurts, J. J. G., Barkhof, F. & Schoonheim, M. M., Oct 2017, In : Multiple Sclerosis Journal. 23, p. 229-230

Research output: Contribution to journalMeeting AbstractAcademic