Amsterdam Neuroscience - Cellular and Molecular Mechanisms

Research Output

In vivo and in vitro NMR spectroscopy reveal a putative novel inborn error involving polyol metabolism

Moolenaar, S. H., Van Der Knaap, M. S., Engelke, U. F. H., Pouwels, P. J. W., Janssen-Zijlstra, F. S. M., Verhoeven, N. M., Jakobs, C. & Wevers, R. A., 23 Jun 2001, In : NMR in Biomedicine. 14, 3, p. 167-176 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Is Epstein-Barr virus present in the CNS of patients with MS?

Morré, S. A., van Beek, J., De Groot, C. J., Killestein, J., Meijer, C. J., Polman, C. H., van der Valk, P., Middeldorp, J. M. & van Den Brule, A. J., 13 Mar 2001, In : Neurology. 56, 5, p. 692

Research output: Contribution to journalArticleAcademicpeer-review

Magnetization transfer histogram parameters reflect all dimensions of MS pathology, including atrophy

Kalkers, N. F., Hintzen, R. Q., Van Waesberghe, J. H. T. M., Lazeron, R. H. C., Van Schijndel, R. A., Adèr, H. J., Polman, C. H. & Barkhof, F., 1 Mar 2001, In : Journal of the Neurological Sciences. 184, 2, p. 155-162 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Optimizing the association between disability and biological markers in MS

Kalkers, N. F., Bergers, E., Castelijns, J. A., Van Walderveen, M. A. A., Bot, J. C. J., Adèr, H. J., Polman, C. H. & Barkhof, F., 9 Oct 2001, In : Neurology. 57, 7, p. 1253-1258 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perivenous support reduces early changes in human vein grafts: studies in whole blood perfused human vein segments

Stooker, W., Niessen, H. W., Baidoshvili, A., Wildevuur, W. R., Van Hinsbergh, V. W., Fritz, J., Wildevuur, C. R. & Eijsman, L., Feb 2001, In : Journal of Thoracic and Cardiovascular Surgery. 121, 2, p. 290-7 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Post-mortem high-resolution MRI of the spinal cord in multiple sclerosis: A correlative study with conventional MRI, histopathology and clinical phenotype

Lycklama À Nijeholt, G. J., Bergers, E., Kamphorst, W., Bot, J., Nicolay, K., Castelijns, J. A., Van Waesberghe, J. H. T. M., Ravid, R., Polman, C. H. & Barkhof, F., 30 Jan 2001, In : Brain. 124, 1, p. 154-166 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Raloxifene affects brain activation patterns in postmenopausal women during visual encoding

Neele, S. J. M., Rombouts, S. A. R. B., Bierlaagh, M. A., Barkhof, F., Scheltens, P. & Netelenbos, J. C., 30 Apr 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 3, p. 1422-1424 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Role for complement as an intermediate between C-reactive protein and intercellular adhesion molecule-1 expression?

Lagrand, W. K., Niessen, H. W., Nijmeijer, R. & Hack, C. E., 28 Aug 2001, In : Circulation. 104, 9, p. E46

Research output: Contribution to journalArticleAcademicpeer-review

Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors

Heideman, D. A., Snijders, P. J., Craanen, M. E., Bloemena, E., Meijer, C. J., Meuwissen, S. G., van Beusechem, V. W., Pinedo, H. M., Curiel, D. T., Haisma, H. J. & Gerritsen, W. R., May 2001, In : Cancer Gene Therapy. 8, 5, p. 342-51 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sporadic Creutzfeldt-Jakob disease in a young Dutch valine homozygote: Atypical molecular phenotype

Head, M. W., Tissingh, G., Uitdehaag, B. M. J., Barkhof, F., Bunn, T. J. R., Ironside, J. W., Kamphorst, W. & Scheltens, P., 22 Aug 2001, In : Annals of Neurology. 50, 2, p. 258-261 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line

Steenbergen, R. D. M., Kramer, D., Meijer, C. J. L. M., Walboomers, J. M. M., Trott, D. A., Cuthbert, A. P., Newbold, R. F., Overkamp, W. J. I., Zdzienicka, M. Z. & Snijders, P. J. F., 6 Jun 2001, In : Journal of the National Cancer Institute. 93, 11, p. 865-872 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2002

Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E-2

Veerhuis, R., Hoozemans, JJM., Janssen, I., Boshuizen, RS., Langeveld, JPM. & Eikelenboom, P., 25 Jan 2002, In : Brain Research. 925, 2, p. 195-203

Research output: Contribution to journalArticleAcademicpeer-review

Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease

Rombouts, S. A. R. B., Barkhof, F., Van Meel, C. S. & Scheltens, P., 1 Dec 2002, In : Journal of Neurology Neurosurgery and Psychiatry. 73, 6, p. 665-671 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Amyloid beta plaque-associated proteins C1q and SAP enhance the A beta 1-42 peptide-induced cytokine secretion by adult human microglia in vitro

Veerhuis, R., van Breemen, MJ., Hoozemans, JJM., Gerritsen, WH., Janssen, I., Ouladhadj, J. & Eikelenboom, P., 2002, In : Neurobiology of Aging. 23, 1, p. S12-S12

Research output: Contribution to journalArticleAcademicpeer-review

Apoptosis in myocardial ischaemia and infarction

Krijnen, P. A. J., Nijmeijer, R., Meijer, C. J. L. M., Visser, C. A., Hack, C. E. & Niessen, H. W. M., Nov 2002, In : Journal of Clinical Pathology. 55, 11, p. 801-11 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

A rapid and reliable enzyme immunoassay PCR-based screening method to identify EBV-carrying gastric carcinomas

van Beek, J., zur Hausen, A., Kranenbarg, E. K., Warring, R. J., Bloemena, E., Craanen, M. E., van de Velde, C. J. H., Middeldorp, J. M., Meijer, C. J. L. M. & van den Brule, A. J. C., Aug 2002, In : Modern Pathology. 15, 8, p. 870-7 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions

Bergers, E., Bot, J. C. J., De Groot, C. J. A., Polman, C. H., Lycklama à Nijeholt, G. J., Castelijns, J. A., Van der Valk, P. & Barkhof, F., 10 Dec 2002, In : Neurology. 59, 11, p. 1766-1771 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiovascular secrets of secretory phospholipase A(2)

Hack, C. E. & Niessen, H. W. M., Jun 2002, In : European Journal of Clinical Investigation. 32, 6, p. 381-2 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Co-localization of cyclo-oxygenase 2 with cyclin D1 and cyclin E in pyramidal neurons in Alzheimer's disease temporal cortex

Hoozemans, JJM., Veerhuis, R., Bruckner, MK., Arendt, T., Rozemuller, AJM. & Eikelenboom, P., 2002, In : Neurobiology of Aging. 23, 1, p. S222-S222

Research output: Contribution to journalArticleAcademicpeer-review

C-reactive protein as a pro-inflammatory mediator in cardiovascular disease by its ability to activate complement: additional proof and hypothetical mechanisms

Lagrand, W. K., Nijmeijer, R., Niessen, H. W. M., Visser, C. A., Hermens, W. T. & Hack, C. E., Apr 2002, In : Netherlands Heart Journal. 10, 4, p. 189-197 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

CT and MRI rating of white matter lesions

Fazekas, F., Barkhof, F., Wahlund, L. O., Pantoni, L., Erkinjuntti, T., Scheltens, P. & Schmidt, R., 1 Jan 2002, In : Cerebrovascular Diseases. 13, SUPPL. 2, p. 31-36 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differentiation of multiple sclerosis from other inflammatory disorders and cerebrovascular disease: Value of spinal MR imaging

Bot, J. C. J., Barkhof, F., Lycklama À Nijeholt, G. L., Van Schaardenburg, D., Voskuyl, A. E., Ader, H. J., Pijnenburg, J. A. L., Polman, C. H., Uitdehaag, B. M. J., Vermeulen, E. G. J. & Castelijns, J. A., 1 Jan 2002, In : Radiology. 223, 1, p. 46-56 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology

Bergers, E., Bot, J. C. J., van der Valk, P., Castelijns, J. A., Nijeholt, G. J. L. A., Kamphorst, W., Polman, C. H., Blezer, E. L. A., Nicolay, K., Ravid, R. & Barkhof, F., 6 May 2002, In : Annals of Neurology. 51, 5, p. 652-656 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis

Steenbergen, R. D. M., OudeEngberink, V. E., Kramer, D., Schrijnemakers, H. F. J., Verheijen, R. H. M., Meijer, C. J. L. M. & Snijders, P. J. F., 1 Jan 2002, In : American Journal of Pathology. 160, 6, p. 1945-1951 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

High numbers of granzyme B/CD8-positive tumour-infiltrating lymphocytes in nasopharyngeal carcinoma biopsies predict rapid fatal outcome in patients treated with curative intent

Oudejans, J. J., Harijadi, H., Kummer, J. A., Tan, I. B., Bloemena, E., Middeldorp, J. M., Bladergroen, B., Dukers, D. F., Vos, W. & Meijer, C. J. L. M., Dec 2002, In : Journal of Pathology. 198, 4, p. 468-75 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Image registration and subtraction to detect active T2 lesions in MS: An interobserver study

Tan, I. L., Van Schijndel, R. A., Fazekas, F., Filippi, M., Freitag, P., Miller, D. H., Yousry, T. A., Pouwels, P. J. W., Adèr, H. J. & Barkhof, F., 1 Jan 2002, In : Journal of Neurology. 249, 6, p. 767-773 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Imaging of white matter lesions

Barkhof, F. & Scheltens, P., 1 Jan 2002, In : Cerebrovascular Diseases. 13, SUPPL. 2, p. 21-30 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Intercellular adhesion molecule-1 in the heart

Niessen, H. W. M., Krijnen, P. A. J., Visser, C. A., Meijer, C. J. L. M. & Hack, C. E., Nov 2002, In : Annals of the New York Academy of Sciences. 973, p. 573-85 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Isotropic 3D fast FLAIR imaging of the brain in multiple sclerosis patients: Initial experience

Tan, I. L., Pouwels, P. J. W., van Schijndel, R. A., Adèr, H. J., Manoliu, R. A. & Barkhof, F., 1 Mar 2002, In : European Radiology. 12, 3, p. 559-567 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis

Baidoshvili, A., Nijmeijer, R., Lagrand, W. K., Hack, C. E. & Niessen, H. W. M., Feb 2002, In : Journal of Clinical Pathology. 55, 2, p. 152-3 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Longitudinal brain volume measurement in multiple sclerosis: Rate of brain atrophy is independent of the disease subtype

Kalkers, N. F., Ameziane, N., Bot, J. C. J., Minneboo, A., Polman, C. H. & Barkhof, F., 1 Oct 2002, In : Archives of Neurology. 59, 10, p. 1572-1576 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Magnetic resonance image registration in multiple sclerosis: Comparison with repositioning error and observer-based variability

Leng Tan, I., Van Schijndel, R. A., Van Walderveen, M. A. A., Quist, M., Bos, R., Pouwels, P. J. W., Desmedt, P., Adr, H. J. & Barkhof, F., 13 May 2002, In : Journal of Magnetic Resonance Imaging. 15, 5, p. 505-510 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?

Van Heerebeek, L., Meischl, C., Stooker, W., Meijer, C. J. L. M., Niessen, H. W. M. & Roos, D., Aug 2002, In : Journal of Clinical Pathology. 55, 8, p. 561-8 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Neuroinflammation in Alzheimer's disease and prion disease

Eikelenboom, P., Bate, C., Van Gool, WA., Hoozemans, JJM., Rozemuller, JM., Veerhuis, R. & Williams, A., Nov 2002, In : GLIA. 40, 2, p. 232-239

Research output: Contribution to journalArticleAcademicpeer-review

New syndrome characterized by hypomyelination with atrophy of the basal ganglia and cerebellum

Van der Knaap, M. S., Naidu, S. B., Pouwels, P. J. W., Bonavita, S., Van Coster, R., Lagae, L., Sperner, J., Surtees, R., Schiffmann, R. & Valk, J., 1 Oct 2002, In : American Journal of Neuroradiology. 23, 9, p. 1466-1474 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Patterns of cerebral atrophy in Dementia with Lewy bodies using voxel-based morphometry

Burton, E. J., Karas, G., Paling, S. M., Barber, R., Williams, E. D., Ballard, C. G., McKeith, I. G., Scheltens, P., Barkhof, F. & O'Brien, J. T., 1 Jan 2002, In : NeuroImage. 17, 2, p. 618-630 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia

Bleeker, M. C. G., Hogewoning, C. J. A., Van Den Brule, A. J. C., Voorhorst, F. J., Van Andel, R. E., Risse, E. K. J., Starink, T. M. & Meijer, C. J. L. M., Sep 2002, In : Journal of the American Academy of Dermatology. 47, 3, p. 351-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perivenous application of fibrin glue reduces early injury to the human saphenous vein graft wall in an ex vivo model

Stooker, W., Niessen, H. W. M., Wildevuur, W. R., van Hinsbergh, V. W. M., Fritz, J., Jansen, E. K., Wildevuur, C. R. H. & Eijsman, L., Feb 2002, In : European Journal of Cardio-thoracic Surgery. 21, 2, p. 212-7 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer

Crul, M., de Klerk, G. J., Swart, M., van't Veer, L. J., de Jong, D., Boerrigter, L., Palmer, P. A., Bol, C. J., Tan, H., de Gast, G. C., Beijnen, J. H. & Schellens, J. H. M., 1 Jun 2002, In : Journal of Clinical Oncology. 20, 11, p. 2726-2735 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine features

Westerman, B. A., Neijenhuis, S., Poutsma, A., Steenbergen, R. D. M., Breuer, R. H. J., Egging, M., van Wijk, I. J. & Oudejans, C. B. M., Apr 2002, In : Clinical Cancer Research. 8, 4, p. 1082-6 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Role of Epstein-Barr virus DNA load monitoring in prevention and early detection of post-transplant lymphoproliferative disease

Stevens, S. J. C., Verschuuren, E. A. M., Verkuujlen, S. A. W. M., Van Den Brule, A. J. C., Meijer, C. J. L. M. & Middeldorp, J. M., Apr 2002, In : Leukemia and Lymphoma. 43, 4, p. 831-40 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Secretory type II phospholipase A(2) binds to ischemic myocardium during myocardial infarction in humans

Nijmeijer, R., Lagrand, W. K., Baidoshvili, A., Lubbers, Y. T. P., Hermens, W. T., Meijer, C. J. L. M., Visser, C. A., Hack, C. E. & Niessen, H. W. M., Jan 2002, In : Cardiovascular Research. 53, 1, p. 138-46 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Selective gene transfer into primary human gastric tumors using epithelial cell adhesion molecule-targeted adenoviral vectors with ablated native tropism

Heideman, D. A. M., van Beusechem, V. W., Offerhaus, G. J. A., Wickham, T. J., Roelvink, P. W., Craanen, M. E., Pinedo, H. M., Meijer, C. J. L. M. & Gerritsen, W. R., 20 Sep 2002, In : Human Gene Therapy. 13, 14, p. 1677-85 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Serial isotropic three-dimensional fast FLAIR imaging: Using image registration and subtraction to reveal active multiple sclerosis lesions

Tan, I. L., Van Schijndel, R. A., Pouwels, P. J. W., Adèr, H. J. & Barkhof, F., 1 Jan 2002, In : American Journal of Roentgenology. 179, 3, p. 777-782 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Structural magnetic resonance imaging in the practical assessment of dementia: Beyond exclusion

Scheltens, P., Fox, N., Barkhof, F. & De Carli, C., 1 Jan 2002, In : Lancet Neurology. 1, 1, p. 13-21 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The pathological cascade of Alzheimer's disease: The role of inflammation and its therapeutic implications

Hoozemans, JJM., Veerhuis, R., Rozemuller, AJM. & Eikelenboom, P., Jun 2002, In : Drugs of Today. 38, 6, p. 429-443

Research output: Contribution to journalArticleAcademicpeer-review

The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E2 secretion by cultured human adult microglia: Implications for Alzheimer's disease

Hoozemans, J. J. M., Veerhuis, R., Janssen, I., Van Elk, E. J., Rozemuller, A. J. M. & Eikelenboom, P., 4 Oct 2002, In : Brain Research. 951, 2, p. 218-226 9 p.

Research output: Contribution to journalArticleAcademicpeer-review