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2020

A 30-Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Chung, K. K., Altmann, D., Barkhof, F., Miszkiel, K., Brex, P. A., O'Riordan, J., Ebner, M., Prados, F., Cardoso, M. J., Vercauteren, T., Ourselin, S., Thompson, A., Ciccarelli, O. & Chard, D. T., Jan 2020, In : Annals of Neurology. 87, 1, p. 63-74 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

Oudega, M. L., Siddiqui, A., Wattjes, M. P., Barkhof, F., Kate, M. T., Muller, M., Bouckaert, F., Vandenbulcke, M., De Winter, F. L., Sienaert, P., Stek, M. L., Comijs, H. C., Korten, N. C. M., Emsell, L., Eikelenboom, P., Rhebergen, D., van Exel, E. & Dols, A., 1 Jan 2020, In : Journal of Geriatric Psychiatry and Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Bortezomib maintenance after R-CHOP, cytarabine and autologous stem cell transplantation in newly diagnosed patients with mantle cell lymphoma, results of a randomised phase II HOVON trial

Doorduijn, J. K., Zijlstra, J. M., Lugtenburg, P. J., Kersten, M. J., Böhmer, L. H., Minnema, M. C., MacKenzie, M. A., van Marwijk Kooij, R., de Jongh, E., Snijders, T. J. F., de Weerdt, O., van Gelder, M., Hoogendoorn, M., Leys, R. B. L., Kibbelaar, R. E., de Jong, D., Chitu, D. A., Van’t Veer, M. B. & Kluin-Nelemans, H. C., 1 Jan 2020, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Breast Implant Prevalence in the Dutch Female Population Assessed by Chest Radiographs

de Boer, M., van Middelkoop, M., Hauptmann, M., van der Bijl, N., Bosmans, J. A. W., Hendriks-Brouwer, N., Schop, S. J., de Boer, J. P., Hijmering, N. J., Overbeek, L. I. H., Lobbes, M. B. I., Klazen, C. A. H., de Jong, D., Rakhorst, H. A., van der Hulst, R. R. W. J. & van Leeuwen, F. E., 2020, In : Aesthetic Surgery Journal. 40, 2, p. 156-164 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Characterization of Mechanical Signature of Eutopic Endometrial Stromal Cells of Endometriosis Patients

Altayyeb, A., Othman, E., Khashbah, M., Esmaeel, A., El-Mokhtar, M., Lambalk, C., Mijatovic, V. & Abdelgawad, M., 1 Jan 2020, In : Reproductive Sciences. 27, 1, p. 364-374 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comorbid amyloid-β pathology affects clinical and imaging features in VCD

Leijenaar, J. F., Groot, C., Sudre, C. H., Bergeron, D., Leeuwis, A. E., Cardoso, M. J., Carrasco, F. P., Laforce, R., Barkhof, F., van der Flier, W. M., Scheltens, P., Prins, N. D. & Ossenkoppele, R., 1 Feb 2020, In : Alzheimers & Dementia. 16, 2, p. 354-364 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CSF cutoffs for MCI due to AD depend on APOEε4 carrier status

Marizzoni, M., Ferrari, C., Babiloni, C., Albani, D., Barkhof, F., Cavaliere, L., Didic, M., Forloni, G., Fusco, F., Galluzzi, S., Hensch, T., Jovicich, J., Marra, C., Molinuevo, J. L., Nobili, F., Parnetti, L., Payoux, P., Ranjeva, J. P., Ribaldi, F., Rolandi, E. & 10 others, Rossini, P. M., Salvatore, M., Soricelli, A., Tsolaki, M., Visser, P. J., Wiltfang, J., Richardson, J. C., Bordet, R., Blin, O. & Frisoni, G. B., 1 Jan 2020, In : Neurobiology of Aging.

Research output: Contribution to journalArticleAcademicpeer-review

Distinct influence of different vascular risk factors on white matter brain lesions in multiple sclerosis

Geraldes, R., Juryńczyk, M., Dos Passos, G., Prichler, A., Chung, K., Hagens, M., Ruggieri, S., Huerga, E., Sastre-Garriga, J., Enzinger, C., Chard, D. T., Barkhof, F., Gasperini, C., Rovira, A., Deluca, G. C. & Palace, J., 1 Jan 2020, In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

Chataway, J., De Angelis, F., Connick, P., Parker, R. A., Plantone, D., Doshi, A., John, N., Stutters, J., MacManus, D., Prados Carrasco, F., Barkhof, F., Ourselin, S., Braisher, M., Ross, M., Cranswick, G., Pavitt, S. H., Giovannoni, G., Gandini Wheeler-Kingshott, C. A., Hawkins, C., Sharrack, B. & 5 others, Bastow, R., Weir, C. J., Stallard, N., Chandran, S. & MS-SMART Investigators, 1 Mar 2020, In : The Lancet Neurology. 19, 3, p. 214-225 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods

de Sitter, A., Visser, M., Brouwer, I., Cover, K. S., van Schijndel, R. A., Eijgelaar, R. S., Müller, D. M. J., Ropele, S., Kappos, L., Rovira, Filippi, M., Enzinger, C., Frederiksen, J., Ciccarelli, O., Guttmann, C. R. G., Wattjes, M. P., Witte, M. G., de Witt Hamer, P. C., Barkhof, F., Vrenken, H. & 2 others, MAGNIMS Study Group & Alzheimer’s Disease Neuroimaging Initiative, Feb 2020, In : European Radiology. 30, 2, p. 1062-1074 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy

Prados, F., Moccia, M., Johnson, A., Yiannakas, M., Grussu, F., Cardoso, M. J., Ciccarelli, O., Ourselin, S., Barkhof, F. & Wheeler-Kingshott, C., 2020, In : NeuroImage. 209, 116489.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Coleman, J. R. I., Peyrot, W. J., Purves, K. L., Davis, K. A. S., Rayner, C., Choi, S. W., Hübel, C., Gaspar, H. A., Kan, C., Van der Auwera, S., Adams, M. J., Lyall, D. M., Choi, K. W., Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J. & 206 others, Agerbo, E., Air, T. M., Andlauer, T. F. M., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. T. F., Bigdeli, T. B., Binder, E. B., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. R. I., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., Direk, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Escott-Price, V., Kiadeh, F. F. H., Finucane, H. K., Foo, J. C., Forstner, A. J., Frank, J., Gaspar, H. A., Gill, M., Goes, F. S., Gordon, S. D., Grove, J., Hall, L. S., Hansen, C. S., Hansen, T. F., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J. J., Hougaard, D. M., Howard, D. M., Ising, M., Jansen, R., Jones, I., Jones, L. A., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Kutalik, Z., Li, Y., Lind, P. A., MacIntyre, D. J., MacKinnon, D. F., Maier, R. M., Maier, W., Marchini, J., Mbarek, H., McGrath, P., McGuffin, P., Medland, S. E., Mehta, D., Middeldorp, C. M., Mihailov, E., Milaneschi, Y., Milani, L., Mondimore, F. M., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M. G., Nyholt, D. R., O’Reilly, P. F., Oskarsson, H., Owen, M. J., Painter, J. N., Pedersen, C. B., Pedersen, M. G., Peterson, R. E., Pettersson, E., Peyrot, W. J., Pistis, G., Posthuma, D., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Rivera, M., Mirza, S. S., Schoevers, R., Schulte, E. C., Shen, L., Shi, J., Shyn, S. I., Sigurdsson, E., Sinnamon, G. C. B., Smit, J. H., Smith, D. J., Stefansson, H., Steinberg, S., Streit, F., Strohmaier, J., Tansey, K. E., Teismann, H., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A. G., Umbricht, D., Van der Auwera, S., van Hemert, A. M., Viktorin, A., Visscher, P. M., Wang, Y., Webb, B. T., Weinsheimer, S. M., Wellmann, J., Willemsen, G., Witt, S. H., Wu, Y., Xi, H. S., Yang, J., Zhang, F., Arolt, V., Baune, B. T., Berger, K., Boomsma, D. I., Cichon, S., Dannlowski, U., de Geus, E. J. C., DePaulo, J. R., Domenici, E., Domschke, K., Esko, T., Grabe, H. J., Hamilton, S. P., Hayward, C., Heath, A. C., Kendler, K. S., Kloiber, S., Lewis, G., Li, Q. S., Lucae, S., Madden, P. A. F., Magnusson, P. K., Martin, N. G., McIntosh, A. M., Metspalu, A., Mors, O., Mortensen, P. B., Müller-Myhsok, B., Nordentoft, M., Nöthen, M. M., O’Donovan, M. C., Paciga, S. A., Pedersen, N. L., Penninx, B. W. J. H., Perlis, R. H., Porteous, D. J., Potash, J. B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T. G., Smoller, J. W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M. M., Werge, T., Lewis, C. M., Levinson, D. F., Breen, G., Børglum, A. D., Sullivan, P. F., Dunn, E. C., Vassos, E., Danese, A., Maughan, B., Grabe, H. J., Lewis, C. M., O’Reilly, P. F., McIntosh, A. M., Smith, D. J., Wray, N. R., Hotopf, M., Eley, T. C., Breen, G. & on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 23 Jan 2020, In : Molecular Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Methylphenidate and galantamine in patients with vascular cognitive impairment-the proof-of-principle study STREAM-VCI

Leijenaar, J. F., Groeneveld, G. J., Klaassen, E. S., Leeuwis, A. E., Scheltens, P., Weinstein, H. C., van Gerven, J. M. A., Barkhof, F., van der Flier, W. M. & Prins, N. D., 2020, In : Alzheimer's Research & Therapy. 12, 1, p. 10 10.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

No evidence for cell-to-cell transmission of the unfolded protein response in cell culture

van Ziel, A. M., Wolzak, K., Nölle, A., Hoetjes, P. J., Berenjeno-Correa, E., van Anken, E., Struys, E. A. & Scheper, W., Jan 2020, In : Journal of Neurochemistry. 152, 2, p. 208-220 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NOX2 Expression Is Increased in Keratinocytes after Burn Injury

Korkmaz, H. I., Ulrich, M. M. W., Çelik, G., Van Wieringen, W. N., Van Zuijlen, P. P. M., Krijnen, P. A. J. & Niessen, H. W. M., 19 Feb 2020, In : Journal of Burn Care and Research. 41, 2, p. 427-432 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ongoing microstructural changes in the cervical cord underpin disability progression in early primary progressive multiple sclerosis

Cortese, R., Tur, C., Prados, F., Schneider, T., Kanber, B., Moccia, M., Wheeler-Kingshott, C. A. M. G., Thompson, A. J., Barkhof, F. & Ciccarelli, O., 2020, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Packaging RNA drugs into extracellular vesicles

van Eijndhoven, M. A. J., Baglio, S. R. & Pegtel, D. M., Jan 2020, In : Annals of Biomedical Engineering. 4, 1, p. 6-8 3 p.

Research output: Contribution to journalArticleAcademic

Open Access

Real-time imaging of multivesicular body-plasma membrane fusion to quantify exosome release from single cells

Bebelman, M. P., Bun, P., Huveneers, S., van Niel, G., Pegtel, D. M. & Verweij, F. J., Jan 2020, In : Nature Protocols. 15, 1, p. 102-121 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy

Rhodius-Meester, H. F. M., van Maurik, I. S., Koikkalainen, J., Tolonen, A., Frederiksen, K. S., Hasselbalch, S. G., Soininen, H., Herukka, S-K., Remes, A. M., Teunissen, C. E., Barkhof, F., Pijnenburg, Y. A. L., Scheltens, P., Lötjönen, J. & van der Flier, W. M., 2020, In : PLoS ONE. 15, 1, p. e0226784 e0226784.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Synaptotagmin-1 and Doc2b Exhibit Distinct Membrane-Remodeling Mechanisms

Sorkin, R., Marchetti, M., Logtenberg, E., Piontek, M. C., Kerklingh, E., Brand, G., Voleti, R., Rizo, J., Roos, W. H., Groffen, A. J. & Wuite, G. J. L., 4 Feb 2020, In : Biophysical Journal. 118, 3, p. 643-656 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

The cardiovascular risk profile of middle-aged women with polycystic ovary syndrome

Meun, C., Gunning, M. N., Louwers, Y. V., Peters, H., Roos-Hesselink, J., Roeters van Lennep, J., Rueda Ochoa, O-L., Appelman, Y., Lambalk, N., Boersma, E., Kavousi, M., Fauser, B. C. JM., Laven, J. S. E. & on behalf of the CREW consortium, 1 Feb 2020, In : Clinical Endocrinology. 92, 2, p. 150-158 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The cardiovascular risk profile of middle age women previously diagnosed with premature ovarian insufficiency: A case-control study

Gunning, M. N., Meun, C., Van Rijn, B. B., Daan, N. M. P., Van Lennep, J. E. R., Appelman, Y., Boersma, E., Hofstra, L., Fauser, C. G. K. M., Rueda-Ochoa, O. L., Ikram, M. A., Kavousi, M., Lambalk, C. B., Eijkemans, M. J. C., Laven, J. S. E., Fauser, B. C. J. M. & on behalf of the CREW consortium, 1 Jan 2020, In : PLoS ONE. 15, 3, e0229576.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative

Simpson, H. B., van den Heuvel, O. A., Miguel, E. C., Reddy, Y. C. J., Stein, D. J., Lewis-Fernández, R., Shavitt, R. G., Lochner, C., Pouwels, P. J. W., Narayanawamy, J. C., Venkatasubramanian, G., Hezel, D. M., Vriend, C., Batistuzzo, M. C., Hoexter, M. Q., de Joode, N. T., Costa, D. L., de Mathis, M. A., Sheshachala, K., Narayan, M. & 15 others, van Balkom, A. J. L. M., Batelaan, N. M., Venkataram, S., Cherian, A., Marincowitz, C., Pannekoek, N., Stovezky, Y. R., Mare, K., Liu, F., Otaduy, M. C. G., Pastorello, B., Rao, R., Katechis, M., Van Meter, P. & Wall, M., 14 Feb 2020, In : BMC Psychiatry. 20, 1, p. 68 68.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Variants in NGLY1 lead to intellectual disability, myoclonus epilepsy, sensorimotor axonal polyneuropathy and mitochondrial dysfunction

Panneman, D. M., Wortmann, S. B., Haaxma, C. A., van Hasselt, P. M., Wolf, N. I., Hendriks, Y., Küsters, B., van Emst-de Vries, S., van de Westerlo, E., Koopman, W. J. H., Wintjes, L., van den Brandt, F., de Vries, M., Lefeber, D. J., Smeitink, J. A. M. & Rodenburg, R. J., 1 Apr 2020, In : Clinical Genetics. 97, 4, p. 556-566 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access
2019

A decrease in vitamin D levels is associated with methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

Oosterom, N., Dirks, N. F., Heil, S. G., de Jonge, R., Tissing, W. J. E., Pieters, R., van den Heuvel-Eibrink, M. M., Heijboer, A. C. & Pluijm, S. M. F., 1 Jan 2019, In : Supportive Care in Cancer. 27, 1, p. 183-190 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A global overview of pleiotropy and genetic architecture in complex traits

Watanabe, K., Stringer, S., Frei, O., Umićević Mirkov, M., de Leeuw, C., Polderman, T. J. C., van der Sluis, S., Andreassen, O. A., Neale, B. M. & Posthuma, D., 1 Sep 2019, In : Nature Genetics. 51, 9, p. 1339-1348 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Aminoacyl-tRNA synthetase deficiencies in search of common themes

Fuchs, S. A., Schene, I. F., Kok, G., Jansen, J. M., Nikkels, P. G. J., van Gassen, K. L. I., Terheggen-Lagro, S. W. J., van der Crabben, S. N., Hoeks, S. E., Niers, L. E. M., Wolf, N. I., de Vries, M. C., Koolen, D. A., Houwen, R. H. J., Mulder, M. F. & van Hasselt, P. M., 1 Feb 2019, In : Genetics in Medicine. 21, 2, p. 319-330

Research output: Contribution to journalArticleAcademicpeer-review

A multi-shell multi-tissue diffusion study of brain connectivity in early multiple sclerosis

Tur, C., Grussu, F., Prados, F., Charalambous, T., Collorone, S., Kanber, B., Cawley, N., Altmann, D. R., Ourselin, S. B., Barkhof, F., Clayden, J. D., Toosy, A. T., Wheeler-Kingshott, C. A. M. G. & Ciccarelli, O., 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

AMYPAD Diagnostic and Patient Management Study: Rationale and design

Frisoni, G. B., Barkhof, F., Altomare, D., Berkhof, J., Boccardi, M., Canzoneri, E., Collij, L., Drzezga, A., Farrar, G., Garibotto, V., Gismondi, R., Gispert, J-D., Jessen, F., Kivipelto, M., Lopes Alves, I., Molinuevo, J-L., Nordberg, A., Payoux, P., Ritchie, C., Savicheva, I. & 8 others, Scheltens, P., Schmidt, M. E., Schott, J., Stephens, A., van Berckel, B., Vellas, B., Walker, Z. & Raffa, N., 1 Mar 2019, In : Alzheimers & Dementia. 15, 3, p. 388-399 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernández, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleó, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., Mengel-From, J. & 37 others, Moreno-Grau, S., Wagner, M., Fortea, J., Keogh, M. J., Blennow, K., Skoog, I., Friese, M. A., Pletnikova, O., Zulaica, M., Lage, C., de Rojas, I., Riedel-Heller, S., Illán-Gala, I., Wei, W., Jeune, B., Hulsman, M., Beker, N., Tesi, N., Collij, L. E., van Berckel, B. N. M., Reinders, M. J. T., van Schoor, N. M., Lemstra, A. W., Pijnenburg, Y. A. L., Scheltens, P., Huisman, M. A., Heutink, P., Posthuma, D., van der Flier, W. M., Holstege, H., DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, 1 Aug 2019, In : Acta Neuropathologica. 138, 2, p. 237-250

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

APOE and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms

Charidimou, A., Zonneveld, H. I., Shams, S., Kantarci, K., Shoamanesh, A., Hilal, S., Yates, P. A., Boulouis, G., Na, H. K., Pasi, M., Biffi, A., Chai, Y. L., Chong, J. R., Wahlund, L-O., Clifford, J. R., Chen, C., Gurol, M. E., Goldstein, J. N., Na, D. L., Barkhof, F. & 4 others, Seo, S. W., Rosand, J., Greenberg, S. M. & Viswanathan, A., 23 Jul 2019, In : Neurology. 93, 4, p. e358-e371

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Apolipoprotein D: a potential biomarker for cerebral amyloid angiopathy

Kuiperij, H. B., Hondius, D. C., Kersten, I., Versleijen, A. A. M., Rozemuller, A. J. M., Greenberg, S. M., Schreuder, F. H. B. M., Klijn, C. J. M. & Verbeek, M. M., 1 Jan 2019, In : Neuropathology and Applied Neurobiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms

Arias-Vásquez, A., Groffen, A. J., Spijker, S., Ouwens, K. G., Klein, M., Vojinovic, D., Galesloot, T. E., Bralten, J., Hottenga, J. J., van der Most, P. J., Kattenberg, V. M., Pool, R., Nolte, I. M., Penninx, B. W. J. H., Fedko, I. O., Dolan, C. V., Nivard, M. G., den Braber, A., van Duijn, C. M., Hoekstra, P. J. & 16 others, Buitelaar, J. K., Kiemeney, L. A., Hoogman, M., Middeldorp, C. M., Draisma, H. H. M., Vermeulen, S. H., Sánchez-Mora, C., Ramos-Quiroga, J. A., Ribasés, M., Hartman, C. A., Kooij, J. J. S., Amin, N., Smit, A. B., Franke, B., Boomsma, D. I. & The EAGLE-ADHD Consortium, 15 May 2019, In : Behavior Genetics. 49, 3, p. 270-285 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis

Eshaghi, A., Kievit, R. A., Prados, F., Sudre, C. H., Nicholas, J., Cardoso, M. J., Chan, D., Nicholas, R., Ourselin, S., Greenwood, J., Thompson, A. J., Alexander, D. C., Barkhof, F., Chataway, J. & Ciccarelli, O., 28 May 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 11020-11027 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Applying the ATN scheme in a memory clinic population: The ABIDE project

Altomare, D., de Wilde, A., Ossenkoppele, R., Pelkmans, W., Bouwman, F., Groot, C., van Maurik, I., Zwan, M., Yaqub, M., Barkhof, F., van Berckel, B. N., Teunissen, C. E., Frisoni, G. B., Scheltens, P. & van der Flier, W. M., 22 Oct 2019, In : Neurology. 93, 17, p. e1635-e1646

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Meijer, M., Rehbach, K., Brunner, J. W., Classen, J. A., Lammertse, H. C. A., van Linge, L. A., Schut, D., Krutenko, T., Hebisch, M., Cornelisse, L. N., Sullivan, P. F., Peitz, M., Toonen, R. F., Brüstle, O. & Verhage, M., 14 May 2019, In : Cell Reports. 27, 7, p. 2199-2211.e6

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association between tumor location and neurocognitive functioning using tumor localization maps

Habets, E. J. J., Hendriks, E. J., Taphoorn, M. J. B., Douw, L., Zwinderman, A. H., Vandertop, W. P., Barkhof, F., de Witt Hamer, P. C. & Klein, M., 1 Sep 2019, In : Journal of Neuro-Oncology. 144, 3, p. 573-582

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Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for Major Depressive Disorder and white matter microstructure in the UK Biobank

Barbu, M. C., Zeng, Y., Shen, X., Cox, S. R., Clarke, T. K., Gibson, J., Adams, M. J., Johnstone, M., Haley, C. S., Lawrie, S. M., Deary, I. J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research team, 1 Jan 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

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Associations of autozygosity with a broad range of human phenotypes

Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., Bartz, T. M. & 416 others, Baumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J-F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M-L., Chen, G., Chen, Y-D. I., Chen, Z., Chiu, Y-F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y-J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K-T., Khor, C. C., de Kleijn, D. P. V., Koh, W-P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I. T., Lee, W-J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G. S., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P-E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H. H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y-C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J-M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C-Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C-K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., de Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O’connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E. S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D-A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T-Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T. N., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 1 Dec 2019, In : Nature Communications. 10, 1, 4957.

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Astrocyte Subtype Vulnerability in Stem Cell Models of Vanishing White Matter

Leferink, P. S., Dooves, S., Hillen, A. E. J., Watanabe, K., Jacobs, G., Gasparotto, L., Cornelissen-Steijger, P., van der Knaap, M. S. & Heine, V. M., 1 Nov 2019, In : Annals of Neurology. 86, 5, p. 780-792 13 p.

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Astrocytic ceramide as possible indicator of neuroinflammation

de Wit, N. M., den Hoedt, S., Martinez-Martinez, P., Rozemuller, A. J., Mulder, M. T. & de Vries, H. E., 25 Feb 2019, In : Journal of Neuroinflammation. 16, 1, 48.

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A two-gene methylation signature for the diagnosis of bladder cancer in urine

Bosschieter, J., Nieuwenhuijzen, J. A., Hentschel, A., van Splunter, A. P., Segerink, L. I., Vis, A. N., Wilting, S. M., Lissenberg-Witte, B. I., A van Moorselaar, R. J. & Steenbergen, R. D., Feb 2019, In : Epigenomics. 11, 3, p. 337-347 11 p.

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Automated fiber tract reconstruction for surgery planning: Extensive validation in language-related white matter tracts

Mancini, M., Vos, S. B., Vakharia, V. N., O'Keeffe, A. G., Trimmel, K., Barkhof, F., Dorfer, C., Soman, S., Winston, G. P., Wu, C., Duncan, J. S., Sparks, R. & Ourselin, S., 1 Jan 2019, In : NeuroImage: Clinical. 23, 101883.

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Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy

Friedman, J., Smith, D. E., Issa, M. Y., Stanley, V., Wang, R., Mendes, M. I., Wright, M. S., Wigby, K., Hildreth, A., Crawford, J. R., Koehler, A. E., Chowdhury, S., Nahas, S., Zhai, L., Xu, Z., Lo, W-S., James, K. N., Musaev, D., Accogli, A., Guerrero, K. & 9 others, Tran, L. T., Omar, T. E. I., Ben-Omran, T., Dimmock, D., Kingsmore, S. F., Salomons, G. S., Zaki, M. S., Bernard, G. & Gleeson, J. G., 1 Dec 2019, In : Nature Communications. 10, 1, 707.

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