Amsterdam Neuroscience - Complex Trait Genetics

Research Output 2000 2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Lifelines Cohort Study & V. A. Million Veteran Program, 1 Jun 2019, In : Nature Genetics. 51, 6, p. 957-972

Research output: Contribution to journalArticleAcademicpeer-review

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

BIOS Consortium, 1 Jan 2019, In : European Journal of Human Genetics.

Research output: Contribution to journalArticleAcademicpeer-review

A comprehensive diagnostic approach to detect underlying causes of obesity in adults

van der Valk, E. S., van den Akker, E. L. T., Savas, M., Kleinendorst, L., Visser, J. A., van Haelst, M. M., Sharma, A. M. & van Rossum, E. F. C., 2019, In : Obesity Reviews. 20, 6, p. 795-804

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Addition of a 161-SNP polygenic risk score to family history-based risk prediction: Impact on clinical management in non- BRCA1/2 breast cancer families

Lakeman, I. M. M., Hilbers, F. S., Rodríguez-Girondo, M., Lee, A., Vreeswijk, M. P. G., Hollestelle, A., Seynaeve, C., Meijers-Heijboer, H., Oosterwijk, J. C., Hoogerbrugge, N., Olah, E., Vasen, H. F. A., van Asperen, C. J. & Devilee, P., 2019, In : Journal of Medical Genetics.

Research output: Contribution to journalArticleAcademicpeer-review

A global overview of pleiotropy and genetic architecture in complex traits

Watanabe, K., Stringer, S., Frei, O., Umićević Mirkov, M., de Leeuw, C., Polderman, T. J. C., van der Sluis, S., Andreassen, O. A., Neale, B. M. & Posthuma, D., 2019, In : Nature Genetics.

Research output: Contribution to journalArticleAcademicpeer-review

A linear mixed-model approach to study multivariate gene–environment interactions

BIOS Consortium, 2019, In : Nature Genetics. 51, 1, p. 180-186 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppälä, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N. & 64 othersBecker, E. J., Beekman, M., Blanché, H. L., Christensen, K., Christiansen, L., Collerton, J. C., Cubaynes, S., Cummings, S. R., Davies, K., Debrabant, B., Deleuze, J-F., Duncan, R., Faul, J. D., Franceschi, C., Galan, P., Gudnason, V., Harris, T. B., Huisman, M., Hurme, M. A., Jagger, C., Jansen, I., Jylhä, M., Kähönen, M., Karasik, D., Kardia, S. L. R., Kingston, A., Kirkwood, T. B. L., Launer, L. J., Lehtimäki, T., Lieb, W., Lyytikäinen, L-P., Martin-Ruiz, C., Min, J., Nebel, A., Newman, A. B., Nie, C., Nohr, E. A., Orwoll, E. S., Perls, T. T., Province, M. A., Psaty, B. M., Raitakari, O. T., Reinders, M. J. T., Robine, J-M., Rotter, J. I., Sebastiani, P., Smith, J., Sørensen, T. I. A., Taylor, K. D., Uitterlinden, A. G., van der Flier, W., van der Lee, S. J., van Duijn, C. M., van Heemst, D., Vaupel, J. W., Weir, D., Ye, K., Zeng, Y., Zheng, W., Holstege, H., Kiel, D. P., Lunetta, K. L., Slagboom, P. E. & Murabito, J. M., 2019, In : Nature Communications. 10, 1, 3669.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A methylation study of long-term depression risk

Clark, S. L., Hattab, M. W., Chan, R. F., Shabalin, A. A., Han, L. K. M., Zhao, M., Smit, J. H., Jansen, R., Milaneschi, Y., Xie, L. Y., van Grootheest, G., Penninx, B. W. J. H., Aberg, K. A. & van den Oord, E. J. C. G., 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernández, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleó, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., Mengel-From, J. & 37 othersMoreno-Grau, S., Wagner, M., Fortea, J., Keogh, M. J., Blennow, K., Skoog, I., Friese, M. A., Pletnikova, O., Zulaica, M., Lage, C., de Rojas, I., Riedel-Heller, S., Illán-Gala, I., Wei, W., Jeune, B., Hulsman, M., Beker, N., Tesi, N., Collij, L. E., van Berckel, B. N. M., Reinders, M. J. T., van Schoor, N. M., Lemstra, A. W., Pijnenburg, Y. A. L., Scheltens, P., Huisman, M. A., Heutink, P., Posthuma, D., van der Flier, W. M., Holstege, H., DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, 1 Aug 2019, In : Acta Neuropathologica. 138, 2, p. 237-250

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A role for vitamin D and omega-3 fatty acids in major depression? An exploration using genomics

Milaneschi, Y., Peyrot, W. J., Nivard, M. G., Mbarek, H., Boomsma, D. I. & W.J.H. Penninx, B., 1 Dec 2019, In : Translational Psychiatry. 9, 1, 219.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Meijer, M., Rehbach, K., Brunner, J. W., Classen, J. A., Lammertse, H. C. A., van Linge, L. A., Schut, D., Krutenko, T., Hebisch, M., Cornelisse, L. N., Sullivan, P. F., Peitz, M., Toonen, R. F., Brüstle, O. & Verhage, M., 2019, In : Cell Reports. 27, 7, p. 2199-2211.e6

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association of Genetic Liability to Psychotic Experiences with Neuropsychotic Disorders and Traits

Legge, S. E., Jones, H. J., Kendall, K. M., Pardiñas, A. F., Menzies, G., Bracher-Smith, M., Escott-Price, V., Rees, E., Davis, K. A. S., Hotopf, M., Savage, J. E., Posthuma, D., Holmans, P., Kirov, G., Owen, M. J., O'Donovan, M. C., Zammit, S. & Walters, J. T. R., 1 Jan 2019, In : JAMA Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Barbu, M. C., Zeng, Y., Shen, X., Cox, S. R., Clarke, T. K., Gibson, J., Adams, M. J., Johnstone, M., Haley, C. S., Lawrie, S. M., Deary, I. J., Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M. & 51 othersAndlauer, T. F. M., Bacanu, S. A., Bækvad-Hansen, M., Bigdeli, T. B., Beekman, A. T. F., Binder, E. B., Blackwood, D. H. R., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. R. I., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Davies, G., Deary, I. J., Degenhardt, F., Jansen, R., Middeldorp, C. M., Milaneschi, Y., Peyrot, W. J., Posthuma, D., Smit, J. H., de Geus, E. J. C., Penninx, B. W. J. H., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 23andMe Research team, Perlis, R. H., Porteous, D. J., Potash, J. B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T. G., Smoller, J. W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M. M., Werge, T., Lewis, C. M., Levinson, D. F., Breen, G., Børglum, A. D. & Sullivan, P. F., 1 Jan 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Associations of autozygosity with a broad range of human phenotypes

Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., Bartz, T. M. & 416 othersBaumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J-F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M-L., Chen, G., Chen, Y-D. I., Chen, Z., Chiu, Y-F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y-J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K-T., Khor, C. C., de Kleijn, D. P. V., Koh, W-P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I. T., Lee, W-J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G. S., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P-E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H. H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y-C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J-M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C-Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C-K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., de Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O’connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E. S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D-A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T-Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T. N., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 2019, In : Nature Communications. 10, 1, 4957.

Research output: Contribution to journalArticleAcademicpeer-review

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Liu, M., Jiang, Y., Wedow, R., Li, Y., Brazel, D. M., Chen, F., Datta, G., Davila-Velderrain, J., McGuire, D., Tian, C., Zhan, X., Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P., Furlotte, N. A., Hinds, D. A. & 35 othersHromatka, B. S., Huber, K. E., Kleinman, A., Litterman, N. K., McIntyre, M. H., Mountain, J. L., Northover, C. A. M., Sathirapongsasuti, J. F., Sazonova, O. V., Shelton, J. F., Shringarpure, S., Tian, C., Tung, J. Y., Vacic, V., Wilson, C. H., Pitts, S. J., Mitchell, A., Skogholt, A. H., Winsvold, B. S., Sivertsen, B. R., Stordal, E., Morken, G., Kallestad, H. V., Heuch, I., Zwart, J-A., Fjukstad, K. K., Pedersen, L. M., Gabrielsen, M. E., Jansen, P. R., Posthuma, D., 23andMe Research team, Jorgenson, E., Stitzel, J. A., Liu, D. J. & Vrieze, S., 2019, In : Nature Genetics.

Research output: Contribution to journalArticleAcademicpeer-review

Astrocyte Subtype Vulnerability in Stem Cell Models of Vanishing White Matter

Leferink, P. S., Dooves, S., Hillen, A. E. J., Watanabe, K., Jacobs, G., Gasparotto, L., Cornelissen-Steijger, P., van der Knaap, M. S. & Heine, V. M., 1 Nov 2019, In : Annals of Neurology. 86

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Astrocytic ceramide as possible indicator of neuroinflammation 11 Medical and Health Sciences 1109 Neurosciences

de Wit, N. M., den Hoedt, S., Martinez-Martinez, P., Rozemuller, A. J., Mulder, M. T. & de Vries, H. E., 2019, In : Journal of Neuroinflammation. 16, 1, 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Astroglia in leukodystrophies

Jorge, M. S. & Bugiani, M., 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 1175. p. 199-225 (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability (Nature Neuroscience, (2018), 21, 9, (1161-1170), 10.1038/s41593-018-0206-1)

the 23andMe Research Team, The Substance Use Disorders Working Group of the Psychiatric Genomics Consortium & International Cannabis Consortium, 1 Jul 2019, In : Nature Neuroscience. 22, 7, p. 1196

Research output: Contribution to journalErratumAcademicpeer-review

Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy

van der Knaap, M. S., Bugiani, M., Mendes, M. I., Riley, L. G., Smith, D. E. C., Rudinger-Thirion, J., Frugier, M., Breur, M., Crawford, J., van Gaalen, J., Schouten, M., Willems, M., Waisfisz, Q., Mau-Them, F. T., Rodenburg, R. J., Taft, R. J., Keren, B., Christodoulou, J., Depienne, C., Simons, C. & 2 othersSalomons, G. S. & Mochel, F., 12 Mar 2019, In : Neurology. 92, 11, p. E1225-E1237

Research output: Contribution to journalArticleAcademicpeer-review

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

Coleman, J. R. I., Bryois, J., Gaspar, H. L. A., Jansen, P. R., Savage, J. E., Skene, N., Plomin, R., Muñoz-Manchado, A. B., Linnarsson, S., Crawford, G., Hjerling-Leffler, J., Sullivan, P. F., Posthuma, D. & Breen, G., 1 Feb 2019, In : Molecular Psychiatry. 24, 2, p. 182-197 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cell Replacement Therapy Improves Pathological Hallmarks in a Mouse Model of Leukodystrophy Vanishing White Matter

Dooves, S., Leferink, P. S., Krabbenborg, S., Breeuwsma, N., Bots, S., Hillen, A. E. J., Jacobs, G., van der Knaap, M. S. & Heine, V. M., 2019, In : Stem Cell Reports. 12, 3, p. 441-450

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Characterization of brainstem TDP-43 distribution in FTD cases with ALS features

Scarioni, M., Gami-Patel, P., Timar, Y. S., Rozemuller, A. J., Hoozemans, J. J., Aronica, E., Raaphorst, J., Pijnenburg, Y. A. & Dijkstra, A. A., Jul 2019, In : European Journal of Neurology. 26, p. 436-436

Research output: Contribution to journalMeeting AbstractAcademic

Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

Glanville, K. P., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Coleman, J. R. I., Hanscombe, K. B., Euesden, J., Choi, S. W., Purves, K. L., Breen, G., Air, T. M., Andlauer, T. F. M., Baune, B. T., Binder, E. B., Blackwood, D. H. R., Boomsma, D. I., Buttenschøn, H. N., Colodro-Conde, L., Dannlowski, U., Direk, N., Dunn, E. C., Forstner, A. J. & 33 othersde Geus, E. J. C., Grabe, H. J., Hamilton, S. P., Jones, I., Jones, L. A., Knowles, J. A., Kutalik, Z., Levinson, D. F., Lewis, G., Lind, P. A., Lucae, S., Magnusson, P. K., McGuffin, P., McIntosh, A. M., Milaneschi, Y., Mors, O., Mostafavi, S., Müller-Myhsok, B., Pedersen, N. L., Penninx, B. W. J. H., Potash, J. B., Preisig, M., Ripke, S., Beekman, A. T. F., Jansen, R., Middeldorp, C. M., Peyrot, W. J., Posthuma, D., Schoevers, R., Smit, J. H., de Geus, E. J. C., Weissman, M. M. & O'Reilly, P. F., 1 Jan 2019, In : Biological Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical, neuroradiological, and biochemical features of SLC35A2-CDG patients

EPGEN Study, 1 May 2019, In : Journal of Inherited Metabolic Disease. 42, 3, p. 553-564

Research output: Contribution to journalArticleAcademicpeer-review

Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population

Alemany, S., Jansen, P. R., Muetzel, R. L., Marques, N., el Marroun, H., Jaddoe, V. W. V., Polderman, T. J. C., Tiemeier, H., Posthuma, D. & White, T., 2019, In : Journal of the American Academy of Child and Adolescent Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia (Molecular Psychiatry, (2018), 10.1038/s41380-018-0118-1)

16p11.2 European Consortium, for the ENIGMA-CNV working group, 2019, In : Molecular Psychiatry.

Research output: Contribution to journalErratumAcademicpeer-review

Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence (Molecular Psychiatry, (2019), 10.1038/s41380-018-0332-x)

Smeland, O. B., Bahrami, S., Frei, O., Shadrin, A., O’Connell, K., Savage, J., Watanabe, K., Krull, F., Bettella, F., Steen, N. E., Ueland, T., Posthuma, D., Djurovic, S., Dale, A. M. & Andreassen, O. A., 2019, In : Molecular Psychiatry.

Research output: Contribution to journalErratumAcademicpeer-review

Open Access

Dementia with Lewy Bodies: A Clinicopathologic Series of False-positive Cases

Netherlands Brain Bank, 1 Jan 2019, In : Alzheimer Disease and Associated Disorders.

Research output: Contribution to journalArticleAcademicpeer-review

De novo and inherited loss-of-function variants of ATP2B2 are associated with rapidly progressive hearing impairment

DOOFNL Consortium, 11 Jan 2019, In : Human Genetics. 138, 1, p. 61-72 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies

Fathy, Y. Y., Jonker, A. J., Oudejans, E., de Jong, F. J. J., van Dam, A. M. W., Rozemuller, A. J. M. & van de Berg, W. D. J., 1 Apr 2019, In : Neuropathology and Applied Neurobiology. 45, 3, p. 262-277 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Direct-to-consumer carrier screening for cystic fibrosis via a hospital website: a 6-year evaluation

Holtkamp, K. C. A., Henneman, L., Gille, J. J. P., Meijers-Heijboer, H., Cornel, M. C. & Lakeman, P., 4 Apr 2019, In : Journal of Community Genetics. 10, 2, p. 249-257

Research output: Contribution to journalArticleAcademicpeer-review

Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease

Broce, I. J., Tan, C. H., Fan, C. C., Jansen, I., Savage, J. E., Witoelar, A., Wen, N., Hess, C. P., Dillon, W. P., Glastonbury, C. M., Glymour, M., Yokoyama, J. S., Elahi, F. M., Rabinovici, G. D., Miller, B. L., Mormino, E. C., Sperling, R. A., Bennett, D. A., McEvoy, L. K., Brewer, J. B. & 14 othersFeldman, H. H., Hyman, B. T., Pericak-Vance, M., Haines, J. L., Farrer, L. A., Mayeux, R., Schellenberg, G. D., Yaffe, K., Sugrue, L. P., Dale, A. M., Posthuma, D., Andreassen, O. A., Karch, C. M. & Desikan, R. S., 11 Feb 2019, In : Acta Neuropathologica. 137, 2, p. 209-226 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Doc2b Ca2+ binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength

Bourgeois-Jaarsma, Q., Verhage, M. & Groffen, A. J., 2019, In : Scientific Reports. 9, 1, p. 14408

Research output: Contribution to journalArticleAcademicpeer-review

Een meisje met het 16p11.2-deletiesyndroom

Kleinendorst, L., Sno, M. & van Haelst, M. M., 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 14, D3441.

Research output: Contribution to journalArticleProfessional

Een meisje met het 16p11.2-deletiesyndroom

Kleinendorst, L., Sno, M. & van Haelst, M. M., 1 Jan 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 14, D3441.

Research output: Contribution to journalArticleProfessional

EIF2AK3 variants in Dutch patients with Alzheimer's disease

Wong, T. H., van der Lee, S. J., van Rooij, J. G. J., Meeter, L. H. H., Frick, P., Melhem, S., Seelaar, H., Ikram, M. A., Rozemuller, A. J., Holstege, H., Hulsman, M., Uitterlinden, A., Neumann, M., Hoozemans, J. J. M., van Duijn, C. M., Rademakers, R. & van Swieten, J. C., 1 Jan 2019, In : Neurobiology of Aging. 73, p. 229.e11-229.e18

Research output: Contribution to journalArticleAcademicpeer-review

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Brazel, D. M., Jiang, Y., Hughey, J. M., Turcot, V., Zhan, X., Gong, J., Batini, C., Weissenkampen, J. D., Liu, M., Surendran, P., Young, R., Barnes, D. R., Nielsen, S. F., Rasheed, A., Samuel, M., Zhao, W., Kontto, J., Perola, M., Caslake, M., de Craen, A. J. M. & 39 othersTrompet, S., Uria-Nickelsen, M., Malarstig, A., Reily, D. F., Hoek, M., Vogt, T., Jukema, J. W., Sattar, N., Ford, I., Packard, C. J., Alam, D. S., Majumder, A. A. S., di Angelantonio, E., Chowdhury, R., Amouyel, P., Arveiler, D., Blankenberg, S., Ferrières, J., Kee, F., Kuulasmaa, K., Müller-Nurasyid, M., Veronesi, G., Virtamo, J., EPIC-CVD Consortium, Frossard, P., Nordestgaard, B. R. G., Saleheen, D., Danesh, J., Hammerschlag, A. R., Posthuma, D., Spector, T., Stram, D. O., Tobin, M. D., Weir, D. R., Kaprio, J., Abecasis, G. R., Liu, D. J., Vrieze, S. & CHD Exome+ Consortium, 2019, In : Biological Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Extensive Phenotyping for Potential Weight-Inducing Factors in an Outpatient Population with Obesity

Savas, M., Wester, V. L., Visser, J. A., Kleinendorst, L., van der Zwaag, B., van Haelst, M. M., van den Akker, E. L. T. & van Rossum, E. F. C., 2019, In : Obesity Facts. p. 369-384

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fbxo41 Promotes Disassembly of Neuronal Primary Cilia

King, C. R., A. A. Quadros, A. R., Chazeau, A., Saarloos, I., van der Graaf, A. J., Verhage, M. & Toonen, R. F., 2019, In : Scientific Reports. 9, 1, 8179.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fetal fraction evaluation in non-invasive prenatal screening (NIPS)

Hestand, M. S., Bessem, M., van Rijn, P., de Menezes, R. X., Sie, D., Bakker, I., Boon, E. M. J., Sistermans, E. A. & Weiss, M. M., 1 Feb 2019, In : European Journal of Human Genetics. 27, 2, p. 198-202 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fetal methotrexate syndrome: A systematic review of case reports

Verberne, E. A., de Haan, E., van Tintelen, J. P., Lindhout, D. & van Haelst, M. M., 1 Aug 2019, In : Reproductive Toxicology. 87, p. 125-139

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Gastrointestinal Dysmotility in MNGIE: From thymidine phosphorylase enzyme deficiency to altered interstitial cells of Cajal

Yadak, R., Breur, M. & Bugiani, M., 2019, In : Orphanet Journal of Rare Diseases. 14, 1, 33.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Huckins, L. M., Dobbyn, A., Ruderfer, D. M., Hoffman, G., Wang, W., Pardiñas, A. F., Rajagopal, V. M., Als, T. D., t. Nguyen, H., Girdhar, K., Boocock, J., Roussos, P., Fromer, M., Kramer, R., Domenici, E., Gamazon, E. R., Purcell, S., CommonMind Consortium, The Schizophrenia Working Group of the PsyUniversity of Copenhagenchiatric Genomics Consortium, iPSYCH-GEMS Schizophrenia Working Group & 12 othersDemontis, D., Børglum, A. D., Walters, J. T. R., C. O’Donovan, M., Sullivan, P., Owen, M. J., Devlin, B., Sieberts, S. K., Cox, N. J., Im, H. K., Sklar, P. & Stahl, E. A., 2019, In : Nature Genetics.

Research output: Contribution to journalArticleAcademicpeer-review