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2020

A 30-Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Chung, K. K., Altmann, D., Barkhof, F., Miszkiel, K., Brex, P. A., O'Riordan, J., Ebner, M., Prados, F., Cardoso, M. J., Vercauteren, T., Ourselin, S., Thompson, A., Ciccarelli, O. & Chard, D. T., Jan 2020, In : Annals of Neurology. 87, 1, p. 63-74 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

Oudega, M. L., Siddiqui, A., Wattjes, M. P., Barkhof, F., Kate, M. T., Muller, M., Bouckaert, F., Vandenbulcke, M., De Winter, F. L., Sienaert, P., Stek, M. L., Comijs, H. C., Korten, N. C. M., Emsell, L., Eikelenboom, P., Rhebergen, D., van Exel, E. & Dols, A., 1 Jan 2020, In : Journal of Geriatric Psychiatry and Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

A tumefactive demyelinating lesion in a person with MS after five years of fingolimod

Jeung, L., Smits, L. M. G., Hoogervorst, E. L. J., van Oosten, B. W. & Frequin, S. T. F. M., 1 May 2020, In : Multiple Sclerosis and Related Disorders. 40, 101978.

Research output: Contribution to journalArticleAcademicpeer-review

CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease

Faura, J., Bustamante, A., Penalba, A., Giralt, D., Simats, A., Martínez-Sáez, E., Alcolea, D., Fortea, J., Lleó, A., Teunissen, C. E., Van Der Flier, W. M., Ibañez, L., Harari, O., Cruchaga, C., Hernández-Guillamón, M., Delgado, P. & Montaner, J., 1 Jan 2020, In : Journal of Alzheimer's Disease. 73, 4, p. 1585-1595 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comorbid amyloid-β pathology affects clinical and imaging features in VCD

Leijenaar, J. F., Groot, C., Sudre, C. H., Bergeron, D., Leeuwis, A. E., Cardoso, M. J., Carrasco, F. P., Laforce, R., Barkhof, F., van der Flier, W. M., Scheltens, P., Prins, N. D. & Ossenkoppele, R., 1 Feb 2020, In : Alzheimers & Dementia. 16, 2, p. 354-364 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparison of Associations with Different Macular Inner Retinal Thickness Parameters in a Large Cohort: The UK Biobank

Khawaja, A. P., Chua, S., Hysi, P. G., Georgoulas, S., Currant, H., Fitzgerald, T. W., Birney, E., Ko, F., Yang, Q., Reisman, C., Garway-Heath, D. F., Hammond, C. J., Khaw, P. T., Foster, P. J., Patel, P. J., Strouthidis, N. & UK Biobank Eye and Vision Consortium, 1 Jan 2020, In : Ophthalmology. 127, 1, p. 62-71 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

CSF cutoffs for MCI due to AD depend on APOEε4 carrier status

Marizzoni, M., Ferrari, C., Babiloni, C., Albani, D., Barkhof, F., Cavaliere, L., Didic, M., Forloni, G., Fusco, F., Galluzzi, S., Hensch, T., Jovicich, J., Marra, C., Molinuevo, J. L., Nobili, F., Parnetti, L., Payoux, P., Ranjeva, J. P., Ribaldi, F., Rolandi, E. & 10 others, Rossini, P. M., Salvatore, M., Soricelli, A., Tsolaki, M., Visser, P. J., Wiltfang, J., Richardson, J. C., Bordet, R., Blin, O. & Frisoni, G. B., 1 Jan 2020, In : Neurobiology of Aging. 89, 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls

Oosterveld, L. P., Verberk, I. M. W., Majbour, N. K., El-Agnaf, O. M., Weinstein, H. C., Berendse, H. W., Teunissen, C. E. & van de Berg, W. D. J., Feb 2020, In : Movement Disorders. 35, 2, p. 288-295 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Distinct influence of different vascular risk factors on white matter brain lesions in multiple sclerosis

Geraldes, R., Juryńczyk, M., Dos Passos, G., Prichler, A., Chung, K., Hagens, M., Ruggieri, S., Huerga, E., Sastre-Garriga, J., Enzinger, C., Chard, D. T., Barkhof, F., Gasperini, C., Rovira, A., Deluca, G. C. & Palace, J., 1 Jan 2020, In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Diurnal Cortisol Secretion Is Not Related to Multiple Sclerosis-Related Fatigue

Malekzadeh, A., Bader, I., van Dieteren, J., Heijboer, A. C., Beckerman, H., Twisk, J. W. R., de Groot, V., Teunissen, C. E. & TREFAMS-ACE Study Group, 28 Jan 2020, In : Frontiers in Neurology. 10, 1363.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

Chataway, J., De Angelis, F., Connick, P., Parker, R. A., Plantone, D., Doshi, A., John, N., Stutters, J., MacManus, D., Prados Carrasco, F., Barkhof, F., Ourselin, S., Braisher, M., Ross, M., Cranswick, G., Pavitt, S. H., Giovannoni, G., Gandini Wheeler-Kingshott, C. A., Hawkins, C., Sharrack, B. & 5 others, Bastow, R., Weir, C. J., Stallard, N., Chandran, S. & MS-SMART Investigators, 1 Mar 2020, In : The Lancet Neurology. 19, 3, p. 214-225 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of measurement properties of health-related quality of life instruments for burns: a systematic review

Legemate, CM., Spronk, I., Mokkink, L. B., Middelkoop, E., Polinder, S., van Baar, M. E. & van der Vlies, C. H., 15 Jan 2020, In : Journal of Trauma and Acute Care Surgery. 88, 4, 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods

de Sitter, A., Visser, M., Brouwer, I., Cover, K. S., van Schijndel, R. A., Eijgelaar, R. S., Müller, D. M. J., Ropele, S., Kappos, L., Rovira, Filippi, M., Enzinger, C., Frederiksen, J., Ciccarelli, O., Guttmann, C. R. G., Wattjes, M. P., Witte, M. G., de Witt Hamer, P. C., Barkhof, F., Vrenken, H. & 2 others, MAGNIMS Study Group & Alzheimer’s Disease Neuroimaging Initiative, Feb 2020, In : European Radiology. 30, 2, p. 1062-1074 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fatigue Profiles in Patients with Multiple Sclerosis are Based on Severity of Fatigue and not on Dimensions of Fatigue

Beckerman, H., Eijssen, I. C., van Meeteren, J., Verhulsdonck, M. C. & de Groot, V., 5 Mar 2020, In : Scientific Reports. 10, 1, p. 4167 4167.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy

Prados, F., Moccia, M., Johnson, A., Yiannakas, M., Grussu, F., Cardoso, M. J., Ciccarelli, O., Ourselin, S., Barkhof, F. & Wheeler-Kingshott, C., 2020, In : NeuroImage. 209, 116489.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

BBMRI Metabolomics Consortium, 2020, In : Nature Communications. 11, 1, 39.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Methylphenidate and galantamine in patients with vascular cognitive impairment-the proof-of-principle study STREAM-VCI

Leijenaar, J. F., Groeneveld, G. J., Klaassen, E. S., Leeuwis, A. E., Scheltens, P., Weinstein, H. C., van Gerven, J. M. A., Barkhof, F., van der Flier, W. M. & Prins, N. D., 2020, In : Alzheimer's Research & Therapy. 12, 1, p. 10 10.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

van Olst, L., Verhaege, D., Franssen, M., Kamermans, A., Roucourt, B., Carmans, S., Ytebrouck, E., van der Pol, S. M. A., Wever, D., Popovic, M., Vandenbroucke, R. E., Sobrino, T., Schouten, M. & de Vries, H. E., 31 Jan 2020, In : Neurobiology of Aging. 89, 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Moving exercise research in multiple sclerosis forward (the MoXFo initiative): Developing consensus statements for research

Dalgas, U., Hvid, L. G., Kwakkel, G., Motl, R. W., de Groot, V., Feys, P., Op't Eijnde, B., Coote, S., Beckerman, H., Pfeifer, K., Streber, R., Peters, S., Riemann-Lorenz, K., Rosenkranz, S. C., Centonze, D., Van Asch, P., Bansi, J., Sandroff, B. M., Pilutti, L. A., Ploughman, M. & 8 others, Freeman, J., Paul, L., Dawes, H., Romberg, A., Kalron, A., Stellmann, J-P., Friese, M. A. & Heesen, C., 12 Mar 2020, In : Multiple Sclerosis. p. 1352458520910360

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination

Houben, E., Janssens, K., Hermans, D., Vandooren, J., van den Haute, C., Schepers, M., Vanmierlo, T., Lambrichts, I., van Horssen, J., Baekelandt, V., Opdenakker, G., Baron, W., Broux, B., Slaets, H. & Hellings, N., 3 Mar 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 5028-5038 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ongoing microstructural changes in the cervical cord underpin disability progression in early primary progressive multiple sclerosis

Cortese, R., Tur, C., Prados, F., Schneider, T., Kanber, B., Moccia, M., Wheeler-Kingshott, C. A. M. G., Thompson, A. J., Barkhof, F. & Ciccarelli, O., 2020, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Packaging RNA drugs into extracellular vesicles

van Eijndhoven, M. A. J., Baglio, S. R. & Pegtel, D. M., Jan 2020, In : Annals of Biomedical Engineering. 4, 1, p. 6-8 3 p.

Research output: Contribution to journalArticleAcademic

Patients’ expectations of autologous hematopoietic stem cell transplantation as a treatment for MS

de Kleermaeker, F. G. C. M., Uitdehaag, B. M. J. & van Oosten, B. W., 2020, In : Multiple Sclerosis and Related Disorders. 37, 101467.

Research output: Contribution to journalArticleAcademicpeer-review

Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in glioma

Bikhezar, F., de Kruijff, R. M., van der Meer, A. J. G. M., Torrelo Villa, G., van der Pol, S. M. A., Becerril Aragon, G., Gasol Garcia, A., Narayan, R. S., de Vries, H. E., Slotman, B. J., Denkova, A. G. & Sminia, P., 1 Jan 2020, In : Journal of Neuro-Oncology. 146, 2, p. 239-246 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Quantifying muscle fatigue during walking in people with multiple sclerosis

Eken, M. M., Richards, R., Beckerman, H., van der Krogt, M., Gerrits, K., Rietberg, M., de Groot, V. & Heine, M., 1 Feb 2020, In : Clinical Biomechanics. 72, p. 94-101 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Real-time imaging of multivesicular body-plasma membrane fusion to quantify exosome release from single cells

Bebelman, M. P., Bun, P., Huveneers, S., van Niel, G., Pegtel, D. M. & Verweij, F. J., Jan 2020, In : Nature Protocols. 15, 1, p. 102-121 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy

Rhodius-Meester, H. F. M., van Maurik, I. S., Koikkalainen, J., Tolonen, A., Frederiksen, K. S., Hasselbalch, S. G., Soininen, H., Herukka, S-K., Remes, A. M., Teunissen, C. E., Barkhof, F., Pijnenburg, Y. A. L., Scheltens, P., Lötjönen, J. & van der Flier, W. M., 2020, In : PLoS ONE. 15, 1, p. e0226784 e0226784.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Specific Nutritional Biomarker Profiles in Mild Cognitive Impairment and Subjective Cognitive Decline Are Associated With Clinical Progression: The NUDAD Project

de Leeuw, F. A., van der Flier, W. M., Tijms, B. M., Scheltens, P., Mendes, V. M., Manadas, B., Bierau, J. R., van Wijk, N., van den Heuvel, E. G. H. M., Mohajeri, M. H., Teunissen, C. E. & Kester, M. I., 27 Jan 2020, In : Journal of the American Medical Directors Association.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative

Simpson, H. B., van den Heuvel, O. A., Miguel, E. C., Reddy, Y. C. J., Stein, D. J., Lewis-Fernández, R., Shavitt, R. G., Lochner, C., Pouwels, P. J. W., Narayanawamy, J. C., Venkatasubramanian, G., Hezel, D. M., Vriend, C., Batistuzzo, M. C., Hoexter, M. Q., de Joode, N. T., Costa, D. L., de Mathis, M. A., Sheshachala, K., Narayan, M. & 15 others, van Balkom, A. J. L. M., Batelaan, N. M., Venkataram, S., Cherian, A., Marincowitz, C., Pannekoek, N., Stovezky, Y. R., Mare, K., Liu, F., Otaduy, M. C. G., Pastorello, B., Rao, R., Katechis, M., Van Meter, P. & Wall, M., 14 Feb 2020, In : BMC Psychiatry. 20, 1, p. 68 68.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access
2019

7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease

Kenkhuis, B., Jonkman, L. E., Bulk, M., Buijs, M., Boon, B. D. C., Bouwman, F. H., Geurts, J. J. G., van de Berg, W. D. J. & van der Weerd, L., 1 Jan 2019, In : NeuroImage: Clinical. 21, 1 p., 101665.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A 30 s test for quantitative assessment of a relative afferent pupillary defect (RAPD): the infrared pupillary asymmetry (IPA)

Meneguette, N. S., de Carvalho, J. E. R. & Petzold, A., 4 Apr 2019, In : Journal of Neurology. 266, 4, p. 969-974

Research output: Contribution to journalArticleAcademicpeer-review

Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis

Leurs, C. E., Lopes Pinheiro, M. A., Wierts, L., den Hoedt, S., Mulder, M. T., Eijlers, A. J. C., Schoonheim, M. M., Balk, L. J., Uitdehaag, B. M. J., Killestein, J. & de Vries, H. E., 1 Feb 2019, In : Multiple Sclerosis and Related Disorders. 28, p. 44-49 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition

Lin, F., Zivadinov, R., Hagemeier, J., Weinstock-Guttman, B., Vaughn, C., Gandhi, S., Jakimovski, D., Hulst, H. E., Benedict, R. H. B., Bergsland, N., Fuchs, T. & Dwyer, M. G., 1 Aug 2019, In : Multiple Sclerosis Journal. 25, 1, p. 1243-1254

Research output: Contribution to journalArticleAcademicpeer-review

Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal

Vermunt, L., van Paasen, A. J. L., Teunissen, C. E., Scheltens, P., Visser, P. J., Tijms, B. M. & Alzheimer's Disease Neuroimaging Initiative, 4 Jun 2019, In : Neurology. 92, 23, p. e2699-e2705

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort

Stamate, D., Kim, M., Proitsi, P., Westwood, S., Baird, A., Nevado-Holgado, A., Hye, A., Bos, I., Vos, S. J. B., Vandenberghe, R., Teunissen, C. E., Kate, M. T., Scheltens, P., Gabel, S., Meersmans, K., Blin, O., Richardson, J., de Roeck, E., Engelborghs, S., Sleegers, K. & 25 others, Bordet, R. G., Ramit, L., Kettunen, P., Tsolaki, M., Verhey, F., Alcolea, D., Lléo, A., Peyratout, G., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Popp, J., Martinez-Lage, P., Bertram, L., Blennow, K., Zetterberg, H., Streffer, J., Visser, P. J., Lovestone, S. & Legido-Quigley, C., 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 933-938

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A multi-shell multi-tissue diffusion study of brain connectivity in early multiple sclerosis

Tur, C., Grussu, F., Prados, F., Charalambous, T., Collorone, S., Kanber, B., Cawley, N., Altmann, D. R., Ourselin, S. B., Barkhof, F., Clayden, J. D., Toosy, A. T., Wheeler-Kingshott, C. A. M. G. & Ciccarelli, O., 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

AMYPAD Diagnostic and Patient Management Study: Rationale and design

Frisoni, G. B., Barkhof, F., Altomare, D., Berkhof, J., Boccardi, M., Canzoneri, E., Collij, L., Drzezga, A., Farrar, G., Garibotto, V., Gismondi, R., Gispert, J-D., Jessen, F., Kivipelto, M., Lopes Alves, I., Molinuevo, J-L., Nordberg, A., Payoux, P., Ritchie, C., Savicheva, I. & 8 others, Scheltens, P., Schmidt, M. E., Schott, J., Stephens, A., van Berckel, B., Vellas, B., Walker, Z. & Raffa, N., 1 Mar 2019, In : Alzheimers & Dementia. 15, 3, p. 388-399 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid – method comparison and round robin study

Mollenhauer, B., Bowman, F. D., Drake, D., Duong, J., Blennow, K., el-Agnaf, O., Shaw, L. M., Masucci, J., Taylor, P., Umek, R. M., Dunty, J. M., Smith, C. L., Stoops, E., Vanderstichele, H., Schmid, A. W., Moniatte, M., Zhang, J., Kruse, N., Lashuel, H. A., Teunissen, C. & 4 others, Schubert, T., Dave, K. D., Hutten, S. J. & Zetterberg, H., 1 Apr 2019, In : Journal of Neurochemistry. 149, 1, p. 126-138

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Huiskamp, M., Moumdjian, L., van Asch, P., Popescu, V., Schoonheim, M. M., Steenwijk, M. D., Vanzeir, E., van Wijmeersch, B., Geurts, J. J. G., Feys, P. & Hulst, H. E., 1 Jan 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access