Research Output 1977 2019

2019

1-Year Outcomes of Delayed Versus Immediate Intervention in Patients With Transient ST-Segment Elevation Myocardial Infarction

Janssens, GN., van der Hoeven, NW., Lemkes, JS., Everaars, H., van de Ven, PM., Marques, KMJ., Nap, A., van Leeuwen, M. A. H., Appelman, JEA., Knaapen, P., Verouden, CJW., Allaart, CP., Brinckman, S., Saraber, CE., Plomp, K., Timmer, J. R., Kedhi, E., Hermanides, R. S., Meuwissen, M., Schaap, J. & 4 othersVan Der Weerdt, A. P., van Rossum, AC., Nijveldt, R. & van Royen, N., 2 Sep 2019, In : JACC Cardiovascular Interventions.

Research output: Contribution to journalArticleAcademicpeer-review

2-Year Clinical Outcomes of an Abluminal Groove–Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent

TARGET AC Investigators, 2019, In : JACC: Cardiovascular Interventions. 12, 17, p. 1679-1687

Research output: Contribution to journalArticleAcademicpeer-review

ACRA Perfusion Study

van Leeuwen, M. A. H., van der Heijden, D. J., Hollander, M. R., Mulder, M. J., van de Ven, P. M., Ritt, M. J. P. F., Kiemeneij, F., van Mieghem, N. M. & van Royen, N., 2019, In : Circulation. Cardiovascular interventions. 12, 4, p. e007641

Research output: Contribution to journalArticleAcademicpeer-review

Agreement of 2D transthoracic echocardiography with cardiovascular magnetic resonance imaging after ST-elevation myocardial infarction

Hendriks, T., Al Ali, L., Maagdenberg, C. G., van Melle, J. P., Hummel, Y. M., Oudkerk, M., van Veldhuisen, D. J., Nijveldt, R., van der Horst, I. C. C., Lipsic, E. & van der Harst, P., 2019, In : European Journal of Radiology. 114, p. 6-13

Research output: Contribution to journalArticleAcademicpeer-review

A ground completely overgrown: Heidegger, Kant and the problem of metaphysics

de Boer, K. & Howard, S., 2019, In : British Journal for the History of Philosophy. 27, 2, p. 358-377

Research output: Contribution to journalArticleAcademicpeer-review

Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Heidt, S., Haasnoot, G. W., Witvliet, M. D., van der Linden-van Oevelen, M. J. H., Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C. A. D., Plaisier, L., Seelen, M. A. J. & 26 othersSanders, J-S., Hepkema, B. G., Lambeck, A. J. A., Bungener, L. B., Roozendaal, C., Tilanus, M. G. J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M. A. C. J., Christiaans, M. H. L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A. M. I., van der Weerd, N. C., ten Berge, I. J. M., Bemelman, F. J., Hoitsma, A., van der Boog, P. J. M., de Fijter, J. W., Betjes, M. G. H., Otten, H. G., Roelen, D. L. & Claas, F. H. J., 2019, In : American Journal of Transplantation.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A mobile one-lead ECG device incorporated in a symptom-driven remote arrhythmia monitoring program. The first 5,982 Hartwacht ECGs

Selder, J. L., Breukel, L., Blok, S., van Rossum, A. C., Tulevski, I. I. & Allaart, C. P., 2019, In : Netherlands Heart Journal. 27, 1, p. 38-45

Research output: Contribution to journalArticleAcademicpeer-review

An irregular narrow complex tachycardia: atrial fibrillation or something else?

Mulder, MJ., Allaart, C. P., Hauer, H. A. & Kemme, M. J. B., 1 Feb 2019, In : Netherlands Heart Journal. 27, 2, p. 112-113 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Antibodies against ARHGDIB are associated with long-term kidney graft loss

Kamburova, E. G., Gruijters, M. L., Kardol-Hoefnagel, T., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C. A. D., Plaisier, L., Melchers, R. C. A., Seelen, M. A. J., Sanders, J. S. & 26 othersHepkema, B. G., Lambeck, A. J. A., Bungener, L. B., Roozendaal, C., Tilanus, M. G. J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M. A. C. J., Christiaans, M. H. L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A. M. I., van der Weerd, N. C., ten Berge, I. J. M., Hoitsma, A., van der Boog, P. J. M., de Fijter, J. W., Betjes, M. G. H., Heidt, S., Roelen, D. L., Claas, F. H., Bemelman, F. J. & Otten, H. G., 2019, In : American Journal of Transplantation.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Aortic valve calcification volumes and chronic brain infarctions in patients undergoing transcatheter aortic valve implantation

Vlastra, W., van den Boogert, T. P. W., Krommenhoek, T., Bronzwaer, A-S. G. T., Mutsaerts, H. J. M. M., Achterberg, H. C., Bron, E. E., Niessen, W. J., Majoie, C. B. L. M., Nederveen, A. J., Baan, J., van Lieshout, J. J., Piek, J. J., Planken, R. N., Henriques, J. P. S. & Delewi, R., 2019, In : International Journal of Cardiovascular Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival

Michielsen, L. A., Wisse, B. W., Kamburova, E. G., Verhaar, M. C., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., Bots, M. L., Drop, A. C. A. D., Plaisier, L., Seelen, M. A. J., Sanders, J-S. F., Hepkema, B. G., Lambeck, A. J., Bungener, L. B. & 24 othersRoozendaal, C., Tilanus, M. G. J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H. L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J. M., Bemelman, F. J., Hoitsma, A., van der Boog, P. J. M., de Fijter, J. W., Betjes, M. G. H., Heidt, S., Roelen, D. L., Claas, F. H., Otten, H. G. & van Zuilen, A. D., 2019, In : Nephrology, Dialysis, Transplantation. 34, 6, p. 1056-1063

Research output: Contribution to journalArticleAcademicpeer-review

A paradox in sex-specific clinical outcomes after bioresorbable scaffold implantation: 2-year results from the AIDA trial

Kerkmeijer, L. S. M., Tijssen, R. Y. G., Hofma, S. H., Pinxterhuis, T. H., Kraak, R. P., Kalkman, D. N., van der Schaaf, R. J., Arkenbout, E. K., Weevers, A. P. J. D., Beijk, M. A., Baan, J., Vis, M. M., Koch, K. T., Tijssen, J. G. P., Piek, J. J., Henriques, J. P. S., de Winter, R. J. & Wykrzykowska, J. J., 2019, In : International Journal of Cardiology.

Research output: Contribution to journalArticleAcademicpeer-review

Artificial Intelligence for Aortic Pressure Waveform Analysis During Coronary Angiography: Machine Learning for Patient Safety

Howard, J. P., Cook, C. M., van de Hoef, T. P., Meuwissen, M., de Waard, G. A., van Lavieren, M. A., Echavarria-Pinto, M., Danad, I., Piek, J. J., Götberg, M., Al-Lamee, R. K., Sen, S., Nijjer, S. S., Seligman, H., van Royen, N., Knaapen, P., Escaned, J., Francis, D. P., Petraco, R. & Davies, J. E., 2019, In : JACC: Cardiovascular Interventions. 12, 20, p. 2093-2101

Research output: Contribution to journalArticleAcademicpeer-review

Artificial intelligence in cardiovascular imaging: state of the art and implications for the imaging cardiologist

Siegersma, K. R., Leiner, T., Chew, D. P., Appelman, Y., Hofstra, L. & Verjans, J. W., 2019, In : Netherlands Heart Journal.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

A TAILOR-MADE EXERCISE PROGRAM DESIGNED FOR IMPROVING CARDIORESPIRATORY FITNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND INCREASED CARDIOVASCULAR RISK

van den Hoek, J., van der Esch, M., van der Leeden, M., Lems, W., Metsios, G., Kitas, G. D., Dekker, J., Reimer, W. S. O., Jorstad, H., L'ami, M. J., Heslinga, M. & Nurmohamed, M., Jun 2019, In : Annals of the Rheumatic Diseases. 78, p. 1061-1061

Research output: Contribution to journalMeeting AbstractAcademic

At last, mobile health leading to a diagnosis in a young patient with congenital heart disease

Koole, M. A. C., Somsen, G. A., Tulevski, I. I., Winter, M. M., Bouma, B. J. & Schuuring, M. J., 2019, In : Netherlands Heart Journal. 27, 3, p. 162-163

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Atrioventricular optimization in cardiac resynchronization therapy with quadripolar leads: should we optimize every pacing configuration including multi-point pacing?

van Everdingen, W. M., Zweerink, A., Salden, O. A. E., Cramer, M. J., Doevendans, P. A., van Rossum, A. C., Prinzen, F. W., Vernooy, K., Allaart, C. P. & Meine, M., 2019, In : Europace. 21, 1, p. e11-e19

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Balloon-assisted tracking technique as 'a way forward' for transradial intervention

Wojciuk, J., Beijk, M. A., Goode, G., Brack, M., Galasko, G., More, R., Roberts, D., Eichhöfer, J., Patel, B., Chauhan, A. & Wiper, A., 2019, In : Coronary Artery Disease. 30, 6, p. 440-447

Research output: Contribution to journalArticleAcademicpeer-review

Between Scylla and Charybdis

te Kolste, H. J., Kimman, G. J., Germans, T. & Timmer, S. A. J., 2019, In : Netherlands Heart Journal. 27, 7-8, p. 387-388

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Between Scylla and Charybdis

te Kolste, H. J., Kimman, G. J., Germans, T. & Timmer, S. A. J., 2019, In : Netherlands Heart Journal. 27, 7-8, p. 383-384

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Blinded Physiological Assessment of Residual Ischemia After Successful Angiographic Percutaneous Coronary Intervention: The DEFINE PCI Study

Jeremias, A., Davies, J. E., Maehara, A., Matsumura, M., Schneider, J., Tang, K., Talwar, S., Marques, K., Shammas, N. W., Gruberg, L., Seto, A., Samady, H., Sharp, A., Ali, Z. A., Mintz, G., Patel, M. & Stone, G. W., 2019, In : JACC: Cardiovascular Interventions. 12, 20, p. 1991-2001

Research output: Contribution to journalArticleAcademicpeer-review

Body mass index related electrocardiographic findings in healthy young individuals with a normal body mass index

Hassing, G. J., van der Wall, H. E. C., van Westen, G. J. P., Kemme, M. J. B., Adiyaman, A., Elvan, A., Burggraaf, J. & Gal, P., 2019, In : Netherlands Heart Journal. 27, 10, p. 506-512

Research output: Contribution to journalArticleAcademicpeer-review

Cardiac Hybrid PET/CCTA Imaging for the Detection of Coronary Artery Disease

Danad, I., 18 Apr 2019

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Cardiology fellows-in-training are exposed to relatively high levels of radiation in the cath lab compared with staff interventional cardiologists—insights from the RECAP trial

Vlastra, W., Claessen, B. E., Beijk, M. A., Sjauw, K. D., Streekstra, G. J., Wykrzykowska, J. J., Vis, M. M., Koch, K. T., de Winter, R. J., Piek, J. J., Henriques, J. P. S. & Delewi, R., 2019, In : Netherlands Heart Journal. 27, 6, p. 330-333

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiovascular magnetic resonance techniques for tissue characterization after acute myocardial injury

Demirkiran, A., Everaars, H., Amier, R. P., Beijnink, C., Bom, M. J., Götte, M. J. W., van Loon, R. B., Selder, J. L., van Rossum, A. C. & Nijveldt, R., 2019, In : European heart journal cardiovascular Imaging. 20, 7, p. 723-734

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment

Sen, S., Ahmad, Y., Dehbi, H-M., Howard, J. P., Iglesias, J. F., Al-Lamee, R., Petraco, R., Nijjer, S., Bhindi, R., Lehman, S., Walters, D., Sapontis, J., Janssens, L., Vrints, C. J., Khashaba, A., Laine, M., van Belle, E., Krackhardt, F., Bojara, W., Going, O. & 41 othersHärle, T., Indolfi, C., Niccoli, G., Ribichini, F., Tanaka, N., Yokoi, H., Takashima, H., Kikuta, Y., Erglis, A., Vinhas, H., Silva, P. C., Baptista, S. R. B., Alghamdi, A., Hellig, F., Koo, B-K., Nam, C-W., Shin, E-S., Doh, J-H., Brugaletta, S., Alegria-Barrero, E., Meuwissen, M., Piek, J. J., van Royen, N., Sezer, M., di Mario, C., Gerber, R. T., Malik, I. S., Sharp, A. S. P., Talwar, S., Tang, K., Samady, H., Altman, J., Seto, A. H., Singh, J., Jeremias, A., Matsuo, H., Kharbanda, R. K., Patel, M. R., Serruys, P., Escaned, J. & Davies, J. E., 2019, In : Journal of the American College of Cardiology. 73, 4, p. 444-453

Research output: Contribution to journalArticleAcademicpeer-review

Clinical outcomes at 2 years of the Absorb bioresorbable vascular scaffold versus the Xience drug-eluting metallic stent in patients presenting with acute coronary syndrome versus stable coronary disease—AIDA trial substudy

Tijssen, R. Y. G., van der Schaaf, R. J., Kraak, R. P., Vink, M. A., Hofma, S. H., Arkenbout, E. K., Weevers, A. P. J. D., Kerkmeijer, L. S. M., Onuma, Y., Serruys, P. W., Beijk, M. A. M., Koch, K. T., Baan, J., Vis, M. M., Piek, J. J., Tijssen, J. G. P., Henriques, J. P. S., de Winter, R. J. & Wykrzykowska, J. J., 2019, In : Catheterization and Cardiovascular Interventions.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of balloon-expandable vs. self-expandable valves in patients undergoing transfemoral transcatheter aortic valve implantation: From the CENTER-collaboration

Vlastra, W., Chandrasekhar, J., Muñoz-Garcia, A. J., Tchétché, D., de Brito, F. S., Barbanti, M., Kornowski, R., Latib, A., D'Onofrio, A., Ribichini, F., Baan, J., Tijssen, J. G. P., Trillo-Nouche, R., Dumonteil, N., Abizaid, A., Sartori, S., D'Errigo, P., Tarantini, G., Lunardi, M., Orvin, K. & 7 othersPagnesi, M., del Valle, R., Modine, T., Dangas, G., Mehran, R., Piek, J. J. & Delewi, R., 2019, In : European Heart Journal. 40, 5, p. 456-465

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparison of Major Adverse Cardiac Events between Instantaneous Wave-Free Ratio and Fractional Flow Reserve-Guided Strategy in Patients with or Without Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial

Lee, J. M., Choi, K. H., Koo, B-K., Dehbi, H-M., Doh, J-H., Nam, C-W., Shin, E-S., Cook, C. M., Al-Lamee, R., Petraco, R., Sen, S., Malik, I. S., Nijjer, S. S., Mejía-Rentería, H., Alegria-Barrero, E., Alghamdi, A., Altman, J., Baptista, S. R. B., Bhindi, R., Bojara, W. & 44 othersBrugaletta, S., Silva, P. C., di Mario, C., Erglis, A., Gerber, R. T., Going, O., Härle, T., Hellig, F., Indolfi, C., Janssens, L., Jeremias, A., Kharbanda, R. K., Khashaba, A., Kikuta, Y., Krackhardt, F., Laine, M., Lehman, S. J., Matsuo, H., Meuwissen, M., Niccoli, G., Piek, J. J., Ribichini, F., Samady, H., Sapontis, J., Seto, A. H., Sezer, M., Sharp, A. S. P., Singh, J., Takashima, H., Talwar, S., Tanaka, N., Tang, K., van Belle, E., van Royen, N., Vinhas, H., Vrints, C. J., Walters, D., Yokoi, H., Samuels, B., Buller, C., Patel, M. R., Serruys, P., Escaned, J. & Davies, J. E., 2019, In : JAMA cardiology.

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive physiological evaluation of epicardial and microvascular coronary domains using vascular conductance and zero flow pressure

van der Hoeven, N. W., de Waard, G. A., Quirós, A., De Hoyos, A., Broyd, C., Nijjer, S. S., van de Hoef, T. P., Petraco, R., Driessen, R. S., Mejía-Rentería, H., Kikuta, Y., Echavarría Pinto, M., van de Ven, P. M., Meuwissen, M., Knaapen, P., Piek, J. J., Davies, J. E., van Royen, N. & Escaned, J., 8 Feb 2019, In : EuroIntervention. 14, 15, p. e1593-e1600

Research output: Contribution to journalArticleAcademicpeer-review

Computed Tomography to Replace Invasive Coronary Angiography?

Knaapen, P., 2019, In : Circulation. Cardiovascular imaging. 12, 2, p. e008710

Research output: Contribution to journalEditorialAcademicpeer-review

Contrast-enhanced ultrasound for quantification of tissue perfusion in humans

Emanuel, A. L., Meijer, R. I., van Poelgeest, E., Spoor, P., Serné, E. H. & Eringa, E. C., 2019, In : Microcirculation. e12588.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Coronary angiography after cardiac arrest without ST-segment elevation

Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R. M., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., Stoel, M., Camaro, C. & 18 othersvan der Hoeven, H., Henriques, J. P., Vlaar, A. P. J., Vink, M. A., van den Bogaard, B., Heestermans, T. A. C. M., de Ruijter, W., Delnoij, T. S. R., Crijns, H. J. G. M., Jessurun, G. A. J., Oemrawsingh, P. V., Gosselink, M. T. M., Plomp, K., Magro, M., Elbers, P. W. G., van de Ven, P. M., Oudemansvan Straaten, H. M. & van Royen, N., 2019, In : New England Journal of Medicine. 380, 15, p. 1397-1407

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Coronary Angiography after Cardiac Arrest without ST-Segment Elevation. Reply

Lemkes, J. S., Janssens, G. N. & van Royen, N., 11 Jul 2019, In : The New England journal of medicine. 381, 2, p. 189-190 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Coronary artery calcification in middle-aged women with premature ovarian insufficiency

On behalf of the CREW-consortium, 2019, In : Clinical Endocrinology. 91, 2, p. 314-322

Research output: Contribution to journalArticleAcademicpeer-review

Coronary Microcirculation Downstream Non-Infarct-Related Arteries in the Subacute Phase of Myocardial Infarction: Implications for Physiology-Guided Revascularization

Mejía-Rentería, H., Lee, J. M., van der Hoeven, N. W., Gonzalo, N., Jiménez-Quevedo, P., Nombela-Franco, L., Núñez-Gil, I. J., Salinas, P., del Trigo, M., Cerrato, E., van Royen, N., Knaapen, P., Koo, B-K., Macaya, C., Fernández-Ortiz, A. & Escaned, J., 2019, In : Journal of the American Heart Association. 8, 9, p. e011534

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Corrigendum to “Wieslander, et al., Ejection fraction in left bundle branch block is disproportionately reduced in relation to amount of myocardial scar” [J Electrocardiol 51(2018) 1071–1076]

Axelsson, J., Wieslander, B., Jablonowski, R., Klem, I., Nijveldt, R., Schelbert, E. B., Sörensson, P., Sigfridsson, A., Chaudhry, U., Platonov, P. G., Borgquist, R., Engblom, H., Strauss, D. G., Arheden, H. K., Atwater, B. D. & Ugander, M., 2019, In : Journal of Electrocardiology.

Research output: Contribution to journalArticleAcademicpeer-review

Cumulative live birth rates in low-prognosis women

Leijdekkers, J. A., Eijkemans, M. J. C., van Tilborg, T. C., Oudshoorn, S. C., van Golde, R. J. T., Hoek, A., Lambalk, C. B., de Bruin, J. P., Fleischer, K., Mochtar, M. H., Kuchenbecker, W. K. H., Laven, J. S. E., Mol, B. W. J., Torrance, H. L., Broekmans, F. J. M., Koks, C. A. M., Verhoeve, H. R., Nap, A. W., Scheffer, G. J., Manger, A. P. & 13 othersSchoot, B. C., Oosterhuis, G. J. E., Sluijmer, A. V., Friederich, J., Verhoeff, A., van Hooff, M. H. A., van Santbrink, E. J. P., Brinkhuis, E. A., Smeenk, J. M. J., Kwee, J., Dekoning, C. H., Groen, H. & van Wely, M., 2019, In : Human Reproduction. 34, 6, p. 1030-1041

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Delirium After Transcatheter Aortic Valve Implantation Under General Anesthesia: Incidence, Predictors, and Relation to Long-Term Survival

van der Wulp, K., van Wely, M., van Heijningen, L., van Bakel, B., Schoon, Y., Verkroost, M., Gehlmann, H., van Garsse, L., Vart, P., Kievit, P., Rikkert, M. O., Morshuis, W. & van Royen, N., 2019, In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Diagnostic Accuracy of a Smartphone-Operated, Single-Lead Electrocardiography Device for Detection of Rhythm and Conduction Abnormalities in Primary Care

Himmelreich, J. C. L., Karregat, E. P. M., Lucassen, W. A. M., van Weert, H. C. P. M., de Groot, J. R., Handoko, M. L., Nijveldt, R. & Harskamp, R. E., 2019, In : Annals of Family Medicine. 17, 5, p. 403-411

Research output: Contribution to journalArticleAcademicpeer-review

Open Access