Research Output 1986 2019

1986

Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in‐vivo α1‐, α2‐ and 5‐HT2‐receptor antagonism and in‐vitro affinity for α1‐, α2‐ and 5‐HT2‐receptors: comparison with ketanserin

Korstanje, C., Sprenkels, R., Doods, H. N., Hugtenburg, J. G., Boddeke, E., Batink, H. D., Thoolen, M. J. M. C. & Van Zwieten, P. A., 1 Jan 1986, In : Journal of Pharmacy and Pharmacology. 38, 5, p. 374-379 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

1988

Anti-ischaemic activity of various calmodulin antagonists

Boddeke, H. W. G. M., Wilffert, B., Hugtenburg, J. G., Jap, T. J. W., Veldsema-Currie, R. D. & Van Zwieten, P. A., 1 Jan 1988, In : Pharmacology. 37, 4, p. 240-247 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The anti-ischaemic activity of the novel compound, CERM 11956, compared with that of bepridil and nifedipine in isolated guinea-pig hearts

Boddeke, E. W. G. M., Wilffert, B., Heynis, J. B., Hugtenburg, J. G., Jap, W. T. J., Veldsema-Currie, R. D. & Van Zwieten, P. A., 10 May 1988, In : European Journal of Pharmacology. 149, 3, p. 195-203 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

1989

A comparison of the cardioprotective effects of calcium antagonists from different classes upon ischaemic damage in the guinea-pig working heart

Hugtenburg, J. G., Mathy, M. J., Veldsema-Currie, R. D., Boddeke, H. W. G. M., Beekeringh, J. J. & van Zwieten, P. A., 1 Jan 1989, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 340, 1, p. 126-134 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardioprotective effect of trimetazidine and nifedipine in guinea-pig hearts subjected to ischaemia

Hugtenburg, J. G., Jap, T. J. W., Mathy, M. J., Van Heiningen, P. N. M., Bohnenn, V. A., Heijnis, J. B., Boddeke, H. W. G. M. & Van Zwieten, P. A., 1 Jan 1989, In : Archives Internationales de Pharmacodynamie et de Therapie. 300, p. 186-208 23 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differences between negative inotropic and vasodilator effects of calcium antagonists acting on extra- and intracellular calcium movements in rat and guinea-pig cardiac preparations

Hugtenburg, J. G., Mathy, M. J., Boddeke, H. W. G. M., Beckeringh, J. J. & van Zwieten, P. A., 1 Jan 1989, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 340, 5, p. 567-575 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

New anti-ischaemic drugs: cytoprotective action with no primary haemodynamic effects

Boddeke, E., Hugtenburg, J., Jap, W., Heynis, J. & Zwieten, P. V., 1 Jan 1989, In : Trends in Pharmacological Sciences. 10, 10, p. 397-400 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Protective activity of nifedipine and R 58735 upon damage caused by global ischemia in the guinea pig heart-lung preparation

Boddeke, H. W. G. M., Jap, T. J. W., Hugtenburg, J. G., Heynis, J. B., Veldsema-Currie, R. D., Wilffert, B. & van Zwieten, P. A., 1 Sep 1989, In : Basic Research in Cardiology. 84, 5, p. 489-498 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The differential effect of calcium antagonists on the positive inotropic effects induced by calcium and monensin in cardiac preparations of rats and guinea-pigs

Hugtenburg, J. G., Mathy, M. J., Beckeringh, J. J. & van Zwieten, P. A., 1 Jan 1989, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 340, 5, p. 558-566 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

1990

In vitro models of cardiac ischaemia and the evaluation of the cardioprotective effects of calcium antagonists and other anti-ischaemic drugs

Hugtenburg, J. G., Beckeringh, J. J., Boddeke, H. W. G. M., Heijnis, J. B., Jap, T. J. W., Mathy, M. J. & Van Zwieten, P. A., 1 Jan 1990, In : Progress in Pharmacology and Clinical Pharmacology. 8, 2, p. 19-35 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

The cardioprotective effect of nifedipine, verapamil and diltiazem in relationship to their vasodilatory activity in isolated rat hearts

Hugtenburg, J. G., Mathy, J. J., Beckeringh, J. J. & Van Zwieten, P. A., 1 Jan 1990, In : European Journal of Pharmacology. 183, 3, p. 793-794 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts

Hugtenburg, J. G., Van Voorst, M. J. D., Van Marle, J., Mathy, M. J., Beckeringh, J. J., Van Veen, H. A., Hendriks, M. G. C. & Van Zwieten, P. A., 13 Mar 1990, In : European Journal of Pharmacology. 178, 1, p. 71-78 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

1991

The influence of calcium antagonists on the adenine nucleotide metabolism in the guinea-pig working heart during ischaemia and reperfusion

Hugtenburg, J. G., Mathy, M. J., de Haan, N., Beckeringh, J. J. & van Zwieten, P. A., 1 May 1991, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 343, 5, p. 496-504 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

1992

ACE-REMMERS. EEN PREPARAATKEUZE VOLGENS DE SOJA-METHODE

Bet, P. M. & Steenhoek, A., 2 Dec 1992, In : Pharmaceutisch Weekblad. 127, 47, p. 1262-1271 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

1995

Biodistribution of Radiolabeled Monoclonal Antibody E48 Igg and F(Ab')2 in Patients with Head and Neck Cancer

Bree, R. D., Roos, J. C., Quak, J. J., Hollander, W. D., Wilhelm, A. J., Lingen, A. V., Snow, G. B. & Van Dongen, G. A. M. S., 1 Mar 1995, In : Clinical Cancer Research. 1, 3, p. 277-286 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Intermittent cocaine exposure causes delayed and long-lasting sensitization of cocaine-induced ACTH secretion in rats

Schmidt, E. D., Tilders, F. J. H., Janszen, A. W. J. W., Binnekade, R., De Vries, T. J. & Schoffelmeer, A. N. M., 24 Oct 1995, In : European Journal of Pharmacology. 285, 3, p. 317-321 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

1996

Carbon-11-labeled daunorubicin and verapamil for probing P-glycoprotein in tumors with PET

Elsinga, P. H., Franssen, E. J. F., Hendrikse, N. H., Fluks, L., Weemaes, A. M. A., Van Der Graaf, W. T. A., De Vries, E. G. E., Visser, G. M. & Vaalburg, W., 1 Sep 1996, In : Journal of Nuclear Medicine. 37, 9, p. 1571-1575 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Regulation of sialoadhesin expression on rat macrophages. Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide

van den Berg, T. K., van Die, I., de Lavalette, C. R., Döpp, E. A., Smit, L. D., van der Meide, P. H., Tilders, F. J., Crocker, P. R. & Dijkstra, C. D., 1 Oct 1996, In : Journal of Immunology. 157, 7, p. 3130-8 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

1997

Cisplatin resistance and DNA repair

Crul, M., Schellens, J. H. M., Beijnen, J. H. & Maliepaard, M., 1 Jan 1997, In : Cancer Treatment Reviews. 23, 5-6, p. 341-366 26 p.

Research output: Contribution to journalArticleAcademicpeer-review

1998

99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein

Hendrikse, N. H., Franssen, E. J. F., Van Der Graaf, W. T. A., Meijer, C., Piers, D. A., Vaalburg, W. & De Vries, E. G. E., 1 Jan 1998, In : British Journal of Cancer. 77, 3, p. 353-358 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

Hendrikse, N. H., Schinkel, A. H., De Vries, E. G. E., Fluks, E., Van Der Graaf, W. T. A., Willemsen, A. T. M., Vaalburg, W. & Franssen, E. J. F., 15 Aug 1998, In : British Journal of Pharmacology. 124, 7, p. 1413-1418 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Enzymatic synthesis of [4-methoxy-11C]daunorubicin for functional imaging of P-glycoprotein with PET

Eriks-Fluks, E., Elsinga, P. H., Hendrikse, N. H., Franssen, E. J. F. & Vaalburg, W., 1 Jul 1998, In : Applied Radiation and Isotopes. 49, 7, p. 811-813 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

1999

A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier

Hendrikse, N. H., De Vries, E. G. E., Eriks-Fluks, L., Van Der Graaf, W. T. A., Hospers, G. A. P., Willemsen, A. T. M., Vaalburg, W. & Franssen, E. J. F., 15 May 1999, In : Cancer Research. 59, 10, p. 2411-2416 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats

Vanderschuren, L. J. M. J., Donné Schmidt, E., De Vries, T. J., Van Moorsel, C. A. P., Tilders, F. J. H. & Schoffelmeer, A. N. M., 1 Nov 1999, In : Journal of Neuroscience. 19, 21, p. 9579-9586 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Downloads (Pure)

Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: Efficacy, tolerability, and cognitive effects

Beenen, L. F. M., Lindeboom, J., Kasteleijn-Nolst Trenité, D. G. A., Heimans, J. J., Snoek, F. J., Touw, D. J., Adèr, H. J. & Van Alphen, H. A. M., 1 Jan 1999, In : Journal of Neurology Neurosurgery and Psychiatry. 67, 4, p. 474-480 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Drug development, radiolabelled drugs and PET

Vaalburg, W., Hendrikse, N. H. & De Vries, E. F. J., 1 Jan 1999, In : Annals of Medicine. 31, 6, p. 432-437 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Geneesmiddelprofiel: Sulesomab (LeukoScan®)

Crul, M., Franssen, E. J. F. & Wilhelm, A. J., 22 Oct 1999, In : Pharmaceutisch Weekblad. 134, 42, p. 1430-1432 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Radioimmunotherapy with rhenium-186-labeled chimeric monoclonal antibody U36 in patients with head and neck squamous cell carcinoma

Colnot, D. R., Quak, J. J., De Bree, R., Roos, J. C., Wilhelm, A. J., Snow, G. B. & Van Dongen, G. A. M. S., 1 Dec 1999, In : Acta oto-rhino-laryngologica belgica. 53, 4, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stressor- or drug-induced sensitization of the corticosterone response is not critically involved in the long-term expression of behavioural sensitization to amphetamine

Schmidt, ED., Tilders, FJH., Binnekade, R., Schoffelmeer, ANM. & De Vries, TJ., 1999, In : Neuroscience. 92, 1, p. 343-352

Research output: Contribution to journalArticleAcademicpeer-review

Visualization of multidrug resistance in vivo

Hendrikse, N. H., Franssen, E. J. F., Van Der Graaf, W. T. A., Vaalburg, W. & De Vries, E. G. E., 31 Mar 1999, In : European Journal of Nuclear Medicine. 26, 3, p. 283-293 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2000

Amphotericin B colloidal dispersion (Amphocil) vs fluconazole for the prevention of fungal infections in neutropenic patients: Data of a prematurely stopped clinical trial

Timmers, G. J., Zweegman, S., Simoons-Smit, A. M., Van Loenen, A. C., Touw, D. & Huijgens, P. C., 2000, In : Bone Marrow Transplantation. 25, 8, p. 879-884 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Enhanced cerebral uptake of receptor ligands by modulation of P- glycoprotein function in the blood-brain barrier

Doze, P., Van Waarde, A., Elsinga, P. H., Hendrikse, N. H. & Vaalburg, W., 16 Mar 2000, In : SYNAPSE. 36, 1, p. 66-74 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vivo delineation of 5-HT(1A) receptors in human brain with [18F]MPPF

Passchier, J., Van Waarde, A., Pieterman, R. M., Elsinga, P. H., Pruim, J., Hendrikse, H. N., Willemsen, A. T. M. & Vaalburg, W., 22 Nov 2000, In : Journal of Nuclear Medicine. 41, 11, p. 1830-1835 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lipopolysaccharide transport from the peritoneal cavity to the blood: is it controlled by the vagus nerve?

Romanovsky, A. A., Ivanov, A. I., Lenczowski, M. J., Kulchitsky, V. A., Van Dam, A. M., Poole, S., Homer, L. D. & Tilders, F. J., 20 Dec 2000, In : Autonomic neuroscience : basic & clinical. 85, 1-3, p. 133-40 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monitoring interactions at ATP-dependent drug efflux pumps

Hendrikse, N. H., 1 Jan 2000, In : Current Pharmaceutical Design. 6, 16, p. 1653-1668 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Phase I therapy study of 186re-labeled chimeric monoclonal antibody U36 in patients with squamous cell carcinoma of the head and neck

Colnot, D. R., Quak, J. J., Roos, J. C., Van Lingen, A., Wilhelm, A. J., Van Kamp, G. J., Huijgens, P. C., Snow, G. B. & Van Dongen, G. A. M. S., 1 Dec 2000, In : Journal of Nuclear Medicine. 41, 12, p. 1999-2010 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative imaging of 5-HT(1A) receptor binding in healthy volunteers with [18F]p-MPPF

Passchier, J., Van Waarde, A., Pieterman, R. M., Elsinga, P. H., Pruim, J., Hendrikse, H. N., Willemsen, A. T. M. & Vaalburg, W., 1 Jul 2000, In : Nuclear Medicine and Biology. 27, 5, p. 473-476 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Safety and biodistribution of 99mtechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients

Stroomer, J. W. G., Roos, J. C., Sproll, M., Quak, J. J., Heider, K. H., Wilhelm, B. J., Castelijns, J. A., Meyer, R., Kwakkelstein, M. O., Snow, G. B., Adolf, G. R. & Van Dongen, G. A. M. S., 1 Aug 2000, In : Clinical Cancer Research. 6, 8, p. 3046-3055 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The blood-brain barrier and oncology: New insights into function and modulation

Bart, J., Groen, H. J. M., Hendrikse, N. H., Van der Graaf, W. T. A., Vaalburg, W. & De Vries, E. G. E., 1 Jan 2000, In : Cancer Treatment Reviews. 26, 6, p. 449-462 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2001

A single administration of interleukin-1 or amphetamine induces long-lasting increases in evoked noradrenaline release in the hypothalamus and sensitization of ACTH and corticosterone responses in rats

Schmidt, E. D., Schoffelmeer, A. N. M., De Vries, T. J., Wardeh, G., Dogterom, G., Bol, J. G. J. M., Binnekade, R. & Tilders, F. J. H., 26 Jun 2001, In : European Journal of Neuroscience. 13, 10, p. 1923-1930 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bewegingsstoornissen door geneesmiddelen: Staken of vervangen is de beste opplossing

Hugtenburg, J. G., 9 Feb 2001, In : Pharmaceutisch Weekblad. 136, 6, p. 202-207 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Een nieuwe klasse oncolytica

Crul, M., Underberg, R. W. M., Beijnen, J. H. & Schellens, J. H. M., 23 Feb 2001, In : Pharmaceutisch Weekblad. 136, 8, p. 260-265 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Eerste en tweede uitgifte van geneesmiddelen: Zinvolle actie ann de balie

Hugtenburg, J. G., Blom, A. T. G. & Gopie, C. T. W., 26 Oct 2001, In : Pharmaceutisch Weekblad. 136, 43, p. 1612-1613 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Expression of interleukin-1 beta in rat dorsal root ganglia

Copray, J. C., Mantingh, I., Brouwer, N., Biber, K., Küst, B. M., Liem, R. S., Huitinga, I., Tilders, F. J., Van Dam, A. M. & Boddeke, H. W., 30 Aug 2001, In : Journal of Neuroimmunology. 118, 2, p. 203-11 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

HIV bij kinderen. De eerste klap is een daalder waard

Gast, M. C. W. & Hugtenburg, J. G., 28 Sep 2001, In : Pharmaceutisch Weekblad. 136, 39, p. 1456-1461 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vivo measurement of [11C]verapamil kinetics in human tissues

Hendrikse, N. H., De Vries, E. G. E., Franssen, E. J. F., Vaalburg, W. & Van Der Graaf, W. T. A., 1 Dec 2001, In : European Journal of Clinical Pharmacology. 56, 11, p. 827-829 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

P-glycoprotein at the blood-brain barrier and analysis of drug transport with positron-emission tomography

Hendrikse, N. H., Bart, J., De Vries, E. G. E., Groen, H. J. M., Van Der Graaf, W. T. A. & Vaalburg, W., 1 Jan 2001, In : Journal of Clinical Pharmacology. 41, 7 SUPPL.

Research output: Contribution to journalArticleAcademicpeer-review

Radioimmunotherapy in patients with head and neck squamous cell carcinoma: Initial experience

Colnot, D. R., Quak, J. J., Roos, J. C., de Bree, R., Wilhelm, A. J., Snow, G. B. & van Dongen, G. A. M. S., 1 Jan 2001, In : Head and Neck. 23, 7, p. 559-565 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ras biochemistry and farnesyl transferase inhibitors: A literature survey

Crul, M., De Klerk, G. J., Beijnen, J. H. & Schellens, J. H. M. S., 17 Apr 2001, In : Anti-Cancer Drugs. 12, 3, p. 163-184 22 p.

Research output: Contribution to journalLiterature reviewAcademicpeer-review