Medical oncology laboratory

Research Output

2021

1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A

Parrino, B., Carbone, D., Cascioferro, S., Pecoraro, C., Giovannetti, E., Deng, D., di Sarno, V., Musella, S., Auriemma, G., Cusimano, M. G., Schillaci, D., Cirrincione, G. & Diana, P., 1 Jan 2021, In : European Journal of Medicinal Chemistry. 209, 112892.

Research output: Contribution to journalArticleAcademicpeer-review

Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Granchi, C., Bononi, G., Ferrisi, R., Gori, E., Mantini, G., Glasmacher, S., Poli, G., Palazzolo, S., Caligiuri, I., Rizzolio, F., Canzonieri, V., Perin, T., Gertsch, J. R., Sodi, A., Giovannetti, E., Macchia, M., Minutolo, F., Tuccinardi, T. & Chicca, A., 1 Jan 2021, In : European Journal of Medicinal Chemistry. 209, 112857.

Research output: Contribution to journalArticleAcademicpeer-review

2020

3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma

Cascioferro, S., Li Petri, G., Parrino, B., el Hassouni, B., Carbone, D., Arizza, V., Perricone, U., Padova, A., Funel, N., Peters, G. J., Cirrincione, G., Giovannetti, E. & Diana, P., 2020, In : Molecules. 25, 2, E329.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A specific microRNA profile as predictive biomarker for systemic treatment in patients with metastatic colorectal cancer

Poel, D., Gootjes, E. C., Bakkerus, L., Trypsteen, W., Dekker, H., van der Vliet, H. J., van Grieken, N. C. T., Verhoef, C., Buffart, T. E. & Verheul, H. M. W., 2020, In : Cancer Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Combining Radiation Therapy With Interferons: Back to the Future

Goedegebuure, R. S. A., Vonk, C., Kooij, L. P., Derks, S. & Thijssen, V. L. J. L., 1 Jan 2020, (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics. 108, 1, 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Computational Analysis of Phosphoproteomics Data in Multi-Omics Cancer Studies

Mantini, G., Pham, T. V., Piersma, S. R. & Jimenez, C. R., 2020, In : Proteomics.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

Van Der Steen, N., Keller, K., Dekker, H., Porcelli, L., Honeywell, R. J., Van Meerloo, J., Musters, R. J. P., Kathmann, I., Frampton, A. E., Liu, D. S. K., Ruijtenbeek, R., Rolfo, C., Pauwels, P., Giovannetti, E. & Peters, G. J., 1 Jan 2020, In : Journal of Cellular Physiology. 235, 11, 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

Zhu, T., Zhu, Y., Xuan, Y., Gao, H., Cai, X., Piersma, S. R., Pham, T. V., Schelfhorst, T., Haas, R. R. G. D., Bijnsdorp, I. V., Sun, R., Yue, L., Ruan, G., Zhang, Q., Hu, M., Zhou, Y., van Houdt, W. J., le Large, T. Y. S., Cloos, J., Wojtuszkiewicz, A. & 56 others, Koppers-Lalic, D., Böttger, F., Scheepbouwer, C., Brakenhoff, R. H., van Leenders, G. J. L. H., Ijzermans, J. N. M., Martens, J. W. M., Steenbergen, R. D. M., Grieken, N. C., Selvarajan, S., Mantoo, S., Lee, S. S., Yeow, S. J. Y., Alkaff, S. M. F., Xiang, N., Sun, Y., Yi, X., Dai, S., Liu, W., Lu, T., Wu, Z., Liang, X., Wang, M., Shao, Y., Zheng, X., Xu, K., Yang, Q., Meng, Y., Lu, C., Zhu, J., Zheng, J., Wang, B., Lou, S., Dai, Y., Xu, C., Yu, C., Ying, H., Lim, T. K., Wu, J., Gao, X., Luan, Z., Teng, X., Wu, P., Huang, S., Tao, Z., Iyer, N. G., Zhou, S., Shao, W., Lam, H., Ma, D., Ji, J., Kon, O. L., Zheng, S., Aebersold, R., Jimenez, C. R. & Guo, T., 2020, In : Genomics, Proteomics and Bioinformatics.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of dexamethasone on the antileukemic effect of cytarabine: role of deoxycytidine kinase

Jaramillo, A. C., Bergman, A. M., Comijn, E. M., Jansen, G., Kaspers, G. J. L., Cloos, J. & Peters, G. J., 1 Jan 2020, (Accepted/In press) In : Nucleosides, Nucleotides and Nucleic Acids.

Research output: Contribution to journalArticleAcademicpeer-review

Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia

Hubeek, I., Broekhuizen, R., Jaramillo, A. C., Pastor-Anglada, M., Kaspers, G. J. L., Jansen, G., Cloos, J. & Peters, G. J., 1 Jan 2020, (Accepted/In press) In : Nucleosides, Nucleotides and Nucleic Acids.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Functional genomic screen in mesothelioma reveals that loss of function of BRCA1-associated-protein-1 induces chemoresistance to ribonucleotide reductase inhibition

Okonska, A., Bühler, S., Rao, V., Ronner, M., Blijlevens, M., van der Meulen-Muileman, I. H., de Menezes, R. X., Wipplinger, M., Oehl, K., Smit, E. F., Weder, W., Stahel, R. A., Penengo, L., van Beusechem, V. W. & Felley-Bosco, E., Feb 2020, In : Molecular Cancer Therapeutics. 19, 2, p. 552-563 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Glucocorticoid resistant pediatric acute lymphoblastic leukemia samples display altered splicing profile and vulnerability to spliceosome modulation

Sciarrillo, R., Wojtuszkiewicz, A., Kooi, I. E., Leon, L. G., Sonneveld, E., Kuiper, R. P., Jansen, G., Giovannetti, E., Kaspers, G. J. L. & Cloos, J., Mar 2020, In : Cancers. 12, 3, 723.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

High-Voltage Electrical Pulses in Oncology: Irreversible Electroporation, Electrochemotherapy, Gene Electrotransfer, Electrofusion, and Electroimmunotherapy

Geboers, B., Scheffer, H. J., Graybill, P. M., Ruarus, A. H., Nieuwenhuizen, S., Puijk, R. S., van den Tol, P. M., Davalos, R. V., Rubinsky, B., de Gruijl, T. D., Miklavčič, D. & Meijerink, M. R., May 2020, In : Radiology. 295, 2, p. 254-272 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach

Van Steenoven, I., Koel-Simmelink, M. J. A., Vergouw, L. J. M., Tijms, B. M., Piersma, S. R., Pham, T. V., Bridel, C., Ferri, G. L., Cocco, C., Noli, B., Worley, P. F., Worley, P. F., Xiao, M. F., Xu, D., Oeckl, P., Otto, M., Van Der Flier, W. M., De Jong, F. J., Jimenez, C. R., Lemstra, A. W. & 1 others, Teunissen, C. E., 18 Jun 2020, In : MOLECULAR NEURODEGENERATION. 15, 1, 36.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Immune checkpoint inhibition: from molecules to clinical application

Taams, L. S. & de Gruijl, T. D., 1 May 2020, In : Clinical and Experimental Immunology. 200, 2, p. 105-107 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds

Li Petri, G., El Hassouni, B., Sciarrillo, R., Funel, N., Mantini, G., Zeeuw van der Laan, E. A., Cascioferro, S., Avan, A., Zucali, P. A., Zaffaroni, N., Lagerweij, T., Parrino, B., Smid, K., Deraco, M., Granchi, C., Braczko, A., Smolenski, R. T., Matherly, L. H., Jansen, G., Assaraf, Y. G. & 5 others, Diana, P., Cloos, J., Peters, G. J., Minutolo, F. & Giovannetti, E., 1 Jan 2020, (Accepted/In press) In : British Journal of Cancer. 123, 4, 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Improving clinical management of colon cancer through CONNECTION, a nation-wide colon cancer registry and stratification effort (CONNECTION II trial): Rationale and protocol of a single arm intervention study

van den Berg, I., van de Weerd, S., Roodhart, J. M. L., Vink, G. R., van den Braak, R. R. J. C., Jimenez, C. R., Elias, S. G., van Vliet, D., Koelink, M., Hong, E., van Grevenstein, W. M. U., van Oijen, M. G. H., Beets-Tan, R. G. H., van Krieken, J. H. J. M., Ijzermans, J. N. M., Medema, J. P. & Koopman, M., 18 Aug 2020, In : BMC Cancer. 20, 1, 776.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Insights from immuno-oncology: The Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19

Ascierto, P. A., Fox, B., Urba, W., Anderson, A. C., Atkins, M. B., Borden, E. C., Brahmer, J., Butterfield, L. H., Cesano, A., Chen, D., De Gruijl, T., Dillman, R. O., Drake, C. G., Emens, L. A., Gajewski, T. F., Gulley, J. L., Stephen Hodi, F., Hwu, P., Kaufman, D., Kaufman, H. & 14 others, Lotze, M., McNeel, D. G., Margolin, K., Marincola, F., Mastrangelo, M. J., Maus, M. V., Parkinson, D. R., Romero, P. J., Sondel, P. M., Spranger, S., Sznol, M., Weiner, G. J., Wiggington, J. M. & Weber, J. S., 16 Apr 2020, In : Journal for Immunotherapy of Cancer. 8, 1, e000878.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma

Koster, B. D., de Jong, T. D., van den Hout, M. F. C. M., Sluijter, B. J. R., Vuylsteke, R. J. C. L. M., Molenkamp, B. G., Vosslamber, S., van den Tol, M. P., van den Eertwegh, A. J. M. & de Gruijl, T. D., 1 Jan 2020, In : OncoImmunology. 9, 1, 1708066.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses

Stolk, D. A., de Haas, A., Vree, J., Duinkerken, S., Lübbers, J., van de Ven, R., Ambrosini, M., Kalay, H., Bruijns, S., van der Vliet, H. J., de Gruijl, T. D. & van Kooyk, Y., 27 May 2020, In : Frontiers in Immunology. 11, 990.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10

Michielon, E., López González, M., Burm, J. L. A., Waaijman, T., Jordanova, E. S., de Gruijl, T. D. & Gibbs, S., 1 Jan 2020, (Accepted/In press) In : Cancer Immunology, Immunotherapy. 69, 11, p. 2319-2331 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

New imidazo[2,1-b][1,3,4]thiadiazole aerivatives anhibit FAK phosphorylation and potentiate the antiproliferative effects of gemcitabine through modulation of the human equilibrative nucleoside transporter-1 in peritoneal mesothelioma

Petri, G. L. I., Pecoraro, C., Randazzo, O., Zoppi, S., Cascioferro, S. M., Parrino, B., Carbone, D., Hassouni, B. E. L., Cavazzoni, A., Zaffaroni, N., Cirrincione, G., Diana, P., Peters, G. J. & Giovannetti, E., 1 Sep 2020, In : Anticancer Research. 40, 9, p. 4913-4919 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Oncolytic adenovirus ORCA-010 increases the type 1 T cell stimulatory capacity of melanoma-conditioned dendritic cells

López González, M., van de Ven, R., de Haan, H., van Eck van der Sluijs, J., Dong, W., van Beusechem, V. W. & de Gruijl, T. D., 1 Aug 2020, In : Clinical and Experimental Immunology. 201, 2, p. 145-160 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity

Santos, J. M., Heiniö, C., Cervera-Carrascon, V., Quixabeira, D. C. A., Siurala, M., Havunen, R., Butzow, R., Zafar, S., de Gruijl, T., Lassus, H., Kanerva, A. & Hemminki, A., 1 Jan 2020, In : Journal for Immunotherapy of Cancer. 8, 1, e000188.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors

Kes, M. M. G., van den Bossche, J., Griffioen, A. W. & Huijbers, E. J. M., 1 Dec 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1874, 2, 188427.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment

Zoetemelk, M., Ramzy, G. M., Rausch, M., Koessler, T., van Beijnum, J. R., Weiss, A., Mieville, V., Piersma, S. R., de Haas, R. R., Delucinge-Vivier, C. L., Andres, A., Toso, C., Henneman, A. A., Ragusa, S., Petrova, T. V., Docquier, M., McKee, T. A., Jimenez, C. R., Daali, Y., Griffioen, A. W. & 3 others, Rubbia-Brandt, L., Dietrich, P-Y. & Nowak-Sliwinska, P., 2020, In : Molecular oncology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pancreatic cancer resistance conferred by stellate cells: Looking for new preclinical models

Che, P. P., Gregori, A., Firuzi, O., Dahele, M., Sminia, P., Peters, G. J. & Giovannetti, E., 3 Aug 2020, In : Experimental hematology & oncology. 9, 1, 18.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression and Glucose Uptake in Muscle Through Adipomuscular Arterioles

Turaihi, A. H., Serné, E. H., Molthoff, C. F. M., Koning, J. J., Knol, J., Niessen, H. W., Jose Th Goumans, M., van Poelgeest, E. M., Yudkin, J. S., Smulders, Y. M., Jimenez, C. R., van Hinsbergh, V. W. & Eringa, E. C., 31 Jan 2020, In : Diabetes. 69, 4, 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Priming the tumor immune microenvironment with chemo(radio)therapy: A systematic review across tumor types

van den Ende, T., van den Boorn, H. G., Hoonhout, N. M., van Etten-Jamaludin, F. S., Meijer, S. L., Derks, S., de Gruijl, T. D., Bijlsma, M. F., van Oijen, M. G. H. & van Laarhoven, H. W. M., Aug 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1874, 1, 188386.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Recent updates on purine and pyrimidine metabolism in physiological and pathological settings

Jordheim, L. P. & Peters, G. J., 1 Jan 2020, (Accepted/In press) In : Nucleosides, Nucleotides and Nucleic Acids.

Research output: Contribution to journalArticleAcademicpeer-review

Resistance to differentiation affects ribo- and deoxyribonucleotide pools and sensitivity to pyrimidine metabolism antagonists in HL60 cells

Peters, G. J., Leyva, A. & Schwartsmann, G., 1 Jan 2020, (Accepted/In press) In : Nucleosides, Nucleotides and Nucleic Acids.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Rigosertib potently protects against colitis-associated intestinal fibrosis and inflammation by regulating PI3K/AKT and NF-κB signaling pathways

Rahmani, F., Asgharzadeh, F., Avan, A., Barneh, F., Parizadeh, M. R., Ferns, G. A., Ryzhikov, M., Ahmadian, M. R., Giovannetti, E., Jafari, M., Khazaei, M. & Hassanian, S. M., 15 May 2020, In : Life Sciences. 249, 117470.

Research output: Contribution to journalArticleAcademicpeer-review

Role of fibrillin-2 in the control of TGF-β activation in tumor angiogenesis and connective tissue disorders

van Loon, K., Yemelyanenko-Lyalenko, J., Margadant, C., Griffioen, A. W. & Huijbers, E. J. M., Apr 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1873, 2, 188354.

Research output: Contribution to journalReview articleAcademicpeer-review

Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes

Affandi, A. J., Grabowska, J., Olesek, K., Lopez Venegas, M., Barbaria, A., Rodríguez, E., Mulder, P. P. G., Pijffers, H. J., Ambrosini, M., Kalay, H., O'Toole, T., Zwart, E. S., Kazemier, G., Nazmi, K., Bikker, F. J., Stöckl, J., van den Eertwegh, A. J. M., de Gruijl, T. D., Storm, G., van Kooyk, Y. & 1 others, den Haan, J. M. M., 16 Oct 2020, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journalArticleAcademicpeer-review

Stereotactic ablative radiotherapy for the comprehensive treatment of 1-3 Oligometastatic tumors (SABR-COMET-3): Study protocol for a randomized phase III trial

Olson, R., Mathews, L., Liu, M., Schellenberg, D., Mou, B., Berrang, T., Harrow, S., Correa, R. J. M., Bhat, V., Pai, H., Mohamed, I., Miller, S., Schneiders, F., Laba, J., Wilke, D., Senthi, S., Louie, A. V., Swaminath, A., Chalmers, A., Gaede, S. & 4 others, Warner, A., De Gruijl, T. D., Allan, A. & Palma, D. A., 5 May 2020, In : BMC Cancer. 20, 1, 380.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting telomerase for its advent in cancer therapeutics

Bajaj, S., Kumar, M. S., Peters, G. J. & Mayur, Y. C., 1 Jan 2020, (Accepted/In press) In : Medicinal Research Reviews. 40, 5, 49 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The continuous rediscovery and the benefit–risk ratio of thioguanine, a comprehensive review

Bayoumy, A. B., Simsek, M., Seinen, M. L., Mulder, C. J. J., Ansari, A., Peters, G. J. & De Boer, N. K., 1 Feb 2020, In : Expert Opinion on Drug Metabolism and Toxicology. 16, 2, p. 111-123 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The hippo pathway transducers yap1/tead induce acquired resistance to trastuzumab in her2-positive breast cancer

González-Alonso, P., Zazo, S., Martín-Aparicio, E., Luque, M., Chamizo, C., Sanz-Álvarez, M., Minguez, P., Gómez-López, G., Cristóbal, I., Caramés, C., García-Foncillas, J., Eroles, P., Lluch, A., Arpí, O., Rovira, A., Albanell, J., Piersma, S. R., Jimenez, C. R., Madoz-Gúrpide, J. & Rojo, F., May 2020, In : Cancers. 12, 5, 1108.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The role of alternative splicing in cancer: From oncogenesis to drug resistance

Sciarrillo, R., Wojtuszkiewicz, A., Assaraf, Y. G., Jansen, G., Kaspers, G. J. L., Giovannetti, E. & Cloos, J., 1 Dec 2020, In : Drug Resistance Updates. 53, 100728.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment

Buckens, O. J., El Hassouni, B., Giovannetti, E. & Peters, G. J., 1 Jan 2020, (Accepted/In press) In : Expert Opinion on Investigational Drugs. 29, 6, 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

Cascioferro, S., Parrino, B., Carbone, D., Schillaci, D., Giovannetti, E., Cirrincione, G. & Diana, P., 13 Aug 2020, In : Journal of Medicinal Chemistry. 63, 15, p. 7923-7956 34 p.

Research output: Contribution to journalReview articleAcademicpeer-review