Medical oncology laboratory

Research Output

2020

3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma

Cascioferro, S., Li Petri, G., Parrino, B., el Hassouni, B., Carbone, D., Arizza, V., Perricone, U., Padova, A., Funel, N., Peters, G. J., Cirrincione, G., Giovannetti, E. & Diana, P., 2020, In : Molecules. 25, 2, E329.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

Van Der Steen, N., Keller, K., Dekker, H., Porcelli, L., Honeywell, R. J., Van Meerloo, J., Musters, R. J. P., Kathmann, I., Frampton, A. E., Liu, D. S. K., Ruijtenbeek, R., Rolfo, C., Pauwels, P., Giovannetti, E. & Peters, G. J., 1 Jan 2020, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Functional genomic screen in mesothelioma reveals that loss of function of BRCA1-associated-protein-1 induces chemoresistance to ribonucleotide reductase inhibition

Okonska, A., Bühler, S., Rao, V., Ronner, M., Blijlevens, M., van der Meulen-Muileman, I. H., de Menezes, R. X., Wipplinger, M., Oehl, K., Smit, E. F., Weder, W., Stahel, R. A., Penengo, L., van Beusechem, V. W. & Felley-Bosco, E., Feb 2020, In : Molecular Cancer Therapeutics. 19, 2, p. 552-563 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression and Glucose Uptake in Muscle Through Adipomuscular Arterioles

Turaihi, A. H., Serné, E. H., Molthoff, C. F. M., Koning, J. J., Knol, J., Niessen, H. W., Jose Th Goumans, M., van Poelgeest, E. M., Yudkin, J. S., Smulders, Y. M., Jimenez, C. R., van Hinsbergh, V. W. & Eringa, E. C., 31 Jan 2020, In : Diabetes. 69, 4, 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Rigosertib potently protects against colitis-associated intestinal fibrosis and inflammation by regulating PI3K/AKT and NF-κB signaling pathways

Rahmani, F., Asgharzadeh, F., Avan, A., Barneh, F., Parizadeh, M. R., Ferns, G. A., Ryzhikov, M., Ahmadian, M. R., Giovannetti, E., Jafari, M., Khazaei, M. & Hassanian, S. M., 15 May 2020, In : Life Sciences. 249, 117470.

Research output: Contribution to journalArticleAcademicpeer-review

Role of fibrillin-2 in the control of TGF-β activation in tumor angiogenesis and connective tissue disorders

van Loon, K., Yemelyanenko-Lyalenko, J., Margadant, C., Griffioen, A. W. & Huijbers, E. J. M., Apr 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1873, 2, 188354.

Research output: Contribution to journalReview articleAcademicpeer-review

The continuous rediscovery and the benefit–risk ratio of thioguanine, a comprehensive review

Bayoumy, A. B., Simsek, M., Seinen, M. L., Mulder, C. J. J., Ansari, A., Peters, G. J. & De Boer, N. K., 1 Feb 2020, In : Expert Opinion on Drug Metabolism and Toxicology. 16, 2, p. 111-123 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors

Cascioferro, S., Parrino, B., Petri, G. L., Cusimano, M. G., Schillaci, D., di Sarno, V., Musella, S., Giovannetti, E., Cirrincione, G. & Diana, P., 1 Apr 2019, In : European Journal of Medicinal Chemistry. 167, p. 200-210 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A brief guide to performing pharmacological studies in vitro: Reflections from the EORTC-PAMM Course “Preclinical and Early-phase Clinical Pharmacology”

Capula, M., Corno, C., Hassouni, B. E. L., Petri, G. L. I., Aranđelović, S. & on Behalf of the EORTC PAMM Group, 1 Jan 2019, In : Anticancer Research. 39, 7, p. 3413-3418

Research output: Contribution to journalReview articleAcademicpeer-review

Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression

Berndsen, R. H., Castrogiovanni, C. D., Weiss, A., Rausch, M., Dallinga, M. G., Miljkovic-Licina, M., Klaassen, I., Meraldi, P., van Beijnum, J. R. & Nowak-Sliwinska, P., 16 Jul 2019, In : British Journal of Cancer. 121, 2, p. 139-149 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression (Nature Communications, (2018), 9, 1, (1845), 10.1038/s41467-018-03962-x)

Ottaviani, S., Stebbing, J., Frampton, A. E., Zagorac, S., Krell, J., de Giorgio, A., Trabulo, S. M., Nguyen, V. T. M., Magnani, L., Feng, H., Giovannetti, E., Funel, N., Gress, T. M., Jiao, L. R., Lombardo, Y., Lemoine, N. R., Heeschen, C. & Castellano, L., 1 Dec 2019, In : Nature Communications. 10, 1, 3738.

Research output: Contribution to journalErratumAcademicpeer-review

Open Access

Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives against Pancreatic Cancer Cells*

Li Petri, G., Cascioferro, S., el Hassouni, B., Carbone, D., Parrino, B., Cirrincione, G., Peters, G. J., Diana, P. & Giovannetti, E., 1 Jan 2019, In : Anticancer Research. 39, 7, p. 3615-3620

Research output: Contribution to journalArticleAcademicpeer-review

Breastfeeding during R-CHOP chemotherapy: please abstain!

Codacci-Pisanelli, G., Honeywell, R. J., Asselin, N., Bellettini, G., Peters, G. J., Giovannetti, E. & Peccatori, F. A., 1 Sep 2019, In : European Journal of Cancer. 119, p. 107-111 5 p.

Research output: Contribution to journalLetterAcademicpeer-review

Open Access

Cancer immunophenotyping by 7 colour multispectral imaging without tyramide signal amplification

Ijselstein, M., Brouwer, T., Abdulrahman, Z., Reidy, E., Ramalheiro, A., Heeren, AM., Vahrmeijer, A., Jordanova, ES. & de Miranda, N., Jan 2019, In : The Journal of Pathology: Clinical Research. 5, 1, p. 3-11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Can circulating tumor and exosomal nucleic acids act as biomarkers for pancreatic ductal adenocarcinoma?

Liu, D. S. K., Mato Prado, M., Giovannetti, E., Jiao, L. R., Krell, J. & Frampton, A. E., 3 Jul 2019, In : Expert review of molecular diagnostics. 19, 7, p. 553-558 6 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Can cytidine deaminase be used as predictive biomarker for gemcitabine toxicity and response?

Peters, G. J., Giovannetti, E., Honeywell, R. J. & Ciccolini, J., 1 Jun 2019, In : British Journal of Clinical Pharmacology. 85, 6, p. 1213-1214 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

CD31-positive microvessel density within adenomas of Lynch Syndrome patients is similar compared to adenomas of non-Lynch patients

Vleugels, J. L. A., van Neerven, S. M., van Leerdam, M. E., Wanders, L. K., de Wit, M., Carvalho, B., Delis-van Diemen, P. M., Kallenberg, F. G. J., Vermeulen, L., Beliën, J. A., East, J. E., Meijer, G. A. & Dekker, E., May 2019, In : Endoscopy International Open. 7, 5, p. E701-E707

Research output: Contribution to journalArticleAcademicpeer-review

Cell death rocks

Griffioen, A. W. & Nowak-Sliwinska, P., 15 Apr 2019, In : Apoptosis. 24, p. 205–207

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies

Stokman, M. F., Bijnsdorp, I. V., Schelfhorst, T., Pham, T. V., Piersma, S. R., Knol, J. C., Giles, R. H., Bongers, E. M. H. F., Knoers, N. V. A. M., Lilien, M. R., Jiménez, C. R. & Renkema, K. Y., 10 Feb 2019, In : Journal of Proteomics. 192, p. 27-36 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson’s Disease and Dementia with Lewy Bodies

Moors, T. E., Paciotti, S., Ingrassia, A., Quadri, M., Breedveld, G., Tasegian, A., Chiasserini, D., Eusebi, P., Duran-Pacheco, G., Kremer, T., Calabresi, P., Bonifati, V., Parnetti, L., Beccari, T. & van de Berg, W. D. J., 1 Feb 2019, In : Molecular Neurobiology. 56, 2, p. 1344-1355 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells

Duinkerken, S., Li, RJE., van Haften, F. J., de Gruijl, TD., Chiodo, F., Schetters, STT. & van Kooyk, Y., 1 Dec 2019, In : Current Opinion Chemical Biology. 53, p. 167-172 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Clinical trials targeting the stroma in pancreatic cancer: A systematic review and meta-analysis

van Mackelenbergh, M. G., Stroes, C. I., Spijker, R., van Eijck, C. H. J., Wilmink, J. W., Bijlsma, M. F. & van Laarhoven, H. W. M., 1 May 2019, In : Cancers. 11, 5, 588.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Coexisting Molecular Determinants of Acquired Oxaliplatin Resistance in Human Colorectal and Ovarian Cancer Cell Lines

Noordhuis, P., Laan, A. C., van de Born, K., Honeywell, R. J. & Peters, G. J., 2019, In : International Journal of Molecular Sciences. 20, 15

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Colorectal cancer growth retardation through induction of apoptosis, using an optimized synergistic cocktail of axitinib, erlotinib, and dasatinib

Berndsen, R. H., Swier, N., van Beijnum, J. R. & Nowak-Sliwinska, P., 2019, In : Cancers. 11, 12, 1878.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Combination Therapies of Artemisinin and its Derivatives as a Viable Approach for Future Cancer Treatment

Kumar, M. S., Yadav, T. T., Khair, R. R., Peters, G. J. & Yergeri, M. C., 2019, In : Current pharmaceutical design. 25, 31, p. 3323-3338

Research output: Contribution to journalArticleAcademicpeer-review

Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer?

Goedegebuure, R. S. A., de Klerk, L. K., Bass, A. J., Derks, S. & Thijssen, V. L. J. L., 2019, In : Frontiers in Immunology. 10, JAN, 3107.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Menden, M. P., Wang, D., Mason, M. J., Szalai, B., Bulusu, K. C., Guan, Y., Yu, T., Kang, J., Jeon, M., Wolfinger, R., Nguyen, T., Zaslavskiy, M., AstraZeneca-Sanger Drug Combination DREAM Consortium, Jang, I. S., Ghazoui, Z., Ahsen, M. E., Vogel, R., Neto, E. C., Norman, T., Tang, E. K. Y. & 7 others, Garnett, M. J., Veroli, G. Y. D., Fawell, S., Stolovitzky, G., Guinney, J., Dry, J. R. & Saez-Rodriguez, J., 1 Dec 2019, In : Nature Communications. 10, 1, 2674.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

Gonzalez, M. L., Oosterhoff, D., Lindenberg, J. J., Milenova, I., Lougheed, S. M., Martianez, T., Dekker, H., Quixabeira, D. C. A., Hangalapura, B., Joore, J., Piersma, S. R., Cervera-Carrascon, V., Santos, J. M., Scheper, R. J., Verheul, H. M. W., Jimenez, C. R., Van De Ven, R., Hemminki, A., Van Beusechem, V. W. & De Gruijl, T. D., 1 Jan 2019, In : OncoImmunology. 8, 10

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Corrigendum to “An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature” (Vaccine (2018) 36(21) (3054–3060), (S0264410X1830433X), (10.1016/j.vaccine.2018.03.064))

Huijbers, E. J. M., van Beijnum, J. R., Lê, C. T., Langman, S., Nowak-Sliwinska, P., Mayo, K. H. & Griffioen, A. W., 9 Jul 2019, In : Vaccine. 37, 30, p. 4231-4232 2 p.

Research output: Contribution to journalErratumAcademicpeer-review

Open Access

Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract

Roos, E., Soer, E. C., Klompmaker, S., Meijer, L. L., Besselink, M. G., Giovannetti, E., Heger, M., Kazemier, G., Klümpen, H. J., Takkenberg, R. B., Wilmink, H., Würdinger, T., Dijk, F., van Gulik, T. M., Verheij, J. & van de Vijver, M. J., 1 Aug 2019, In : Critical Reviews in Oncology/Hematology. 140, p. 8-16

Research output: Contribution to journalReview articleAcademicpeer-review

Cutaneous Toxicity After Chemoradiotherapy and PD-L1 Inhibition in Two Patients with Esophageal Adenocarcinoma: More than Meets the Eye

van den Ende, T., Menting, S. P., Ambarus, C. A., van Oijen, M. G. H. & van Laarhoven, H. W. M., 1 Apr 2019, In : Oncologist. 24, 4, p. e149-e153

Research output: Contribution to journalArticleAcademicpeer-review

CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage

el Hassouni, B., Mantini, G., Immordino, B., Peters, G. J. & Giovannetti, E., 2019, In : Molecules. 24, 24

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line

van der Steen, N., Leonetti, A., Keller, K., Dekker, H., Funel, N., Lardon, F., Ruijtenbeek, R., Tiseo, M., Rolfo, C., Pauwels, P., Peters, G. J. & Giovannetti, E., 2019, In : Biochemical Pharmacology. 166, p. 128-138

Research output: Contribution to journalArticleAcademicpeer-review

Diagnosing pancreatic ductal adenocarcinoma using plasma extracellular vesicle RNA profiles

Frampton, A. E. & Giovannetti, E., 4 Dec 2019, In : Gut.

Research output: Contribution to journalComment/Letter to the editorAcademic

Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma

Shigeta, K., Datta, M., Hato, T., Kitahara, S., Chen, I. X., Matsui, A., Kikuchi, H., Mamessier, E., Aoki, S., Ramjiawan, R. R., Ochiai, H., Bardeesy, N., Huang, P., Cobbold, M., Zhu, A. X., Jain, R. K. & Duda, D. G., 2019, In : Hepatology.

Research output: Contribution to journalArticleAcademicpeer-review

E-drug delivery: a futuristic approach

Yadav, K. S., Kapse-Mistry, S., Peters, G. J. & Mayur, Y. C., 1 Apr 2019, In : Drug Discovery Today. 24, 4, p. 1023-1030 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Folate receptors and transporters: Biological role and diagnostic/therapeutic targets in cancer and other diseases

Frigerio, B., Bizzoni, C., Jansen, G., Leamon, C. P., Peters, G. J., Low, P. S., Matherly, L. H. & Figini, M., 12 Mar 2019, In : JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 38, 1, 125.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

From ‘targeted therapy’ to targeted therapy*

Peters, G. J., 2019, In : Anticancer Research. 39, 7, p. 3341-3345

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glyco-dendrimers as intradermal anti-tumor vaccine targeting multiple skin DC subsets

Duinkerken, S., Horrevorts, S. K., Kalay, H., Ambrosini, M., Rutte, L., de Gruijl, T. D., Garcia-Vallejo, J. J. & van Kooyk, Y., 1 Jan 2019, In : Theranostics. 9, 20, p. 5797-5809

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers

Moosavi, F., Giovannetti, E., Saso, L. & Firuzi, O., 17 Nov 2019, In : Critical Reviews in Clinical Laboratory Sciences. 56, 8, p. 533-566 34 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access