Medical oncology laboratory

Research Output 1989 2019

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2019

Modification of Drug Response in Cancer by MicroRNAs

Meijer, L. L., Puik, J. R., Vivaldi, C., Capula, M., Vasile, E., Kazemier, G. & Giovannetti, E., 2019, RSC Drug Discovery Series. Royal Society of Chemistry, Vol. 2019-January. p. 416-451 (RSC Drug Discovery Series).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

2017

Immunotherapy in NSCLC: A Promising and Revolutionary Weapon

Giovannetti, E., 2017, Advances in Experimental Medicine and Biology Series. Springer

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Liquid Biopsies in Esophageal, Gastric and Pancreatic Cancers

Giovannetti, E., 2017, Current Clinical Pathology Series. Humana Press

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Pancreatic Cancer: Prevention, Detection and Treatment

Giovannetti, E., Peters, GJ., Maftouh, M. & Avan, A., 2017, Gastrointestinal Cancers: Prevention, Detection and Treatment..

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Re-emerging antimetabolites with novel mechanism of action with respect to epigenetic regulation: Basic aspects

Sarkisjan, D., Steenbergen, R. D. M., Cloos, J. & Peters, G. J., 17 Apr 2017, Chemotherapy for Leukemia: Novel Drugs and Treatment. Springer Singapore, p. 311-326 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

2016

CYB5A (Cytochrome B5 Type A (microsomal)

Gomez, V. E., Avan, A., Peters, GJ. & Giovannetti, E., 2016, Atlas Genet Cytogenet Oncol Hematol .

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

2015

Pharmacology and Clinical Development of New Molecularly Targeted Agents

Giovannetti, E. & Galvani, E., 2015, Targeted Therapies for Solid Tumors. p. 9-29

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2013

Angiostatic Cancer Therapy by Targeting Galectins in the Tumor Vasculature

Schulkens, I. A. E., Griffioen, A. W. & Thijssen, V. L., 2013, Galectins and Disease Implications for Targeted Therapeutics. p. 233-247 (ACS Symposium Series).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Immuuntherapie bij prostaatkanker

de Gruijl, T. D. & Gerritsen, W. R., 2013, Handboek Immuuntherapie in de Interne Geneeskunde. van Zuiden Communications BV, p. 363-374

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

MIR211 (microRNA 211)

Avan, A., Maftouh, M., Peters, G. J. & Giovannetti, E., 2013, Atlas Genet Cytogenet Oncol Haematol.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2012

Antigen targeting to dendritic cells for cancer immunotherapy

Oosterhoff, D., Curiel, D. T. & de Gruijl, T. D., 2012, Cancer Immunotherapy: Paradigms, Practice and Potential. Springer

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Clinical trials with α-galactosylceramide (KRN7000) in advanced cancer

Schneiders, F. L., Scheper, R. J., Bontkes, H. J., von Blomberg, B. M. E., Eertwegh, A. J. M., de Gruijl, T. D. & Van Der Vliet, H. J., 1 Jan 2012, Natural Killer T cells: Balancing the Regulation of Tumor Immunity. Springer New York, p. 169-183 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Meningiomas: clinical needs and molecular insights

Peerdeman, S. M., Okay, S. & Jimenez, C. R., 2012, Tumors of the Central Nervous System. p. 39-46

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2011

Clinical trials with a-Galactosylceramide (KRN7000) in advanced cancer

Schneiders, F. L., Scheper, R. J., Bontkes, H. J., von Blomberg, B. M. E., van den Eertwegh, A. J. M., de Gruijl, T. D. & van der Vliet, J. J., 2011, Natural killer T cells: Balancing the regulation of tumor immunity, Cancer drug discovery and development. Springer Science + Business Media, p. 1

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Serum profiling using semi-automated serum peptide capture with magnetic reversed phase (C18) beads

Knol, J. C. & Jimenez, C. R., 2011, Nanoproteomics: Methods and protocols. Humana Press, Methods Mol Biol, p. 3-16

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2010

Surrogate markers of anti-angiogenic therapies

Boven, E., Meijerink, M. R., Vroling, L. & van der Veldt, A. A. M., 2010, Angiogenesis & Therapeutic Targets of Cancer. Bentham Science Publication, p. 330-353

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2008

OplAnalyzer: A Toolbox for MALDI-TOF Mass Spectrometry Data Analysis

Pham, T. V. & Jimenez, C. R., 2008, Advances in Mass Data Analysis of Images and Signals in Medicine, Biotechnology, Chemistry and Food Industry. p. 73-81

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2007

Chemistry and Biology of Pteridines and Folates

Jansen, G. & Peters, GJ., 2007, Proceedings 13th International Symposium on Chemistry and Biology of Pteridines and Folates. Jansen, G. & Peters, G. J. (eds.). SHS Publications, Heilbronn, Germany, p. 1-607 607 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Effects of polymorphisms in folate-related genes on methotrexate sensitivity and risk of acute lymphoblastic leukemia

de Jonge, R., Tissing, W. J., van Zelst, B. D., Jansen, G., Kaspers, GJL., Peters, GJ., Pieters, R. & Lindemans, J., 2007, In: "Chemistry and Biology of Pteridines and Folates" . Jansen, G. & Peters, G. J. (eds.). SHS Publications, Heilbronn, Germany, p. 515-534 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

The interaction between folate homeostasis and MRPs/ABCCs and BCRP/ABCG2 expression: role in cellular drug resistance

Hooijberg, J. H., Lemos, C., Jansen, G., Assaraf, Y. G., Pieters, R., Kaspers, GJL., Priest, D. G., Wielinga, P. & Peters, GJ., 2007, In: "Chemistry and Biology of Pteridines and Folates". Jansen, G. & Peters, G. J. (eds.). SHS Publications, Heilbronn, Germany, p. 189-204 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

2001

Antimetabolites

Peters, GJ. & Jansen, G., 2001, In: "Oxford Textbook of Oncology". Souhami, RL., Tannock, I., Hohenberger, P. & Horiot, JC. (eds.). Oxford University Press, p. 663-713 51 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Kinetics of reduced folate carrier and membrane-associated folate receptor mediated transport of antifolates

Mauritz, R., Peters, GJ., Kathmann, G. A. M., Rosowsky, A., Pinedo, HM. & Jansen, G., 2001, In: "Chemistry and Biology of Pteridines and Folates". Milstein, S., Kapatos, G., Levine, RA. & Shane, B. (eds.). Kluwer Academic Publishers, p. 649-654 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Role of multidrug resistance proteins (MRP) in resistance to antifolates and folate homeostasis

Jansen, G., Assaraf, Y. G., Priest, D. G., Kool, M., Kathman, I., Hooijberg, J. H., Scheper, RJ., Dijkmans, BAC., Kaspers, GJL. & Peters, GJ., 2001, In: "Chemistry and Biology of Pteridines and Folates". Milstien, S., Kapatos, G., Levine, RA. & Shane, B. (eds.). Kluwer Academic Publishers, p. 643-648 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

1997

Activity of folylpolyglutamate synthetase and hydrolase in clinical specimens of head and necks tumors

Jansen, G., Kathman, I., Hordijk, G. J., Slootweg, P. J., Peters, GJ. & van der Laan, B. F. A. M., 1997, In: "Chemistry and Biology of Pteridines and Folates". Pfleiderer, W. & Rokos, H. (eds.). Blackwell, p. 459-462 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Altered metabolism of (anti)folates in pyrimethamine resistant Chinese hamster ovary cells

Jansen, G., Barr, HM., Kathman, I., Peters, GJ., Bunni, M. A., Priest, D. G. & Assaraf, Y. G., 1997, In: "Chemistry and Biology of Pteridines and Folates". Blackwell, p. 253-256 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

A novel mechanism of resistance to polyglutamatable antifolates in human CEM leukemia cells: association with the expression of an altered reduced folate carrier (RFC) with enhanced efficiency for folic acid uptake

Mauritz, R., Kathman, I., Assaraf, Y. G., Drori, S., Priest, D. G., Bunni, M. A., Pinedo, HM., Peters, GJ. & Jansen, G., 1997, In: "Chemistry and Biology of Pteridines and Folates". Pfleiderer, W. & Rokos, H. (eds.). Blackwell, p. 157-162 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Mechanisms of methotrexate (MTX) resistance and its circumvention by novel antifolates in childhood leukemia

Rots, M. G., Pieters, R., Veerman, A. J. P., van Zantwijk, C. H., Noordhuis, P., Peters, GJ. & Jansen, G., 1997, In: "Chemistry and Biology of Pteridines and Folates". Pfleiderer, W. & Rokos, H. (eds.). Blackwell, p. 175-180 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Mechanisms of resistance against methotrexate and novel antifolates in human CCRF-CEM leukemia cells

Kathmann, I., Mauritz, R., Noordhuis, P., Voorn, D. A., Aardewijn, P., Schornagel, J. H., Pinedo, HM., Peters, GJ. & Jansen, G., 1997, In: "Chemistry and Biology of Pteridines and Folates". Pfleiderer, W. & Rokos, H. (eds.). Blackwell, p. 257-261 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Multilayered tumor cell line cultures as in vitro drug screening model for new thymidylate synthase (TS) inhibitors

Smid, K., Smitskamp-Wilms, E., Jansen, G., Pinedo, HM. & Peters, GJ., 1997, In: "Chemistry and Biology of Pteridines and Folates". Blackwell, p. 237-240 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Preclinical activity of PT523 in relation to transport

Peters, GJ., Braakhuis, BJM., Rosowsky, A., Kegel, A., Rots, M. G., van der Wilt, C. L., Pinedo, HM. & Jansen, G., 1997, In: "Chemistry and Biology of Pteridines and Folates". Pfleiderer, W. & Rokos, H. (eds.). Blackwell, p. 267-270 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and resistant leukemia cells

Jansen, G., Assaraf, Y. G., Kathman, I., Mauritz, R., Sprecher, H., Priest, D. G., Bunni, M. A., Schornagel, J. H., Pinedo, HM. & Peters, GJ., 1997, In: "Chemistry and Biology of Pteridines and Folates". Pfleiderer, W. & Rokos, H. (eds.). Blackwell, p. 111-122 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Role of cell culture medium folate levels on growth inhibition by thymidylate synthase inhibitors in squamous cell cancer and colon cancer cells

Backus, H. H. J., Wouters, D., van der Wilt, C. L., Jansen, G., Kuiper, C. M., van Groeningen, C. J., Pinedo, HM. & Peters, GJ., 1997, In: "Chemistry and Biology of Pteridines and Folates". Blackwell, p. 299-232 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Role of folylpolyglutamate hydrolase in methotrexate resistance in childhood leukemia

Noordhuis, P., Rots, M. G., van Zantwijk, C. H., Pieters, R., Veerman, A. J. P., Peters, GJ. & Jansen, G., 1997, In: "Chemistry and Biology of Pteridines and Folates". Pfleiderer, W. & Rokos, H. (eds.). Blackwell, p. 463-466 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

1996

Resistance to antimetabolites

Peters, GJ. & Jansen, G., 1996, In: "Principles of antineoplastic drug development and pharmacology" . Schilsky, RL., Milano, G. & Ratain, MJ. (eds.). Marcel Dekker, Inc, NY, p. 543-584 42 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Sensitivity for novel antifolates in childhood leukemia cells with resistance to methotrexate

Bekkenk, M., Mauritz, R., Pieters, R., Rots, M. G., van Zantwijk, C. H., Veerman, A. J. P., Peters, GJ. & Jansen, G., 1996, In: "Drug resistance in leukemia and lymphoma". Pieters, R., Kaspers, GJL. & Veerman, AJP. (eds.). Harwood Academic Publishers, p. 173-181 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

1995

The impact of transport-associated resistance in anticancer therapy

Broxterman, HJ., Jansen, G., Linn, S. C. & Lankelma, J., 1995, In: "Drug transport in antimicrobial and anticancer chemotherapy". Georgopapadakou, NH. (ed.). Marcel Dekker, Inc, NY, p. 21-62 42 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional