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2020

3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma

Cascioferro, S., Li Petri, G., Parrino, B., el Hassouni, B., Carbone, D., Arizza, V., Perricone, U., Padova, A., Funel, N., Peters, G. J., Cirrincione, G., Giovannetti, E. & Diana, P., 2020, In : Molecules. 25, 2, E329.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

Van Der Steen, N., Keller, K., Dekker, H., Porcelli, L., Honeywell, R. J., Van Meerloo, J., Musters, R. J. P., Kathmann, I., Frampton, A. E., Liu, D. S. K., Ruijtenbeek, R., Rolfo, C., Pauwels, P., Giovannetti, E. & Peters, G. J., 1 Jan 2020, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Functional genomic screen in mesothelioma reveals that loss of function of BRCA1-associated-protein-1 induces chemoresistance to ribonucleotide reductase inhibition

Okonska, A., Bühler, S., Rao, V., Ronner, M., Blijlevens, M., van der Meulen-Muileman, I. H., de Menezes, R. X., Wipplinger, M., Oehl, K., Smit, E. F., Weder, W., Stahel, R. A., Penengo, L., van Beusechem, V. W. & Felley-Bosco, E., Feb 2020, In : Molecular Cancer Therapeutics. 19, 2, p. 552-563 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression and Glucose Uptake in Muscle Through Adipomuscular Arterioles

Turaihi, A. H., Serné, E. H., Molthoff, C. F. M., Koning, J. J., Knol, J., Niessen, H. W., Jose Th Goumans, M., van Poelgeest, E. M., Yudkin, J. S., Smulders, Y. M., Jimenez, C. R., van Hinsbergh, V. W. & Eringa, E. C., 31 Jan 2020, In : Diabetes.

Research output: Contribution to journalArticleAcademicpeer-review

2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors

Cascioferro, S., Parrino, B., Petri, G. L., Cusimano, M. G., Schillaci, D., di Sarno, V., Musella, S., Giovannetti, E., Cirrincione, G. & Diana, P., 1 Apr 2019, In : European Journal of Medicinal Chemistry. 167, p. 200-210 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression

Berndsen, R. H., Castrogiovanni, C. D., Weiss, A., Rausch, M., Dallinga, M. G., Miljkovic-Licina, M., Klaassen, I., Meraldi, P., van Beijnum, J. R. & Nowak-Sliwinska, P., 16 Jul 2019, In : British Journal of Cancer. 121, 2, p. 139-149 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives against Pancreatic Cancer Cells*

Li Petri, G., Cascioferro, S., el Hassouni, B., Carbone, D., Parrino, B., Cirrincione, G., Peters, G. J., Diana, P. & Giovannetti, E., 1 Jan 2019, In : Anticancer Research. 39, 7, p. 3615-3620

Research output: Contribution to journalArticleAcademicpeer-review

Cancer immunophenotyping by 7 colour multispectral imaging without tyramide signal amplification

Ijselstein, M., Brouwer, T., Abdulrahman, Z., Reidy, E., Ramalheiro, A., Heeren, AM., Vahrmeijer, A., Jordanova, ES. & de Miranda, N., Jan 2019, In : The Journal of Pathology: Clinical Research. 5, 1, p. 3-11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CD31-positive microvessel density within adenomas of Lynch Syndrome patients is similar compared to adenomas of non-Lynch patients

Vleugels, J. L. A., van Neerven, S. M., van Leerdam, M. E., Wanders, L. K., de Wit, M., Carvalho, B., Delis-van Diemen, P. M., Kallenberg, F. G. J., Vermeulen, L., Beliën, J. A., East, J. E., Meijer, G. A. & Dekker, E., May 2019, In : Endoscopy International Open. 7, 5, p. E701-E707

Research output: Contribution to journalArticleAcademicpeer-review

Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies

Stokman, M. F., Bijnsdorp, I. V., Schelfhorst, T., Pham, T. V., Piersma, S. R., Knol, J. C., Giles, R. H., Bongers, E. M. H. F., Knoers, N. V. A. M., Lilien, M. R., Jiménez, C. R. & Renkema, K. Y., 10 Feb 2019, In : Journal of Proteomics. 192, p. 27-36 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson’s Disease and Dementia with Lewy Bodies

Moors, T. E., Paciotti, S., Ingrassia, A., Quadri, M., Breedveld, G., Tasegian, A., Chiasserini, D., Eusebi, P., Duran-Pacheco, G., Kremer, T., Calabresi, P., Bonifati, V., Parnetti, L., Beccari, T. & van de Berg, W. D. J., 1 Feb 2019, In : Molecular Neurobiology. 56, 2, p. 1344-1355 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Coexisting Molecular Determinants of Acquired Oxaliplatin Resistance in Human Colorectal and Ovarian Cancer Cell Lines

Noordhuis, P., Laan, A. C., van de Born, K., Honeywell, R. J. & Peters, G. J., 2019, In : International Journal of Molecular Sciences. 20, 15

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Colorectal cancer growth retardation through induction of apoptosis, using an optimized synergistic cocktail of axitinib, erlotinib, and dasatinib

Berndsen, R. H., Swier, N., van Beijnum, J. R. & Nowak-Sliwinska, P., 2019, In : Cancers. 11, 12, 1878.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Combination Therapies of Artemisinin and its Derivatives as a Viable Approach for Future Cancer Treatment

Kumar, M. S., Yadav, T. T., Khair, R. R., Peters, G. J. & Yergeri, M. C., 2019, In : Current pharmaceutical design. 25, 31, p. 3323-3338

Research output: Contribution to journalArticleAcademicpeer-review

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Menden, M. P., Wang, D., Mason, M. J., Szalai, B., Bulusu, K. C., Guan, Y., Yu, T., Kang, J., Jeon, M., Wolfinger, R., Nguyen, T., Zaslavskiy, M., AstraZeneca-Sanger Drug Combination DREAM Consortium, Jang, I. S., Ghazoui, Z., Ahsen, M. E., Vogel, R., Neto, E. C., Norman, T., Tang, E. K. Y. & 7 others, Garnett, M. J., Veroli, G. Y. D., Fawell, S., Stolovitzky, G., Guinney, J., Dry, J. R. & Saez-Rodriguez, J., 1 Dec 2019, In : Nature Communications. 10, 1, 2674.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

Gonzalez, M. L., Oosterhoff, D., Lindenberg, J. J., Milenova, I., Lougheed, S. M., Martianez, T., Dekker, H., Quixabeira, D. C. A., Hangalapura, B., Joore, J., Piersma, S. R., Cervera-Carrascon, V., Santos, J. M., Scheper, R. J., Verheul, H. M. W., Jimenez, C. R., Van De Ven, R., Hemminki, A., Van Beusechem, V. W. & De Gruijl, T. D., 1 Jan 2019, In : OncoImmunology. 8, 10

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cutaneous Toxicity After Chemoradiotherapy and PD-L1 Inhibition in Two Patients with Esophageal Adenocarcinoma: More than Meets the Eye

van den Ende, T., Menting, S. P., Ambarus, C. A., van Oijen, M. G. H. & van Laarhoven, H. W. M., 1 Apr 2019, In : Oncologist. 24, 4, p. e149-e153

Research output: Contribution to journalArticleAcademicpeer-review

CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage

el Hassouni, B., Mantini, G., Immordino, B., Peters, G. J. & Giovannetti, E., 2019, In : Molecules. 24, 24

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line

van der Steen, N., Leonetti, A., Keller, K., Dekker, H., Funel, N., Lardon, F., Ruijtenbeek, R., Tiseo, M., Rolfo, C., Pauwels, P., Peters, G. J. & Giovannetti, E., 2019, In : Biochemical Pharmacology. 166, p. 128-138

Research output: Contribution to journalArticleAcademicpeer-review

Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma

Shigeta, K., Datta, M., Hato, T., Kitahara, S., Chen, I. X., Matsui, A., Kikuchi, H., Mamessier, E., Aoki, S., Ramjiawan, R. R., Ochiai, H., Bardeesy, N., Huang, P., Cobbold, M., Zhu, A. X., Jain, R. K. & Duda, D. G., 2019, In : Hepatology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Folate receptors and transporters: Biological role and diagnostic/therapeutic targets in cancer and other diseases

Frigerio, B., Bizzoni, C., Jansen, G., Leamon, C. P., Peters, G. J., Low, P. S., Matherly, L. H. & Figini, M., 12 Mar 2019, In : JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 38, 1, 125.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

From ‘targeted therapy’ to targeted therapy*

Peters, G. J., 2019, In : Anticancer Research. 39, 7, p. 3341-3345

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glyco-dendrimers as intradermal anti-tumor vaccine targeting multiple skin DC subsets

Duinkerken, S., Horrevorts, S. K., Kalay, H., Ambrosini, M., Rutte, L., de Gruijl, T. D., Garcia-Vallejo, J. J. & van Kooyk, Y., 1 Jan 2019, In : Theranostics. 9, 20, p. 5797-5809

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

High-throughput RNAi screening reveals cancer-selective lethal targets in the RNA spliceosome

Blijlevens, M., van der Meulen-Muileman, I. H., de Menezes, R. X., Smit, E. F. & van Beusechem, V. W., 23 May 2019, In : Oncogene. 38, 21, p. 4142-4153 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Human testis phosphoproteome reveals kinases as potential targets in spermatogenesis and testicular cancer

Castillo, J., Knol, J. C., Korver, C. M., Piersma, S. R., Pham, T. V., de Goeij-de Haas, R. R., van Pelt, A. M. M., Jimenez, C. R. & Jansen, B. J. H., 1 Mar 2019, In : Molecular and Cellular Proteomics. 18, p. S132-S144

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hybrid ligands with calixarene and thiodigalactoside groups: Galectin binding and cytotoxicity

Zhang, H., Ippel, H., Miller, M. C., Wong, T. J., Griffioen, A. W., Mayo, K. H. & Pieters, R. J., 2019, In : Organic Chemistry Frontiers. 6, 16, p. 2981-2990

Research output: Contribution to journalArticleAcademicpeer-review

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

Beekhof, R., van Alphen, C., Henneman, A. A., Knol, J. C., Pham, T. V., Rolfs, F., Labots, M., Henneberry, E., le Large, T. Y., de Haas, R. R., Piersma, S. R., Vurchio, V., Bertotti, A., Trusolino, L., Verheul, H. M. & Jimenez, C. R., 1 Apr 2019, In : Molecular Systems Biology. 15, 4, p. e8250 e8250.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Loss of stromal galectin-1 enhances multiple myeloma development: Emphasis on a role in osteoclasts

Muller, J., Duray, E., Lejeune, M., Dubois, S., Plougonven, E., Léonard, A., Storti, P., Giuliani, N., Cohen-Solal, M., Hempel, U., Thijssen, V. L., Beguin, Y., Heusschen, R. & Caers, J., 1 Feb 2019, In : Cancers. 11, 2, 261.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Metronomic cyclophosphamide attenuates mTOR-mediated expansion of regulatory T cells, but does not impact clinical outcome in patients with metastatic renal cell cancer treated with everolimus

Werter, I. M., Huijts, C. M., Lougheed, S. M., Hamberg, P., Polee, M. B., Tascilar, M., Los, M., Haanen, J. B. A. G., Helgason, H. H., Verheul, H. M., de Gruijl, T. D., van der Vliet, H. J. & Dutch WIN-O Consortium, 1 May 2019, In : Cancer Immunology, Immunotherapy. 68

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNAs as a drug resistance mechanism to targeted therapies in EGFR-mutated NSCLC: Current implications and future directions

Leonetti, A., Assaraf, Y. G., Veltsista, P. D., El Hassouni, B., Tiseo, M. & Giovannetti, E., 1 Jan 2019, In : Drug Resistance Updates. 42, p. 1-11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer

Leonetti, A., Wever, B., Mazzaschi, G., Assaraf, Y. G., Rolfo, C., Quaini, F., Tiseo, M. & Giovannetti, E., 1 Sep 2019, In : Drug Resistance Updates. 46, p. 100644 100644.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression

Komor, M. A., de Wit, M., van den Berg, J., Martens de Kemp, S. R., Delis-van Diemen, P. M., Bolijn, A. S., Tijssen, M., Schelfhorst, T., Piersma, S. R., Chiasserini, D., Sanders, J., Rausch, C., Hoogstrate, Y., Stubbs, A. P., de Jong, M., Jenster, G., Carvalho, B., Meijer, G. A., Jimenez, C. R., Fijneman, R. J. A. & 1 others, In collaboration with the NGS-ProToCol Consortium, 14 Aug 2019, In : International Journal of Cancer.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neoadjuvant cisplatin and paclitaxel modulate tumor-infiltrating T cells in patients with cervical cancer

Heeren, A. M., van Luijk, I. F., Lakeman, J., Pocorni, N., Kole, J., de Menezes, R. X., Kenter, G. G., Bosse, T., de Kroon, C. D. & Jordanova, E. S., 1 Nov 2019, In : Cancer Immunology, Immunotherapy. 68, 11, p. 1759-1767 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

New avenues in pancreatic cancer: exploiting microRNAs as predictive biomarkers and new approaches to target aberrant metabolism

Capula, M., Mantini, G., Funel, N. & Giovannetti, E., 2 Dec 2019, In : Expert Review of Clinical Pharmacology. 12, 12, p. 1081-1090

Research output: Contribution to journalArticleAcademicpeer-review

Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment

Nowak-Sliwinska, P., van Beijnum, J. R., Huijbers, E. J. M., Gasull, P. C., Mans, L., Bex, A. & Griffioen, A. W., 22 Jan 2019, In : British Journal of Cancer. 120, 2, p. 218-228 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacogenetics of treatments for pancreatic cancer

el Hassouni, B., Li Petri, G., Liu, D. S. K., Cascioferro, S., Parrino, B., Hassan, W., Diana, P., Ali, A., Frampton, A. E. & Giovannetti, E., 3 Jun 2019, In : Expert Opinion on Drug Metabolism and Toxicology. 15, 6, p. 437-447 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Phase 1 study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell carcinoma

Huijts, C. M., Werter, I. M., Lougheed, S. M., Goedegebuure, R. S., van Herpen, C. M., Hamberg, P., Tascilar, M., Haanen, J. B., Verheul, H. M., de Gruijl, T. D., van der Vliet, H. J. & Dutch WIN-O Consortium, Feb 2019, In : Cancer Immunology, Immunotherapy. 68, 2, p. 319-329

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Platelets: the holy grail in cancer blood biomarker research?

Sabrkhany, S., Kuijpers, M. J. E., Griffioen, A. W. & Oude Egbrink, M. G. A., 15 Feb 2019, In : Angiogenesis. 22, 1

Research output: Contribution to journalArticleAcademicpeer-review

Proteins in stool as biomarkers for non-invasive detection of colorectal adenomas with high risk of progression

Komor, M. A., Bosch, L. J. W., Coupé, V. M. H., Rausch, C., Pham, T. V., Piersma, S. R., Mongera, S., Mulder, C. J. J., Dekker, E., Kuipers, E. J., van de Wiel, M. A., Carvalho, B., Fijneman, R. J. A., Jimenez, C. R., Meijer, G. A. & de Wit, M., Nov 2019, In : Journal of Pathology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Proteome analysis of non-small cell lung cancer cell line secretomes and patient sputum reveals biofluid biomarker candidates for cisplatin response prediction

Böttger, F., Schaaij-Visser, T. B., de Reus, I., Piersma, S. R., Pham, T. V., Nagel, R., Brakenhoff, R. H., Thunnissen, E., Smit, E. F. & Jimenez, C. R., 30 Mar 2019, In : Journal of Proteomics. 196, p. 106-119

Research output: Contribution to journalArticleAcademicpeer-review