Medical oncology laboratory

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Review article
2020

Combining Radiation Therapy With Interferons: Back to the Future

Goedegebuure, R. S. A., Vonk, C., Kooij, L. P., Derks, S. & Thijssen, V. L. J. L., 1 Jan 2020, (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics. 108, 1, 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Computational Analysis of Phosphoproteomics Data in Multi-Omics Cancer Studies

Mantini, G., Pham, T. V., Piersma, S. R. & Jimenez, C. R., 2020, In : Proteomics.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Insights from immuno-oncology: The Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19

Ascierto, P. A., Fox, B., Urba, W., Anderson, A. C., Atkins, M. B., Borden, E. C., Brahmer, J., Butterfield, L. H., Cesano, A., Chen, D., De Gruijl, T., Dillman, R. O., Drake, C. G., Emens, L. A., Gajewski, T. F., Gulley, J. L., Stephen Hodi, F., Hwu, P., Kaufman, D., Kaufman, H. & 14 others, Lotze, M., McNeel, D. G., Margolin, K., Marincola, F., Mastrangelo, M. J., Maus, M. V., Parkinson, D. R., Romero, P. J., Sondel, P. M., Spranger, S., Sznol, M., Weiner, G. J., Wiggington, J. M. & Weber, J. S., 16 Apr 2020, In : Journal for Immunotherapy of Cancer. 8, 1, e000878.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors

Kes, M. M. G., van den Bossche, J., Griffioen, A. W. & Huijbers, E. J. M., 1 Dec 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1874, 2, 188427.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Priming the tumor immune microenvironment with chemo(radio)therapy: A systematic review across tumor types

van den Ende, T., van den Boorn, H. G., Hoonhout, N. M., van Etten-Jamaludin, F. S., Meijer, S. L., Derks, S., de Gruijl, T. D., Bijlsma, M. F., van Oijen, M. G. H. & van Laarhoven, H. W. M., Aug 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1874, 1, 188386.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Role of fibrillin-2 in the control of TGF-β activation in tumor angiogenesis and connective tissue disorders

van Loon, K., Yemelyanenko-Lyalenko, J., Margadant, C., Griffioen, A. W. & Huijbers, E. J. M., Apr 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1873, 2, 188354.

Research output: Contribution to journalReview articleAcademicpeer-review

Targeting telomerase for its advent in cancer therapeutics

Bajaj, S., Kumar, M. S., Peters, G. J. & Mayur, Y. C., 1 Jan 2020, (Accepted/In press) In : Medicinal Research Reviews. 40, 5, 49 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The continuous rediscovery and the benefit–risk ratio of thioguanine, a comprehensive review

Bayoumy, A. B., Simsek, M., Seinen, M. L., Mulder, C. J. J., Ansari, A., Peters, G. J. & De Boer, N. K., 1 Feb 2020, In : Expert Opinion on Drug Metabolism and Toxicology. 16, 2, p. 111-123 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The role of alternative splicing in cancer: From oncogenesis to drug resistance

Sciarrillo, R., Wojtuszkiewicz, A., Assaraf, Y. G., Jansen, G., Kaspers, G. J. L., Giovannetti, E. & Cloos, J., 1 Dec 2020, In : Drug Resistance Updates. 53, 100728.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment

Buckens, O. J., El Hassouni, B., Giovannetti, E. & Peters, G. J., 1 Jan 2020, (Accepted/In press) In : Expert Opinion on Investigational Drugs. 29, 6, 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

Cascioferro, S., Parrino, B., Carbone, D., Schillaci, D., Giovannetti, E., Cirrincione, G. & Diana, P., 13 Aug 2020, In : Journal of Medicinal Chemistry. 63, 15, p. 7923-7956 34 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2019

A brief guide to performing pharmacological studies in vitro: Reflections from the EORTC-PAMM Course “Preclinical and Early-phase Clinical Pharmacology”

Capula, M., Corno, C., Hassouni, B. E. L., Petri, G. L. I., Aranđelović, S. & on Behalf of the EORTC PAMM Group, 1 Jan 2019, In : Anticancer Research. 39, 7, p. 3413-3418

Research output: Contribution to journalReview articleAcademicpeer-review

Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells

Duinkerken, S., Li, RJE., van Haften, F. J., de Gruijl, TD., Chiodo, F., Schetters, STT. & van Kooyk, Y., 1 Dec 2019, In : Current Opinion Chemical Biology. 53, p. 167-172 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Clinical trials targeting the stroma in pancreatic cancer: A systematic review and meta-analysis

van Mackelenbergh, M. G., Stroes, C. I., Spijker, R., van Eijck, C. H. J., Wilmink, J. W., Bijlsma, M. F. & van Laarhoven, H. W. M., 1 May 2019, In : Cancers. 11, 5, 588.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer?

Goedegebuure, R. S. A., de Klerk, L. K., Bass, A. J., Derks, S. & Thijssen, V. L. J. L., 2019, In : Frontiers in Immunology. 10, JAN, 3107.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract

Roos, E., Soer, E. C., Klompmaker, S., Meijer, L. L., Besselink, M. G., Giovannetti, E., Heger, M., Kazemier, G., Klümpen, H. J., Takkenberg, R. B., Wilmink, H., Würdinger, T., Dijk, F., van Gulik, T. M., Verheij, J. & van de Vijver, M. J., 1 Aug 2019, In : Critical Reviews in Oncology/Hematology. 140, p. 8-16

Research output: Contribution to journalReview articleAcademicpeer-review

E-drug delivery: a futuristic approach

Yadav, K. S., Kapse-Mistry, S., Peters, G. J. & Mayur, Y. C., 1 Apr 2019, In : Drug Discovery Today. 24, 4, p. 1023-1030 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers

Moosavi, F., Giovannetti, E., Saso, L. & Firuzi, O., 17 Nov 2019, In : Critical Reviews in Clinical Laboratory Sciences. 56, 8, p. 533-566 34 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Light and shadow on innovative clinical trial designs: reflections from the EORTC-PAMM course on ‘preclinical and early-phase clinical pharmacology’

Leonetti, A., Boyd, L., Giuliani, J., Giovannetti, E., Garajová, I. & on Behalf of the EORTC PAMM Group, 2 Nov 2019, In : Expert Review of Clinical Pharmacology. 12, 11, p. 1033-1036 4 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Notch pathway in small-cell lung cancer: from preclinical evidence to therapeutic challenges

Leonetti, A., Facchinetti, F., Minari, R., Cortellini, A., Rolfo, C. D., Giovannetti, E. & Tiseo, M., 1 Jun 2019, In : Cellular Oncology. 42, 3, p. 261-273 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Novel targeted strategies to overcome resistance in small-cell lung cancer: focus on PARP inhibitors and rovalpituzumab tesirine

van den Borg, R., Leonetti, A., Tiseo, M., Giovannetti, E. & Peters, G. J., 3 Jun 2019, In : Expert Review of Anticancer Therapy. 19, 6, p. 461-471 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

PTEN alterations as a potential mechanism for tumor cell escape from PD-1/PD-L1 inhibition

Cretella, D., Digiacomo, G., Giovannetti, E. & Cavazzoni, A., 1 Sep 2019, In : Cancers. 11, 9, 1318.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer

Leonetti, A., Sharma, S., Minari, R., Perego, P., Giovannetti, E. & Tiseo, M., 29 Oct 2019, In : British Journal of Cancer. 121, 9, p. 725-737 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Role of angiogenesis in adenomyosis-associated abnormal uterine bleeding and subfertility: a systematic review

Harmsen, M. J., Wong, C. F. C., Mijatovic, V., Griffioen, A. W., Groenman, F., Hehenkamp, W. J. K. & Huirne, J. A. F., 11 Sep 2019, In : Human Reproduction Update. 25, 5, p. 647-671 25 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance

Parrino, B., Schillaci, D., Carnevale, I., Giovannetti, E., Diana, P., Cirrincione, G. & Cascioferro, S., 2019, In : European Journal of Medicinal Chemistry. 161, p. 154-178 25 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

el Hassouni, B., Granchi, C., Vallés-Martí, A., Supadmanaba, I. G. P., Bononi, G., Tuccinardi, T., Funel, N., Jimenez, C. R., Peters, G. J., Giovannetti, E. & Minutolo, F., 21 Aug 2019, In : Seminars in Cancer Biology.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology

El Hassouni, B., Mantini, G., Li Petri, G., Capula, M., Boyd, L., Weinstein, H. N. W., Vallés-Marti, A., Kouwenhoven, M. C. M., Giovannetti, E., Westerman, B. A., Peters, G. J. & EORTC PAMM Group, 1 Jan 2019, In : Anticancer Research. 39, 7, p. 3303-3309 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Tumor microbiome: Pancreatic cancer and duodenal fluids contain multitudes, ...but do they contradict themselves?

Meijer, L. L., Zwart, E. S., Brandt, B. W., Mebius, R., Deng, D., Giovannetti, E., Zaura, E. & Kazemier, G., Dec 2019, In : Critical Reviews in Oncology/Hematology. 144

Research output: Contribution to journalReview articleAcademicpeer-review

Unlocking the therapeutic potential of primary tumor-draining lymph nodes

Rotman, J., Koster, B. D., Jordanova, E. S., Heeren, A. M. & de Gruijl, T. D., 1 Oct 2019, In : Cancer Immunology, Immunotherapy. 68, 10, p. 1681-1688 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

Perego, P., Hempel, G., Linder, S., Bradshaw, T. D., Larsen, A. K., Peters, G. J., Phillips, R. M. & EORTC PAMM Group, Mar 2018, In : Cancer Chemotherapy and Pharmacology. 81, 3, p. 427-441 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Combined exosomal RNA and circulating tumor DNA for epidermal growth factor mutation detection in non-small cell lung cancer

Lazzari, C., Gregorc, V., Cangi, M. G., Giovannetti, E., Bulotta, A. & Santarpia, M., 2018, In : Journal of Thoracic Disease. 10, p. S4023-S4027

Research output: Contribution to journalReview articleAcademicpeer-review

Consensus guidelines for the use and interpretation of angiogenesis assays

Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A. C., Auerbach, R., Augustin, H. G., Bates, D. O., van Beijnum, J. R., Bender, R. H. F., Bergers, G., Bikfalvi, A., Bischoff, J., Böck, B. C., Brooks, P. C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., Cimpean, A. M. & 66 others, Cleaver, O., Coukos, G., Davis, G. E., De Palma, M., Dimberg, A., Dings, R. P. M., Djonov, V., Dudley, A. C., Dufton, N. P., Fendt, S-M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesquière, B., Gong, Y., Griffin, R. J., Harris, A. L., Hughes, C. C. W., Hultgren, N. W., Iruela-Arispe, M. L., Irving, M., Jain, R. K., Kalluri, R., Kalucka, J., Kerbel, R. S., Kitajewski, J., Klaassen, I., Kleinmann, H. K., Koolwijk, P., Kuczynski, E., Kwak, B. R., Marien, K., Melero-Martin, J. M., Munn, L. L., Nicosia, R. F., Noel, A., Nurro, J., Olsson, A-K., Petrova, T. V., Pietras, K., Pili, R., Pollard, J. W., Post, M. J., Quax, P. H. A., Rabinovich, G. A., Raica, M., Randi, A. M., Ribatti, D., Ruegg, C., Schlingemann, R. O., Schulte-Merker, S., Smith, L. E. H., Song, J. W., Stacker, S. A., Stalin, J., Stratman, A. N., Van de Velde, M., van Hinsbergh, V. W. M., Vermeulen, P. B., Waltenberger, J., Weinstein, B. M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M. C. & Griffioen, A. W., 1 Aug 2018, In : Angiogenesis. 21, 3, p. 425-532 108 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?

Jaramillo Mantilla, CA., Al Saig, F., Cloos, J., Jansen, G. & Peters, GJ., 19 Mar 2018, In : Cancer Drug Resistance. 1, p. 6-29 24 p., DOI: 10.20517/cdr.2018.02.

Research output: Contribution to journalReview articleAcademicpeer-review

Noncoding RNAs emerging as novel biomarkers in pancreatic cancer

Garajová, I., Balsano, R., Tommasi, C. & Giovannetti, E., 2018, In : Current pharmaceutical design. 24, 39, p. 4601-4604

Research output: Contribution to journalReview articleAcademicpeer-review

Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis

Meijer, L. L., Alberga, A. J., de Bakker, J. K., van der Vliet, H. J., Le Large, T. Y. S., van Grieken, N. C. T., de Vries, R., Daams, F., Zonderhuis, B. M. & Kazemier, G., 1 Sep 2018, In : Annals of Surgical Oncology. 25, 9, p. 2681-2692 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Positive & negative roles of innate effector cells in controlling cancer progression

Stolk, D., van der Vliet, H. J., de Gruijl, T. D., van Kooyk, Y. & Exley, M. A., 2018, In : Frontiers in Immunology. 9, SEP, 1990.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Primary and metastatic brain cancer genomics and emerging biomarkers for immunomodulatory cancer treatment

Passiglia, F., Caglevic, C., Giovannetti, E., Pinto, J. A., Manca, P., Taverna, S., Listì, A., Gil-Bazo, I., Raez, L. E., Russo, A. & Rolfo, C., 2018, In : Seminars in Cancer Biology. 52, Pt 2, p. 259-268 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma

Petri, G. L., Cascioferro, S., Parrino, B., Peters, G. J., Diana, P. & Giovannetti, E., 2018, In : Pharmacogenomics. 19, 10, p. 811-814 4 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The role of pharmacology in anticancer drug development

EORTC-Pharmacology and Molecular Mechanism Group, 2018, In : ADMET & DMPK. 6, 1, p. 4-14

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Transporter and lysosomal mediated (Multi)drug resistance to tyrosine kinase inhibitors and potential strategies to overcome resistance

de Klerk, D. J., Honeywell, R. J., Jansen, G. & Peters, G. J., 2018, In : Cancers. 10, 12, 503.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Unleashing the Full Potential of Oncolytic Adenoviruses against Cancer by Applying RNA Interference: The Force Awakens

Brachtlova, T. & van Beusechem, V. W., 23 Nov 2018, In : Cells. 7, 12, 21 p., 228.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

WDR48 (WD repeat domain 48)

Olazabal-Herrero, A., Peters, G. J., Giovannetti, E. & Rodriguez, J. A., 2018, In : Atlas of Genetics and Cytogenetics in Oncology and Haematology. 22, 2, p. 44-50

Research output: Contribution to journalReview articleAcademicpeer-review

2017

Anaplastic lymphoma kinase inhibition in metastatic non-small cell lung cancer: Clinical impact of alectinib

Muller, I. B., De Langen, A. J., Giovannetti, E. & Peters, G. J., 13 Sep 2017, In : OncoTargets and Therapy. 10, p. 4535-4541 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?

Ramjiawan, R. R., Griffioen, A. W. & Duda, D. G., 1 May 2017, In : Angiogenesis. 20, 2, p. 185-204 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Cerebrospinal fluid biomarkers for the diagnosis and prognosis of Parkinson's disease: Protocol for a systematic review and individual participant data meta-analysis

Eusebi, P., Hansson, O., Paciotti, S., Orso, M., Chiasserini, D., Calabresi, P., Blennow, K. & Parnetti, L., 2017, In : BMJ Open. 7, 11, e018177.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Drug resistance in pancreatic cancer: Impact of altered energy metabolism

Grasso, C., Jansen, G. & Giovannetti, E., 1 Jun 2017, In : Critical Reviews in Oncology/Hematology. 114, p. 139-152 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Efficacy, pharmacokinetic and pharmacodynamic evaluation of apaziquone in the treatment of non-muscle invasive bladder cancer

Phillips, R. M., Hendriks, H. R., Sweeney, J. B., Reddy, G. & Peters, G. J., Jul 2017, In : Expert Opinion on Drug Metabolism and Toxicology. 13, 7, p. 783-791 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment

Berndsen, R. H., Abdul, U. K., Weiss, A., Zoetemelk, M., te Winkel, M. T., Dyson, P. J., Griffioen, A. W. & Nowak-Sliwinska, P., 1 May 2017, In : Angiogenesis. 20, 2, p. 245-267 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies

Le Large, T. Y. S., Bijlsma, M. F., Kazemier, G., van Laarhoven, H. W. M., Giovannetti, E. & Jimenez, C. R., 1 Jun 2017, In : Seminars in Cancer Biology. 44, p. 153-169 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review