Research Output

2020

A randomised comparison of the effect of haemodynamic monitoring with CardioMEMS in addition to standard care on quality of life and hospitalisations in patients with chronic heart failure: Design and rationale of the MONITOR HF multicentre randomised clinical trial

Brugts, J. J., Veenis, J. F., Radhoe, S. P., Linssen, G. C. M., van Gent, M., Borleffs, C. J. W., van Ramshorst, J., van Pol, P., Tukkie, R., Spee, R. F., Emans, M. E., Kok, W., van Halm, V., Handoko, L., Beeres, S. L. M. A., Post, M. C., Boersma, E., Lenzen, M. J., Manintveld, O. C., Koffijberg, H. & 10 others, van Baal, P., Versteegh, M., Smilde, T. D., van Heerebeek, L., Rienstra, M., Mosterd, A., Delnoy, P. P. H., Asselbergs, F. W., Brunner-la Rocca, H. P. & de Boer, R. A., 1 Jan 2020, In : Netherlands Heart Journal. 28, 1, p. 16-26 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

Van Der Steen, N., Keller, K., Dekker, H., Porcelli, L., Honeywell, R. J., Van Meerloo, J., Musters, R. J. P., Kathmann, I., Frampton, A. E., Liu, D. S. K., Ruijtenbeek, R., Rolfo, C., Pauwels, P., Giovannetti, E. & Peters, G. J., 1 Jan 2020, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

van der Stoel, M., Schimmel, L., Nawaz, K., van Stalborch, A. M., de Haan, A., Klaus-Bergmann, A., Valent, E. T., Koenis, D. S., van Nieuw Amerongen, G. P., de Vries, C. J., de Waard, V., Gloerich, M., van Buul, J. D. & Huveneers, S., 12 Feb 2020, In : Journal of Cell Science. 133, 3, jcs239947 .

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure)

Stienen, S., Ferreira, J. P., Kobayashi, M., Preud'homme, G., Dobre, D., Machu, J-L., Duarte, K., Bresso, E., Devignes, M-D., López, N., Girerd, N., Aakhus, S., Ambrosio, G., Brunner-La Rocca, H-P., Fontes-Carvalho, R., Fraser, A. G., van Heerebeek, L., Heymans, S., de Keulenaer, G., Marino, P. & 8 others, McDonald, K., Mebazaa, A., Papp, Z., Raddino, R., Tschöpe, C., Paulus, W. J., Zannad, F. & Rossignol, P., 16 Feb 2020, In : Biomarkers. 25, 2, p. 1-11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on 'coronary microvascular dysfunction in cardiovascular disease'

Padro, T., Manfrini, O., Bugiardini, R., Canty, J., Cenko, E., De Luca, G., Duncker, D. J., Eringa, E. C., Koller, A., Tousoulis, D., Trifunovic, D., Vavlukis, M., de Wit, C. & Badimon, L., 8 Feb 2020, In : Cardiovascular Research.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In vitro endothelial hyperpermeability occurs early following traumatic hemorrhagic shock

van Leeuwen, A. L. I., Naumann, D. N., Dekker, N. A. M., Hordijk, P. L., Hutchings, S. D., Boer, C. & van den Brom, C. E., 6 Jan 2020, In : Clinical Hemorheology and Microcirculation.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

KBTBD13 is an actin-binding protein that modulates muscle kinetics

de Winter, J. M., Molenaar, J. P., Yuen, M., van der Pijl, R., Shen, S., Conijn, S., van de Locht, M., Willigenburg, M., Bogaards, S. J. P., van Kleef, E. S., Lassche, S., Persson, M., Rassier, D. E., Sztal, T. E., Ruparelia, A. A., Oorschot, V., Ramm, G., Hall, T. E., Xiong, Z., Johnson, C. N. & 21 others, Li, F., Kiss, B., Lozano-Vidal, N., Boon, R. A., Marabita, M., Nogara, L., Blaauw, B., Rodenburg, R. J., Küsters, B., Doorduin, J., Beggs, A. H., Granzier, H., Campbell, K., Ma, W., Irving, T., Malfatti, E., Romero, N. B., Bryson-Richardson, R. J., van Engelen, B. G. M., Voermans, N. C. & Ottenheijm, C. A. C., 3 Feb 2020, In : Journal of Clinical Investigation. 130, 2, p. 754-767 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Long noncoding RNAs in key cellular processes involved in aortic aneurysms

Wu, Z., Trenner, M., Boon, R. A., Spin, J. M. & Maegdefessel, L., 2020, In : Atherosclerosis. 292, p. 112-118 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Metabolic-vascular coupling in skeletal muscle: A potential role for capillary pericytes?

Attrill, E., Ramsay, C., Ross, R., Richards, S., Sutherland, B. A., Keske, M. A., Eringa, E. C. & Premilovac, D., 24 Feb 2020, In : Clinical and experimental pharmacology and physiology. 47, 3, p. 520-528 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nebulin: big protein with big responsibilities

Yuen, M. & Ottenheijm, C. A. C., 25 Jan 2020, In : Journal of Muscle Research and Cell Motility.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Laitila, J. M., McNamara, E. L., Wingate, C. D., Goullee, H., Ross, J. A., Taylor, R. L., van der Pijl, R., Griffiths, L. M., Harries, R., Ravenscroft, G., Clayton, J. S., Sewry, C., Lawlor, M. W., Ottenheijm, C. A. C., Bakker, A. J., Ochala, J., Laing, N. G., Wallgren-Pettersson, C., Pelin, K. & Nowak, K. J., 17 Feb 2020, In : Acta neuropathologica communications. 8, 1, 18.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Oral geranylgeranylacetone treatment increases heat shock protein expression in human atrial tissue

van Marion, D. M. S., Dorsch, L., Hoogstra-Berends, F., Kakuchaya, T., Bockeria, L., de Groot, N. M. S. & Brundel, B. J. J. M., Jan 2020, In : Heart Rhythm. 17, 1, p. 115-122 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in vivo

Keske, M. A., Barrett, E. J., Lindner, J. R., Richter, E. A., Liu, Z., McConell, G. K., Askew, C. D., Serné, E. H., Premilovac, D., Richards, S. M., Rattigan, S. & Eringa, E. C., 1 Mar 2020, In : American Journal of Physiology - Endocrinology and Metabolism. 318, 3, p. E311-E312

Research output: Contribution to journalLetterAcademicpeer-review

Open Access

Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression and Glucose Uptake in Muscle Through Adipomuscular Arterioles

Turaihi, A. H., Serné, E. H., Molthoff, C. F. M., Koning, J. J., Knol, J., Niessen, H. W., Jose Th Goumans, M., van Poelgeest, E. M., Yudkin, J. S., Smulders, Y. M., Jimenez, C. R., van Hinsbergh, V. W. & Eringa, E. C., 31 Jan 2020, In : Diabetes.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological interventions to reduce edema following cardiopulmonary bypass: A systematic review and meta-analysis

Dekker, N. A. M., van Leeuwen, A. L. I., van de Ven, P. M., de Vries, R., Hordijk, P. L., Boer, C. & van den Brom, C. E., 2020, In : Journal of Critical Care. 56, p. 63-72 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Preserved single muscle fiber specific force in facioscapulohumeral muscular dystrophy

Lassche, S., Voermans, N. C., van der Pijl, R., van den Berg, M., Heerschap, A., van Hees, H., Kusters, B., van der Maarel, S. M., Ottenheijm, C. A. C. & van Engelen, B. G. M., 21 Jan 2020, In : Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

RNA-based therapeutics in cardiovascular disease

Pham, T. P., Kremer, V. & Boon, R. A., 14 Feb 2020, In : Current opinion in cardiology.

Research output: Contribution to journalArticleAcademicpeer-review

Role of HDACs in cardiac electropathology: Therapeutic implications for atrial fibrillation

Brundel, B. J. J. M., Li, J. & Zhang, D., Mar 2020, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1867, 3, 118459.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Sarrah is an Aging-Regulated Anti-Apoptotic Long Non-Coding RNA in Cardiomyocytes that Augments Recovery from Acute Myocardial Infarction

Trembinski, DJ., Bink, DI., Theodorou, K., Sommer, J., Fischer, A., van Bergen, A., Kuo, C-C., Costa, IG., Schürmann, CN., Leisegang, M. S., Brandes, R. P., Alekseeva, T., Brill, B., Wietelmann, A., Johnson, C. N., Spring-Connell, A., Kaulich, M., Werfel, S., Engelhardt, S., Hirt, M. N. & 12 others, Yorgan, K., Eschenhagen, T., Kirchhof, L., Hofmann, P., Jaé, N., Wittig, I., Hamdani, N., Bischof, C., Krishnan, J., Houtkooper, R. H., Dimmeler, S. & Boon, RA., 2020, (Accepted/In press) In : Nature Communications.

Research output: Contribution to journalArticleAcademicpeer-review

The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition

Glaser, S. F., Heumüller, A. W., Tombor, L., Hofmann, P., Muhly-Reinholz, M., Fischer, A., Günther, S., Kokot, K. E., Hassel, D., Kumar, S., Jo, H., Boon, R. A., Abplanalp, W., John, D., Boeckel, J-N. & Dimmeler, S., 7 Feb 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 8, 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Unfolding Discoveries in Heart Failure

Paulus, W. J., 13 Feb 2020, In : The New England journal of medicine. 382, 7, p. 679-682 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019

6-mercaptopurine, an agonist of Nur77, reduces progression of pulmonary hypertension by enhancing BMP signalling

Kurakula, K., Sun, X-Q., Happé, C., da Silva Goncalves Bos, D., Szulcek, R., Schalij, I., Wiesmeijer, K., Lodder, K., Tu, L., Guignabert, C., de Vries, C. J., de Man, F., Noordegraaf, A. V., Ten Dijke, P., Goumans, M-J. & Bogaard, H. J., 2019, In : The European respiratory journal.

Research output: Contribution to journalArticleAcademicpeer-review

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W. D., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., Varró, A., Dobrev, D., Ai, X., Janssen, P. M. L., Kass, D. A., Jones, W. K., Gilbert, R. J. & Sadayappan, S., 1 Apr 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 236-246 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Age-related regulation and region-specific distribution of ion channel subunits promoting atrial fibrillation in human left and right atria

Biliczki, P., Boon, R. A., Girmatsion, Z., Bukowska, A., Ördög, B., Kaess, B. M., Hohnloser, S. H., Goette, A., Varró, A., Moritz, A., Nattel, S. & Ehrlich, J. R., 1 Aug 2019, In : Europace. 21, 8, p. 1261-1269 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice

Carmody, C., Ogawa-Wong, A. N., Martin, C., Luongo, C., Zuidwijk, M., Sager, B., Petersen, T., Roginski Guetter, A., Janssen, R., Wu, E. Y., Bogaards, S., Neumann, N. M., Hau, K., Marsili, A., Boelen, A., Silva, J. E., Dentice, M., Salvatore, D., Wagers, A. J., Larsen, P. R. & 2 others, Simonides, W. S. & Zavacki, A. M., 1 Jan 2019, In : Endocrinology. 160, 5, p. 1205-1222

Research output: Contribution to journalArticleAcademicpeer-review

Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy

Kuster, D. W. D., Lynch, T. L., Barefield, D. Y., Sivaguru, M., Kuffel, G., Zilliox, M. J., Lee, K. H., Craig, R., Namakkal-Soorappan, R. & Sadayappan, S., 1 Dec 2019, In : Cardiovascular Research. 115, 14, p. 1986-1997 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Arterial Remodeling and Dysfunction in the ZSF1 Rat Model of Heart Failure With Preserved Ejection Fraction

Leite, S., Cerqueira, R. J., Ibarrola, J., Fontoura, D., Fernández-Celis, A., Zannad, F., Falcão-Pires, I., Paulus, W. J., Leite-Moreira, A. F., Rossignol, P., López-Andrés, N. & Lourenço, A. P., 1 Jul 2019, In : Circulation. Heart failure. 12, 7, e005596.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Bosutinib Protects against Vascular Leakage by Improving Endothelial Cell-Matrix Adhesion

Botros, L., Pronk, M., Juschten, J., Liddle, J., Tuinman, P. R., van Bezu, J., Huveneers, S., Bogaard, H. J., van Hinsbergh, V., Hordijk, P. & Aman, J., 2019, In : Journal of Vascular Research. 56, p. 15-15

Research output: Contribution to journalMeeting AbstractAcademic

Cardiac Disorders and Pathophysiology of Sarcomeric Proteins

van der Velden, J. & Stienen, G. J. M., 1 Jan 2019, In : Physiological Reviews. 99, 1, p. 381-426 46 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin

Juni, R. P., Kuster, D. W. D., Goebel, M., Helmes, M., Musters, R. J. P., van der Velden, J., Koolwijk, P., Paulus, W. J. & van Hinsbergh, V. W. M., 1 Sep 2019, In : JACC: Basic to Translational Science. 4, 5, p. 575-591

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle

Stam, K., Cai, Z., van der Velde, N., van Duin, R., Lam, E., van der Velden, J., Hirsch, A., Duncker, D. J. & Merkus, D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4465-4480

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparison of different chemically modified inhibitors of miR-199b in vivo

Duygu, B., Juni, R. P., Ottaviani, L., Bitsch, N., Wit, J. B. M., de Windt, L. J. & da Costa Martins, P. A., 1 Jan 2019, In : Biochemical Pharmacology. 159, p. 106-115

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Contrast-enhanced ultrasound for quantification of tissue perfusion in humans

Emanuel, A. L., Meijer, R. I., van Poelgeest, E., Spoor, P., Serné, E. H. & Eringa, E. C., 1 Jan 2019, In : Microcirculation. 27, 1, e12588.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access

CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity

Majolée, J., Pronk, M. C. A., Jim, K. K., van Bezu, J. S. M., van der Sar, A. M., Hordijk, P. L. & Kovačević, I., 1 Dec 2019, In : Scientific Reports. 9, 1, 8131.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells

Sánchez-Duffhues, G., Williams, E., Benderitter, P., Orlova, V., van Wijhe, M., Garcia de Vinuesa, A., Kerr, G., Caradec, J., Lodder, K., de Boer, H. C., Goumans, M-J., Eekhoff, E. M. W., Morales-Piga, A., Bachiller-Corral, J., Koolwijk, P., Bullock, A. N., Hoflack, J. & Ten Dijke, P., Nov 2019, In : JBMR Plus. 3, 11, e10230.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Diaphragm contractile weakness due to reduced mechanical loading: Role of titin

van der Pijl, R. J., Granzier, H. L. & Ottenheijm, C. A. C., 1 Aug 2019, In : American Journal of Physiology: Cell Physiology. 317, 2, p. C167-C176

Research output: Contribution to journalArticleAcademicpeer-review

Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model

Waddingham, M. T., Sonobe, T., Tsuchimochi, H., Edgley, A. J., Sukumaran, V., Chen, Y. C., Hansra, S. S., Schwenke, D. O., Umetani, K., Aoyama, K., Yagi, N., Kelly, D. J., Gaderi, S., Herwig, M., Kolijn, D., Mügge, A., Paulus, W. J., Ogo, T., Shirai, M., Hamdani, N. & 1 others, Pearson, J. T., 2019, In : Journal of Molecular and Cellular Cardiology. 137, p. 119-131

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DISRUPTED CELLULAR BARRIERS IN KIDNEY FAILURE: The endothelium and the peritoneal membrane

Vila Cuenca, M., 2019, 222 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University Amsterdam

Open Access

Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction

Miranda-Silva, D., Wüst, R. C. I., Conceição, G., Gonçalves-Rodrigues, P., Gonçalves, N. D., Gonçalves, A., Kuster, D. W. D., Leite-Moreira, A. F., van der Velden, J., de Sousa Beleza, J. M., Magalhães, J., Stienen, G. J. M. & Falcão-Pires, I., 2019, In : Acta Physiologica. e13378.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes

Noll, B., Benz, D., Frey, Y., Meyer, F., Lauinger, M., Eisler, S. A., Schmid, S., Hordijk, P. L. & Olayioye, M. A., 2019, In : Journal of Cell Science. 132, 11, jcs223172.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

Zhang, D., Hu, X., Li, J., Liu, J., Baks-Te Bulte, L., Wiersma, M., Malik, N-U-A., van Marion, D. M. S., Tolouee, M., Hoogstra-Berends, F., Lanters, E. A. H., van Roon, A. M., de Vries, A. A. F., Pijnappels, D. A., de Groot, N. M. S., Henning, R. H. & Brundel, B. J. J. M., 1 Dec 2019, In : Nature Communications. 10, 1, 1307.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Do Existing Definitions Identify Subgroup Phenotypes or Reflect the Natural History of Heart Failure With Preserved Ejection Fraction?

Senni, M., Caravita, S. & Paulus, W. J., 30 Jul 2019, In : Circulation. 140, 5, p. 366-369 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation

Roesthuis, L., van der Hoeven, H., Sinderby, C., Frenzel, T., Ottenheijm, C., Brochard, L., Doorduin, J. & Heunks, L., Oct 2019, In : Intensive Care Medicine. 45, 10, p. 1372-1381 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells

Uthman, L., Homayr, A., Juni, R. P., Spin, E. L., Kerindongo, R., Boomsma, M., Hollmann, M. W., Preckel, B., Koolwijk, P., van Hinsbergh, V. W. M., Zuurbier, C. J., Albrecht, M. & Weber, N. C., 2019, In : Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 53, 5, p. 865-886

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

End-diastolic force pre-activates cardiomyocytes and determines contractile force: role of titin and calcium

Najafi, A., van de Locht, M., Schuldt, M., Schönleitner, P., van Willigenburg, M., Bollen, I., Goebel, M., Ottenheijm, C. A. C., van der Velden, J., Helmes, M. & Kuster, D. W. D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4521-4531

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exosomes and non-coding RNA, the healers of the heart?

Pham, T. P. & Boon, R. A., 18 Jul 2019, In : Cardiovascular Research.

Research output: Contribution to journalArticleAcademicpeer-review

Expiratory muscle dysfunction in critically ill patients: towards improved understanding

Shi, Z-H., Jonkman, A., de Vries, H., Jansen, D., Ottenheijm, C., Girbes, A., Spoelstra-de Man, A., Zhou, J-X., Brochard, L. & Heunks, L., 1 Aug 2019, In : Intensive Care Medicine. 45, 8, p. 1061-1071 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access