Research Output 1997 2020

Filter
Article
2019

6-mercaptopurine, an agonist of Nur77, reduces progression of pulmonary hypertension by enhancing BMP signalling

Kurakula, K., Sun, X-Q., Happé, C., da Silva Goncalves Bos, D., Szulcek, R., Schalij, I., Wiesmeijer, K., Lodder, K., Tu, L., Guignabert, C., de Vries, C. J., de Man, F., Noordegraaf, A. V., Ten Dijke, P., Goumans, M-J. & Bogaard, H. J., 2019, In : The European respiratory journal.

Research output: Contribution to journalArticleAcademicpeer-review

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W. D., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., Varró, A., Dobrev, D., Ai, X., Janssen, P. M. L., Kass, D. A., Jones, W. K., Gilbert, R. J. & Sadayappan, S., 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 236-246 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice

Carmody, C., Ogawa-Wong, A. N., Martin, C., Luongo, C., Zuidwijk, M., Sager, B., Petersen, T., Roginski Guetter, A., Janssen, R., Wu, E. Y., Bogaards, S., Neumann, N. M., Hau, K., Marsili, A., Boelen, A., Silva, J. E., Dentice, M., Salvatore, D., Wagers, A. J., Larsen, P. R. & 2 othersSimonides, W. S. & Zavacki, A. M., 1 Jan 2019, In : Endocrinology. 160, 5, p. 1205-1222

Research output: Contribution to journalArticleAcademicpeer-review

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin

Juni, R. P., Kuster, D. W. D., Goebel, M., Helmes, M., Musters, R. J. P., van der Velden, J., Koolwijk, P., Paulus, W. J. & van Hinsbergh, V. W. M., 1 Sep 2019, In : JACC: Basic to Translational Science. 4, 5, p. 575-591

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle

Stam, K., Cai, Z., van der Velde, N., van Duin, R., Lam, E., van der Velden, J., Hirsch, A., Duncker, D. J. & Merkus, D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4465-4480

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice

Martínez-Martínez, S., Lozano-Vidal, N., López-Maderuelo, M. D., Jiménez-Borreguero, L. J., Armesilla, Á. L. & Redondo, J. M., 1 Jan 2019, In : FEBS Journal. 286, 1, p. 46-65

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of different chemically modified inhibitors of miR-199b in vivo

Duygu, B., Juni, R., Ottaviani, L., Bitsch, N., Wit, J. B. M., de Windt, L. J. & da Costa Martins, P. A., 1 Jan 2019, In : Biochemical Pharmacology. 159, p. 106-115

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity

Majolée, J., Pronk, M. C. A., Jim, K. K., van Bezu, J. S. M., van der Sar, A. M., Hordijk, P. L. & Kovačević, I., 1 Dec 2019, In : Scientific Reports. 9, 1, 8131.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Diaphragm contractile weakness due to reduced mechanical loading: Role of titin

van der Pijl, R. J., Granzier, H. L. & Ottenheijm, C. A. C., 1 Aug 2019, In : American Journal of Physiology: Cell Physiology. 317, 2, p. C167-C176

Research output: Contribution to journalArticleAcademicpeer-review

Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model

Waddingham, M. T., Sonobe, T., Tsuchimochi, H., Edgley, A. J., Sukumaran, V., Chen, Y. C., Hansra, S. S., Schwenke, D. O., Umetani, K., Aoyama, K., Yagi, N., Kelly, D. J., Gaderi, S., Herwig, M., Kolijn, D., Mügge, A., Paulus, W. J., Ogo, T., Shirai, M., Hamdani, N. & 1 othersPearson, J. T., 2019, In : Journal of Molecular and Cellular Cardiology. 137, p. 119-131

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction

Miranda-Silva, D., Wüst, R. C. I., Conceição, G., Gonçalves-Rodrigues, P., Gonçalves, N. D., Gonçalves, A., Kuster, D. W. D., Leite-Moreira, A. F., van der Velden, J., de Sousa Beleza, J. M., Magalhães, J., Stienen, G. J. M. & Falcão-Pires, I., 2019, In : Acta Physiologica. e13378.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes

Noll, B., Benz, D., Frey, Y., Meyer, F., Lauinger, M., Eisler, S. A., Schmid, S., Hordijk, P. L. & Olayioye, M. A., 2019, In : Journal of Cell Science. 132, 11, jcs223172.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

Zhang, D., Hu, X., Li, J., Liu, J., Baks-Te Bulte, L., Wiersma, M., Malik, N-U-A., van Marion, D. M. S., Tolouee, M., Hoogstra-Berends, F., Lanters, E. A. H., van Roon, A. M., de Vries, A. A. F., Pijnappels, D. A., de Groot, N. M. S., Henning, R. H. & Brundel, B. J. J. M., 21 Mar 2019, In : Nature Communications. 10, 1, 1307.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation

Roesthuis, L., van der Hoeven, H., Sinderby, C., Frenzel, T., Ottenheijm, C., Brochard, L., Doorduin, J. & Heunks, L., Oct 2019, In : Intensive Care Medicine. 45, 10, p. 1372-1381 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells

Uthman, L., Homayr, A., Juni, R. P., Spin, E. L., Kerindongo, R., Boomsma, M., Hollmann, M. W., Preckel, B., Koolwijk, P., van Hinsbergh, V. W. M., Zuurbier, C. J., Albrecht, M. & Weber, N. C., 2019, In : Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 53, 5, p. 865-886

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

End-diastolic force pre-activates cardiomyocytes and determines contractile force: role of titin and calcium

Najafi, A., van de Locht, M., Schuldt, M., Schönleitner, P., van Willigenburg, M., Bollen, I., Goebel, M., Ottenheijm, C. A. C., van der Velden, J., Helmes, M. & Kuster, D. W. D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4521-4531

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Extracellular SPARC increases cardiomyocyte contraction during health and disease

Deckx, S., Johnson, D. M., Rienks, M., Carai, P., van Deel, E., van der Velden, J., Sipido, K. R., Heymans, S. & Papageorgiou, A-P., 1 Apr 2019, In : PLoS ONE. 14, 4, e0209534.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Extra energy for hearts with a genetic defect: ENERGY trial

van Driel, B. O., van Rossum, A. C., Michels, M., Huurman, R. & van der Velden, J., 2019, In : Netherlands Heart Journal. 27, 4, p. 200-205 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts

van der Wijk, A-E., Lachkar, N., de Vos, J., Grootemaat, A. E., van der Wel, N. N., Hordijk, P. L., Bakker, E. N. T. P. & vanBavel, E., 1 Jan 2019, In : Stroke. 50, 6, p. 1590-1594

Research output: Contribution to journalArticleAcademicpeer-review

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach

Bruijnen, S. T. G., Chandrupatla, D. M. S. H., Giovanonni, L., Neri, D., Vugts, D. J., Huisman, M. C., Hoekstra, O. S., Musters, R. J. P., Lammertsma, A. A., van Dongen, G. A. M. S., Jansen, G., Molthoff, C. F. M. & van der Laken, C. J., 7 Jan 2019, In : Molecular Pharmaceutics. 16, 1, p. 273-281

Research output: Contribution to journalArticleAcademicpeer-review

FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB

Pronk, M. C. A., Majolée, J., Loregger, A., van Bezu, J. S. M., Zelcer, N., Hordijk, P. L. & Kovačević, I., 1 Mar 2019, In : Molecular Biology of the Cell. 30, 5, p. 607-621 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes

van Velzen, H. G., Schinkel, A. F. L., van Grootel, R. W. J., van Slegtenhorst, M. A., van der Velden, J., Strachinaru, M. & Michels, M., 2019, In : Netherlands Heart Journal. 27, 3, p. 117-126 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology

Wiersma, V. I., van Ziel, A. M., Vazquez-Sanchez, S., Nölle, A., Berenjeno-Correa, E., Bonaterra-Pastra, A., Clavaguera, F., Tolnay, M., Musters, R. J. P., van Weering, J. R. T., Verhage, M., Hoozemans, J. J. M. & Scheper, W., 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation

Cremer, S., Michalik, K. M., Fischer, A., Pfisterer, L., Jaé, N., Winter, C., Boon, R. A., Muhly-Reinholz, M., John, D., Uchida, S., Weber, C., Poller, W., Günther, S., Braun, T., Li, D. Y., Maegdefessel, L., Perisic Matic, L., Hedin, U., Soehnlein, O., Zeiher, A. & 1 othersDimmeler, S., 2019, In : Circulation. 139, 10, p. 1320-1334 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypertrofische cardiomyopathie

van Driel, B., Asselbergs, F. W., de Boer, R. A., van Rossum, A. C., van Tintelen, J. P., van der Velden, J. & Michels, M., 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 8, D2790.

Research output: Contribution to journalArticleProfessional

Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells

Reinhard, N. R., van der Niet, S., Chertkova, A., Postma, M., Hordijk, P. L., Gadella Jr, T. W. J. & Goedhart, J., 2019, In : Small GTPases.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

IL-6 counteracts the inhibitory effect of IL-4 on osteogenic differentiation of human adipose stem cells

Bastidas-Coral, A. P., Hogervorst, J. M. A., Forouzanfar, T., Kleverlaan, C. J., Koolwijk, P., Klein-Nulend, J. & Bakker, A. D., 2019, In : Journal of Cellular Physiology. 234, 11, p. 20520-20532

Research output: Contribution to journalArticleAcademicpeer-review

Indoxyl sulfate stimulates angiogenesis by regulating reactive oxygen species production via CYP1B1

Pei, J., Juni, R., Harakalova, M., Duncker, D. J., Asselbergs, F. W., Koolwijk, P., van Hinsbergh, V. W. M., Verhaar, M. C., Mokry, M. & Cheng, C., 2019, In : Toxins. 11, 8, 454.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes

Hemerich, D., Pei, J., Harakalova, M., van Setten, J., Boymans, S., Boukens, B. J., Efimov, I. R., Michels, M., van der Velden, J., Vink, A., Cheng, C., van der Harst, P., Moore, J. H., Mokry, M., Tragante, V. & Asselbergs, F. W., 25 Jan 2019, In : Circulation. Genomic and precision medicine.

Research output: Contribution to journalArticleAcademicpeer-review

JNK2 in myeloid cells impairs insulin's vasodilator effects in muscle during early obesity development through perivascular adipose tissue dysfunction

Meijer, R. I., Hoevenaars, F. P. M., Serné, E. H., Yudkin, J. S., Kokhuis, T. J. A., Weijers, E. M., van Hinsbergh, V. W. M., Smulders, Y. M. & Eringa, E. C., 2019, In : American Journal of Physiology. Heart and Circulatory Physiology. 317, 2, p. H364-H374

Research output: Contribution to journalArticleAcademicpeer-review

Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling

Hofmann, P., Sommer, J., Theodorou, K., Kirchhof, L., Fischer, A., Li, Y., Perisic, L., Hedin, U., Maegdefessel, L., Dimmeler, S. & Boon, R. A., 2019, In : Cardiovascular Research. 115, 1, p. 230-242 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Meijer and Vloedman's histochemical demonstration of mitochondrial coupling obeys Lambert-Beer's law in the myocardium

Peters, E. L., Comerford, D., Vaz, F. M. & van der Laarse, W. J., 29 Jan 2019, In : Histochemistry and Cell Biology. 151, 1, p. 85-90 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Metabolic-vascular coupling in skeletal muscle: A potential role for capillary pericytes?

Attrill, E., Ramsay, C., Ross, R., Richards, S., Sutherland, B. A., Keske, M. A., Eringa, E. C. & Premilovac, D., 2019, In : Clinical and experimental pharmacology and physiology.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle fiber dysfunction contributes to weakness in inclusion body myositis

Lassche, S., Rietveld, A., Heerschap, A., van Hees, H. W., Hopman, M. T. E., Voermans, N. C., Saris, C. G. J., van Engelen, B. G. M. & Ottenheijm, C. A. C., 2019, In : Neuromuscular Disorders. 29, 6, p. 468-476

Research output: Contribution to journalArticleAcademicpeer-review

Muscle weakness in a S. pneumoniae sepsis mouse model

Witteveen, E., Wieske, L., Manders, E., Verhamme, C., Ottenheijm, C. A. C., Schultz, M. J., van Schaik, I. N. & Horn, J., Jan 2019, In : Annals of Translational Medicine. 7, 1, 9.

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy

Parbhudayal, R. Y., Güçlü, A., Zweerink, A., Biesbroek, P. S., Croisille, P., Clarysse, P., Michels, M., Stooker, W., Vonk, A. B. A., van der Ven, P. M., van Rossum, A. C., van der Velden, J. & Nijveldt, R., 2019, In : International Journal of Cardiovascular Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

Rol, N., de Raaf, M. A., Sun, X. Q., Kuiper, V. P., da Silva Gonçalves Bos, D., Happé, C., Kurakula, K., Dickhoff, C., Thuillet, R., Tu, L., Guignabert, C., Schalij, I., Lodder, K., Pan, X., Herrmann, F. E., van Nieuw Amerongen, G. P., Koolwijk, P., Vonk-Noordegraaf, A., de Man, F. S., Wollin, L. & 3 othersGoumans, M-J., Szulcek, R. & Bogaard, H. J., 2019, In : Cardiovascular Research. 115, 2, p. 432-439

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pathogenic effect of a TGFBR1 mutation in a family with Loeys–Dietz syndrome

Cozijnsen, L., Plomp, A. S., Post, J. G., Pals, G., Bogunovic, N., Yeung, K. K., Niessen, H. W. M., Goumans, M-J. T. H., Barge-Schaapveld, D. Q. C. M. & Micha, D., 2019, In : Molecular Genetics and Genomic Medicine. e943.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS

Leisegang, M. S., Bibli, S-I., Günther, S., Pflüger-Müller, B., Oo, J. A., Höper, C., Seredinski, S., Yekelchyk, M., Schmitz-Rixen, T., Schürmann, C., Hu, J., Looso, M., Sigala, F., Boon, R. A., Fleming, I. & Brandes, R. P., 2019, In : European Heart Journal. 40, 30, p. 2523-2533

Research output: Contribution to journalArticleAcademicpeer-review

Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone

Andersen, S., Birkmose Axelsen, J., Ringgaard, S., Randel Nyengaard, J., Holm Nielsen, S., Genovese, F., Asser Karsdal, M., Adler Hyldebrandt, J., Brandt Sørensen, C., de Man, F. S., Jan Bogaard, H., Erik Nielsen-Kudsk, J. & Andersen, A., Apr 2019, In : Pulmonary Circulation. 9, 2, p. 204589401984865

Research output: Contribution to journalArticleAcademicpeer-review

Recessive MYH7-related myopathy in two families

Beecroft, S. J., van de Locht, M., de Winter, J. M., Ottenheijm, C. A., Sewry, C. A., Mohammed, S., Ryan, M. M., Woodcock, I. R., Sanders, L., Gooding, R., Davis, M. R., Oates, E. C., Laing, N. G., Ravenscroft, G., McLean, C. A. & Jungbluth, H., 2019, In : Neuromuscular Disorders. 29, 6, p. 456-467

Research output: Contribution to journalArticleAcademicpeer-review

Right ventricular oxygen delivery as a determinant of right ventricular functional reserve during exercise in juvenile swine with chronic pulmonary hypertension

Cai, Z., van Duin, R. W. B., Stam, K., Uitterdijk, A., van der Velden, J., Vonk Noordegraaf, A., Duncker, D. J. & Merkus, D., 1 Oct 2019, In : American Journal of Physiology. Heart and Circulatory Physiology. 317, 4, p. H840-H850

Research output: Contribution to journalArticleAcademicpeer-review

Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm

Kumar, S., Boon, R. A., Maegdefessel, L., Dimmeler, S. & Jo, H., 2019, In : Circulation Research. 124, 4, p. 619-630

Research output: Contribution to journalArticleAcademicpeer-review

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

van Marion, D. M. S., Hu, X., Zhang, D., Hoogstra-Berends, F., Seerden, J-P. G., Loen, L., Heeres, A., Steen, H., Henning, R. H. & Brundel, B. J. J. M., 1 Jan 2019, In : DRUG DESIGN DEVELOPMENT AND THERAPY. 13, p. 345-364

Research output: Contribution to journalArticleAcademicpeer-review