Research Output per year
Research Output 1997 2020
- 1 - 50 out of 965 results
- Publication Year, Title (descending)
2019
6-mercaptopurine, an agonist of Nur77, reduces progression of pulmonary hypertension by enhancing BMP signalling
Kurakula, K., Sun, X-Q., Happé, C., da Silva Goncalves Bos, D., Szulcek, R., Schalij, I., Wiesmeijer, K., Lodder, K., Tu, L., Guignabert, C., de Vries, C. J., de Man, F., Noordegraaf, A. V., Ten Dijke, P., Goumans, M-J. & Bogaard, H. J., 2019, In : The European respiratory journal.Research output: Contribution to journal › Article › Academic › peer-review
Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury
Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W. D., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., Varró, A., Dobrev, D., Ai, X., Janssen, P. M. L., Kass, D. A., Jones, W. K., Gilbert, R. J. & Sadayappan, S., 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 236-246 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice
Carmody, C., Ogawa-Wong, A. N., Martin, C., Luongo, C., Zuidwijk, M., Sager, B., Petersen, T., Roginski Guetter, A., Janssen, R., Wu, E. Y., Bogaards, S., Neumann, N. M., Hau, K., Marsili, A., Boelen, A., Silva, J. E., Dentice, M., Salvatore, D., Wagers, A. J., Larsen, P. R. & 2 others, 1 Jan 2019, In : Endocrinology. 160, 5, p. 1205-1222Research output: Contribution to journal › Article › Academic › peer-review
Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin
Juni, R. P., Kuster, D. W. D., Goebel, M., Helmes, M., Musters, R. J. P., van der Velden, J., Koolwijk, P., Paulus, W. J. & van Hinsbergh, V. W. M., 1 Sep 2019, In : JACC: Basic to Translational Science. 4, 5, p. 575-591Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle
Stam, K., Cai, Z., van der Velde, N., van Duin, R., Lam, E., van der Velden, J., Hirsch, A., Duncker, D. J. & Merkus, D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4465-4480Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice
Martínez-Martínez, S., Lozano-Vidal, N., López-Maderuelo, M. D., Jiménez-Borreguero, L. J., Armesilla, Á. L. & Redondo, J. M., 1 Jan 2019, In : FEBS Journal. 286, 1, p. 46-65Research output: Contribution to journal › Article › Academic › peer-review
Comparison of different chemically modified inhibitors of miR-199b in vivo
Duygu, B., Juni, R., Ottaviani, L., Bitsch, N., Wit, J. B. M., de Windt, L. J. & da Costa Martins, P. A., 1 Jan 2019, In : Biochemical Pharmacology. 159, p. 106-115Research output: Contribution to journal › Article › Academic › peer-review
Open Access
CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity
Majolée, J., Pronk, M. C. A., Jim, K. K., van Bezu, J. S. M., van der Sar, A. M., Hordijk, P. L. & Kovačević, I., 1 Dec 2019, In : Scientific Reports. 9, 1, 8131.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Diaphragm contractile weakness due to reduced mechanical loading: Role of titin
van der Pijl, R. J., Granzier, H. L. & Ottenheijm, C. A. C., 1 Aug 2019, In : American Journal of Physiology: Cell Physiology. 317, 2, p. C167-C176Research output: Contribution to journal › Article › Academic › peer-review
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model
Waddingham, M. T., Sonobe, T., Tsuchimochi, H., Edgley, A. J., Sukumaran, V., Chen, Y. C., Hansra, S. S., Schwenke, D. O., Umetani, K., Aoyama, K., Yagi, N., Kelly, D. J., Gaderi, S., Herwig, M., Kolijn, D., Mügge, A., Paulus, W. J., Ogo, T., Shirai, M., Hamdani, N. & 1 others, 2019, In : Journal of Molecular and Cellular Cardiology. 137, p. 119-131Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction
Miranda-Silva, D., Wüst, R. C. I., Conceição, G., Gonçalves-Rodrigues, P., Gonçalves, N. D., Gonçalves, A., Kuster, D. W. D., Leite-Moreira, A. F., van der Velden, J., de Sousa Beleza, J. M., Magalhães, J., Stienen, G. J. M. & Falcão-Pires, I., 2019, In : Acta Physiologica. e13378.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes
Noll, B., Benz, D., Frey, Y., Meyer, F., Lauinger, M., Eisler, S. A., Schmid, S., Hordijk, P. L. & Olayioye, M. A., 2019, In : Journal of Cell Science. 132, 11, jcs223172.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
Zhang, D., Hu, X., Li, J., Liu, J., Baks-Te Bulte, L., Wiersma, M., Malik, N-U-A., van Marion, D. M. S., Tolouee, M., Hoogstra-Berends, F., Lanters, E. A. H., van Roon, A. M., de Vries, A. A. F., Pijnappels, D. A., de Groot, N. M. S., Henning, R. H. & Brundel, B. J. J. M., 21 Mar 2019, In : Nature Communications. 10, 1, 1307.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation
Roesthuis, L., van der Hoeven, H., Sinderby, C., Frenzel, T., Ottenheijm, C., Brochard, L., Doorduin, J. & Heunks, L., Oct 2019, In : Intensive Care Medicine. 45, 10, p. 1372-1381 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells
Uthman, L., Homayr, A., Juni, R. P., Spin, E. L., Kerindongo, R., Boomsma, M., Hollmann, M. W., Preckel, B., Koolwijk, P., van Hinsbergh, V. W. M., Zuurbier, C. J., Albrecht, M. & Weber, N. C., 2019, In : Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 53, 5, p. 865-886Research output: Contribution to journal › Article › Academic › peer-review
Open Access
End-diastolic force pre-activates cardiomyocytes and determines contractile force: role of titin and calcium
Najafi, A., van de Locht, M., Schuldt, M., Schönleitner, P., van Willigenburg, M., Bollen, I., Goebel, M., Ottenheijm, C. A. C., van der Velden, J., Helmes, M. & Kuster, D. W. D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4521-4531Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Evolution of heterotopic bone in fibrodysplasia ossificans progressiva: An [18F]NaF PET/CT study
Botman, E., Raijmakers, P. G. H. M., Yaqub, M., Teunissen, B., Netelenbos, C., Lubbers, W., Schwarte, L. A., Micha, D., Bravenboer, N., Schoenmaker, T., de Vries, T. J., Pals, G., Smit, J. M., Koolwijk, P., Trotter, D. G., Lammertsma, A. A. & Eekhoff, E. M. W., 1 Jul 2019, In : Bone. 124, p. 1-6Research output: Contribution to journal › Article › Academic › peer-review
EXPRESS: Preserving right ventricular function in patients with pulmonary arterial hypertension: single centre experience with a cardiac magnetic resonance imaging-guided treatment strategy
Huis In 't Veld, A. E., Van de Veerdonk, M. C., Spruijt, O., Groeneveldt, J. A., Marcus, J. T., Westerhof, N., Bogaard, H. J. & Vonk-Noordegraaf, A., 11 Jan 2019, In : Pulmonary Circulation. p. 2045894018824553Research output: Contribution to journal › Article › Academic › peer-review
Extracellular SPARC increases cardiomyocyte contraction during health and disease
Deckx, S., Johnson, D. M., Rienks, M., Carai, P., van Deel, E., van der Velden, J., Sipido, K. R., Heymans, S. & Papageorgiou, A-P., 1 Apr 2019, In : PLoS ONE. 14, 4, e0209534.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Extra energy for hearts with a genetic defect: ENERGY trial
van Driel, B. O., van Rossum, A. C., Michels, M., Huurman, R. & van der Velden, J., 2019, In : Netherlands Heart Journal. 27, 4, p. 200-205 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts
van der Wijk, A-E., Lachkar, N., de Vos, J., Grootemaat, A. E., van der Wel, N. N., Hordijk, P. L., Bakker, E. N. T. P. & vanBavel, E., 1 Jan 2019, In : Stroke. 50, 6, p. 1590-1594Research output: Contribution to journal › Article › Academic › peer-review
F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach
Bruijnen, S. T. G., Chandrupatla, D. M. S. H., Giovanonni, L., Neri, D., Vugts, D. J., Huisman, M. C., Hoekstra, O. S., Musters, R. J. P., Lammertsma, A. A., van Dongen, G. A. M. S., Jansen, G., Molthoff, C. F. M. & van der Laken, C. J., 7 Jan 2019, In : Molecular Pharmaceutics. 16, 1, p. 273-281Research output: Contribution to journal › Article › Academic › peer-review
FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB
Pronk, M. C. A., Majolée, J., Loregger, A., van Bezu, J. S. M., Zelcer, N., Hordijk, P. L. & Kovačević, I., 1 Mar 2019, In : Molecular Biology of the Cell. 30, 5, p. 607-621 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes
van Velzen, H. G., Schinkel, A. F. L., van Grootel, R. W. J., van Slegtenhorst, M. A., van der Velden, J., Strachinaru, M. & Michels, M., 2019, In : Netherlands Heart Journal. 27, 3, p. 117-126 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology
Wiersma, V. I., van Ziel, A. M., Vazquez-Sanchez, S., Nölle, A., Berenjeno-Correa, E., Bonaterra-Pastra, A., Clavaguera, F., Tolnay, M., Musters, R. J. P., van Weering, J. R. T., Verhage, M., Hoozemans, J. J. M. & Scheper, W., 2019, In : Acta Neuropathologica.Research output: Contribution to journal › Article › Academic › peer-review
Heat shock protein inducer GGA*-59 reverses contractile and structural remodeling via restoration of the microtubule network in experimental Atrial Fibrillation
Hu, X., Li, J., van Marion, D. M. S., Zhang, D. & Brundel, B. J. J. M., 1 Sep 2019, In : Journal of Molecular and Cellular Cardiology. 134, p. 86-97Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation
Cremer, S., Michalik, K. M., Fischer, A., Pfisterer, L., Jaé, N., Winter, C., Boon, R. A., Muhly-Reinholz, M., John, D., Uchida, S., Weber, C., Poller, W., Günther, S., Braun, T., Li, D. Y., Maegdefessel, L., Perisic Matic, L., Hedin, U., Soehnlein, O., Zeiher, A. & 1 others, 2019, In : Circulation. 139, 10, p. 1320-1334 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Homocysteine-induced inverse expression of tissue factor and DPP4 in endothelial cells is related to NADPH oxidase activity
Korkmaz, H. I., Hahn, N. E., Jansen, K. M., Musters, R. J. P., van Bezu, J., van Wieringen, W. N., van Zuijlen, P. P. M., Ulrich, M. M. W., Niessen, H. W. M. & Krijnen, P. A. J., 2019, In : Physiology International. 106, 1, p. 29-38 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Hypertrofische cardiomyopathie
van Driel, B., Asselbergs, F. W., de Boer, R. A., van Rossum, A. C., van Tintelen, J. P., van der Velden, J. & Michels, M., 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 8, D2790.Research output: Contribution to journal › Article › Professional
Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells
Reinhard, N. R., van der Niet, S., Chertkova, A., Postma, M., Hordijk, P. L., Gadella Jr, T. W. J. & Goedhart, J., 2019, In : Small GTPases.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
IL-6 counteracts the inhibitory effect of IL-4 on osteogenic differentiation of human adipose stem cells
Bastidas-Coral, A. P., Hogervorst, J. M. A., Forouzanfar, T., Kleverlaan, C. J., Koolwijk, P., Klein-Nulend, J. & Bakker, A. D., 2019, In : Journal of Cellular Physiology. 234, 11, p. 20520-20532Research output: Contribution to journal › Article › Academic › peer-review
Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology
Bogunovic, N., Meekel, J. P., Micha, D., Blankensteijn, J. D., Hordijk, P. L. & Yeung, K. K., 2019, In : Scientific Reports. 9, 1, 6837.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Indoxyl sulfate stimulates angiogenesis by regulating reactive oxygen species production via CYP1B1
Pei, J., Juni, R., Harakalova, M., Duncker, D. J., Asselbergs, F. W., Koolwijk, P., van Hinsbergh, V. W. M., Verhaar, M. C., Mokry, M. & Cheng, C., 2019, In : Toxins. 11, 8, 454.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes
Hemerich, D., Pei, J., Harakalova, M., van Setten, J., Boymans, S., Boukens, B. J., Efimov, I. R., Michels, M., van der Velden, J., Vink, A., Cheng, C., van der Harst, P., Moore, J. H., Mokry, M., Tragante, V. & Asselbergs, F. W., 25 Jan 2019, In : Circulation. Genomic and precision medicine.Research output: Contribution to journal › Article › Academic › peer-review
JNK2 in myeloid cells impairs insulin's vasodilator effects in muscle during early obesity development through perivascular adipose tissue dysfunction
Meijer, R. I., Hoevenaars, F. P. M., Serné, E. H., Yudkin, J. S., Kokhuis, T. J. A., Weijers, E. M., van Hinsbergh, V. W. M., Smulders, Y. M. & Eringa, E. C., 2019, In : American Journal of Physiology. Heart and Circulatory Physiology. 317, 2, p. H364-H374Research output: Contribution to journal › Article › Academic › peer-review
Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling
Hofmann, P., Sommer, J., Theodorou, K., Kirchhof, L., Fischer, A., Li, Y., Perisic, L., Hedin, U., Maegdefessel, L., Dimmeler, S. & Boon, R. A., 2019, In : Cardiovascular Research. 115, 1, p. 230-242 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Meijer and Vloedman's histochemical demonstration of mitochondrial coupling obeys Lambert-Beer's law in the myocardium
Peters, E. L., Comerford, D., Vaz, F. M. & van der Laarse, W. J., 29 Jan 2019, In : Histochemistry and Cell Biology. 151, 1, p. 85-90 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Metabolic-vascular coupling in skeletal muscle: A potential role for capillary pericytes?
Attrill, E., Ramsay, C., Ross, R., Richards, S., Sutherland, B. A., Keske, M. A., Eringa, E. C. & Premilovac, D., 2019, In : Clinical and experimental pharmacology and physiology.Research output: Contribution to journal › Article › Academic › peer-review
Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels
Dekker, N. A. M., van Leeuwen, A. L. I., van Strien, W. W. J., Majolée, J., Szulcek, R., Vonk, A. B. A., Hordijk, P. L., Boer, C. & van den Brom, C. E., 2019, In : Critical Care. 23, 1, 117.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Muscle fiber dysfunction contributes to weakness in inclusion body myositis
Lassche, S., Rietveld, A., Heerschap, A., van Hees, H. W., Hopman, M. T. E., Voermans, N. C., Saris, C. G. J., van Engelen, B. G. M. & Ottenheijm, C. A. C., 2019, In : Neuromuscular Disorders. 29, 6, p. 468-476Research output: Contribution to journal › Article › Academic › peer-review
Muscle weakness in a S. pneumoniae sepsis mouse model
Witteveen, E., Wieske, L., Manders, E., Verhamme, C., Ottenheijm, C. A. C., Schultz, M. J., van Schaik, I. N. & Horn, J., Jan 2019, In : Annals of Translational Medicine. 7, 1, 9.Research output: Contribution to journal › Article › Academic › peer-review
Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy
Parbhudayal, R. Y., Güçlü, A., Zweerink, A., Biesbroek, P. S., Croisille, P., Clarysse, P., Michels, M., Stooker, W., Vonk, A. B. A., van der Ven, P. M., van Rossum, A. C., van der Velden, J. & Nijveldt, R., 2019, In : International Journal of Cardiovascular Imaging.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension
Rol, N., de Raaf, M. A., Sun, X. Q., Kuiper, V. P., da Silva Gonçalves Bos, D., Happé, C., Kurakula, K., Dickhoff, C., Thuillet, R., Tu, L., Guignabert, C., Schalij, I., Lodder, K., Pan, X., Herrmann, F. E., van Nieuw Amerongen, G. P., Koolwijk, P., Vonk-Noordegraaf, A., de Man, F. S., Wollin, L. & 3 others, 2019, In : Cardiovascular Research. 115, 2, p. 432-439Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Pathogenic effect of a TGFBR1 mutation in a family with Loeys–Dietz syndrome
Cozijnsen, L., Plomp, A. S., Post, J. G., Pals, G., Bogunovic, N., Yeung, K. K., Niessen, H. W. M., Goumans, M-J. T. H., Barge-Schaapveld, D. Q. C. M. & Micha, D., 2019, In : Molecular Genetics and Genomic Medicine. e943.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS
Leisegang, M. S., Bibli, S-I., Günther, S., Pflüger-Müller, B., Oo, J. A., Höper, C., Seredinski, S., Yekelchyk, M., Schmitz-Rixen, T., Schürmann, C., Hu, J., Looso, M., Sigala, F., Boon, R. A., Fleming, I. & Brandes, R. P., 2019, In : European Heart Journal. 40, 30, p. 2523-2533Research output: Contribution to journal › Article › Academic › peer-review
Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone
Andersen, S., Birkmose Axelsen, J., Ringgaard, S., Randel Nyengaard, J., Holm Nielsen, S., Genovese, F., Asser Karsdal, M., Adler Hyldebrandt, J., Brandt Sørensen, C., de Man, F. S., Jan Bogaard, H., Erik Nielsen-Kudsk, J. & Andersen, A., Apr 2019, In : Pulmonary Circulation. 9, 2, p. 204589401984865Research output: Contribution to journal › Article › Academic › peer-review
Recessive MYH7-related myopathy in two families
Beecroft, S. J., van de Locht, M., de Winter, J. M., Ottenheijm, C. A., Sewry, C. A., Mohammed, S., Ryan, M. M., Woodcock, I. R., Sanders, L., Gooding, R., Davis, M. R., Oates, E. C., Laing, N. G., Ravenscroft, G., McLean, C. A. & Jungbluth, H., 2019, In : Neuromuscular Disorders. 29, 6, p. 456-467Research output: Contribution to journal › Article › Academic › peer-review
Right ventricular oxygen delivery as a determinant of right ventricular functional reserve during exercise in juvenile swine with chronic pulmonary hypertension
Cai, Z., van Duin, R. W. B., Stam, K., Uitterdijk, A., van der Velden, J., Vonk Noordegraaf, A., Duncker, D. J. & Merkus, D., 1 Oct 2019, In : American Journal of Physiology. Heart and Circulatory Physiology. 317, 4, p. H840-H850Research output: Contribution to journal › Article › Academic › peer-review
Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm
Kumar, S., Boon, R. A., Maegdefessel, L., Dimmeler, S. & Jo, H., 2019, In : Circulation Research. 124, 4, p. 619-630Research output: Contribution to journal › Article › Academic › peer-review
Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation
van Marion, D. M. S., Hu, X., Zhang, D., Hoogstra-Berends, F., Seerden, J-P. G., Loen, L., Heeres, A., Steen, H., Henning, R. H. & Brundel, B. J. J. M., 1 Jan 2019, In : DRUG DESIGN DEVELOPMENT AND THERAPY. 13, p. 345-364Research output: Contribution to journal › Article › Academic › peer-review