Research Output 1997 2019

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2019

6-mercaptopurine, an agonist of Nur77, reduces progression of pulmonary hypertension by enhancing BMP signalling

Kurakula, K., Sun, X-Q., Happé, C., da Silva Goncalves Bos, D., Szulcek, R., Schalij, I., Wiesmeijer, K. C., Lodder, K., Tu, L., Guignabert, C., de Vries, C. J. M., de Man, F. S., Noordegraaf, A. V., Ten Dijke, P., Goumans, M-J. & Bogaard, H. J., 4 Jul 2019, In : The European respiratory journal.

Research output: Contribution to journalArticleAcademicpeer-review

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W. D., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., Varró, A., Dobrev, D., Ai, X., Janssen, P. M. L., Kass, D. A., Jones, W. K., Gilbert, R. J. & Sadayappan, S., 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 236-246

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes

Noll, B., Benz, D., Frey, Y., Meyer, F., Lauinger, M., Eisler, S. A., Schmid, S., Hordijk, P. L. & Olayioye, M. A., 2019, In : Journal of Cell Science. 132, 11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

Zhang, D., Hu, X., Li, J., Liu, J., Baks-Te Bulte, L., Wiersma, M., Malik, N-U-A., van Marion, D. M. S., Tolouee, M., Hoogstra-Berends, F., Lanters, E. A. H., van Roon, A. M., de Vries, A. A. F., Pijnappels, D. A., de Groot, N. M. S., Henning, R. H. & Brundel, B. J. J. M., 21 Mar 2019, In : Nature Communications. 10, 1, 1307.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Extra energy for hearts with a genetic defect: ENERGY trial

van Driel, B. O., van Rossum, A. C., Michels, M., Huurman, R. & van der Velden, J., 2019, In : Netherlands Heart Journal. 27, 4, p. 200-205

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach

Bruijnen, S. T. G., Chandrupatla, D. M. S. H., Giovanonni, L., Neri, D., Vugts, D. J., Huisman, M. C., Hoekstra, O. S., Musters, R. J. P., Lammertsma, A. A., van Dongen, G. A. M. S., Jansen, G., Molthoff, C. F. M. & van der Laken, C. J., Jan 2019, In : Molecular Pharmaceutics. 16, 1, p. 273-281

Research output: Contribution to journalArticleAcademicpeer-review

FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB

Pronk, M. C. A., Majolée, J., Loregger, A., van Bezu, J. S. M., Zelcer, N., Hordijk, P. L. & Kovačević, I., 1 Mar 2019, In : Molecular Biology of the Cell. 30, 5, p. 607-621 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes

van Velzen, H. G., Schinkel, A. F. L., van Grootel, R. W. J., van Slegtenhorst, M. A., van der Velden, J., Strachinaru, M. & Michels, M., 2019, In : Netherlands Heart Journal. 27, 3, p. 117-126

Research output: Contribution to journalArticleAcademicpeer-review

Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation

Cremer, S., Michalik, K. M., Fischer, A., Pfisterer, L., Jaé, N., Winter, C., Boon, R. A., Muhly-Reinholz, M., John, D., Uchida, S., Weber, C., Poller, W., Günther, S., Braun, T., Li, D. Y., Maegdefessel, L., Perisic Matic, L., Hedin, U., Soehnlein, O., Zeiher, A. & 1 othersDimmeler, S., 2019, In : Circulation. 139, 10, p. 1320-1334 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypertrofische cardiomyopathie

van Driel, B., Asselbergs, F. W., de Boer, R. A., van Rossum, A. C., van Tintelen, J. P., van der Velden, J. & Michels, M., 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 8, D2790.

Research output: Contribution to journalArticleProfessional

IL-6 counteracts the inhibitory effect of IL-4 on osteogenic differentiation of human adipose stem cells

Bastidas-Coral, A. P., Hogervorst, J. M. A., Forouzanfar, T., Kleverlaan, C. J., Koolwijk, P., Klein-Nulend, J. & Bakker, A. D., 2019, In : Journal of Cellular Physiology. 234, 11, p. 20520-20532

Research output: Contribution to journalArticleAcademicpeer-review

Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology

Bogunovic, N., Meekel, J. P., Micha, D., Blankensteijn, J. D., Hordijk, P. L. & Yeung, K. K., 2019, In : Scientific Reports. 9, 1, 6837.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes

Hemerich, D., Pei, J., Harakalova, M., van Setten, J., Boymans, S., Boukens, B. J., Efimov, I. R., Michels, M., van der Velden, J., Vink, A., Cheng, C., van der Harst, P., Moore, J. H., Mokry, M., Tragante, V. & Asselbergs, F. W., 25 Jan 2019, In : Circulation. Genomic and precision medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling

Hofmann, P., Sommer, J., Theodorou, K., Kirchhof, L., Fischer, A., Li, Y., Perisic, L., Hedin, U., Maegdefessel, L., Dimmeler, S. & Boon, R. A., 2019, In : Cardiovascular Research. 115, 1, p. 230-242

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue

Saxton, S. N., Clark, B. J., Withers, S. B., Eringa, E. C. & Heagerty, A. M., 2019, In : Physiological Reviews. 99, 4, p. 1701-1763

Research output: Contribution to journalArticleAcademicpeer-review

Meijer and Vloedman's histochemical demonstration of mitochondrial coupling obeys Lambert-Beer's law in the myocardium

Peters, E. L., Comerford, D., Vaz, F. M. & van der Laarse, W. J., 29 Jan 2019, In : Histochemistry and Cell Biology. 151, 1, p. 85-90 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle fiber dysfunction contributes to weakness in inclusion body myositis

Lassche, S., Rietveld, A., Heerschap, A., van Hees, H. W., Hopman, M. T. E., Voermans, N. C., Saris, C. G. J., van Engelen, B. G. M. & Ottenheijm, C. A. C., 2019, In : Neuromuscular Disorders.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle weakness in a S. pneumoniae sepsis mouse model

Witteveen, E., Wieske, L., Manders, E., Verhamme, C., Ottenheijm, C. A. C., Schultz, M. J., van Schaik, I. N. & Horn, J., Jan 2019, In : Annals of Translational Medicine. 7, 1, 9.

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy

Parbhudayal, R. Y., Güçlü, A., Zweerink, A., Biesbroek, P. S., Croisille, P., Clarysse, P., Michels, M., Stooker, W., Vonk, A. B. A., van der Ven, P. M., van Rossum, A. C., van der Velden, J. & Nijveldt, R., 2019, In : International Journal of Cardiovascular Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

Rol, N., de Raaf, M. A., Sun, X. Q., Kuiper, V. P., da Silva Gonçalves Bos, D., Happé, C., Kurakula, K., Dickhoff, C., Thuillet, R., Tu, L., Guignabert, C., Schalij, I., Lodder, K., Pan, X., Herrmann, F. E., van Nieuw Amerongen, G. P., Koolwijk, P., Vonk-Noordegraaf, A., de Man, F. S., Wollin, L. & 3 othersGoumans, M-J., Szulcek, R. & Bogaard, H. J., 2019, In : Cardiovascular Research. 115, 2, p. 432-439

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone

Andersen, S., Birkmose Axelsen, J., Ringgaard, S., Randel Nyengaard, J., Holm Nielsen, S., Genovese, F., Asser Karsdal, M., Adler Hyldebrandt, J., Brandt Sørensen, C., de Man, F. S., Jan Bogaard, H., Erik Nielsen-Kudsk, J. & Andersen, A., Apr 2019, In : Pulmonary Circulation. 9, 2, p. 204589401984865

Research output: Contribution to journalArticleAcademicpeer-review

Recessive MYH7-related myopathy in two families

Beecroft, S. J., van de Locht, M., de Winter, J. M., Ottenheijm, C. A., Sewry, C. A., Mohammed, S., Ryan, M. M., Woodcock, I. R., Sanders, L., Gooding, R., Davis, M. R., Oates, E. C., Laing, N. G., Ravenscroft, G., McLean, C. A. & Jungbluth, H., 2019, In : Neuromuscular Disorders.

Research output: Contribution to journalArticleAcademicpeer-review

Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm

Kumar, S., Boon, R. A., Maegdefessel, L., Dimmeler, S. & Jo, H., 2019, In : Circulation Research. 124, 4, p. 619-630

Research output: Contribution to journalArticleAcademicpeer-review

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

van Marion, D. M. S., Hu, X., Zhang, D., Hoogstra-Berends, F., Seerden, J-P. G., Loen, L., Heeres, A., Steen, H., Henning, R. H. & Brundel, B. J. J. M., 2019, In : DRUG DESIGN DEVELOPMENT AND THERAPY. 13, p. 345-364

Research output: Contribution to journalArticleAcademicpeer-review

Sex differences in hypertrophic cardiomyopathy: new insights

van Driel, B., Nijenkamp, L., Huurman, R., Michels, M. & van der Velden, J., 2019, In : Current opinion in cardiology. 34, 3, p. 254-259

Research output: Contribution to journalArticleAcademicpeer-review

Stabilization of cell-cell junctions by active Vitamin D ameliorates uraemia-induced loss of human endothelial barrier function

Cuenca, M. V., van Bezu, J., Beelen, R. H. J., Vervloet, M. G. & Hordijk, P. L., 2019, In : Nephrology, Dialysis, Transplantation. 34, 2, p. 252-264 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Piroddi, N., Witjas-Paalberends, E. R., Ferrara, C., Ferrantini, C., Vitale, G., Scellini, B., Wijnker, P. J. M., Sequiera, V., Dooijes, D., Dos Remedios, C., Schlossarek, S., Leung, M. C., Messer, A., Ward, D. G., Biggeri, A., Tesi, C., Carrier, L., Redwood, C. S., Marston, S. B., van der Velden, J. & 1 othersPoggesi, C., 7 Jan 2019, In : The Journal of general physiology. 151, 1, p. 18-29 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Untying the knot: protein quality control in inherited cardiomyopathies

Dorsch, L. M., Schuldt, M., Knežević, D., Wiersma, M., Kuster, D. W. D., van der Velden, J. & Brundel, B. J. J. M., 1 May 2019, In : Pflugers Archiv European Journal of Physiology. 471, 5, p. 795-806

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Adaptations in muscle oxidative capacity, fiber size, and oxygen supply capacity after repeated-sprint training in hypoxia combined with chronic hypoxic exposure

van der Zwaard, S., Brocherie, F., Kom, B. L. G., Millet, G. P., Deldicque, L., van der Laarse, W. J., Girard, O. & Jaspers, R. T., 2018, In : Journal of Applied Physiology. 124, 6, p. 1403-1412

Research output: Contribution to journalArticleAcademicpeer-review

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability

Amado-Azevedo, J., de Menezes, R. X., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M. & Hordijk, P. L., 2018, In : PLoS ONE. 13, 7, e0201231.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants

Boas, S. E. M., Carvalho, J., van den Broek, M., Weijers, E. M., Goumans, M-J., Koolwijk, P. & Merks, R. M. H., 2018, In : PLoS Computational Biology. 14, 7, e1006239.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

An in vitro method to keep human aortic tissue sections functionally and structurally intact

Meekel, J. P., Groeneveld, M. E., Bogunovic, N., Keekstra, N., Musters, R. J. P., Zandieh-Doulabi, B., Pals, G., Micha, D., Niessen, H. W. M., Wiersema, A. M., Kievit, J. K., Hoksbergen, A. W. J., Wisselink, W., Blankensteijn, J. D. & Yeung, K. K., 1 Dec 2018, In : Scientific Reports. 8, 1, 8094.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling

Meijering, R. A. M., Wiersma, M., Zhang, D., Lanters, E. A. H., Hoogstra-Berends, F., Scholma, J., Diks, S., Qi, X. Y., de Groot, N. M. S., Nattel, S., Henning, R. H. & Brundel, B. J. J. M., 1 Nov 2018, In : Heart Rhythm. 15, 11, p. 1708-1716 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Burst-like transcription of mutant and wildtype MYH7-alleles as possible origin of cell-to-cell contractile imbalance in Hypertrophic Cardiomyopathy

Montag, J., Kowalski, K., Makul, M., Ernstberger, P., Radocaj, A., Beck, J., Becker, E., Tripathi, S., Keyser, B., Mühlfeld, C., Wissel, K., Pich, A., van der Velden, J., dos Remedios, C. G., Perrot, A., Francino, A., Navarro-López, F., Brenner, B. & Kraft, T., 9 Apr 2018, In : Frontiers in Physiology. 9, APR, 359.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiovascular Function of Modern Pigs Does not Comply with Allometric Scaling Laws

Van Essen, G. J., Hekkert, M. T. L., Sorop, O., Heinonen, I., Van Der Velden, J., Merkus, D. & Duncker, D. J., 1 Aug 2018, In : Scientific Reports. 8, 1, 792.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization

Manavski, Y., Lucas, T., Glaser, S. F., Dorsheimer, L., Guenther, S., Braun, T., Rieger, M. A., Zeiher, A. M., Boon, R. A. & Dimmeler, S., 2 Mar 2018, In : Circulation Research. 122, 5, p. 670-677

Research output: Contribution to journalArticleAcademicpeer-review

Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S. & 1 othersHandoko, M. L., 1 Jan 2018, In : Circulation. 137, 9, p. 910-924 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Converse role of class I and class IIa HDACs in the progression of atrial fibrillation

Zhang, D., Hu, X., Li, J., Hoogstra-Berends, F., Zhuang, Q., Esteban, M. A., de Groot, N., Henning, R. H. & Brundel, B. J. J. M., 1 Dec 2018, In : Journal of Molecular and Cellular Cardiology. 125, p. 39-49 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Correction: Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor

Smeets, M. W. J., Bierings, R., Meems, H., Mul, F. P. J., Geerts, D., Vlaar, A. P. J., Voorberg, J. & Hordijk, P. L., 21 Mar 2018, In : PLoS ONE. 13, 3, e0194958.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Critical determinants of combined sprint and endurance performance: an integrative analysis from muscle fiber to the human body

van der Zwaard, S., van der Laarse, W. J., Weide, G., Bloemers, F. W., Hofmijster, M. J., Levels, K., Noordhof, D. A., de Koning, J. J., de Ruiter, C. J. & Jaspers, R. T., 31 Mar 2018, In : FASEB Journal. 32, p. 2110-2123 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

Brynnel, A., Hernandez, Y., Kiss, B., Lindqvist, J., Adler, M., Kolb, J., van der Pijl, R., Gohlke, J., Strom, J., Smith, J., Ottenheijm, C. & Granzier, H. L., 19 Dec 2018, In : eLife. 7, e40532.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3)

Joureau, B., de Winter, J. M., Conijn, S., Bogaards, S. J. P., Kovacevic, I., Kalganov, A., Persson, M., Lindqvist, J., Stienen, G. J. M., Irving, T. C., Ma, W., Yuen, M., Clarke, N. F., Rassier, D. E., Malfatti, E., Romero, N. B., Beggs, A. H. & Ottenheijm, C. A. C., 1 Feb 2018, In : Annals of Neurology. 83, 2, p. 269-282 14 p.

Research output: Contribution to journalArticleAcademicpeer-review