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3beta-OH-tibolone acutely dilates rat muscle arterioles similar to 3alpha-OH-tibolone

Korstjens, I. J. M., van der Mooren, M. J., Kloosterboer, H. J. & Sipkema, P., 2008, In : Menopause. 15, 2, p. 386-387

Research output: Contribution to journalArticleAcademicpeer-review

6-mercaptopurine, an agonist of Nur77, reduces progression of pulmonary hypertension by enhancing BMP signalling

Kurakula, K., Sun, X-Q., Happé, C., da Silva Goncalves Bos, D., Szulcek, R., Schalij, I., Wiesmeijer, K., Lodder, K., Tu, L., Guignabert, C., de Vries, C. J., de Man, F., Noordegraaf, A. V., Ten Dijke, P., Goumans, M-J. & Bogaard, H. J., 2019, In : The European respiratory journal.

Research output: Contribution to journalArticleAcademicpeer-review

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W. D., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., Varró, A., Dobrev, D., Ai, X., Janssen, P. M. L., Kass, D. A., Jones, W. K., Gilbert, R. J. & Sadayappan, S., 1 Apr 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 236-246 11 p.

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Open Access

Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice

Steinbusch, L. K. M., Luiken, J. J. F. P., Vlasblom, R., Chabowski, A., Hoebers, N. T. H., Coumans, W. A., Vroegrijk, I. O. C. M., Voshol, P. J., Ouwens, D. M., Glatz, J. F. C. & Diamant, M., 2011, In : American Journal of Physiology - Endocrinology and Metabolism. 301, 4, p. E618-E627

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Absence of Myocardial Thyroid Hormone Inactivating Deiodinase Results in Restrictive Cardiomyopathy in Mice

Ueta, C. B., Oskouei, B. N., Olivares, E. L., Pinto, J. R., Correa, M. M., Simovic, G., Simonides, W. S., Hare, J. M. & Bianco, A. C., 2012, In : Molecular Endocrinology. 26, 5, p. 809-818

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Absence of thrombospondin-2 causes age-related dilated cardiomyopathy

Swinnen, M., Vanhoutte, D., Van Almen, G. C., Hamdani, N., Schellings, M. W. M., D'hooge, J., van der Velden, J., Weaver, M. S., Sage, E. H., Bornstein, P., Verheyen, F. K., VandenDriessche, T., Chuah, MK., Westermann, D., Paulus, W. J., Van de Werf, F., Schroen, B., Carmeliet, P., Pinto, Y. M. & Heymans, S., 2009, In : Circulation. 120, 16, p. 1585-1597 30 p.

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A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity

Amado-Azevedo, J., Reinhard, N. R., van Bezu, J., Menezes, R. X., Van Beusechem, V. W., Van Nieuw Amerongen, G. P., Van Hinsbergh, V. W. M. & Hordijk, P. L., 1 Dec 2017, In : Scientific Reports. 7, 1, 10132.

Research output: Contribution to journalArticleAcademicpeer-review

A critical appraisal of transpulmonary and diastolic pressure gradients

Handoko, M. L., De Man, F. S., Oosterveer, F. P. T., Bogaard, H-J., Vonk-Noordegraaf, A. & Westerhof, N., Sep 2016, In : Physiological Reports. 4, 17, e12910.

Research output: Contribution to journalArticleAcademicpeer-review

Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration

Schaefer, A., Riet, J. T., Ritz, K., Hoogenboezem, M., Anthony, E. C., Mul, F. P. J., de Vries, C. J., Daemen, M. J., Figdor, C. G., van Buul, J. D. & Hordijk, P. L., 1 Jan 2014, In : Journal of Cell Science. 127, 20, p. 4470-4482 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activated complement is more extensively present in diseased aortic valves than naturally occurring complement inhibitors: a sign of ongoing inflammation

ter Weeme, M., Vonk, A. B. A., Kupreishvili, K., van Ham, M., Zeerleder, S., Wouters, D., Stooker, W., Eijsman, L., van Hinsbergh, V. W. M., Krijnen, P. A. J. & Niessen, H. W. M., 2010, In : European Journal of Clinical Investigation. 40, 1, p. 4-10

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Activated protein C in the treatment of acute lung injury and acute respiratory distress syndrome

Cornet, A. D., van Nieuw Amerongen, G. P., Beishuizen, A., Schultz, M. J., Girbes, A. R. J. & Groeneveld, A. B. J., 2009, In : Expert Opinion on Drug Discovery. 4, 3, p. 219-227

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Activation of AMP-Activated Protein Kinase by 5-Aminoimidazole-4-Carboxamide-1-beta-D-Ribofuranoside in the Muscle Microcirculation Increases Nitric Oxide Synthesis and Microvascular Perfusion

Bradley, E. A., Eringa, E. C., Stehouwer, C. D. A., Korstjens, I., van Nieuw Amerongen, G. P., Musters, R. J. P., Sipkema, P., Clark, M. G. & Rattigan, S., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 6, p. 1137-1142 7 p.

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Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice

Singh, S. R., Zech, A. T. L., Geertz, B., Reischmann-Düsener, S., Osinska, H., Prondzynski, M., Krämer, E., Meng, Q., Redwood, C., van der Velden, J., Robbins, J., Schlossarek, S. & Carrier, L., 1 Oct 2017, In : Circulation. Heart failure. 10, 10, e004140.

Research output: Contribution to journalArticleAcademicpeer-review

Activation of extracellular signal-related kinase in abdominal aortic aneurysm

Groeneveld, M. E., van Burink, M. V., Begieneman, M. P. V., Niessen, H. W. M., Wisselink, W., Eringa, E. & Yeung, K. K., May 2016, In : European Journal of Clinical Investigation. 46, 5, p. 440-447 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation

Zhang, D., Wu, C-T., Qi, X., Meijering, R. A. M., Hoogstra-Berends, F., Tadevosyan, A., Cubukcuoglu Deniz, G., Durdu, S., Akar, A. R., Sibon, O. C. M., Nattel, S., Henning, R. H. & Brundel, B. J. J. M., 21 Jan 2014, In : Circulation. 129, 3, p. 346-58 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation

Brundel, BJJM., Ausma, J., van Gelder, IC., Van Der Want, JJL., van Gilst, WH., Crijns, HJGM. & Henning, RH., May 2002, In : Cardiovascular Research. 54, 2, p. 380-389

Research output: Contribution to journalArticleAcademicpeer-review

Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease

Ottenheijm, C. A. C., Heunks, L. M. A., Li, Y. P., Jin, B., Minnaard, R., Van Hees, H. W. H. & Dekhuijzen, P. N. R., 1 Nov 2006, In : American Journal of Respiratory and Critical Care Medicine. 174, 9, p. 997-1002 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Active standing reduces wave reflection in the presence of increased peripheral resistance in young and old healthy individuals

Davis, S. C. A. T., Westerhof, B. E., van den Bogaard, B., Bogert, L. W. J., Truijen, J., Kim, Y-S., Westerhof, N. & van Lieshout, J. J., Apr 2011, In : Journal of Hypertension. 29, 4, p. 682-689 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-beta

Groenendijk, B. C. W., Benus, G. F. J. D., Klous, A., Pacheco, Y. M., Volger, O. L., Fledderus, J. O., Ferreira, V., Engelse, M. A., Pannekoek, H., ten Dijke, P., Horrevoets, A. J. G. & de Vries, C. J. M., 2011, In : Experimental Cell Research. 317, 2, p. 131-142

Research output: Contribution to journalArticleAcademicpeer-review

Acute effects of sildenafil on exercise pulmonary hemodynamics and capacity in patients with COPD

Holverda, S., Rietema, H., Bogaard, H. J., Westerhof, N., Postmus, P. E., Boonstra, A. & Vonk Noordegraaf, A., 2008, In : Pulmonary Pharmacology and Therapeutics. 21, 3, p. 558-564

Research output: Contribution to journalArticleAcademicpeer-review

Acute myocardial infarction does not affect functional characteristics of adipose-derived stem cells in rats, but reduces the number of stem cells in adipose tissue

Naaijkens, B. A., Krijnen, P. A. J., Meinster, E., van der Horst, E., Vo, K., Musters, R. J. P., Kamp, O., Niessen, H. W. M., Juffermans, L. J. M. & van Dijk, A., Dec 2015, In : Cell and Tissue Research. 362, 3, p. 623-632 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Adaptations in muscle oxidative capacity, fiber size, and oxygen supply capacity after repeated-sprint training in hypoxia combined with chronic hypoxic exposure

van der Zwaard, S., Brocherie, F., Kom, B. L. G., Millet, G. P., Deldicque, L., van der Laarse, W. J., Girard, O. & Jaspers, R. T., 2018, In : Journal of Applied Physiology. 124, 6, p. 1403-1412

Research output: Contribution to journalArticleAcademicpeer-review

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

Stellos, K., Gatsiou, A., Stamatelopoulos, K., Perisic Matic, L., John, D., Lunella, F. F., Jaé, N., Rossbach, O., Amrhein, C., Sigala, F., Boon, R. A., Fürtig, B., Manavski, Y., You, X., Uchida, S., Keller, T., Boeckel, J-N., Franco-Cereceda, A., Maegdefessel, L., Chen, W. & 6 othersSchwalbe, H., Bindereif, A., Eriksson, P., Hedin, U., Zeiher, A. M. & Dimmeler, S., 2016, In : Nature Medicine. 22, 10, p. 1140-1150 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Adhesion molecules involved in transendothelial migration of human hematopoietic progenitor cells

Voermans, C., Rood, PML., Hordijk, PL., Gerritsen, WR. & van der Schoot, CE., 2000, In : Stem Cells. 18, 6, p. 435-443

Research output: Contribution to journalArticleAcademicpeer-review

Adipose tissue-derived stromal cells acquire endothelial-like features upon reprogramming with SOX18

Fontijn, R. D., Favre, J., Naaijkens, B. A., Meinster, E., Paauw, N. J., Ragghoe, S. L., Nauta, T. D., van den Broek, M. A., Weijers, E. M., Niessen, H. W. M., Koolwijk, P. & Horrevoets, A. J. G., Nov 2014, In : Stem Cell Research. 13, 3 Pt A, p. 367-378 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Adipose tissue metabolism and inflammation are differently affected by weight loss in obese mice due to either a high-fat diet restriction or change to a low-fat diet

Hoevenaars, F. P. M., Keijer, J., Herreman, L., Palm, I., Hegeman, M. A., Swarts, H. J. & van Schothorst, E. M., 2014, In : Genes & nutrition. 9, 3, 391.

Research output: Contribution to journalArticleAcademicpeer-review

ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease

Sequeira Oliveira, V., Najafi, A., Wijnker, P. J. M., dos Remedios, C. G., Michels, M., Kuster, D. W. D. & van der Velden, J., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. E7003-E7012

Research output: Contribution to journalArticleAcademicpeer-review

Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction

Carluccio, E., Biagioli, P., Alunni, G., Murrone, A., Leonelli, V., Pantano, P., Biscottini, E., Paulus, W. J. & Ambrosio, G., 2011, In : European Journal of Heart Failure. 13, 3, p. 292-302

Research output: Contribution to journalArticleAcademicpeer-review

A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability

Amado-Azevedo, J., de Menezes, R. X., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M. & Hordijk, P. L., 2018, In : PLoS ONE. 13, 7, e0201231.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Age-dependent changes in myosin composition correlate with enhanced economy of contraction in guinea-pig hearts

Van Der Velden, J., Moorman, A. F. M. & Stienen, G. J. M., 1 Mar 1998, In : Journal of Physiology. 507, 2, p. 497-510 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice

Carmody, C., Ogawa-Wong, A. N., Martin, C., Luongo, C., Zuidwijk, M., Sager, B., Petersen, T., Roginski Guetter, A., Janssen, R., Wu, E. Y., Bogaards, S., Neumann, N. M., Hau, K., Marsili, A., Boelen, A., Silva, J. E., Dentice, M., Salvatore, D., Wagers, A. J., Larsen, P. R. & 2 othersSimonides, W. S. & Zavacki, A. M., 1 Jan 2019, In : Endocrinology. 160, 5, p. 1205-1222

Research output: Contribution to journalArticleAcademicpeer-review

A Large Human Centrifuge for Exploration and Exploitation Research

van Loon, J. J. W. A., Baeyens, J. P., Berte, J., Blanc, S., Braak, L., Bok, K., Bos, J. E., Boyle, R., Bravenboer, N., Eekhoff, E. M. W., Chouker, A., Clement, G., Cras, P., Cross, E., Custaud, M. A., de Angelis, M., Delavaux, T., Delfos, R., Poelma, C., Denise, P. & 38 othersFelsenberg, D., Fong, K., Fuller, C., Grillner, S., Groen, E., Harlaar, J., Heer, M., Heglund, N., Hinghofer-Szalkay, H., Goswami, N., Hughes-Fulford, M., Iwase, S., Karemaker, J. M., Langdahl, B. L., Linnarsson, D., Lüthen, C., Monici, M., Mulder, E., Narici, M. V., Norsk, P., Paloski, W., Prisk, K., Rutten, M., Singer, P., Stegeman, D. F., Stephan, A., Stienen, G. J. M., Suedfeld, P., Tesch, P., Ullrich, O., van den Berg, R., van de Heyning, P., Delahaye, A., Veyt, J., Vico, L., Woodward, E., Young, L. & Wuyts, F. L., 2012, In : Annales Kinesiologiae. 3, 1, p. 107-121

Research output: Contribution to journalArticleAcademic

Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: antiangiogenic properties of a new class of antitumor agents

Zerp, S. F., Vink, S. R., Ruiter, G. A., Koolwijk, P., Peters, E., van der Luit, A. H., de Jong, D., Budde, M., Bartelink, H., van Blitterswijk, W. J. & Verheij, M., 2008, In : Anti-Cancer Drugs. 19, 1, p. 65-75

Research output: Contribution to journalArticleAcademicpeer-review

A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants

Boas, S. E. M., Carvalho, J., van den Broek, M., Weijers, E. M., Goumans, M-J., Koolwijk, P. & Merks, R. M. H., 2018, In : PLoS Computational Biology. 14, 7, e1006239.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Alpha-1-adrenoceptor stimulation induces nitric oxide release in rat pulmonary arteries

Boer, C., Scheffer, G. J., De Lange, J. J., Westerhof, N. & Sipkema, P., 1 Jan 1999, In : Journal of Vascular Research. 36, 1, p. 79-81 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alteration of the Beta-Adrenergic Signaling Pathway in Human Heart Failure

Hamdani, N. & Linke, W. A., 2012, In : Current Pharmaceutical Biotechnology. 13, 13, p. 2522-2531

Research output: Contribution to journalArticleAcademicpeer-review

Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy

Gineste, C., Ottenheijm, C. A. C., Le Fur, Y., Banzet, S., Pecchi, E., Vilmen, C., Cozzone, P. J., Koulmann, N., Hardeman, E. C., Bendahan, D. & Gondin, J., 2014, In : PLoS ONE. 9, 9, e109066.

Research output: Contribution to journalArticleAcademicpeer-review

Alterations in contractile protein composition and function in human atrial dilatation and atrial fibrillation

Eiras, S., Narolska, N. A., van Loon, R. B., Boontje, N. M., Zaremba, R., Jimenez, C. R., Visser, F. C., Stooker, W., van der Velden, J. & Stienen, G. J. M., 1 Sep 2006, In : Journal of Molecular and Cellular Cardiology. 41, 3, p. 467-477 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alterations in excitation-contraction coupling in chronically ischemic or hibernating myocardium

Bito, V., Heinzel, F. R., Claus, P., Bijnens, B., Verbeken, E., Van der Velden, J., Stienen, G. & Sipido, K. R., 9 Sep 2005, In : Experimental and Clinical Cardiology. 10, 3, p. 142-145 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alterations in gene expression of proteins involved in the calcium handling in patients with atrial fibrillation

Van Gelder, IC., Brundel, BJJM., Henning, RH., Tuinenburg, AE., Tieleman, RG., Deelman, L., Grandjean, JG., De Kam, PJ., Van Gilst, WH. & Crijns, HJGM., Apr 1999, In : JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. 10, 4, p. 552-560

Research output: Contribution to journalArticleAcademicpeer-review

Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction.

van der Velden, J., Merkus, D., Klarenbeek, B. R., James, A. T., Boontje, N. M., Dekkers, D. H., Stienen, G. J., Lamers, J. M. & Duncker, D. J., 26 Nov 2004, In : Circulation Research. 95, 11, p. e85-95 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+ channels

Brundel, B. J., Van Gelder, I. C., Henning, R. H., Tuinenburg, A. E., Wietses, M., Grandjean, J. G., Wilde, A. A., Van Gilst, W. H. & Crijns, H. J., 1 Mar 2001, In : Journal of the American College of Cardiology. 37, 3, p. 926-32 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Altered contractility of skeletal muscle in mice deficient in titin's M-Band region

Ottenheijm, C. A. C., Hidalgo, C., Rost, K., Gotthardt, M. & Granzier, H., 2009, In : Journal of Molecular Biology. 393, 1, p. 10-26

Research output: Contribution to journalArticleAcademicpeer-review

Altered intracellular localization and mobility of SBDS protein upon mutation in Shwachman-Diamond syndrome

Orelio, C., van der Sluis, R. M., Verkuijlen, P., Nethe, M., Hordijk, P. L., van den Berg, T. K. & Kuijpers, T. W., 2011, In : PLoS ONE. 6, 6, p. e20727

Research output: Contribution to journalArticleAcademicpeer-review

Altered jugular vein and ductus venosus flow velocities in fetuses with increased nuchal translucency and distended jugular lymphatic sacs

de Mooij, Y. M., Bartelings, M. M., Twisk, J. W. R., Lamberts, R. R., Gittenberger-de Groot, A. C., van Vugt, J. M. G. & Bekker, M. N., 2010, In : American Journal of Obstetrics and Gynecology. 202, 6, p. 566.e1-566.e8

Research output: Contribution to journalArticleAcademicpeer-review

Altered myocardial force generation in end-stage human heart failure

Papp, Z., van der Velden, J., Borbely, A., Edes, I. & Stienen, G. J. M., 2014, In : ESC Heart Failure. 1, 2, p. 160-165

Research output: Contribution to journalArticleAcademicpeer-review

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Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography

van den Brom, C. E., Huisman, M. C., Vlasblom, R., Boontje, N., Duijst, S., Lubberink, J. M., Molthoff, C. F. M., Lammertsma, A. A., van der Velden, J., Boer, C., Ouwens, D. M. & Diamant, M., 2009, In : Cardiovascular Diabetology. 8, 39.

Research output: Contribution to journalArticleAcademic

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Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2)

Ottenheijm, C. A. C., Hooijman, P., DeChene, E. T., Stienen, G. J. M., Beggs, A. H. & Granzier, H., 2010, In : Journal of Structural Biology. 170, 2, p. 334-343

Research output: Contribution to journalArticleAcademicpeer-review