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2018

p47phox-Dependent Reactive Oxygen Species Stimulate Nuclear Translocation of the FoxO1 Transcription Factor During Metabolic Inhibition in Cardiomyoblasts

Ter Horst, E. N., Hahn, N. E., Geerts, D., Musters, R. J. P., Paulus, W. J., van Rossum, A. C., Meischl, C., Piek, J. J., Niessen, H. W. M. & Krijnen, P. A. J., 1 Sep 2018, In : Cell Biochemistry and Biophysics. 76, 3, p. 401-410 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

Lindqvist, J., van den Berg, M., van der Pijl, R., Hooijman, P. E., Beishuizen, A., Elshof, J., de Waard, M., Girbes, A., Spoelstra-de Man, A., Shi, Z-H., van den Brom, C., Bogaards, S., Shen, S., Strom, J., Granzier, H., Kole, J., Musters, R. J. P., Paul, M. A., Heunks, L. M. A. & Ottenheijm, C. A. C., 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. 472-485 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate

Chandrupatla, D. M. S. H., Molthoff, C. F. M., Ritsema, W. I. G. R., Vos, R., Elshof, E., Matsuyama, T., Low, P. S., Musters, R. J. P., Hammond, A., Windhorst, A. D., Lammertsma, A. A., van der Laken, C. J., Brands, R. & Jansen, G., 2018, In : Translational research : the journal of laboratory and clinical medicine. 199, p. 24-38 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T. N., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 379 othersFeitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y-D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., du, M., Dubé, M-P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A-E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H-J. R., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, A. R., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J-H. K., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K-H., Lin, L-A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C-T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, JA., Lubitz, S. A., Lyytikäinen, L-P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. L. R., Nordestgaard, B. R. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Polderman, T. J., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H. -H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J-C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., 2018, In : Nature Genetics. 50, 1, p. 26-35

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Reduction of vascular leakage by imatinib is associated with preserved microcirculatory perfusion and reduced renal injury markers in a rat model of cardiopulmonary bypass

Koning, N. J., de Lange, F., van Meurs, M., Jongman, R. M., Ahmed, Y., Schwarte, L. A., van Nieuw Amerongen, G. P., Vonk, A. B. A., Niessen, H. W., Baufreton, C. & Boer, C., 1 Jun 2018, In : British Journal of Anaesthesia. 120, 6, p. 1165-1175 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Red wine polyphenols do not improve obesity-associated insulin resistance: A randomized controlled trial

Woerdeman, J., Del Rio, D., Calani, L., Eringa, E. C., Smulders, Y. M. & Serné, E. H., 1 Jan 2018, In : Diabetes, Obesity and Metabolism. 20, 1, p. 206-210 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

Gorter, T. M., van Veldhuisen, D. J., Bauersachs, J., Borlaug, B. A., Celutkiene, J., Coats, A. J. S., Crespo-Leiro, M. G., Guazzi, M., Harjola, V. P., Heymans, S., Hill, L., Lainscak, M., Lam, C. S. P., Lund, L. H., Lyon, A. R., Mebazaa, A., Mueller, C., Paulus, W. J., Pieske, B., Piepoli, M. F. & 9 othersRuschitzka, F., Rutten, F. H., Seferovic, P. M., Solomon, S. D., Shah, S. J., Triposkiadis, F., Wachter, R., Tschöpe, C. & de Boer, R. A., 1 Jan 2018, In : European Journal of Heart Failure. 20, 1, p. 16-37 22 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy

Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Krueger, M., Poggesi, C., Ho, C. Y., Kuster, D. W. D., Michels, M. & van der Velden, J., Jun 2018, In : Circulation. Heart failure. 11, 6, e004133.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome

Schimmel, L., van der Stoel, M., Rianna, C., van Stalborch, A-M., de Ligt, A., Hoogenboezem, M., Tol, S., van Rijssel, J., Szulcek, R., Bogaard, H. J., Hofmann, P., Boon, R., Radmacher, M., de Waard, V., Huveneers, S. & van Buul, J. D., 18 Sep 2018, In : Cell Reports. 24, 12, p. 3115-3124 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Stretch-induced compliance: A novel adaptive biological mechanism following acute cardiac load

Leite-Moreira, A. M., Almeida-Coelho, J., Neves, J. S., Pires, A. L., Ferreira-Martins, J., Castro-Ferreira, R., Ladeiras-Lopes, R., Conceição, G., Miranda-Silva, D., Rodrigues, P., Hamdani, N., Herwig, M., Falcão-Pires, I., Paulus, W. J., Linke, W. A., Lourenço, A. P. & Leite-Moreira, A. F., 2018, In : Cardiovascular Research. 114, 5, p. 656-667

Research output: Contribution to journalArticleAcademicpeer-review

Switch in Laminin beta 2 to Laminin beta 1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report

Wagner, J. U. G., Chavakis, E., Rogg, E-M., Muhly-Reinholz, M., Glaser, S. F., Guenther, S., John, D., Bonini, F., Zeiher, A. M., Schaefer, L., Hannocks, M-J., Boon, R. A. & Dimmeler, S., May 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 5, p. 1170-1177

Research output: Contribution to journalArticleAcademicpeer-review

The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model

Pouwer, M. G., Pieterman, E. J., Verschuren, L., Caspers, M. P. M., Kluft, C., Garcia, R. A., Aman, J., Jukema, J. W. & Princen, H. M. G., 12 Jun 2018, In : Frontiers in cardiovascular medicine. 5, 55.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The covalently immobilized antimicrobial peptide LL37 acts as a VEGF mimic and stimulates endothelial cell proliferation

Szulcek, R., Bollensdorff, C., Hordijk, P. & Gabriel, M., 2018, In : Biochemical and Biophysical Research Communications. 496, 3, p. 887-890

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB

Kovačević, I., Sakaue, T., Majoleé, J., Pronk, M. C., Maekawa, M., Geerts, D., Fernandez-Borja, M., Higashiyama, S. & Hordijk, P. L., 2018, In : Journal of Cell Biology. 217, 3, p. 1015-1032

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effectiveness of affordable technology in rehabilitation to improve mobility and physical activity: Amount (activity and mobility using technology) rehabilitation trial

Sherrington, C., Hassett, L., van den Berg, M., Lindley, R., Crotty, M., McCluskey, A., van der Ploeg, H., Smith, S. & Schurr, K., 15 Jul 2018, In : Annals of Physical and Rehabilitation Medicine. 61, p. e86

Research output: Contribution to journalArticleAcademicpeer-review

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

Neumann, P., Jae, N., Knau, A., Glaser, S. F., Fouani, Y., Rossbach, O., Krueger, M., John, D., Bindereif, A., Grote, P., Boon, R. A. & Dimmeler, S., 16 Jan 2018, In : Nature Communications. 9, 237.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP and a novel regulator of endothelial integrity

Amado-Azevedo, J., Reinhard, N. R., van Bezu, J., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M. & Hordijk, P. L., 1 Feb 2018, In : Vascular Pharmacology. 101, p. 38-47 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Titin-based mechanosensing modulates muscle hypertrophy

van der Pijl, R., Strom, J., Conijn, S., Lindqvist, J., Labeit, S., Granzier, H. & Ottenheijm, C. A. C., 2018, In : Journal of Cachexia, Sarcopenia and Muscle. 9, 5, p. 947-961 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system

Wiersma, M., Beuren, T. M. A., de Vrij, E. L., Reitsema, V. A., Bruintjes, J. J., Bouma, H. R., Brundel, B. J. J. M. & Henning, R. H., 1 Sep 2018, In : Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology. 223, p. 23-28 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology

Seferović, P. M., Petrie, M. C., Filippatos, G. S., Anker, S. D., Rosano, G., Bauersachs, J., Paulus, W. J., Komajda, M., Cosentino, F., de Boer, R. A., Farmakis, D., Doehner, W., Lambrinou, E., Lopatin, Y., Piepoli, M. F., Theodorakis, M. J., Wiggers, H., Lekakis, J., Mebazaa, A., Mamas, M. A. & 13 othersTschöpe, C., Hoes, A. W., Seferović, J. P., Logue, J., McDonagh, T., Riley, J. P., Milinković, I., Polovina, M., van Veldhuisen, D. J., Lainscak, M., Maggioni, A. P., Ruschitzka, F. & McMurray, J. J. V., 2018, In : European Journal of Heart Failure. 20, 5, p. 853-872

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy

Parbhudayal, R. Y., Garra, A. R., Götte, M. J. W., Michels, M., Pei, J., Harakalova, M., Asselbergs, F. W., van Rossum, A. C., van der Velden, J. & Kuster, D. W. D., Oct 2018, In : Journal of Molecular and Cellular Cardiology. 123, p. 59-63 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock

Trieu, M., Van Meurs, M., Van Leeuwen, A. L. I., Van Slyke, P., Hoang, V., Geeraedts, L. M. G., Boer, C. & Van Den Brom, C. E., 1 Feb 2018, In : Anesthesiology. 128, 2, p. 361-374 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin D attenuates endothelial dysfunction in uremic rats and maintains human endothelial stability

Cuenca, M. V., Ferrantelli, E., Meinster, E., Pouw, S. M., Kovačević, I., de Menezes, R. X., Niessen, H. W., Beelen, R. H. J., Hordijk, P. L. & Vervloet, M. G., 1 Sep 2018, In : Journal of the American Heart Association. 7, 17, e008776.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity

Amado-Azevedo, J., Reinhard, N. R., van Bezu, J., Menezes, R. X., Van Beusechem, V. W., Van Nieuw Amerongen, G. P., Van Hinsbergh, V. W. M. & Hordijk, P. L., 1 Dec 2017, In : Scientific Reports. 7, 1, 10132.

Research output: Contribution to journalArticleAcademicpeer-review

Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice

Singh, S. R., Zech, A. T. L., Geertz, B., Reischmann-Düsener, S., Osinska, H., Prondzynski, M., Krämer, E., Meng, Q., Redwood, C., van der Velden, J., Robbins, J., Schlossarek, S. & Carrier, L., 1 Oct 2017, In : Circulation. Heart failure. 10, 10, e004140.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

Lynch, T. L., Kuster, D. W. D., Gonzalez, B., Balasubramanian, N., Nair, N., Day, S., Calvino, J. E., Tan, Y., Liebetrau, C., Troidl, C., Hamm, C. W., Güçlü, A., McDonough, B., Marian, A. J., van der Velden, J., Seidman, C. E., Huggins, G. S. & Sadayappan, S., 1 Apr 2017, In : JACC: Basic to Translational Science. 2, 2, p. 122-131 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiac Thyroid Hormone Metabolism and Heart Failure

Janssen, R., Muller, A. & Simonides, W. S., 2017, In : EUROPEAN THYROID JOURNAL. 6, 3, p. 130-137

Research output: Contribution to journalArticleAcademicpeer-review

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy

Bollen, I. A. E., van der Meulen, M., de Goede, K., Kuster, D. W. D., Dalinghaus, M. & van der Velden, J., 22 Dec 2017, In : Frontiers in Physiology. 8, 01103.

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Characteristics and Long-Term Outcome of Hypertrophic Cardiomyopathy in Individuals With a MYBPC3 (Myosin-Binding Protein C) Founder Mutation

van Velzen, H. G., Schinkel, A. F. L., Oldenburg, R. A., van Slegtenhorst, M. A., Frohn-Mulder, I. M. E., van der Velden, J. & Michels, M., Aug 2017, In : Circulation-cardiovascular genetics. 10, 4, e001660.

Research output: Contribution to journalArticleAcademicpeer-review

Combined intravital microscopy and contrast-enhanced ultrasonography of the mouse hindlimb to study insulin-induced vasodilation and muscle perfusion

Turaihi, A. H., van Poelgeest, E. M., van Hinsbergh, V. W. M., Serné, E. H., Smulders, Y. M. & Eringa, E. C., 20 Mar 2017, In : Journal of Visualized Experiments. 2017, 121, e54912.

Research output: Contribution to journalArticleAcademicpeer-review

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill

van den Berg, M., Hooijman, P. E., Beishuizen, A., de Waard, M. C., Paul, M. A., Hartemink, K. J., van Hees, H. W. H., Lawlor, M. W., Brocca, L., Bottinelli, R., Pellegrino, M. A., Stienen, G. J. M., Heunks, L. M. A., Wüst, R. C. I. & Ottenheijm, C. A., 15 Dec 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 12, p. 1544-1558 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of early-onset preeclampsia on cardiovascular risk in the fifth decade of life

Bokslag, A., Teunissen, P. W., Franssen, C., van Kesteren, F., Kamp, O., Ganzevoort, W., Paulus, W. J. & de Groot, C. J. M., May 2017, In : American Journal of Obstetrics and Gynecology. 216, 5, p. 523.e1-523.e7 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Empagliflozin decreases myocardial cytoplasmic Na(+) through inhibition of the cardiac Na(+)/H(+) exchanger in rats and rabbits

Baartscheer, A., Schumacher, C. A., Wüst, R. C. I., Fiolet, J. W. T., Stienen, G. J. M., Coronel, R. & Zuurbier, C. J., Mar 2017, In : Diabetologia. 60, 3, p. 568-573 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Endoplasmic reticulum stress is associated with autophagy and cardiomyocyte remodeling in experimental and human atrial fibrillation

Wiersma, M., Meijering, R. A. M., Qi, X. Y., Zhang, D., Liu, T., Hoogstra-Berends, F., Sibon, O. C. M., Henning, R. H., Nattel, S. & Brundel, B. J. J. M., 1 Oct 2017, In : Journal of the American Heart Association. 6, 10, e006458.

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial CD2AP binds the receptor ICAM-1 to control mechanosignaling, leukocyte adhesion, and the route of leukocyte diapedesis in vitro

Schaefer, A., Van Duijn, T. J., Majolee, J., Burridge, K. & Hordijk, P. L., 15 Jun 2017, In : Journal of Immunology. 198, 12, p. 4823-4836 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A

Manavski, Y., Abel, T., Hu, J., Kleinlützum, D., Buchholz, C. J., Belz, C., Augustin, H. G., Boon, R. A. & Dimmeler, S., 11 Apr 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 15, p. 3993-3998 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Nolte, I. M., Munoz, M. L., Tragante, V., Amare, A. T., Jansen, R., Vaez, A., Von Der Heyde, B., Avery, C. L., Bis, J. C., Dierckx, B., Van Dongen, J., Gogarten, S. M., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S. J., Jaju, D., Kerr, K. F., Kluttig, A., Krijthe, B. P. & 144 othersKumar, J., Van Der Laan, S. W., Lyytikäinen, L. P., Maihofer, A. X., Minassian, A., Van Der Most, P. J., Müller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J. D., Thayer, J. F., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M. H., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D. G., De Bakker, P. I. W., Barcella, M., Bayoumi, R., Bieringa, R. J., Boomsma, D., Boucher, G., Britton, A. R., Christophersen, I. E., Dietrich, A., Ehret, G. B., Ellinor, P. T., Eskola, M., Felix, J. F., Floras, J. S., Franco, O. H., Friberg, P., Gademan, M. G. J., Geyer, M. A., Giedraitis, V., Hartman, C. A., Hemerich, D., Hofman, A., Hottenga, J. J., Huikuri, H., Hutri-Kähönen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A. M., Kors, J. A., Kumari, M., Kuznetsova, T., Laurie, C. C., Lefrandt, J. D., Li, Y., Li, Y., Liao, D., Limacher, M. C., Lin, H. J., Lindgren, C. M., Lubitz, S. A., Mahajan, A., McKnight, B., Meyer Zu Schwabedissen, H., Milaneschi, Y., Mononen, N., Morris, A. P., Nalls, M. A., Navis, G., Neijts, M., Nikus, K., North, K. E., O'Connor, D. T., Ormel, J., Perz, S., Peters, A., Psaty, B. M., Raitakari, O. T., Risbrough, V. B., Sinner, M. F., Siscovick, D., Smit, J. H., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Staessen, J. A., Stein, P. K., Stilp, A. M., Stolarz-Skrzypek, K., Strauch, K., Sundström, J., Swenne, C. A., Syvänen, A. C., Tardif, J. C., Taylor, K. D., Teumer, A., Thornton, T. A., Tinker, L. E., Uitterlinden, A. G., Van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K. C., Willemsen, G., Wong, Q., Zhang, Z. M., Zonderman, A. B., Cusi, D., Evans, M. K., Greiser, H. K., Van Der Harst, P., Hassan, M., Ingelsson, E., Järvelin, M. R., Kääb, S., Kähönen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimäki, T., Lind, L., Nievergelt, C. M., O'Donnell, C. J., Oldehinkel, A. J., Penninx, B., Reiner, A. P., Riese, H., Van Roon, A. M., Rioux, J. D., Rotter, J. I., Sofer, T., Stricker, B. H., Tiemeier, H., Vrijkotte, T. G. M., Asselbergs, F. W., Brundel, B. J. J. M., Heckbert, S. R., Whitsel, E. A., Den Hoed, M., Snieder, H. & De Geus, E. J. C., 14 Jun 2017, In : Nature Communications. 8, 15805.

Research output: Contribution to journalArticleAcademicpeer-review

Genotype-specific pathogenic effects in human dilated cardiomyopathy

Bollen, I. A. E., Schuldt, M., Harakalova, M., Vink, A., Asselbergs, F. W., Pinto, J. R., Krueger, M., Kuster, D. W. D. & van der Velden, J., 15 Jul 2017, In : Journal of Physiology - London. 595, 14, p. 4677-4693

Research output: Contribution to journalArticleAcademicpeer-review

Hyperoxia does not directly affect vascular tone in isolated arteries from mice

Smit, B., Smulders, Y. M., De Waard, M. C., Oudemans-Van Straaten, H. M., Girbes, A. R. J., Eringa, E. C. & Spoelstra - De Man, A. M. E., 1 Aug 2017, In : PLoS ONE. 12, 8, e0182637.

Research output: Contribution to journalArticleAcademicpeer-review

Hypoxia decreases osteogenic differentiation potential but enhances vasculogenic differentiation potential of human adipose stem cells on biphasic calcium phosphate scaffolds in fibrin gels

van Esterik, F. A. S., Hogervorst, J. M. A., Koolwijk, P. & Klein-Nulend, J., 2017, In : Journal of Stem Cells. 12, 2, p. 41-52 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro

Nauta, T. D., van den Broek, M., Gibbs, S., van der Pouw-Kraan, T. C. T. M., Oudejans, C. B., van Hinsbergh, V. W. M. & Koolwijk, P., 2017, In : Angiogenesis. 20, 1, p. 39-54

Research output: Contribution to journalArticleAcademicpeer-review

IGF-1 attenuates hypoxia-induced atrophy but inhibits myoglobin expression in C2C12 skeletal muscle myotubes

Peters, E. L., van der Linde, S. M., Vogel, I. S. P., Haroon, M., Offringa, C., de Wit, G. M. J., Koolwijk, P., van der Laarse, W. J. & Jaspers, R. T., 1 Sep 2017, In : International Journal of Molecular Sciences. 18, 9, 1889.

Research output: Contribution to journalArticleAcademicpeer-review

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy

Montag, J., Syring, M., Rose, J., Weber, A. L., Ernstberger, P., Mayer, A. K., Becker, E., Keyser, B., Dos Remedios, C., Perrot, A., van der Velden, J., Francino, A., Navarro-Lopez, F., Ho, C. Y., Brenner, B. & Kraft, T., 30 Nov 2017, In : Journal of Muscle Research and Cell Motility. p. 1-12 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vitro model to study the effects of matrix stiffening on Ca2+ handling and myofilament function in isolated adult rat cardiomyocytes

van Deel, E. D., Najafi, A., Fontoura, D., Valent, E., Goebel, M., Kardux, K., Falcao-Pires, I. & van der Velden, J., 15 Jul 2017, In : Journal of Physiology - London. 595, 14, p. 4597-4610

Research output: Contribution to journalArticleAcademicpeer-review

Lamin A/C-Related Cardiac Disease Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation

Hoorntje, E. T., Bollen, I. A., Barge-Schaapveld, D. Q., van Tienen, F. H. J., te Meerman, G. J., Jansweijer, J. A., van Essen, A. J., Volders, P. G., Constantinescu, A. A., van den Akker, P. C., van Spaendonck-Zwarts, K. Y., Oldenburg, R. A., Marcelis, C. L., van der Smagt, J. J., Hennekam, E. A., Vink, A., Bootsma, M., Aten, E., Wilde, A. A. M., van den Wijngaard, A. & 5 othersBroers, J. L., Jongbloed, J. D., van der Velden, J., van den Berg, M. P. & van Tintelen, J. P., Aug 2017, In : Circulation-cardiovascular genetics. 10, 4, e001631.

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Life-long tailoring of management for patients with hypertrophic cardiomyopathy: Awareness and decision-making in changing scenarios

Michels, M., Olivotto, I., Asselbergs, F. W. & van der Velden, J., 1 Mar 2017, In : Netherlands Heart Journal. 25, 3, p. 186-199 14 p.

Research output: Contribution to journalArticleAcademicpeer-review