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2020

Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes

Heuberger, J. A. A. C., Posthuma, J. J., Ziagkos, D., Rotmans, J. I., Daniels, J. M. A., Gal, P., Stuurman, F. E., Spronk, H. M. H., Ten Cate, H., Burggraaf, J., Moerland, M. & Cohen, A. F., 1 Jan 2020, (Accepted/In press) In : European Journal of Applied Physiology. 120, 8, 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity

Botros, L., Pronk, M. C. A., Juschten, J., Liddle, J., Morsing, S. K. S. H., van Buul, J. D., Bates, R. H., Tuinman, P. R., van Bezu, J. S. M., Huveneers, S., Bogaard, H. J., van Hinsbergh, V. W. M., Hordijk, P. L. & Aman, J., 20 Mar 2020, In : Journal of Cell Science. 133, 9, jcs240077.

Research output: Contribution to journalArticleAcademicpeer-review

Cellular senescence impairs the reversibility of pulmonary arterial hypertension

van der Feen, D. E., Bossers, G. P. L., Hagdorn, Q. A. J., Moonen, J. R., Kurakula, K., Szulcek, R., Chappell, J., Vallania, F., Donato, M., Kok, K., Kohli, J. S., Petersen, A. H., van Leusden, T., Demaria, M., Goumans, M. J. T. H., De Boer, R. A., Khatri, P., Rabinovitch, M., Berger, R. M. F. & Bartelds, B., 29 Jul 2020, In : Science Translational Medicine. 12, 554, eaaw4974.

Research output: Contribution to journalArticleAcademicpeer-review

Combination therapy with oral treprostinil for pulmonary arterial hypertension: A double-blind placebo-controlled clinical trial

White, R. J., Jerjes-Sanchez, C., Meyer, G. M. B., Pulido, T., Sepulveda, P., Wang, K. Y., Grünig, E., Hiremath, S., Yu, Z., Zhang, G., Yip, W. L. J., Zhang, S., Khan, A., Deng, C. Q., Grover, R., Tapson, V. F., Svetliza, G. N., Lescano, A. J., Bortman, G. R., Diez, F. A. & 166 others, Botta, C. E., Fitzgerald, J., Feenstra, E., Kermeen, F. D., Keogh, A. M., Williams, T. J., Yousseff, P. P., Ng, B. J. H., Smallwood, D. M. N., Dwyer, N. B., Brown, M. R., Lang, I. M., Steringer-Mascherbauer, R., Arakaki, J. O., Campos, F., De Amorim Correa, R., De Souza, R., Meyer, G. M. B., Moreira, M. C., Yoo, H., Lapa, M. S., Swiston, J., Hirani, N., Mehta, S., Michelakis, E., Sepulveda, P., Zagolin, M., Liu, J., Zhang, S., Pan, L., Chunde, B., Qun, Y., Cheng, X., Yu, Z., Li, X., Hua, Y., Zhang, G., Zhu, X., Chen, Y., Cheng, Z., Yang, Y., Zhou, D., Shen, J., Nielsen-Kudsk, J. E., Carlsen, J., Bourdin, A., Hachulla, E., Dromer, C., Chaouat, A., Reynaud-Gauber, M., Seronde, M. F., Klose, H., Halank, M., Hoffken, G., Ewert, R., Rosenkranz, S., Grunig, E., Kruger, U., Kronsbein, J., Hauptmeier, B. M., Koch, A., Held, M., Lange, T. J., Neurohr, C., Wilkens, H., Wirtz, H., Konstantinides, S., Argyropoulou-Pataka, P., Orfanos, S., Hiremath, S., Kerkar, P. G., Suresh, P. V., Baxi, H. A., Oomman, A., Abhaichand, R. K., Edla Kumar, P. K., Chopra, V., Mehrotra, R., Rajput, R. K., Sawhney, J. S., Bimalendu, S., Sharma, K. H., Srinivasa Sastry, B. K., Kramer, M. R., Segel, M. J., Ben-Dov, I., Berkman, N., Yigla, M., Adir, Y., D'Alto, M., Vizza, C. D., Scelsi, L., Vitulo, P., Pulido, T. R., Jerjes-Sanchez, C., Boonstra, A., Vonk, M. C., Sobkowicz, B., Mularek-Kubzdela, T., Torbicki, A., Podolec, P., Teik, L. S., Yip, W. L. J., Chang, H. J., Kim, H. K., Park, J. B., Chang, S. A., Kim, D. K., Chung, W. J., Song, J. M., Nissell, M., Hjalmarsson, C., Rundqvist, B., Huang, W. C., Cheng, C. C., Hsu, C. H., Hsu, H. H., Wang, K. Y., Coghlan, J. G., Kiely, D. G., Pepke-Zaba, J. W., Lordan, J. L., Corris, P. A., Cadaret, L., Hansdottir, S., Oudiz, R. J., Badesch, D. B., Mathier, M., Schilz, R., Hill, N., Waxman, A., Markin, C. J., Zwicke, D. L., Fisher, M., Franco, V., Sood, N., Park, M. H., Allen, R., Feldman, J. P., Balasubramanian, V., Seeram, V. K., Bajwa, A., Thompson, A. B., Migliore, C., Elwing, J., McConnell, J. W., Mehta, J. P., Rahaghi, F. F., Rame, J. E., Khan, A., Patel, B., Oren, R. M., Klinger, J. R., Alnuaimat, H., Allen, S., Harvey, W., Eggert, M. S., Hage, A., Miller, C. E., Awdish, R., Cajigas, H., Grinnan, D., Trichon, B. H., McDonough, C., White, R. J. & Rischard, F., 15 Mar 2020, In : American Journal of Respiratory and Critical Care Medicine. 201, 6, p. 707-717 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of checkpoint inhibitors in advanced non-small cell lung cancer at population level from the National Immunotherapy Registry

On behalf of all participants of NVALT Immunotherapy Register (see addendum), 1 Feb 2020, In : Lung Cancer. 140, p. 107-112 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

ERS International Congress, Madrid, 2019: highlights from the Respiratory Intensive Care Assembly

Satici, C., López-Padilla, D., Schreiber, A., Kharat, A., Swingwood, E., Pisani, L., Patout, M., Bos, L. D., Scala, R., Schultz, M. J. & Heunks, L., Jan 2020, In : BMJ Open. 6, 1

Research output: Contribution to journalArticleAcademicpeer-review

Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells

Szulcek, R., Sanchez-Duffhues, G., Rol, N., Pan, X., Tsonaka, R., Dickhoff, C., Yung, L. M., Manz, X. D., Kurakula, K., Kiełbasa, S. M., Mei, H., Timens, W., Yu, P. B., Bogaard, H-J. & Goumans, M-J., 2020, In : Angiogenesis.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Functional genomic screen in mesothelioma reveals that loss of function of BRCA1-associated-protein-1 induces chemoresistance to ribonucleotide reductase inhibition

Okonska, A., Bühler, S., Rao, V., Ronner, M., Blijlevens, M., van der Meulen-Muileman, I. H., de Menezes, R. X., Wipplinger, M., Oehl, K., Smit, E. F., Weder, W., Stahel, R. A., Penengo, L., van Beusechem, V. W. & Felley-Bosco, E., Feb 2020, In : Molecular Cancer Therapeutics. 19, 2, p. 552-563 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Imaging Responses to Immunotherapy with Novel PET Tracers

Niemeijer, A-L., Hoekstra, O. S., Smit, E. F. & de Langen, A. J., May 2020, In : Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 61, 5, p. 641-642 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Influence of Age on Upper Arm Cuff Blood Pressure Measurement

Picone, D. S., Schultz, M. G., Otahal, P., Black, J. A., Bos, W. J., Chen, C. H., Cheng, H. M., Cremer, A., Dwyer, N., Fonseca, R., Hughes, A. D., Kim, H. L., Lacy, P. S., Laugesen, E., Ohte, N., Omboni, S., Ott, C., Pereira, T., Pucci, G., Roberts-Thomson, P. & 12 others, Rossen, N. B., Schmieder, R. E., Sueta, D., Takazawa, K., Wang, J., Weber, T., Westerhof, B. E., Williams, B., Yamada, H., Yamamoto, E., Sharman, J. E. & Invasive Blood Pressure Consortium, 1 Mar 2020, In : Hypertension (Dallas, Tex. : 1979). 75, 3, p. 844-850 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Manz, X. D., Albers, H. J., Symersky, P., Aman, J., van der Meer, A. D., Bogaard, H. J. & Szulcek, R., 24 May 2020, In : Journal of visualized experiments : JoVE. 2020, 159, 10 p., e61068.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

Stanicek, L., Lozano-Vidal, N., Bink, D. I., Hooglugt, A., Yao, W., Wittig, I., van Rijssel, J., van Buul, J. D., van Bergen, A., Klems, A., Ramms, A. S., Le Noble, F., Hofmann, P., Szulcek, R., Wang, S. P., Offermanns, S., Ercanoglu, M. S., Kwon, H. B., Stainier, D., Huveneers, S. & 3 others, Kurian, L., Dimmeler, S. & Boon, R. A., 1 Dec 2020, In : Communications Biology. 3, 1, 265.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Microchannels are an architectural cue that promotes integration and vascularization of silk biomaterials in vivo

Tang, F., Manz, X. D., Bongers, A., Odell, R. A., Joukhdar, H., Whitelock, J. M., Lord, M. S. & Rnjak-Kovacina, J., 9 Mar 2020, In : ACS Biomaterials Science and Engineering. 6, 3, p. 1476-1486 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

No evidence for increased prevalence of colorectal carcinoma in 399 Dutch patients with Birt-Hogg-Dubé syndrome

van de Beek, I., Glykofridis, I. E., Wolthuis, R. M. F., Gille, H. J. J. P., Johannesma, P. C., Meijers-Heijboer, H. E. J., van Moorselaar, J. R. A. & Houweling, A. C., Feb 2020, In : British Journal of Cancer. 122, 4, p. 590-594 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Noninvasive Prediction of Elevated Wedge Pressure in Pulmonary Hypertension Patients Without Clear Signs of Left-Sided Heart Disease: External Validation of the OPTICS Risk Score

Jansen, S. M. A., Huis In 't Veld, A. E., Jacobs, W., Grotjohan, H. P., Waskowsky, M., van der Maten, J., van der Weerdt, A., Hoekstra, R., Overbeek, M. J., Mollema, S. A., Tolen, P. H. C. G., Hassan El Bouazzaoui, L. H., Vriend, J. W. J., Roorda, J. M. M., de Nooijer, R., van der Lee, I., Voogel, B. A. J., Peels, K., Macken, T., Aerts, J. M. & 4 others, Vonk Noordegraaf, A., Handoko, M. L., de Man, F. S. & Bogaard, H. J., 4 Aug 2020, In : Journal of the American Heart Association. 9, 15, p. e015992

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pulmonary vascular imaging characteristics after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension

Braams, N. J., Ruigrok, D., Schokker, M. G. M., Padervinskiene, L., de Man, F. S., Marcus, J. T., Lely, R. J., Beijk, M. A. M., Klok, F. A., Huisman, M. V., Nossent, E. J., Vonk Noordegraaf, A., Symersky, P., Bogaard, H. J. & Meijboom, L. J., Mar 2020, In : Journal of Heart and Lung Transplantation. 39, 3, p. 248-256 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Quality of initial anticoagulant treatment and risk of CTEPH after acute pulmonary embolism

Boon, G. J. A. M., van Rein, N., Bogaard, H. J., Ende-Verhaar, Y. M., Huisman, M. V., Kroft, L. J. M., van der Meer, F. J. M., Meijboom, L. J., Symersky, P., Noordegraaf, A. V. & Klok, F. A., 1 Apr 2020, In : PLoS ONE. 15, 4, e0232354.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Safety and efficacy of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension in the Netherlands

van Thor, M. C. J., Lely, R. J., Braams, N. J., ten Klooster, L., Beijk, M. A. M., Heijmen, R. H., van den Heuvel, D. A. F., Rensing, B. J. W. M., Snijder, R. J., Vonk Noordegraaf, A., Nossent, E. J., Meijboom, L. J., Symersky, P., Mager, J. J., Bogaard, H. J. & Post, M. C., Feb 2020, In : Netherlands Heart Journal. 28, 2, p. 81-88 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sugen–morphine model of pulmonary arterial hypertension

Agarwal, S., Harter, Z. J., Krishnamachary, B., Chen, L., Nguyen, T., Voelkel, N. F. & Dhillon, N. K., 1 Jan 2020, In : Pulmonary Circulation. 10, 1

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Effects of Mercaptopurine on Pulmonary Vascular Resistance and BMPR2 Expression in Pulmonary Arterial Hypertension

Botros, L., Szulcek, R., Jansen, S. M. A., Kurakula, K., Goumans, M-J. T. H., van Kuilenburg, A. B. P., Vonk Noordegraaf, A., de Man, F. S., Aman, J. & Bogaard, H. J., 15 Jul 2020, In : American Journal of Respiratory and Critical Care Medicine. 202, 2, p. 296-299 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension

Sindi, H. A., Russomanno, G., Satta, S., Abdul-Salam, V. B., Jo, K. B., Qazi-Chaudhry, B., Ainscough, A. J., Szulcek, R., Jan Bogaard, H., Morgan, C. C., Pullamsetti, S. S., Alzaydi, M. M., Rhodes, C. J., Piva, R., Eichstaedt, C. A., Grünig, E., Wilkins, M. R. & Wojciak-Stothard, B., 1 Dec 2020, In : Nature Communications. 11, 1, 1185.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The role of surgery for stage I non-small cell lung cancer in octogenarians in the era of stereotactic body radiotherapy in the Netherlands

de Ruiter, J. C., Heineman, D. J., Daniels, J. M., van Diessen, J. N., Damhuis, R. A. & Hartemink, K. J., Jun 2020, In : Lung Cancer. 144, p. 64-70 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

What goals do patients and oncologists have when starting a medical treatment for metastatic lung cancer?

Mieras, A., Pasman, HRW., Klop, HT., Onwuteaka-Philipsen, BD., Tarasevych, S. & Tiemessen, M., 11 Aug 2020, In : Clinical Lung Cancer.

Research output: Contribution to journalArticleAcademicpeer-review

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Thaventhiran, J. E. D., Lango Allen, H., Burren, O. S., Rae, W., Greene, D., Staples, E., Zhang, Z., Farmery, J. H. R., Simeoni, I., Rivers, E., Maimaris, J., Penkett, C. J., Stephens, J., Deevi, S. V. V., Sanchis-Juan, A., Gleadall, N. S., Thomas, M. J., Sargur, R. B., Gordins, P., Baxendale, H. E. & 616 others, Brown, M., Tuijnenburg, P., Worth, A., Hanson, S., Linger, R. J., Buckland, M. S., Rayner-Matthews, P. J., Gilmour, K. C., Samarghitean, C., Seneviratne, S. L., Sansom, D. M., Lynch, A. G., Megy, K., Ellinghaus, E., Ellinghaus, D., Jorgensen, S. F., Karlsen, T. H., Stirrups, K. E., Cutler, A. J., Kumararatne, D. S., Chandra, A., Edgar, J. D. M., Herwadkar, A., Cooper, N., Grigoriadou, S., Huissoon, A. P., Goddard, S., Jolles, S., Schuetz, C., Boschann, F., Abbs, S., Adhya, Z., Adlard, J., Afzal, M., Ahmed, I., Ahmed, M., Ahmed, S., Aitman, T. J., Alachkar, H., Alamelu, J., Alikhan, R., Allen, C. E., Allen, L., Allsup, D. J., Alvi, A., Ambegaonkar, G., Anantharachagan, A., Ancliff, P., Anderson, J., Antrobus, R., Armstrong, R., Arno, G., Arumugakani, G., Arya, R., Ashford, S., Astle, W. J., Attwood, A., Austin, S., Aydinok, Y., Ayub, W., Babbs, C., Bacchelli, C., Baglin, T., Bakchoul, T., Bariana, T. K., Barratt, J., Barwell, J., Baski, J., Bates, R. W., Batista, J., Baxendale, H. E., Baynam, G., Bennett, D. L., Bethune, C., Bhatnagar, N., Bibi, S., Bierzynska, A., Biss, T., Bitner-Glindzicz, M. A. K., Bleda, M., Blesneac, I., Boardman, B., Boddana, P., Bogaard, H. J., Booth, C., Boyce, S., Bradley, J. R., Brady, A., Breen, G., Brennan, P., Brewer, C., Briley, A., Brown, M., Brown, R., Browning, M. J., Brownlie, M., Bryson, C. J., Buchan, R. J., Buck, J., Buckland, M. S., Bueser, T., Diz, C. B., Burns, S. O., Burren, O. S., Calleja, P., Carmichael, J., Carr-White, G., Carss, K. J., Casey, R., Chalmers, E., Chambers, J., Chambers, J., Chan, M. M. Y., Chan, M. V., Chandra, A., Cheng, F., Chinn, I. K., Chinnery, P. F., Chitre, M., Chong, S., Christian, M. T., Church, C., Clement, E. M., Brod, N. C., Clifford, H., Clowes, V. E., Coghlan, G., Colby, E., Cole, T. R. P., Collins, J. H., Collins, P. W., Condliffe, R., Cook, H. T., Cook, S., Cookson, V., Cooper, N., Corris, P. A., Creaser-Myers, A., Crisp-Hihn, A., Curry, N. S., Cutler, A. J., Da Costa, R., Danesino, C., Daniels, M. J., Darby, D., Daugherty, L. C., Davies, E. G., Davies, S., Davis, J., de Bree, G. J., Deacock, S., Deegan, P. B., Deevi, S. V. V., Dempster, J., Dent, T., Deshpande, C., Devlin, L. A., Dewhurst, E. F., Dixit, A. K., Dixon, P. H., Doffinger, R., Dolling, H., Dormand, N., Downes, K., Drazyk, A. M., Drewe, E., Duarte, D., Dutt, T., Edgar, J. D. M., Edwards, K. E., Egner, W., Ekani, M. N., El-Shanawany, T., Elkhalifa, S., Elston, T., Emmerson, I., Erber, W. N., Erwood, M., Estiu, M. C., Evans, D. G., Evans, G., Everington, T., Eyries, M., Farmery, J. H. R., Favier, R., Firth, H. V., Fitzpatrick, M. M., Fletcher, D., Flinter, F. A., Fox, J. C., Frary, A. J., French, C. E., Freson, K., Frontini, M., Furie, B., Gale, D. P., Gall, H. J., Gardham, A., Gaspar, H. B., Gattens, M., Ghali, N., Ghataorhe, P. K., Ghio, S., Ghofrani, H. A., Ghurye, R., Gibbs, J. S. R., Gilbert, R. D., Gilmour, K. C., Girerd, B., Girling, J. C., Gissen, P., Gleadall, N. S., Goddard, S., Gordins, P., Gorman, K. M., Gosal, D., Graf, S., Grassi, L., Greene, D., Greenhalgh, A. J., Greenhalgh, L., Greinacher, A., Gresele, P., Griffiths, P. G., Griffiths, S., Grigoriadou, S., Grozeva, D., Hackett, S. J., Hadden, R. D. M., Hadinnapola, C., Hague, R., Hague, W. M., Haimel, M., Hall, M., Halmagyi, C., Hammerton, T., Hanson, H. L., Harkness, K., Harper, A. R., Harper, L., Harris, C., Harrison, C., Hart, D., Hassan, A., Hayman, G., Heemskerk, J. W. M., Hegde, S., Henderson, A., Henderson, R. H., Hensiek, A., Henskens, Y. M. C., Herwadkar, A., Hodgson, J., Hoffman, J., Holden, S., Holder, M., Horvath, R., Houlden, H., Houweling, A. C., Howard, L. S., Hu, F., Hudson, G., Hughes, S., Hughes, S., Huis in ‘t Veld, A. E., Huissoon, A. P., Humbert, M., Hurles, M. E., Hurst, J. A., Irvine, V., Izatt, L., James, R., Jeevaratnam, P., Johnson, M., Johnson, S. A., Jolles, S., Jolley, J. D., Jones, B., Jones, J., Josifova, D., Jurkute, N., Karim, Y. M., Karoshi, M. A., Kasanicki, M. A., Kazkaz, H., Kazmi, R., Keeling, D., Kelleher, P., Kelly, A. M., Kempster, C., Kennedy, F., Kiani, S., Kiely, D. G., Kingston, N., Kinsey, S., Klein, N., Klima, R., Knox, E., Kostadima, M. A., Kovacs, G., Koziell, A. B., Kreuzhuber, R., Krishnakumar, D., Kuijpers, T. W., Kumar, A., Kumararatne, D. S., Kurian, M. A., Laffan, J., Laffan, M. A., Lalloo, F., Lambert, M. P., Lango Allen, H., Lawman, S. H. A., Lawrie, A., Layton, D. M., Lear, S. E., Lees, M. M., Lentaigne, C., Levine, A. P., Lewington, A. J. P., Li, W., Liesner, R., Linger, R. J., Liu, B., Longhurst, H., Lorenzo, L. E., Louka, E., Hadeler, S. L., Lyons, P. A., Macdougall, M., Machado, R. D., MacKenzie Ross, R. V., Mackillop, L. H., MacLaren, R., Madan, B., Magee, L., Mahdi-Rogers, M., Maher, E. R., Maimaris, J., Makris, M., Mangles, S., Manson, A., Manzur, A., Mapeta, R., Marchbank, K. J., Mark, P. B., Marks, S., Markus, H. S., Marschall, H. U., Marshall, A., Martin, J. M., Masati, L., Mathias, M., Matser, V., Matthews, E. L., Maw, A., Maxwell, H., McAlinden, P., McCarthy, M. I., McDermott, E. M., McGowan, S. J., McJannet, C., McKinney, H., Meacham, S., Mead, A. J., Castello, I. M., Meehan, S., Megy, K., Mehta, S., Mercer, C. L., Michaelides, M., Michell, A. C., Milford, D., Millar, C. M., Millar, H., Mistry, A., Moenen, F., Moledina, S., Montani, D., Moore, A. T., Moore, J., Morrell, N. W., Morrisson, V., Mozere, M., Muir, K. W., Mumford, A. D., Murng, S. H. K., Nasir, I., Nejentsev, S., Newnham, M., Ng, J., Ngoh, A., Noorani, S., Noori, M., Nurden, P., O’Sullivan, J. M., Obaji, S., Okoli, S., Oksenhendler, E., Olschewski, A., Olschewski, H., Ong, A. C. M., Ong, K. R., Oram, H., Ormondroyd, E., Othman, S., Ouwehand, W. H., Pantazis, A., Papadia, S., Papandreou, A., Park, S. M., Parker, A. P. J., Parry, D., Parsons, G., Pasi, K. J., Paterson, J., Payne, J. H., Peacock, A. J., Peerlinck, K., Penkett, C. J., Pepke-Zaba, J., Perry, D., Petersen, R., Piechowski-Jozwiak, B., Pinto, F., Polwarth, G. J., Ponsford, M. J., Prasad, S., Prokopenko, I., Psaila, B., Pyle, A., Qasim, W., Quinn, E., Quinti, I., Raina, S., Ranganathan, L., Rankin, J., Rankin, S., Rao, A., Raymond, F. L., Rayner-Matthews, P. J., Rehnstrom, K., Reid, E., Reilly, M. M., Renton, T., Revel-Vilk, S., Rhodes, C. J., Rice, A. S. C., Richards, E. E., Richards, M., Richardson, S., Richter, A., Robert, L., Roberts, I., Rondina, M. T., Rosser, E., Rothwell, P., Roughley, C., Roy, N. B., Rue-Albrecht, K., Sadeghi-Alavijeh, O., Saleem, M. A., Salmon, R. M., Samani, N. J., Samarghitean, C., Sambrook, J. G., Sanchis-Juan, A., Sandford, R., Santra, S., Sargur, R. B., Satchell, S. C., Savic, S., Scelsi, L., Schotte, G., Schulman, S., Schulze, H., Scott, R., Scully, M., Searle, C., Seeger, W., Seneviratne, S. L., Sewell, W. A. C., Seyres, D., Shackley, F., Shamardina, O., Shapiro, S. E., Sharma, P., Shehata, H. A., Shipley, D., Shtoyerman, R., Sibson, K., Side, L., Simeoni, I., Simpson, M., Sims, M. C., Sinha, M. D., Sivapalaratnam, S., Skytte, A. B., Smith, K. G. C., Snape, K., Sneddon, L., Sohal, A., Soubrier, F., Southgate, L., Southwood, M., Splitt, M., Staines, S., Staples, E., Stark, H., Stauss, H., Steele, C. L., Stein, D., Stein, P. E., Stephens, J., Stirrups, K. E., Stock, S., Stubbs, M. J., Suntharalingam, J., Swietlik, E. M., Symington, E., Tait, R. C., Talks, K., Tan, R. Y. Y., Taylor, G. B., Thachil, J., Thaventhiran, J. E. D., Themistocleous, A. C., Thomas, D. C., Thomas, E., Thomas, M. J., Thomas, P., Thompson, D. A., Thomson, K., Thrasher, A. J., Thys, C., Tilly, T., Tischkowitz, M., Titterton, C., Todd, J. A., Toh, C. H., Tool, A. T. J., Toshner, M. R., Traylor, M., Treacy, C. M., Treadaway, P., Trembath, R. C., Trippier, S., Tuna, S., Turek, W., Turro, E., Upton, P. D., Urniaz, R., Vale, T., Van Geet, C., van Zuydam, N., Vandersteen, A. M., Vazquez-Lopez, M., Veltman, M. W. M., Vogt, J., von Ziegenweidt, J., Noordegraaf, A. V., Vora, A., Vries, M. J. A., Wakeling, E. L., Walker, N., Walker, S. M., Walsh, R., Wanjiku, I., Ware, J. S., Warner, T. Q., Wassmer, E., Watkins, H., Watson, H. G., Watt, C., Waugh, D., Webb, N., Webster, A. R., Wei, W., Welch, A., Welch, S. B., Werring, D., Wessels, J., Westbury, S. K., Westwood, J. P. W., Wharton, J., Whitehorn, D., Whitworth, J., Wilkins, M. R., Willcocks, L., Williams, D. J., Williamson, C., Wong, E. K. S., Wood, N., Wood, Y., Woods, C. G., Woodward, E. R., Workman, S., Wort, S. J., Worth, A., Yates, K., Yeatman, N., Yong, P. F. K., Young, T., Yu, P., Yu-Wai-Man, P., Zlamalova, E., Lyons, P. A., Hurles, M. E., Savic, S., Burns, S. O., Kuijpers, T. W., Turro, E., Ouwehand, W. H., Thrasher, A. J., Smith, K. G. C. & Primary Immunodeficiency Consortium for the NIHR Bioresource, 1 Jan 2020, (Accepted/In press) In : Nature. 583, 7814, 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Whole-genome sequencing of patients with rare diseases in a national health system

NIHR BioResource for the 100,000 Genomes Project, 2 Jul 2020, In : Nature. 583, 7814, p. 96-102 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019

6-mercaptopurine, an agonist of Nur77, reduces progression of pulmonary hypertension by enhancing BMP signalling

Kurakula, K., Sun, X-Q., Happé, C., da Silva Goncalves Bos, D., Szulcek, R., Schalij, I., Wiesmeijer, K., Lodder, K., Tu, L., Guignabert, C., de Vries, C. J., de Man, F., Noordegraaf, A. V., Ten Dijke, P., Goumans, M-J. & Bogaard, H. J., 2019, In : The European respiratory journal.

Research output: Contribution to journalArticleAcademicpeer-review

Afatinib in NSCLC With HER2 Mutations: Results of the Prospective, Open-Label Phase II NICHE Trial of European Thoracic Oncology Platform (ETOP)

Dziadziuszko, R., Smit, E. F., Dafni, U., Wolf, J., Wasąg, B., Biernat, W., Finn, S. P., Kammler, R., Tsourti, Z., Rabaglio, M., Ruepp, B., Roschitzki-Voser, H., Stahel, R. A., Felip, E. & Peters, S., 1 Jun 2019, In : Journal of Thoracic Oncology. 14, 6, p. 1086-1094 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

ALK immunohistochemistry positive, FISH negative NSCLC is infrequent, but associated with impaired survival following treatment with crizotinib

Thunnissen, E., Lissenberg-Witte, B. I., van den Heuvel, M. M., Monkhorst, K., Skov, B. G., Sørensen, J. B., Mellemgaard, A., Dingemans, A. M. C., Speel, E. J. M., de Langen, A. J., Hashemi, S. M. S., Bahce, I., van der Drift, M. A., Looijen-Salamon, M. G., Gosney, J., Postmus, P. E., Samii, S. M. S., Duplaquet, F., Weynand, B., Durando, X. & 15 others, Penault-Llorca, F., Finn, S., Grady, A. O., Oz, B., Akyurek, N., Buettner, R., Wolf, J., Bubendorf, L., Duin, S., Marondel, I., Heukamp, L. C., Timens, W., Schuuring, E. M. D., Pauwels, P. & Smit, E. F., 2019, In : Lung Cancer. 138, p. 13-18 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assembly 13: placing the pulmonary circulation in the heart of ERS

Vonk Noordegraaf, A., Delcroix, M., Jiminez, D., Sitbon, O. & Bogaard, H. J., 2019, In : Breathe. 15, 1, p. 88-89 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension

Gomez-Puerto, M. C., van Zuijen, I., Huang, C. J. Z., Szulcek, R., Pan, X., van Dinther, M. A. H., Kurakula, K., Wiesmeijer, C. C., Goumans, M-J., Bogaard, H-J., Morrell, N. W., Rana, A. A. & ten Dijke, P., 1 Nov 2019, In : Journal of Pathology. 249, 3, p. 356-367 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia

Gorman, K. M., Meyer, E., Grozeva, D., Spinelli, E., McTague, A., Sanchis-Juan, A., Carss, K. J., Bryant, E., Reich, A., Schneider, A. L., Pressler, R. M., Simpson, M. A., Debelle, G. D., Wassmer, E., Morton, J., Sieciechowicz, D., Jan-Kamsteeg, E., Paciorkowski, A. R., King, M. D., Cross, J. H. & 14 others, Poduri, A., Mefford, H. C., Scheffer, I. E., Haack, T. B., McCullagh, G., Deciphering Developmental Disorders Study, NIHR BioResource, UK10K Consortium, Millichap, J. J., Carvill, G. L., Clayton-Smith, J., Maher, E. R., Raymond, F. L. & Kurian, M. A., 2 May 2019, In : American journal of human genetics. 104, 5, p. 948-956 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Brigatinib in Crizotinib-Refractory ALK+ NSCLC: 2-Year Follow-up on Systemic and Intracranial Outcomes in the Phase 2 ALTA Trial

Huber, R. M., Hansen, K. H., Paz-Ares Rodríguez, L., West, H. L., Reckamp, K. L., Leighl, N. B., Tiseo, M., Smit, E. F., Kim, D-W., Gettinger, S. N., Hochmair, M. J., Kim, S-W., Langer, C. J., Ahn, M-J., Kim, E. S., Kerstein, D., Groen, H. J. M. & Camidge, D. R., Nov 2019, In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Case report: Pulmonary hemorrhage as a rare cause of lung ultrasound A/B-profile

Haaksma, M. E., Nossent, E. J., Elbers, P. & Tuinman, P. R., 1 Jan 2019, In : F1000Research. 8, 788.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

Hodgson, J., Swietlik, E. M., Salmon, R. M., Hadinnapola, C., Nikolic, I., Wharton, J., Guo, J., Liley, J., Haimel, M., Bleda, M., Southgate, L., Machado, R. D., Martin, J. M., Treacy, C. M., Yates, K., Daugherty, L. C., Shamardina, O., Whitehorn, D., Holden, S., Bogaard, H. J. & 41 others, Church, C., Coghlan, G., Condliffe, R., Corris, P. A., Danesino, C., Eyries, M., Gall, H., Ghio, S., Ghofrani, H-A., Gibbs, J. S. R., Girerd, B., Houweling, A. C., Howard, L., Humbert, M., Kiely, D. G., Kovacs, G., Lawrie, A., MacKenzie Ross, R. V., Moledina, S., Montani, D., Olschewski, A., Olschewski, H., Ouwehand, W. H., Peacock, A. J., Pepke-Zaba, J., Prokopenko, I., Rhodes, C. J., Scelsi, L., Seeger, W., Soubrier, F., Suntharalingam, J., Toshner, M. R., Trembath, R. C., Vonk Noordegraaf, A., Wort, S. J., Wilkins, M. R., Yu, P. B., Li, W., Gräf, S., Upton, P. D. & Morrell, N. W., 29 Oct 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Chemotherapy and Tyrosine Kinase Inhibitors in the last month of life in patients with metastatic lung cancer: A patient file study in the Netherlands

Mieras, A., Becker-Commissaris, A., Pasman, H. R. W., Dingemans, A. M. M. C., Kok, E. V., Cornelissen, R., Jacobs, W., van den Berg, J. W., Welling, A., Bogaarts, B. A. H. A., Pronk, L. & Onwuteaka-Philipsen, B. D., 2019, In : European Journal of Cancer Care. e13210.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical outcomes stratified by baseline functional class after initial combination therapy for pulmonary arterial hypertension

White, R. J., Vonk-Noordegraaf, A., Rosenkranz, S., Oudiz, R. J., McLaughlin, V. V., Hoeper, M. M., Grünig, E., Ghofrani, H-A., Chakinala, M. M., Barberà, J. A., Blair, C., Langley, J. & Frost, A. E., 12 Sep 2019, In : Respiration Research. 20, 1, 208.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clonality analysis of pulmonary tumors by genome-wide copy number profiling

Vincenten, J. P. L., van Essen, H. F., Lissenberg-Witte, B. I., Bulkmans, N. W. J., Krijgsman, O., Sie, D., Eijk, P. P., Smit, E. F., Ylstra, B. & Thunnissen, E., 2019, In : PLoS ONE. 14, 10, e0223827.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions

Prins, H. J., Duijkers, R., van der Valk, P., Schoorl, M., Daniels, J. M. A., van der Werf, T. S. & Boersma, W. G., 2019, In : The European respiratory journal. 53, 5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Definition of synchronous oligo-metastatic non-small cell lung cancer - a consensus report

Dingemans, A-M. C., Hendriks, L. E. L., Berghmans, T., Levy, A., Hasan, B., Faivre-Finn, C., Giaj-Levra, M., Giaj-Levra, N., Girard, N., Greillier, L., Lantuéjoul, S., Edwards, J., O'Brien, M., Reck, M., Smit, E. F., Van Schil, P., Postmus, P. E., Ramella, S., Lievens, Y., Gaga, M. & 18 others, Peled, N., Scagliotti, G. V., Senan, S., Paz-Ares, L., Guckenberger, M., McDonald, F., Ekman, S., Cufer, T., Gietema, H., Infante, M., Dziadziuszko, R., Peters, S., Porta, R. R., Vansteenkiste, J., Dooms, C., de Ruysscher, D., Besse, B. & Novello, S., 1 Dec 2019, In : Journal of Thoracic Oncology. 14, 12, p. 2109-2119 11 p.

Research output: Contribution to journalArticleAcademicpeer-review