Alex Poot

DR.

20122020

Research output per year

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Research Output

2020

Design, Synthesis, Radiosynthesis and Biological Evaluation of Fenretinide Analogues as Anticancer and Metabolic Syndrome-Preventive Agents

Patruno, I., Thompson, D., Dall'Angelo, S., Windhorst, A. D., Vugts, D. J., Poot, A. J., Mody, N. & Zanda, M., 4 Jun 2020, In : ChemMedChem. 15, 16, 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Head-to-head comparison of DFO* and DFO chelators: selection of the best candidate for clinical 89Zr-immuno-PET

Chomet, M., Schreurs, M., Bolijn, M. J., Verlaan, M., Beaino, W., Brown, K., Poot, A. J., Windhorst, A. D., Gill, H., Marik, J., Williams, S., Cowell, J., Gasser, G., Mindt, T. L., van Dongen, G. A. M. S. & Vugts, D. J., 5 Sep 2020, In : European Journal of Nuclear Medicine and Molecular Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

Fully Automated 89 Zr Labeling and Purification of Antibodies

Poot, A. J., Adamzek, K. W. A., Windhorst, A. D., Vosjan, M. J. W. D., Kropf, S., Wester, H-J., van Dongen, G. A. M. S. & Vugts, D. J., 2019, In : Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60, 5, p. 691-695

Research output: Contribution to journalArticleAcademicpeer-review

In vivo imaging of TGFβ signalling components using positron emission tomography

Rotteveel, L., Poot, A. J., Bogaard, H. J., ten Dijke, P., Lammertsma, A. A. & Windhorst, A. D., Dec 2019, In : Drug Discovery Today. 24, 12, p. 2258-2272

Research output: Contribution to journalReview articleAcademicpeer-review

The in vivo and in vitro validation of two activin-receptor like kinase 5 targeting PET tracers

Rotteveel, L., Poot, A., Dijke, P., Bogaard, H. J., Lammertsma, A. & Windhorst, A., May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, p. S64-S65

Research output: Contribution to journalMeeting AbstractAcademic

2018

From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application

Pekošak, A., Filp, U., Poot, A. J. & Windhorst, A. D., 1 Aug 2018, In : Molecular Imaging and Biology. 20, 4, p. 510-532 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Synthesis and Preclinical Evaluation of the First Carbon-11 Labeled PET Tracers Targeting Substance P1-7

Pekošak, A., Bulc, J. Ž., Korat, Š., Schuit, R. C., Kooijman, E., Vos, R., Rongen, M., Verlaan, M., Takkenkamp, K., Beaino, W., Poot, A. J. & Windhorst, A. D., 2018, In : Molecular Pharmaceutics. 15, 11, p. 4872-4883

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M. & 3 others, de Gruijl, T. D., Smit, E. F. & de Langen, A. J., 1 Dec 2018, In : Nature Communications. 9, 1, 4664.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Whole body PD-L1 PET in patients with NSCLC and melanoma.

Leung, D. K., De langen, J., Raunig, D., Niemeijer, A-L. N., Smit, E. F., Boellaard, R., Vallez-Garcia, D., van Dongen, G. A. M. S., Windhorst, A. D., Huisman, M. C., Glaudemans, A. W. J. M., Hendrikse, N. H., Smith, R. A., Poot, A. J., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M., Du, S. & Hayes, W., 2018, In : Journal of Clinical Oncology. 36, 5_suppl, p. 139-139 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

2017

A rapid and highly enantioselective C-11C bond formation of l-[11C]phenylalanine via chiral phase-transfer catalysis

Pekošak, A., Filp, U., Škrinjar, J., Poot, A. J. & Windhorst, A. D., 2017, In : Organic and Biomolecular Chemistry. 15, 3, p. 570-575 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET

Vugts, D. J., Klaver, C., Sewing, C., Poot, A. J., Adamzek, K., Huegli, S., Mari, C., Visser, G. W. M., Valverde, I. E., Gasser, G., Mindt, T. L. & van Dongen, G. A. M. S., 1 Feb 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, 2, p. 286-295 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development of [11C]vemurafenib employing a carbon-11 carbonylative Stille coupling and preliminary evaluation in mice bearing melanoma tumor xenografts

Slobbe, P., Windhorst, A. D., Adamzek, K., Bolijn, M., Schuit, R. C., Heideman, D. A. M., van Dongen, G. A. M. S. & Poot, A. J., 13 Jun 2017, In : Oncotarget. 8, 24, p. 38337-38350 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Efficient Synthesis of 11C-Acrylesters, 11C-Acrylamides and Their Application in Michael Addition Reactions for PET Tracer Development

Filp, U., Pees, A. L., Taddei, C., Pekošak, A., Gee, A. D., Windhorst, A. D. & Poot, A. J., 15 Sep 2017, In : European Journal of Organic Chemistry. 2017, 34, p. 5154-5162 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fluorine-18 labelled building blocks for PET tracer synthesis

Van Der Born, D., Pees, A., Poot, A. J., Orru, R. V. A., Windhorst, A. D. & Vugts, D. J., 7 Aug 2017, In : Chemical Society Reviews. 46, 15, p. 4709-4773 65 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Radiosynthesis of 1-iodo-2-[11C]methylpropane and 2-methyl-1-[11C]propanol and its application for alkylation reactions and C―C bond formation

Rotteveel, L., Poot, A. J., Funke, U., Pekošak, A., Filp, U., Lammertsma, A. A. & Windhorst, A. D., 1 Oct 2017, In : Journal of Labelled Compounds and Radiopharmaceuticals. 60, 12, p. 566-576 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stereocontrolled [11C]Alkylation of N-Terminal Glycine Schiff Bases To Obtain Dipeptides

Filp, U., Pekošak, A., Poot, A. J. & Windhorst, A. D., 10 Oct 2017, In : European Journal of Organic Chemistry. 2017, 37, p. 5592-5596 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stereoselective 11C Labeling of a “Native” Tetrapeptide by Using Asymmetric Phase-Transfer Catalyzed Alkylation Reactions

Pekošak, A., Rotstein, B. H., Collier, T. L., Windhorst, A. D., Vasdev, N. & Poot, A. J., 3 Feb 2017, In : European Journal of Organic Chemistry. 2017, 5, p. 1019-1024 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Whole body PD-1 and PD-L1 PET in pts with NSCLC

Niemeijer, A-L., Smit, E., Bahce, I., Hoekstra, O., Huisman, M., van Dongen, G. A., Windhorst, B., Hendrikse, N., Poot, A. J., Vugts, D., Leung, D. K., Hayes, W., Smith, R. A., Wilson, L. M., Thunnissen, E. & de langen, J., Sep 2017, In : Annals of Oncology. 28

Research output: Contribution to journalMeeting AbstractAcademic

Whole Body PD-1 and PD-L1 PET in Pts with NSCLC

Niemeijer, A., Smit, E., Van Dongen, G., Windhorst, A. D., Huisman, M., Hendrikse, N., Bahce, I., Lueng, D., Smith, R., Hayes, W., Wilson, L., Bonacorsi, S., Donnelly, D., Morin, P., Poot, A., Vugts, D., Thunnissen, E. & De Langen, J., Nov 2017, In : Journal of Thoracic Oncology. 12, 11, p. S1817-S1817

Research output: Contribution to journalMeeting AbstractAcademic

Whole body PD-1 and PD-L1 PET with Zr-89-nivolumab and F-18-BMS-986192 in pts with NSCLC.

Niemeijer, A-L. N., Smit, E. F., van Dongen, G. A. M. S., Windhorst, A. D., Huisman, M. C., Hendrikse, N. H., Leung, D. K., Smith, R. A., Hayes, W., Thunnissen, E., Poot, A. J. & Vugts, D. J., 20 May 2017, In : Journal of Clinical Oncology. 35

Research output: Contribution to journalMeeting AbstractAcademic

2016

Enantioselective synthesis of carbon-11 labeled L-alanine using phase transfer catalysis of Schiff bases

Filp, U., Pekosak, A., Poot, A. J. & Windhorst, A. D., 13 Oct 2016, In : TETRAHEDRON. 72, 41, p. 6551-6557

Research output: Contribution to journalArticleAcademicpeer-review

2015

A comparative PET imaging study with the reversible and irreversible EGFR tyrosine kinase inhibitors [C-11]erlotinib and [F-18]afatinib in lung cancer-bearing mice

Slobbe, P., Windhorst, A. D., Stigter-van Walsum, M., Smit, E. F., Niessen, H. G., Solca, F., Stehle, G., van Dongen, G. A. M. S. & Poot, A. J., 2015, In : EJNMMI Research. 5, 14.

Research output: Contribution to journalArticleAcademicpeer-review

Improved synthesis and application of [C-11]benzyl iodide in positron emission tomography radiotracer production

Pekosak, A., Filp, U. R., Rotteveel, L., Poot, A. J. & Windhorst, A. D., 2015, In : Journal of Labelled Compounds and Radiopharmaceuticals. 58, 8, p. 342-348

Research output: Contribution to journalArticleAcademicpeer-review

2014

Development of [F-18]afatinib as new TKI-PET tracer for EGFR positive tumors

Slobbe, P., Windhorst, A. D., Stigter-van Walsum, M., Schuit, R. C., Smit, E. F., Niessen, H. G., Solca, F., Stehle, G., van Dongen, G. A. M. S. & Poot, A. J., 2014, In : Nuclear Medicine and Biology. 41, 9, p. 749-757

Research output: Contribution to journalArticleAcademicpeer-review

2013

[C-11]Sorafenib: Radiosynthesis and preclinical evaluation in tumor-bearing mice of a new TKI-PET tracer

Poot, A. J., van der Wildt, B., Stigter-van Walsum, M., Rongen, M., Schuit, R. C., Hendrikse, N. H., Eriksson, P. A. J., van Dongen, G. A. M. S. & Windhorst, A. D., 2013, In : Nuclear Medicine and Biology. 40, 4, p. 488-497

Research output: Contribution to journalArticleAcademicpeer-review

Imaging of TKI-Target Interactions for Personalized Cancer Therapy

Poot, A. J., Slobbe, P., Hendrikse, N. H., Windhorst, A. D. & van Dongen, G. A. M. S., 2013, In : Clinical Pharmacology & Therapeutics. 93, 3, p. 239-241

Research output: Contribution to journalArticleAcademicpeer-review

2012

PET imaging with radiolabeled antibodies and tyrosine kinase inhibitors: immuno-PET and TKI-PET

van Dongen, G. A. M. S., Poot, A. J. & Vugts, D. J., 2012, In : Tumor Biology. 33, 3, p. 607-615

Research output: Contribution to journalArticleAcademicpeer-review

PET imaging with small-molecule tyrosine kinase inhibitors: TKI-PET

Slobbe, P., Poot, A. J., Windhorst, A. D. & van Dongen, G. A. M. S., 2012, In : Drug Discovery Today. 17, 21-22, p. 1175-1187

Research output: Contribution to journalArticleAcademicpeer-review