Anne-Marie van Dam

DR., (Principal Investigator)

20002019
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Research Output 2000 2019

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2019

Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies

Fathy, Y. Y., Jonker, A. J., Oudejans, E., de Jong, F. J. J., van Dam, A. M. W., Rozemuller, A. J. M. & van de Berg, W. D. J., 1 Apr 2019, In : Neuropathology and Applied Neurobiology. 45, 3, p. 262-277 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Enhanced GABAergic immunoreactivity in hippocampal neurons and astroglia of multiple sclerosis patients

Kiljan, S., Prins, M., Baselmans, B. M., Bol, J. G. J. M., Schenk, G. J. & van Dam, A-M., 1 Jan 2019, In : Journal of Neuropathology and Experimental Neurology. 78, 6, p. 480-491

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Tissue transglutaminase promotes early differentiation of oligodendrocyte progenitor cells

Espitia Pinzon, N., van Mierlo, H., de Jonge, J. C., Brevé, J. J. P., Bol, J. G. J. M., Drukarch, B., van Dam, A-M. & Baron, W., 14 May 2019, In : Frontiers in Cellular Neuroscience. 13, 281.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018
Open Access

Correction: Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis

Chrobok, N. L., Bol, J. G. J. M., Jongenelen, C. A., Brevé, J. J. P., El Alaoui, S., Fidalgo-Lopez, J., Fournet, G., Joseph, B., Wilhelmus, M. M. M., Drukarch, B. & van Dam, A-M., 2018, In : PLoS ONE. 13, 12, p. e0209522

Research output: Contribution to journalArticleAcademicpeer-review

Galectin-4, a Negative Regulator of Oligodendrocyte Differentiation, Is Persistently Present in Axons and Microglia/Macrophages in Multiple Sclerosis Lesions

de Jong, C. G. H. M., Stancic, M., Pinxterhuis, T. H., van Horssen, J., van Dam, A-M., Gabius, H-J. & Baron, W., 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 11, p. 1024-1038 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis

Hoeijmakers, L., Meerhoff, G. F., de Vries, J. W., Ruigrok, S. R., van Dam, A-M., van Leuven, F., Korosi, A. & Lucassen, P. J., Jan 2018, In : Neurobiology of Aging. 61, p. 112-123 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Transglutaminase 6 antibodies are not yet mainstream in neuro-coeliac disease

Mulder, C. J. J., Rouvroye, M. D. & van Dam, A-M., Jan 2018, In : Digestive and Liver Disease. 50, 1, p. 96-97 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Astrocyte-derived tissue Transglutaminase affects fibronectin deposition, but not aggregation, during cuprizone-induced demyelination

Espitia Pinzon, N., Sanz-Morello, B., Brevé, J. J. P., Bol, J. G. J. M., Drukarch, B., Bauer, J., Baron, W. & Van Dam, A. M., 27 Jan 2017, In : Scientific Reports. 7, 40995.

Research output: Contribution to journalArticleAcademicpeer-review

Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy

Grace, P. M., Loram, L. C., Christianson, J. P., Strand, K. A., Flyer-Adams, J. G., Penzkover, K. R., Forsayeth, J. R., van Dam, A. M., Mahoney, M. J., Maier, S. F., Chavez, R. A. & Watkins, L. R., 1 Jan 2017, In : Brain, Behavior, and Immunity. 59, p. 49-54 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model

Hoeijmakers, L., Ruigrok, S. R., Amelianchik, A., Ivan, D., van Dam, A. M., Lucassen, P. J. & Korosi, A., 1 Jul 2017, In : Brain, Behavior, and Immunity. 63, p. 160-175 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monocyte behaviour and tissue transglutaminase expression during experimental autoimmune encephalomyelitis in transgenic CX3CR1gfp/gfp mice

Chrobok, N. L., Jaouen, A., Fenrich, K. K., Bol, J. G. J. M., Wilhelmus, M. M. M., Drukarch, B., Debarbieux, F. & van Dam, A. M., 1 Mar 2017, In : Amino Acids. 49, 3, p. 643-658 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monocyte-derived tissue transglutaminase in multiple sclerosis patients: reflecting an anti-inflammatory status and function of the cells?

Sestito, C., Brevé, J. J. P., van Eggermond, M. C. J. A., Killestein, J., Teunissen, C. E., van Rossum, J., Wilhelmus, M. M. M., Drukarch, B., van den Elsen, P. J. & van Dam, A-M., 21 Dec 2017, In : Journal of Neuroinflammation. 14, 1, p. 257

Research output: Contribution to journalArticleAcademicpeer-review

2016

Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior

Hu, P., Wang, Y., Liu, J., Meng, F-T., Qi, X-R., Chen, L., van Dam, A-M., Joëls, M., Lucassen, P. J. & Zhou, J-N., Jul 2016, In : Hippocampus. 26, 7, p. 911-23 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats

Loram, L. C., Strand, K. A., Taylor, F. R., Sloane, E., Van Dam, A-M., Rieger, J., Maier, S. F. & Watkins, L. R., May 2015, In : Brain Behavior and Immunity. 46, p. 50-54 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Brain region-specific gene expression profiles in freshly isolated rat microglia

Doorn, K. J., Brevé, J. J. P., Drukarch, B., Boddeke, H. W., Huitinga, I., Lucassen, P. J. & van Dam, A-M., 2015, In : Frontiers in Cellular Neuroscience. 9, p. 84

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration

van Strien, M. E., de Vries, H. E., Chrobok, N. L., Bol, J. G. J. M., Breve, J. J. P., van der Pol, S. M. P., Kooij, G., van Buul, J. D., Karpuj, M., Steinman, L., Wilhelmus, M. M., Sestito, C., Drukarch, B. & Van Dam, A-M., Nov 2015, In : Brain Behavior and Immunity. 50, p. 141-154 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients

Prins, M., Dutta, R., Baselmans, B., Brevé, J. J. P., Bol, J. G. J. M., Deckard, S. A., van der Valk, P., Amor, S., Trapp, B. D., de Vries, H. E., Drukarch, B. & van Dam, A-M., 23 Aug 2014, In : Acta Neuropathologica Communinications. 2, p. 98

Research output: Contribution to journalArticleAcademicpeer-review

Hippocampal proliferation is increased in presymptomatic Parkinson's disease and due to microglia

Doorn, K. J., Drukarch, B., van Dam, A-M. & Lucassen, P. J., 2014, In : Neural Plasticity. 2014, p. 959154

Research output: Contribution to journalArticleAcademicpeer-review

Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients

Doorn, K. J., Goudriaan, A., Blits-Huizinga, C., Bol, J. G. J. M., Rozemuller, A. J., Hoogland, P. V. J. M., Lucassen, P. J., Drukarch, B., van de Berg, W. D. J. & van Dam, A-M., Mar 2014, In : Brain Pathology. 24, 2, p. 152-65 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models

Schuh, C., Wimmer, I., Hametner, S., Haider, L., Van Dam, A-M., Liblau, R. S., Smith, K. J., Probert, L., Binder, C. J., Bauer, J., Bradl, M., Mahad, D. & Lassmann, H., Aug 2014, In : Acta Neuropathologica. 128, 2, p. 247-266 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

The novel target

van Dam, A. M. W., 2014, In : International Innovation. 162, p. 13-15

Research output: Contribution to journalArticlePopular

Tissue transglutaminase in marmoset experimental multiple sclerosis: discrepancy between white and grey matter

Espitia Pinzon, N., Stroo, E., 't Hart, B. A., Bol, J. G. J. M., Drukarch, B., Bauer, J. & van Dam, A-M., 2014, In : PLoS ONE. 9, 6, p. e100574

Research output: Contribution to journalArticleAcademicpeer-review

2013

Interleukin-1β and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis

Prins, M., Eriksson, C., Wierinckx, A., Bol, J. G. J. M., Binnekade, R., Tilders, F. J. H. & Van Dam, A-M., 2013, In : PLoS ONE. 8, 12, p. e83835 e83835.

Research output: Contribution to journalArticleAcademicpeer-review

2012
19 Downloads (Pure)

A Single-Day Treatment with Mifepristone Is Sufficient to Normalize Chronic Glucocorticoid Induced Suppression of Hippocampal Cell Proliferation

Hu, P., Oomen, C., van Dam, A-M., Wester, J., Zhou, J-N., Joëls, M. & Lucassen, P. J., 2012, In : PLoS ONE. 7, 9

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease

Doorn, K. J., Lucassen, P. J., Boddeke, H. W., Prins, M., Berendse, H. W., Drukarch, B. & van Dam, A-M., 2012, In : Progress in Neurobiology. 98, 2, p. 222-238 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Appearance of tissue transglutaminase in astrocytes in multiple sclerosis lesions: a role in cell adhesion and migration?

van Strien, M. E., Drukarch, B., Bol, J. G., van der Valk, P., van Horssen, J., Gerritsen, W. H., Breve, J. J. & van Dam, A-M., 2011, In : Brain Pathology. 21, 1, p. 44-54 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Downloads (Pure)

Astrocyte-derived tissue transglutaminase interacts with fibronectin: a role in astrocyte adhesion and migration?

van Strien, M. E., Brevé, J. J. P., Fratantoni, S., Schreurs, M. W. J., Bol, J. G. J. M., Jongenelen, C. A. M., Drukarch, B. & van Dam, A-M., 2011, In : PLoS ONE. 6, 9

Research output: Contribution to journalArticleAcademicpeer-review

File

Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease

Verhaar, R., Jongenelen, C. A. M., Gerard, M., Baekelandt, V., Van Dam, A-M., Wilhelmus, M. M. M. & Drukarch, B., Jun 2011, In : Neurochemistry International. 58, 7, p. 785-793 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

49 Downloads (Pure)

Cholinergic imbalance in the multiple sclerosis hippocampus

Kooi, E-J., Prins, M., Bajic, N., Beliën, J. A. M., Gerritsen, W. H., van Horssen, J., Aronica, E., van Dam, A-M., Hoozemans, J. J. M., Francis, P. T., van der Valk, P. & Geurts, J. J. G., Sep 2011, In : Acta Neuropathologica. 122, 3, p. 313-322 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Linker, R. A., Lee, D-H., Ryan, S., van Dam, A. M., Conrad, R., Bista, P., Zeng, W., Hronowsky, X., Buko, A., Chollate, S., Ellrichmann, G., Brück, W., Dawson, K., Goelz, S., Wiese, S., Scannevin, R. H., Lukashev, M. & Gold, R., Mar 2011, In : Brain. 134, Pt 3, p. 678-692 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Novel role of transglutaminase 1 in corpora amylacea formation?

Wilhelmus, M. M. M., Verhaar, R., Bol, J. G. J. M., van Dam, A-M., Hoozemans, J. J. M., Rozemuller, A. J. M. & Drukarch, B., 2011, In : Neurobiology of Aging. 32, 5, p. 845-856 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes during CNS remyelination

Van Strien, M. E., Baron, W., Bakker, E. N. T. P., Bauer, J., Bol, J. G. J. M., Brevé, J. J. P., Binnekade, R., Van Der Laarse, W. J., Drukarch, B. & Van Dam, A-M., Nov 2011, In : GLIA. 59, 11, p. 1622-1634 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010

Anti-inflammatory effect by lentiviral-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages

van Strien, M. E., Mercier, D., Drukarch, B., Brevé, J. J. P., Poole, S., Binnekade, R., Bol, J. G. J. M., Blits, B., Verhaagen, J. & van Dam, A-M., May 2010, In : Gene Therapy. 17, 5, p. 662-671 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2009

Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy

Sloane, E., Ledeboer, A., Seibert, W., Coats, B., van Strien, M., Maier, S. F., Johnson, K. W., Chavez, R., Watkins, L. R., Leinwand, L., Milligan, E. D. & Van Dam, A. M., Jan 2009, In : Brain Behavior and Immunity. 23, 1, p. 92-100 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2008

Validated sandwich ELISA for the quantification of tissue transglutaminase in tissue homogenates and cell lysates of multiple species

Brevé, J. J. P., Drukarch, B., van Strien, M. & van Dam, A-M., 20 Mar 2008, In : Journal of Immunological Methods. 332, 1-2, p. 142-50 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2007

Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin

Verwer, R. W. H., Sluiter, A. A., Balesar, R. A., Baayen, J. C., Noske, D. P., Dirven, C. M. F., Wouda, J., van Dam, A. M., Lucassen, P. J. & Swaab, D. F., Dec 2007, In : Brain. 130, Pt 12, p. 3321-35 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

2006

Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging

Phinney, A. L., Andringa, G., Bol, J. G. J. M., Wolters, E. C., van Muiswinkel, F. L., van Dam, A-M. W. & Drukarch, B., May 2006, In : Parkinsonism and Related Disorders. 12, 4, p. 228-38 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2005

Alteration of the extracellular matrix interferes with raft association of neurofascin in oligodendrocytes. Potential significance for multiple sclerosis?

Maier, O., van der Heide, T., van Dam, A-M., Baron, W., de Vries, H. & Hoekstra, D., Feb 2005, In : Molecular and Cellular Neuroscience. 28, 2, p. 390-401 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Detoxication enzyme inducers modify cytokine production in rat mixed glial cells

Wierinckx, A., Brevé, J., Mercier, D., Schultzberg, M., Drukarch, B. & Van Dam, A-M., Sep 2005, In : Journal of Neuroimmunology. 166, 1-2, p. 132-143 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis

Vroon, A., Kavelaars, A., Limmroth, V., Lombardi, M. S., Goebel, M. U., Van Dam, A-M., Caron, M. G., Schedlowski, M. & Heijnen, C. J., 1 Apr 2005, In : Journal of Immunology. 174, 7, p. 4400-6 7 p.

Research output: Contribution to journalArticleAcademicpeer-review