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Research Output 1988 2019

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Article

AMYPAD Diagnostic and Patient Management Study: Rationale and design

Frisoni, G. B., Barkhof, F., Altomare, D., Berkhof, J., Boccardi, M., Canzoneri, E., Collij, L., Drzezga, A., Farrar, G., Garibotto, V., Gismondi, R., Gispert, J-D., Jessen, F., Kivipelto, M., Lopes Alves, I., Molinuevo, J-L., Nordberg, A., Payoux, P., Ritchie, C., Savicheva, I. & 8 othersScheltens, P., Schmidt, M. E., Schott, J., Stephens, A., van Berckel, B., Vellas, B., Walker, Z. & Raffa, N., Mar 2019, In : Alzheimers & Dementia. 15, 3, p. 388-399

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N′-(3-[ 3 H] 3 methoxy phenyl)-N′-methylguanidine ([ 3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist

Metaxas, A., van Berckel, B. N. M., Klein, P. J., Verbeek, J., Nash, E. C., Kooijman, E. J. M., Renjaän, V. R. A., Golla, S. S. V., Boellaard, R., Christiaans, J. A. M., Windhorst, A. D. & Leysen, J. E., 19 Feb 2019, In : Pharmacology Research and Perspectives. 7, 1, e00458.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease

Brugnolo, A., de Carli, F., Pagani, M., Morbelli, S., Jonsson, C., Chincarini, A., Frisoni, G. B., Galluzzi, S., Perneczky, R., Drzezga, A., van Berckel, B. N. M., Ossenkoppele, R., Didic, M., Guedj, E., Arnaldi, D., Massa, F., Grazzini, M., Pardini, M., Mecocci, P., Dottorini, M. E. & 3 othersBauckneht, M., Sambuceti, G. & Nobili, F., 12 Mar 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 383-394

Research output: Contribution to journalArticleAcademicpeer-review

High amyloid burden is associated with fewer specific words during spontaneous speech in individuals with subjective cognitive decline

Verfaillie, S. C. J., Witteman, J., Slot, R. E. R., Pruis, I. J., Vermaat, L. E. W., Prins, N. D., Schiller, N. O., van de Wiel, M., Scheltens, P., van Berckel, B. N. M., van der Flier, W. M. & Sikkes, S. A. M., 2019, In : Neuropsychologia. 131, p. 184-192

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prognostic value of Alzheimer's biomarkers in mild cognitive impairment: the effect of age at onset

Alzheimer’s Disease Neuroimaging Initiative, 2 Jul 2019, In : Journal of Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Semi-quantitative cerebral blood flow parameters derived from non-invasive [15O]H2O PET studies

Koopman, T., Yaqub, M., Heijtel, D. F., Nederveen, A. J., van Berckel, B. N., Lammertsma, A. A. & Boellaard, R., 1 Jan 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 1, p. 163-172

Research output: Contribution to journalArticleAcademicpeer-review

2018

An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease

Scheltens, P., Prins, N., Lammertsma, A., Yaqub, M., Gouw, A., Wink, A. M., Chu, H. M., van Berckel, B. N. M. & Alam, J., 1 Apr 2018, In : Annals of Clinical and Translational Neurology. 5, 4, p. 464-473 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort: The ABIDE Project

de Wilde, A., van der Flier, W. M., Pelkmans, W., Bouwman, F., Verwer, J., Groot, C., van Buchem, M. M., Zwan, M., Ossenkoppele, R., Yaqub, M., Kunneman, M., Smets, E. M. A., Barkhof, F., Lammertsma, A. A., Stephens, A., van Lier, E., Biessels, G. J., van Berckel, B. N. & Scheltens, P., 1 Sep 2018, In : JAMA Neurology. p. 1062-1070 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease

Groot, C., Sudre, C. H., Barkhof, F., Teunissen, C. E., van Berckel, B. N. M., Seo, S. W., Ourselin, S., Scheltens, P., Cardoso, M. J., van der Flier, W. M. & Ossenkoppele, R., 13 Nov 2018, In : Neurology. 91, 20, p. e1851-e1859

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of the Novel PET Tracer [11C]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates

van der Aart, J., Yaqub, M., Kooijman, E. J. M., Bakker, J., Langermans, J. A. M., Schuit, R. C., Hofman, M. B. M., Christiaans, J. A. M., Lammertsma, A. A., Windhorst, A. D. & van Berckel, B. N. M., 10 Oct 2018, In : Molecular Imaging and Biology.

Research output: Contribution to journalArticleAcademicpeer-review

First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

van der Aart, J., Golla, S. S. V., van der Pluijm, M., Schwarte, L. A., Schuit, R. C., Klein, P. J., Metaxas, A., Windhorst, A. D., Boellaard, R., Lammertsma, A. A. & van Berckel, B. N. M., 1 Jan 2018, In : EJNMMI Research. 8, 69.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease

Scheltens, N. M. E., van der Weijden, K., Adriaanse, S. M., van Assema, D., Oomen, P. P., Krudop, W. A., Lammertsma, A. A., Barkhof, F., Koene, T., Teunissen, C. E., Scheltens, P., van der Flier, W. M., Pijnenburg, Y. A. L., Yaqub, M., Ossenkoppele, R. & van Berckel, B. N. M., 1 Jan 2018, In : NeuroImage: Clinical. 19, p. 625-632 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Parametric methods for [18F]flortaucipir PET

Golla, S. S. V., Wolters, E. E., Timmers, T., Ossenkoppele, R., van der Weijden, C. W. J., Scheltens, P., Schwarte, L., Mintun, M. A., Devous Sr, M. D., Schuit, R. C., Windhorst, A. D., Lammertsma, A. A., Yaqub, M., van Berckel, B. N. M. & Boellaard, R., 2018, In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia

Bergeron, D., Gorno-Tempini, M. L., Rabinovici, G. D., Santos-Santos, M. A., Seeley, W., Miller, B. L., Pijnenburg, Y., Keulen, M. A., Groot, C., van Berckel, B. N. M., van der Flier, W. M., Scheltens, P., Rohrer, J. D., Warren, J. D., Schott, J. M., Fox, N. C., Sanchez-Valle, R., Grau-Rivera, O., Gelpi, E., Seelaar, H. & 66 othersPapma, J. M., van Swieten, J. C., Hodges, J. R., Leyton, C. E., Piguet, O., Rogalski, E. J., Mesulam, M. M., Koric, L., Nora, K., Pariente, J., Dickerson, B., Mackenzie, I. R., Hsiung, G-Y. R., Belliard, S., Irwin, D. J., Wolk, D. A., Grossman, M., Jones, M., Harris, J., Mann, D., Snowden, J. S., Chrem-Mendez, P., Calandri, I. L., Amengual, A. A., Miguet-Alfonsi, C., Magnin, E., Magnani, G., Santangelo, R., Deramecourt, V., Pasquier, F., Mattsson, N., Nilsson, C., Hansson, O., Keith, J., Masellis, M., Black, S. E., Matías-Guiu, J. A., Cabrera-Martin, M-N., Paquet, C., Dumurgier, J., Teichmann, M., Sarazin, M., Bottlaender, M., Dubois, B., Rowe, C. C., Villemagne, V. L., Vandenberghe, R., Granadillo, E., Teng, E., Mendez, M., Meyer, P. T., Frings, L., Lleó, A., Blesa, R., Fortea, J., Seo, S. W., Diehl-Schmid, J., Grimmer, T., Frederiksen, K. S., Sánchez-Juan, P., Chételat, G., Jansen, W., Bouchard, R. M. W., Laforce, R. J., Visser, P. J. & Ossenkoppele, R., 2018, In : Annals of Neurology. 84, 5, p. 729-740

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Mattsson, N., Groot, C., Jansen, W. J., Landau, S. M., Villemagne, V. L., Engelborghs, S., Mintun, M. M., Lleo, A., Molinuevo, J. L., Jagust, W. J., Frisoni, G. B., Ivanoiu, A., Chételat, G., Resende de Oliveira, C., Rodrigue, K. M., Kornhuber, J., Wallin, A., Klimkowicz-Mrowiec, A., Kandimalla, R., Popp, J. & 75 othersAalten, P. P., Aarsland, D., Alcolea, D., Almdahl, I. S., Baldeiras, I., van Buchem, M. A., Cavedo, E., Chen, K., Cohen, A. D., Förster, S., Fortea, J., Frederiksen, K. S., Freund-Levi, Y., Gill, K. D., Gkatzima, O., Grimmer, T., Hampel, H., Herukka, S. K., Johannsen, P., van Laere, K., de Leon, M. J., Maier, W., Marcusson, J., Meulenbroek, O., Møllergård, H. M., Morris, J. C., Mroczko, B., Nordlund, A., Prabhakar, S., Peters, O., Rami, L., Rodríguez-Rodríguez, E., Roe, C. M., Rüther, E., Santana, I., Schröder, J., Seo, S. W., Soininen, H., Spiru, L., Stomrud, E., Struyfs, H., Teunissen, C. E., Verhey, F. R. J., Vos, S. J. B., van Waalwijk van Doorn, L. J. C., Waldemar, G., Wallin, Å. K., Wiltfang, J., Vandenberghe, R., Brooks, D. J., Fladby, T., Rowe, C. C., Drzezga, A., Verbeek, M. M., Sarazin, M., Wolk, D. A., Fleisher, A. S., Klunk, W. E., Na, D. L., Sánchez-Juan, P., Lee, D. Y., Nordberg, A., Tsolaki, M., Camus, V., Rinne, J. O., Fagan, A. M., Zetterberg, H., Blennow, K., Rabinovici, G. D., Hansson, O., van Berckel, B. N. M., van der Flier, W. M., Scheltens, P., Visser, P. J. & Ossenkoppele, R., 1 Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 913-924 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Resilience to cognitive impairment in the oldest-old: Design of the EMIF-AD 90+ study

Legdeur, N., Badissi, M., Carter, S. F., de Crom, S., van de Kreeke, A., Vreeswijk, R., Trappenburg, M. C., Oudega, M. L., Koek, H. L., van Campen, J. P., Keijsers, C. J. P. W., Amadi, C., Hinz, R., Gordon, M. F., Novak, G., Podhorna, J., Serné, E., Verbraak, F., Yaqub, M., Hillebrand, A. & 12 othersGriffa, A., Pendleton, N., Kramer, S. E., Teunissen, C. E., Lammertsma, A., Barkhof, F., van Berckel, B. N. M., Scheltens, P., Muller, M., Maier, A. B., Herholz, K. & Visser, P. J., 26 Nov 2018, In : BMC Geriatrics. 18, 1, 289.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Secondary prevention of Alzheimer's dementia: neuroimaging contributions

ten Kate, M., Ingala, S., Schwarz, A. J., Fox, N. C., Chételat, G., van Berckel, B. N. M., Ewers, M., Foley, C., Gispert, J. D., Hill, D., Irizarry, M. C., Lammertsma, A. A., Molinuevo, J. L., Ritchie, C., Scheltens, P., Schmidt, M. E., Visser, P. J., Waldman, A., Wardlaw, J., Haller, S. & 1 othersBarkhof, F., 30 Oct 2018, In : Alzheimer's Research & Therapy. 10, 1, p. 112

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Alzheimer's biomarkers in daily practice (ABIDE) project: Rationale and design

de Wilde, A., van Maurik, I. S., Kunneman, M., Bouwman, F., Zwan, M., Willemse, E. A. J., Biessels, G. J., Minkman, M., Pel, R., Schoonenboom, N. S. M., Smets, E. M. A., Wattjes, M. P., Barkhof, F., Stephens, A., van Lier, E. J., Batrla-Utermann, R., Scheltens, P., Teunissen, C. E., van Berckel, B. N. M. & van der Flier, W. M., 2017, In : Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 6, p. 143-151 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET

Fällmar, D., Haller, S., Lilja, J., Danfors, T., Kilander, L., Tolboom, N., Egger, K., Kellner, E., Croon, P. M., Verfaillie, S. C. J., van Berckel, B. N. M., Ossenkoppele, R., Barkhof, F. & Larsson, E. M., 1 Oct 2017, In : European Radiology. 27, 10, p. 4237-4246 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Diagnostic impact of [18F]flutemetamol PET in early-onset dementia

Zwan, M. D., Bouwman, F. H., Konijnenberg, E., Van Der Flier, W. M., Lammertsma, A. A., Verhey, F. R. J., Aalten, P., Van Berckel, B. N. M. & Scheltens, P., 17 Jan 2017, In : Alzheimer's Research and Therapy. 9, 1, 2.

Research output: Contribution to journalArticleAcademicpeer-review

Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM

Van Der Aart, J., Van Der Doef, T. F., Horstman, P., Huisman, M. C., Schuit, R. C., Van Lingen, A., Windhorst, A. D., Van Berckel, B. N. M. & Lammertsma, A. A., 1 Aug 2017, In : Journal of Nuclear Medicine. 58, 8, p. 1330-1333 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Model selection criteria for dynamic brain PET studies

Golla, S. S. V., Adriaanse, S. M., Yaqub, M., Windhorst, A. D., Lammertsma, A. A., van Berckel, B. N. M. & Boellaard, R., 6 Dec 2017, In : EJNMMI PHYSICS. 4, 1, 30.

Research output: Contribution to journalArticleAcademicpeer-review

Partial volume correction of brain PET studies using iterative deconvolution in combination with HYPR denoising

Golla, S. S. V., Lubberink, M., van Berckel, B. N. M., Lammertsma, A. A. & Boellaard, R., Dec 2017, In : EJNMMI Research. 7, 1, 36.

Research output: Contribution to journalArticleAcademicpeer-review

Quantification of Tau Load Using [18F]AV1451 PET

Golla, S. S. V., Timmers, T., Ossenkoppele, R., Groot, C., Verfaillie, S., Scheltens, P., van der Flier, W. M., Schwarte, L., Mintun, M. A., Devous, M., Schuit, R. C., Windhorst, A. D., Lammertsma, A. A., Boellaard, R., van Berckel, B. N. M. & Yaqub, M., 1 Dec 2017, In : Molecular Imaging and Biology. 19, 6, p. 963-971 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synthesis, radiolabeling and preclinical evaluation of a [11C]GMOM derivative as PET radiotracer for the ion channel of the N-methyl-D-aspartate receptor

Klein, P. J., Schuit, R. C., Metaxas, A., Christiaans, J. AM., Kooijman, E., Lammertsma, A. A., van Berckel, B. NM. & Windhorst, A. D., 1 Aug 2017, In : Nuclear Medicine and Biology. 51, p. 25-32 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Bos, I., Vos, S. J., Frölich, L., Kornhuber, J., Wiltfang, J., Maier, W., Peters, O., Rüther, E., Engelborghs, S., Niemantsverdriet, E., De Roeck, E. E., Tsolaki, M., Freund-Levi, Y., Johannsen, P., Vandenberghe, R., Lleó, A., Alcolea, D., Frisoni, G. B., Galluzzi, S., Nobili, F. & 18 othersMorbelli, S., Drzezga, A., Didic, M., van Berckel, B. N., Salmon, E., Bastin, C., Dauby, S., Santana, I., Baldeiras, I., de Mendonça, A., Silva, D., Nordlund, A., Coloma, P. M., Wientzek, A., Alexander, M., Novak, G. P., Gordon, M. F. & Alzheimer's Disease Neuroimaging Initiative, 1 Aug 2017, In : Neurobiology of Aging. 56, p. 33-40 8 p.

Research output: Contribution to journalArticleAcademicpeer-review