1992 …2020

Research output per year

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Personal profile

Research interests

Ylstra received a bachelors in Physics in 1988 from the University of Amsterdam (UvA, NL) and commenced with a masters in Genetics at the Vrije Universiteit (VU, NL). In 1995 he received his PhD degree from the same university for work performed at the Universities of Vienna (A) and Nijmegen (NL), Plant Research International (NL) and The John Innes Institute (UK). He was awarded a 2-year NATO fellowship for his post-doctoral work at the University of California in Berkeley (USA) on genome-wide RNA screens . From 1998 he worked at the Comprehensive Cancer Center of the University of California, San Francisco (USA) and was involved in the development of DNA arrays for copy number analysis. In 2001 he accepted his current position at the VU University Medical Center, Cancer Center Amsterdam heading the Tumor Genome Analysis Core. The core has a strong genome laboratory and bioinformatics (pre-)processing track record, with an emphasis on DNA analysis from archival material, see more under http://www.tgac.nl.

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Research Output

Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma

Strijker, M., Soer, E. C., de Pastena, M., Creemers, A., Balduzzi, A., Beagan, J. J., Busch, O. R., van Delden, O. M., Halfwerk, H., van Hooft, J. E., van Lienden, K. P., Marchegiani, G., Meijer, S. L., van Noesel, C. J., Reinten, R. J., Roos, E., Schokker, S., Verheij, J., van de Vijver, M. J., Waasdorp, C. & 6 others, Wilmink, J. W., Ylstra, B., Besselink, M. G., Bijlsma, M. F., Dijk, F. & van Laarhoven, H. W., 1 Mar 2020, In : International Journal of Cancer. 146, 5, p. 1445-1456 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer

Barat, A., Smeets, D., Moran, B., Zhang, W., Cao, S., Das, S., Klinger, R., Betge, J., Murphy, V., Bacon, O., Kay, E. W., Van Grieken, N. C. T., Verheul, H. M. W., Gaiser, T., Schulte, N., Ebert, M. P., Fender, B., Hennessy, B. T., McNamara, D. A., O’Connor, D. & 10 others, Gallagher, W. M., Cremolini, C., Loupakis, F., Parikh, A., Mancao, C., Ylstra, B., Lambrechts, D., Lenz, H. J., Byrne, A. T. & Prehn, J. H. M., 1 Dec 2020, In : Scientific Reports. 10, 1, 9778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

IBD-Associated Dysplastic Lesions Show More Chromosomal Instability Than Sporadic Adenomas

Wanders, L. K., Cordes, M., Voorham, Q., Sie, D., de Vries, S. D., d’Haens, G. R. A. M., de Boer, N. K. H., Ylstra, B., van Grieken, N. C. T., Meijer, G. A., Dekker, E. & Carvalho, B., Feb 2020, In : Inflammatory Bowel Diseases. 26, 2, p. 167-180 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

ACE: Absolute Copy number Estimation from low-coverage whole-genome sequencing data

Poell, J. B., Mendeville, M., Sie, D., Brink, A., Brakenhoff, R. H. & Ylstra, B., 15 Aug 2019, In : Bioinformatics. 35, 16, p. 2847-2849

Research output: Contribution to journalArticleAcademicpeer-review

Aggressive genomic features in clinically indolent primary HHV8-negative effusion-based lymphoma

Mendeville, M., Roemer, M. G. M., van den Hout, M. F. C. M., Los-de Vries, G. T., Bladergroen, R., Stathi, P., Hijmering, N. J., Rosenwald, A., Ylstra, B. & de Jong, D., 24 Jan 2019, In : Blood. 133, 4, p. 377-380 4 p.

Research output: Contribution to journalLetterAcademicpeer-review

Open Access