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Research Output 1993 2019

Open Access

Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N′-(3-[ 3 H] 3 methoxy phenyl)-N′-methylguanidine ([ 3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist

Metaxas, A., van Berckel, B. N. M., Klein, P. J., Verbeek, J., Nash, E. C., Kooijman, E. J. M., Renjaän, V. R. A., Golla, S. S. V., Boellaard, R., Christiaans, J. A. M., Windhorst, A. D. & Leysen, J. E., 19 Feb 2019, In : Pharmacology Research and Perspectives. 7, 1, e00458.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

FEASIBILITY OF A FIRST PEDIATRIC METABOLITE IN SAFETY TESTING PILOT STUDY USING AN ORAL C-14-MIDAZOLAM MICROTRACER.

van Groen, B. D., van Duijn, E., de Vries, A., Mooij, M. G., Windhorst, A. D., Hendrikse, N. H., Tibboel, D., Vaes, W. H. J. & de Wildt, S. N., Mar 2019, In : Clinical Pharmacology & Therapeutics. 105, p. S38-S38

Research output: Contribution to journalMeeting AbstractAcademic

Fully Automated 89 Zr Labeling and Purification of Antibodies

Poot, A. J., Adamzek, K. W. A., Windhorst, A. D., Vosjan, M. J. W. D., Kropf, S., Wester, H-J., van Dongen, G. A. M. S. & Vugts, D. J., 2019, In : Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60, 5, p. 691-695

Research output: Contribution to journalArticleAcademicpeer-review

Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2019, In : Clinical and Translational Imaging. 7, 1, p. 61-63

Research output: Contribution to journalComment/Letter to the editorAcademic

P52 Low and erratic exposure of oral acetaminophen in critically ill children determined with a 14 C microtracer study: a case for IV acetaminophen for acute pain management?

Kleiber, N., Calvier, E., Mooij, MG., Krekels, EHJ., Vaes, WH., Windhorst, AD., Hendrikse, H., Tibboel, D., Knibbe, CAJ. & de Wildt, SN., Jun 2019, In : Archives of Disease in Childhood. 104, 6, p. e38.2-e39

Research output: Contribution to journalArticleAcademicpeer-review

Status of the ‘consensus nomenclature rules in radiopharmaceutical sciences’ initiative

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2019, In : Nuclear Medicine and Biology. 71, p. 19-22

Research output: Contribution to journalEditorialAcademicpeer-review

Synthesis, radiolabelling and preclinical evaluation of novel NMDA ligands as potential tracers for positron emission tomography

Klein, PJ., 2 Apr 2019, 199 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

The in vivo and in vitro validation of two activin-receptor like kinase 5 targeting PET tracers

Rotteveel, L., Poot, A., Dijke, P., Bogaard, H. J., Lammertsma, A. & Windhorst, A., May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, p. S64-S65

Research output: Contribution to journalMeeting AbstractAcademic

2018

A dual-labeled cRGD-based PET/optical tracer for pre-operative staging and intraoperative treatment of colorectal cancer

Sibinga Mulder, B. G., Handgraaf, H. J., Vugts, D. J., Sewing, C., Windhorst, A. D., Stammes, M., de Geus-Oei, L-F., Bordo, M. W., Mieog, J. S. D., van de Velde, C. J., Frangioni, J. V. & Vahrmeijer, A. L., 20 Oct 2018, In : American journal of nuclear medicine and molecular imaging. 8, 5, p. 282-291 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26Al Microtracer Approach

de Ligt, R., van Duijn, E., Grossouw, D., Bosgra, S., Burggraaf, J., Windhorst, A., Peeters, P. A. M., van der Luijt, G. A., Alexander-White, C. & Vaes, W. H. J., 2018, In : Cts-clinical and translational science. 11, 6, p. 573-581

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Asymmetric radiochemical alkylation reactions to acquire carbon-11 labeled amino acids and small peptides

Filp, U. R., 2018, 168 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Carbon-11 Labeled Amino Acids and Peptides: Chemistry and Applications

Pekosak, A., 2018, 246 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Evaluation of the Novel PET Tracer [11C]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates

van der Aart, J., Yaqub, M., Kooijman, E. J. M., Bakker, J., Langermans, J. A. M., Schuit, R. C., Hofman, M. B. M., Christiaans, J. A. M., Lammertsma, A. A., Windhorst, A. D. & van Berckel, B. N. M., 10 Oct 2018, In : Molecular Imaging and Biology.

Research output: Contribution to journalArticleAcademicpeer-review

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

Pees, A., Sewing, C., Vosjan, M. J. W. D., Tadino, V., Herscheid, J. D. M., Windhorst, A. D. & Vugts, D. J., 6 Sep 2018, In : Chemical Communications. 54, 72, p. 10179-10182 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

van der Aart, J., Golla, S. S. V., van der Pluijm, M., Schwarte, L. A., Schuit, R. C., Klein, P. J., Metaxas, A., Windhorst, A. D., Boellaard, R., Lammertsma, A. A. & van Berckel, B. N. M., 1 Jan 2018, In : EJNMMI Research. 8, 69.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fluorine-18 Labelled Building Blocks for PET Tracer Synthesis: Overview and Recent Advances in 18F-Trifluoromethylation

van der Born, D., 1 Nov 2018, 246 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application

Pekošak, A., Filp, U., Poot, A. J. & Windhorst, A. D., 1 Aug 2018, In : Molecular Imaging and Biology. 20, 4, p. 510-532 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state

Villa, A., Klein, B., Janssen, B., Pedragosa, J., Pepe, G., Zinnhardt, B., Vugts, D. J., Gelosa, P., Sironi, L., Beaino, W., Damont, A., Dollé, F., Jego, B., Winkeler, A., Ory, D., Solin, O., Vercouillie, J., Funke, U., Laner-Plamberger, S., Blomster, L. V. & 7 othersChristophersen, P., Vegeto, E., Aigner, L., Jacobs, A., Planas, A. M., Maggi, A. & Windhorst, A. D., 2018, In : Theranostics. 8, 19, p. 5400-5418 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of the allosteric P2X receptor antagonist [C]SMW139 as a PET tracer of microglial activation

Janssen, B., Vugts, D. J., Wilkinson, S. M., Ory, D., Chalon, S., Hoozemans, J. J. M., Schuit, R. C., Beaino, W., Kooijman, E. J. M., van den Hoek, J., Chishty, M., Doméné, A., Van der Perren, A., Villa, A., Maggi, A., Molenaar, G. T., Funke, U., Shevchenko, R. V., Baekelandt, V., Bormans, G. & 3 othersLammertsma, A. A., Kassiou, M. & Windhorst, A. D., 26 Apr 2018, In : Scientific Reports. 8, 1, p. 6580

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate

Chandrupatla, D. M. S. H., Jansen, G., Mantel, E., Low, P. S., Matsuyama, T., Musters, R. P., Windhorst, A. D., Lammertsma, A. A., Molthoff, C. F. M. & van der Laken, C. J., 2018, In : Contrast media & molecular imaging. 2018, 8092781.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Improving metabolic stability of fluorine-18 labeled verapamil analogs

Raaphorst, R. M., Luurtsema, G., Schokker, C. J., Attia, K. A., Schuit, R. C., Elsinga, P. H., Lammertsma, A. A. & Windhorst, A. D., 30 Jul 2018, In : Nuclear Medicine and Biology. 64-65, p. 47-56 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., Feb 2018, In : Nuklearmedizin. 57, 1, p. 40-41 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., MacH, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : Radiochimica acta. 106, 7, p. 623-625

Research output: Contribution to journalComment/Letter to the editorAcademic

In vivo evaluation of two tissue transglutaminase PET tracers in an orthotopic tumour xenograft model

van der Wildt, B., Wilhelmus, M. M. M., Beaino, W., Kooijman, E. J. M., Schuit, R. C., Bol, J. G. J. M., Breve, J. J. P., Pasternack, R., Lammertsma, A. A., Windhorst, A. D. & Drukarch, B., 2018, In : EJNMMI Research. 8, 1, 39.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Letter to the editor: International consensus radiochemistry nomenclature guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : Current Radiopharmaceuticals. 11, 1, p. 73-75

Research output: Contribution to journalComment/Letter to the editorAcademic

Open letter to journal editors on: international consensus radiochemistry nomenclature guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : American journal of nuclear medicine and molecular imaging. 8, 1, p. 70-72 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open letter to journal editors on: International consensus radiochemistry nomenclature guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., Apr 2018, In : Journal of Labelled Compounds and Radiopharmaceuticals. 61, 4, p. 402-404 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : Nuclear Medicine Communications. 39, 3, p. 193-195 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open letter to journal editors on: international consensus radiochemistry nomenclature guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : Journal of Radioanalytical and Nuclear Chemistry. 315, 3, p. 443-445

Research output: Contribution to journalComment/Letter to the editorAcademic

Open letter to journal editors on: International consensus radiochemistry nomenclature guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : Journal of Labelled Compounds and Radiopharmaceuticals. 61, 4, p. 402-404

Research output: Contribution to journalComment/Letter to the editorAcademic

Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : Annals of nuclear medicine. 32, 3, p. 236-238

Research output: Contribution to journalComment/Letter to the editorAcademic

Parametric methods for [18F]flortaucipir PET

Golla, S. S. V., Wolters, E. E., Timmers, T., Ossenkoppele, R., van der Weijden, C. W. J., Scheltens, P., Schwarte, L., Mintun, M. A., Devous Sr, M. D., Schuit, R. C., Windhorst, A. D., Lammertsma, A. A., Yaqub, M., van Berckel, B. N. M. & Boellaard, R., 2018, In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticleAcademicpeer-review

PET imaging of microglial activation - Beyond targeting TSPO

Janssen, B., Vugts, D. J., Windhorst, A. D. & Mach, R. H., 2018, In : Molecules. 23, 3, 607.

Research output: Contribution to journalReview articleAcademicpeer-review

Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate

Chandrupatla, D. M. S. H., Molthoff, C. F. M., Ritsema, W. I. G. R., Vos, R., Elshof, E., Matsuyama, T., Low, P. S., Musters, R. J. P., Hammond, A., Windhorst, A. D., Lammertsma, A. A., van der Laken, C. J., Brands, R. & Jansen, G., 2018, In : Translational research : the journal of laboratory and clinical medicine. 199, p. 24-38 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Reproducibility and Repeatability of Semiquantitative 18F-Fluorodihydrotestosterone Uptake Metrics in Castration-Resistant Prostate Cancer Metastases: A Prospective Multicenter Study

Vargas, H. A., Kramer, G. M., Scott, A. M., Weickhardt, A., Meier, A. A., Parada, N., Beattie, B. J., Humm, J. L., Staton, K. D., Zanzonico, P. B., Lyashchenko, S. K., Lewis, J. S., Yaqub, M., Sosa, R. E., van den Eertwegh, A. J., Davis, I. D., Ackermann, U., Pathmaraj, K., Schuit, R. C., Windhorst, A. D. & 7 othersChua, S., Weber, W. A., Larson, S. M., Scher, H. I., Lammertsma, A. A., Hoekstra, O. S. & Morris, M. J., 2018, In : Journal of Nuclear Medicine. 59, 10, p. 1516-1523 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synthesis and Preclinical Evaluation of the First Carbon-11 Labeled PET Tracers Targeting Substance P1-7

Pekošak, A., Bulc, J. Ž., Korat, Š., Schuit, R. C., Kooijman, E., Vos, R., Rongen, M., Verlaan, M., Takkenkamp, K., Beaino, W., Poot, A. J. & Windhorst, A. D., 2018, In : Molecular Pharmaceutics. 15, 11, p. 4872-4883

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

Verbeek, J., Eriksson, J., Syvänen, S., Huisman, M., Schuit, R. C., Molthoff, C. F. M., Voskuyl, R. A., de Lange, E. C., Lammertsma, A. A. & Windhorst, A. D., Dec 2018, In : EJNMMI radiopharmacy and chemistry. 3, p. 11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M. & 3 othersde Gruijl, T. D., Smit, E. F. & de Langen, A. J., 1 Dec 2018, In : Nature Communications. 9, 1, 4664.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Whole body PD-L1 PET in patients with NSCLC and melanoma.

Leung, D. K., De langen, J., Raunig, D., Niemeijer, A-L. N., Smit, E. F., Boellaard, R., Vallez-Garcia, D., van Dongen, G. A. M. S., Windhorst, A. D., Huisman, M. C., Glaudemans, A. W. J. M., Hendrikse, N. H., Smith, R. A., Poot, A. J., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M., Du, S. & Hayes, W., 2018, In : Journal of Clinical Oncology. 36, 5_suppl, p. 139-139 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

2017

[18F]FLUORO-PEG-FOLATE PET: A NOVEL IMAGING TECHNIQUE TO VISUALIZE RHEUMATOID ARTHRITIS

Verweij, N., Bruijnen, S., Gent, Y., Huisman, M., Jansen, G., Molthoff, C., Chen, Q., Low, P., Windhorst, A., Lammertsma, A., Hoekstra, O., Voskuyl, A. & van der Laken, C., Jun 2017, p. 1020-1021.

Research output: Contribution to conferencePosterAcademic

A rapid and highly enantioselective C-11C bond formation of l-[11C]phenylalanine via chiral phase-transfer catalysis

Pekošak, A., Filp, U., Škrinjar, J., Poot, A. J. & Windhorst, A. D., 2017, In : Organic and Biomolecular Chemistry. 15, 3, p. 570-575 6 p.

Research output: Contribution to journalArticleAcademicpeer-review