Bert Windhorst

PROF.DR., (Principal Investigator)

1993 …2019
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Research Output 1993 2019

A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies

Perani, D., Iaccarino, L., Lammertsma, A. A., Windhorst, A. D., Edison, P., Boellaard, R., Hansson, O., Nordberg, A., Jacobs, A. H., IMBI Project, Bottlaender, M., Brooks, D., Carroll, M. A., Chalon, S., Gee, A., Gerhard, A., Halldin, C., Herholz, K., Herth, M. M., Hinz, R. & 13 othersKnudsen, G. M., Kuhnast, B., López-Picón, F., Moresco, R. M., Pappata, S., Rinne, J. O., Rodriguez-Vieitez, E., Santiago-Ribeiro, M. J., Turkheimer, F. E., van Laere, K., Varrone, A., Vercouillie, J. & Winkeler, A., 1 Aug 2019, In : Alzheimer's and Dementia. 15, 8, p. 1081-1103

Research output: Contribution to journalArticleAcademicpeer-review

Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies

Perani, D., Iaccarino, L., Jacobs, A. H. & IMBI Brain Imaging Working Group, 1 Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 327-332

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessment of simplified methods for quantification of 18F-FDHT uptake in patients with metastatic castration-resistant prostate cancer

Kramer, G. M., Yaqub, M., Vargas, H. A., Schuit, R. C., Windhorst, A. D., van den Eertwegh, A. J. M., van der Veldt, A. A. M., Bergman, A. M., Burnazi, E. M., Lewis, J. S., Chua, S., Staton, K. D., Beattie, B. J., Humm, J. L., Davis, I. D., Weickhardt, A. J., Scott, A. M., Morris, M. J., Hoekstra, O. S. & Lammertsma, A. A., 1 Sep 2019, In : Journal of Nuclear Medicine. 60, 9, p. 1221-1227

Research output: Contribution to journalArticleAcademicpeer-review

Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N′-(3-[ 3 H] 3 methoxy phenyl)-N′-methylguanidine ([ 3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist

Metaxas, A., van Berckel, B. N. M., Klein, P. J., Verbeek, J., Nash, E. C., Kooijman, E. J. M., Renjaän, V. R. A., Golla, S. S. V., Boellaard, R., Christiaans, J. A. M., Windhorst, A. D. & Leysen, J. E., 1 Feb 2019, In : Pharmacology Research and Perspectives. 7, 1, e00458.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Correction: Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source (Chemical Communications (2018) 54 (10179-10182) DOI: 10.1039/c8cc03206h)

Pees, A., Sewing, C., Vosjan, M. J. W. D., Tadino, V., Herscheid, J. D. M., Windhorst, A. D. & Vugts, D. J., 1 Jan 2019, In : Chemical Communications. 55, 38, p. 5523

Research output: Contribution to journalErratumAcademicpeer-review

Open Access

Evaluation of the Novel PET Tracer [C-11]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates

van der Aart, J., Yaqub, M., Kooijman, E. J. M., Bakker, J., Langermans, J. A. M., Schuit, R. C., Hofman, M. B. M., Christiaans, J. A. M., Lammertsma, A. A., Windhorst, A. D. & van Berckel, B. N. M., 15 Aug 2019, In : Molecular Imaging and Biology. 21, 4, p. 676-685

Research output: Contribution to journalArticleAcademicpeer-review

FEASIBILITY OF A FIRST PEDIATRIC METABOLITE IN SAFETY TESTING PILOT STUDY USING AN ORAL C-14-MIDAZOLAM MICROTRACER.

van Groen, B. D., van Duijn, E., de Vries, A., Mooij, M. G., Windhorst, A. D., Hendrikse, N. H., Tibboel, D., Vaes, W. H. J. & de Wildt, S. N., Mar 2019, In : Clinical Pharmacology & Therapeutics. 105, p. S38-S38

Research output: Contribution to journalMeeting AbstractAcademic

Fully Automated 89 Zr Labeling and Purification of Antibodies

Poot, A. J., Adamzek, K. W. A., Windhorst, A. D., Vosjan, M. J. W. D., Kropf, S., Wester, H-J., van Dongen, G. A. M. S. & Vugts, D. J., 2019, In : Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60, 5, p. 691-695

Research output: Contribution to journalArticleAcademicpeer-review

Imaging P-glycoprotein: The gatekeeper of the blood-brain barrier: Development of novel fluorine-18 labeled positron emission tomography tracers to investigate P-glycoprotein at the blood-brain barrier

Raaphorst, R. M., 2019, 162 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

Imaging P-glycoprotein: The gatekeeper of the blood-brain barrier

Raaphorst, RM., 13 Nov 2019

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

In vivo imaging of TGFβ signalling components using positron emission tomography

Rotteveel, L., Poot, A. J., Bogaard, H. J., ten Dijke, P., Lammertsma, A. A. & Windhorst, A. D., Dec 2019, In : Drug Discovery Today. 24, 12, p. 2258-2272

Research output: Contribution to journalReview articleAcademicpeer-review

Kinetics and 28 day test-retest repeatability and reproducibility of [C-11]UCB-J brain PET imaging

Tuncel, H., Boellaard, R., De Vries, E. F. J., Feltes, P. K., Verfaillie, S. C. J., Coomans, E. M., Wolters, E. E., Sweeney, S. P., Ryan, J. M., Ivarsson, M., Lynch, B. A., Schober, P., Scheltens, P., Schuit, R. C., Windhorst, A. D., De Deyn, P. P., van Berckel, B. N. M. & Golla, S. S. V., Oct 2019, In : European Journal of Nuclear Medicine and Molecular Imaging. 46, SUPPL 1, p. S32-S32

Research output: Contribution to journalMeeting AbstractAcademic

Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 6 Feb 2019, In : Clinical and Translational Imaging. 7, 1, p. 61-63 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Point-of-care lung ultrasonography for pneumonia in children: Does size really matter?

Kleiber, N., Calvier, E., Mooij, MG., Krekels, EHJ., Vaes, WH., Windhorst, AD., Hendrikse, H., Tibboel, D., Knibbe, CAJ. & de Wildt, SN., 1 Jan 2019, In : Archives of Disease in Childhood. 104, 1, p. 2-3 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Status of the ‘consensus nomenclature rules in radiopharmaceutical sciences’ initiative

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 1 Apr 2019, In : Nuclear Medicine and Biology. 71, p. 19-22 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Synthesis, radiolabelling and preclinical evaluation of novel NMDA ligands as potential tracers for positron emission tomography

Klein, PJ., 2019, 199 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

The in vivo and in vitro validation of two activin-receptor like kinase 5 targeting PET tracers

Rotteveel, L., Poot, A., Dijke, P., Bogaard, H. J., Lammertsma, A. & Windhorst, A., May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, p. S64-S65

Research output: Contribution to journalMeeting AbstractAcademic

2018

A dual-labeled cRGD-based PET/optical tracer for pre-operative staging and intraoperative treatment of colorectal cancer

Sibinga Mulder, B. G., Handgraaf, H. J., Vugts, D. J., Sewing, C., Windhorst, A. D., Stammes, M., de Geus-Oei, L-F., Bordo, M. W., Mieog, J. S. D., van de Velde, C. J., Frangioni, J. V. & Vahrmeijer, A. L., 20 Oct 2018, In : American journal of nuclear medicine and molecular imaging. 8, 5, p. 282-291 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26Al Microtracer Approach

de Ligt, R., van Duijn, E., Grossouw, D., Bosgra, S., Burggraaf, J., Windhorst, A., Peeters, P. A. M., van der Luijt, G. A., Alexander-White, C. & Vaes, W. H. J., 2018, In : Cts-clinical and translational science. 11, 6, p. 573-581

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Asymmetric radiochemical alkylation reactions to acquire carbon-11 labeled amino acids and small peptides

Filp, U. R., 2018, 168 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Carbon-11 Labeled Amino Acids and Peptides: Chemistry and Applications

Pekosak, A., 2018, 246 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

Pees, A., Sewing, C., Vosjan, M. J. W. D., Tadino, V., Herscheid, J. D. M., Windhorst, A. D. & Vugts, D. J., 6 Sep 2018, In : Chemical Communications. 54, 72, p. 10179-10182 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

van der Aart, J., Golla, S. S. V., van der Pluijm, M., Schwarte, L. A., Schuit, R. C., Klein, P. J., Metaxas, A., Windhorst, A. D., Boellaard, R., Lammertsma, A. A. & van Berckel, B. N. M., 1 Jan 2018, In : EJNMMI Research. 8, 69.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fluorine-18 Labelled Building Blocks for PET Tracer Synthesis: Overview and Recent Advances in 18F-Trifluoromethylation

van der Born, D., 1 Nov 2018, 246 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application

Pekošak, A., Filp, U., Poot, A. J. & Windhorst, A. D., 1 Aug 2018, In : Molecular Imaging and Biology. 20, 4, p. 510-532 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state

Villa, A., Klein, B., Janssen, B., Pedragosa, J., Pepe, G., Zinnhardt, B., Vugts, D. J., Gelosa, P., Sironi, L., Beaino, W., Damont, A., Dollé, F., Jego, B., Winkeler, A., Ory, D., Solin, O., Vercouillie, J., Funke, U., Laner-Plamberger, S., Blomster, L. V. & 7 othersChristophersen, P., Vegeto, E., Aigner, L., Jacobs, A., Planas, A. M., Maggi, A. & Windhorst, A. D., 2018, In : Theranostics. 8, 19, p. 5400-5418 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of the allosteric P2X receptor antagonist [C]SMW139 as a PET tracer of microglial activation

Janssen, B., Vugts, D. J., Wilkinson, S. M., Ory, D., Chalon, S., Hoozemans, J. J. M., Schuit, R. C., Beaino, W., Kooijman, E. J. M., van den Hoek, J., Chishty, M., Doméné, A., Van der Perren, A., Villa, A., Maggi, A., Molenaar, G. T., Funke, U., Shevchenko, R. V., Baekelandt, V., Bormans, G. & 3 othersLammertsma, A. A., Kassiou, M. & Windhorst, A. D., 26 Apr 2018, In : Scientific Reports. 8, 1, p. 6580

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate

Chandrupatla, D. M. S. H., Jansen, G., Mantel, E., Low, P. S., Matsuyama, T., Musters, R. P., Windhorst, A. D., Lammertsma, A. A., Molthoff, C. F. M. & van der Laken, C. J., 2018, In : Contrast media & molecular imaging. 2018, 8092781.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Improving metabolic stability of fluorine-18 labeled verapamil analogs

Raaphorst, R. M., Luurtsema, G., Schokker, C. J., Attia, K. A., Schuit, R. C., Elsinga, P. H., Lammertsma, A. A. & Windhorst, A. D., 30 Jul 2018, In : Nuclear Medicine and Biology. 64-65, p. 47-56 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., MacH, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : Radiochimica acta. 106, 7, p. 623-625

Research output: Contribution to journalComment/Letter to the editorAcademic

International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., Feb 2018, In : Nuklearmedizin. 57, 1, p. 40-41 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Letter to the editor: International consensus radiochemistry nomenclature guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : Current Radiopharmaceuticals. 11, 1, p. 73-75

Research output: Contribution to journalComment/Letter to the editorAcademic

Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., 2018, In : Nuclear Medicine Communications. 39, 3, p. 193-195 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademic