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Research Output 1993 2019

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Open Access

Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N′-(3-[ 3 H] 3 methoxy phenyl)-N′-methylguanidine ([ 3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist

Metaxas, A., van Berckel, B. N. M., Klein, P. J., Verbeek, J., Nash, E. C., Kooijman, E. J. M., Renjaän, V. R. A., Golla, S. S. V., Boellaard, R., Christiaans, J. A. M., Windhorst, A. D. & Leysen, J. E., 19 Feb 2019, In : Pharmacology Research and Perspectives. 7, 1, e00458.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fully Automated 89 Zr Labeling and Purification of Antibodies

Poot, A. J., Adamzek, K. W. A., Windhorst, A. D., Vosjan, M. J. W. D., Kropf, S., Wester, H-J., van Dongen, G. A. M. S. & Vugts, D. J., 2019, In : Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60, 5, p. 691-695

Research output: Contribution to journalArticleAcademicpeer-review

P52 Low and erratic exposure of oral acetaminophen in critically ill children determined with a 14 C microtracer study: a case for IV acetaminophen for acute pain management?

Kleiber, N., Calvier, E., Mooij, MG., Krekels, EHJ., Vaes, WH., Windhorst, AD., Hendrikse, H., Tibboel, D., Knibbe, CAJ. & de Wildt, SN., Jun 2019, In : Archives of Disease in Childhood. 104, 6, p. e38.2-e39

Research output: Contribution to journalArticleAcademicpeer-review

2018

A dual-labeled cRGD-based PET/optical tracer for pre-operative staging and intraoperative treatment of colorectal cancer

Sibinga Mulder, B. G., Handgraaf, H. J., Vugts, D. J., Sewing, C., Windhorst, A. D., Stammes, M., de Geus-Oei, L-F., Bordo, M. W., Mieog, J. S. D., van de Velde, C. J., Frangioni, J. V. & Vahrmeijer, A. L., 20 Oct 2018, In : American journal of nuclear medicine and molecular imaging. 8, 5, p. 282-291 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26Al Microtracer Approach

de Ligt, R., van Duijn, E., Grossouw, D., Bosgra, S., Burggraaf, J., Windhorst, A., Peeters, P. A. M., van der Luijt, G. A., Alexander-White, C. & Vaes, W. H. J., 2018, In : Cts-clinical and translational science. 11, 6, p. 573-581

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of the Novel PET Tracer [11C]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates

van der Aart, J., Yaqub, M., Kooijman, E. J. M., Bakker, J., Langermans, J. A. M., Schuit, R. C., Hofman, M. B. M., Christiaans, J. A. M., Lammertsma, A. A., Windhorst, A. D. & van Berckel, B. N. M., 10 Oct 2018, In : Molecular Imaging and Biology.

Research output: Contribution to journalArticleAcademicpeer-review

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

Pees, A., Sewing, C., Vosjan, M. J. W. D., Tadino, V., Herscheid, J. D. M., Windhorst, A. D. & Vugts, D. J., 6 Sep 2018, In : Chemical Communications. 54, 72, p. 10179-10182 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

van der Aart, J., Golla, S. S. V., van der Pluijm, M., Schwarte, L. A., Schuit, R. C., Klein, P. J., Metaxas, A., Windhorst, A. D., Boellaard, R., Lammertsma, A. A. & van Berckel, B. N. M., 1 Jan 2018, In : EJNMMI Research. 8, 69.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state

Villa, A., Klein, B., Janssen, B., Pedragosa, J., Pepe, G., Zinnhardt, B., Vugts, D. J., Gelosa, P., Sironi, L., Beaino, W., Damont, A., Dollé, F., Jego, B., Winkeler, A., Ory, D., Solin, O., Vercouillie, J., Funke, U., Laner-Plamberger, S., Blomster, L. V. & 7 othersChristophersen, P., Vegeto, E., Aigner, L., Jacobs, A., Planas, A. M., Maggi, A. & Windhorst, A. D., 2018, In : Theranostics. 8, 19, p. 5400-5418 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of the allosteric P2X receptor antagonist [C]SMW139 as a PET tracer of microglial activation

Janssen, B., Vugts, D. J., Wilkinson, S. M., Ory, D., Chalon, S., Hoozemans, J. J. M., Schuit, R. C., Beaino, W., Kooijman, E. J. M., van den Hoek, J., Chishty, M., Doméné, A., Van der Perren, A., Villa, A., Maggi, A., Molenaar, G. T., Funke, U., Shevchenko, R. V., Baekelandt, V., Bormans, G. & 3 othersLammertsma, A. A., Kassiou, M. & Windhorst, A. D., 26 Apr 2018, In : Scientific Reports. 8, 1, p. 6580

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate

Chandrupatla, D. M. S. H., Jansen, G., Mantel, E., Low, P. S., Matsuyama, T., Musters, R. P., Windhorst, A. D., Lammertsma, A. A., Molthoff, C. F. M. & van der Laken, C. J., 2018, In : Contrast media & molecular imaging. 2018, 8092781.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Improving metabolic stability of fluorine-18 labeled verapamil analogs

Raaphorst, R. M., Luurtsema, G., Schokker, C. J., Attia, K. A., Schuit, R. C., Elsinga, P. H., Lammertsma, A. A. & Windhorst, A. D., 30 Jul 2018, In : Nuclear Medicine and Biology. 64-65, p. 47-56 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

International Consensus Radiochemistry Nomenclature Guidelines

Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., Jeong, J. M., Mach, R. H., Mindt, T. L., Pike, V. W. & Windhorst, A. D., Feb 2018, In : Nuklearmedizin. 57, 1, p. 40-41 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vivo evaluation of two tissue transglutaminase PET tracers in an orthotopic tumour xenograft model

van der Wildt, B., Wilhelmus, M. M. M., Beaino, W., Kooijman, E. J. M., Schuit, R. C., Bol, J. G. J. M., Breve, J. J. P., Pasternack, R., Lammertsma, A. A., Windhorst, A. D. & Drukarch, B., 2018, In : EJNMMI Research. 8, 1, 39.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Parametric methods for [18F]flortaucipir PET

Golla, S. S. V., Wolters, E. E., Timmers, T., Ossenkoppele, R., van der Weijden, C. W. J., Scheltens, P., Schwarte, L., Mintun, M. A., Devous Sr, M. D., Schuit, R. C., Windhorst, A. D., Lammertsma, A. A., Yaqub, M., van Berckel, B. N. M. & Boellaard, R., 2018, In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticleAcademicpeer-review

Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate

Chandrupatla, D. M. S. H., Molthoff, C. F. M., Ritsema, W. I. G. R., Vos, R., Elshof, E., Matsuyama, T., Low, P. S., Musters, R. J. P., Hammond, A., Windhorst, A. D., Lammertsma, A. A., van der Laken, C. J., Brands, R. & Jansen, G., 2018, In : Translational research : the journal of laboratory and clinical medicine. 199, p. 24-38 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Reproducibility and Repeatability of Semiquantitative 18F-Fluorodihydrotestosterone Uptake Metrics in Castration-Resistant Prostate Cancer Metastases: A Prospective Multicenter Study

Vargas, H. A., Kramer, G. M., Scott, A. M., Weickhardt, A., Meier, A. A., Parada, N., Beattie, B. J., Humm, J. L., Staton, K. D., Zanzonico, P. B., Lyashchenko, S. K., Lewis, J. S., Yaqub, M., Sosa, R. E., van den Eertwegh, A. J., Davis, I. D., Ackermann, U., Pathmaraj, K., Schuit, R. C., Windhorst, A. D. & 7 othersChua, S., Weber, W. A., Larson, S. M., Scher, H. I., Lammertsma, A. A., Hoekstra, O. S. & Morris, M. J., 2018, In : Journal of Nuclear Medicine. 59, 10, p. 1516-1523 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synthesis and Preclinical Evaluation of the First Carbon-11 Labeled PET Tracers Targeting Substance P1-7

Pekošak, A., Bulc, J. Ž., Korat, Š., Schuit, R. C., Kooijman, E., Vos, R., Rongen, M., Verlaan, M., Takkenkamp, K., Beaino, W., Poot, A. J. & Windhorst, A. D., 2018, In : Molecular Pharmaceutics. 15, 11, p. 4872-4883

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

Verbeek, J., Eriksson, J., Syvänen, S., Huisman, M., Schuit, R. C., Molthoff, C. F. M., Voskuyl, R. A., de Lange, E. C., Lammertsma, A. A. & Windhorst, A. D., Dec 2018, In : EJNMMI radiopharmacy and chemistry. 3, p. 11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M. & 3 othersde Gruijl, T. D., Smit, E. F. & de Langen, A. J., 1 Dec 2018, In : Nature Communications. 9, 1, 4664.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A rapid and highly enantioselective C-11C bond formation of l-[11C]phenylalanine via chiral phase-transfer catalysis

Pekošak, A., Filp, U., Škrinjar, J., Poot, A. J. & Windhorst, A. D., 2017, In : Organic and Biomolecular Chemistry. 15, 3, p. 570-575 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging

Raaphorst, R. M., Savolainen, H., Cantore, M., van de Steeg, E., van Waarde, A., Colabufo, N. A., Elsinga, P. H., Lammertsma, A. A., Windhorst, A. D. & Luurtsema, G., 20 Sep 2017, In : Pharmaceuticals. 10, 3, 76.

Research output: Contribution to journalArticleAcademicpeer-review

Development of [11C]vemurafenib employing a carbon-11 carbonylative Stille coupling and preliminary evaluation in mice bearing melanoma tumor xenografts

Slobbe, P., Windhorst, A. D., Adamzek, K., Bolijn, M., Schuit, R. C., Heideman, D. A. M., van Dongen, G. A. M. S. & Poot, A. J., 13 Jun 2017, In : Oncotarget. 8, 24, p. 38337-38350 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development of fluorine-18 labeled peptidic PET tracers for imaging active tissue transglutaminase

van der Wildt, B., Wilhelmus, M. M. M., Kooijman, E. J. M., Jongenelen, C. A. M., Schuit, R. C., Büchold, C., Pasternack, R., Lammertsma, A. A., Drukarch, B. & Windhorst, A. D., 1 Jan 2017, In : Nuclear Medicine and Biology. 44, p. 90-104 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Efficient Synthesis of 11C-Acrylesters, 11C-Acrylamides and Their Application in Michael Addition Reactions for PET Tracer Development

Filp, U., Pees, A. L., Taddei, C., Pekošak, A., Gee, A. D., Windhorst, A. D. & Poot, A. J., 15 Sep 2017, In : European Journal of Organic Chemistry. 2017, 34, p. 5154-5162 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of [18F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood-brain barrier in rats: Kinetics, metabolism, and selectivity

Savolainen, H., Windhorst, A. D., Elsinga, P. H., Cantore, M., Colabufo, N. A., Willemsen, A. T. M. & Luurtsema, G., 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 4, p. 1286-1298 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM

Van Der Aart, J., Van Der Doef, T. F., Horstman, P., Huisman, M. C., Schuit, R. C., Van Lingen, A., Windhorst, A. D., Van Berckel, B. N. M. & Lammertsma, A. A., 1 Aug 2017, In : Journal of Nuclear Medicine. 58, 8, p. 1330-1333 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography

Chandrupatla, D. M. S. H., Jansen, G., Vos, R., Verlaan, M., Chen, Q., Low, P. S., Windhorst, A. D., Lammertsma, A. A., van der Laken, C. J. & Molthoff, C. F. M., 31 May 2017, In : Arthritis Research and Therapy. 19, 1, 114.

Research output: Contribution to journalArticleAcademicpeer-review

Model selection criteria for dynamic brain PET studies

Golla, S. S. V., Adriaanse, S. M., Yaqub, M., Windhorst, A. D., Lammertsma, A. A., van Berckel, B. N. M. & Boellaard, R., 6 Dec 2017, In : EJNMMI PHYSICS. 4, 1, 30.

Research output: Contribution to journalArticleAcademicpeer-review

Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques

Hakimzadeh, N., Pinas, V. A., Molenaar, G., de Waard, V., Lutgens, E., van Eck-Smit, B. L. F., de Bruin, K., Piek, J. J., Eersels, J. L. H., Booij, J., Verberne, H. J. & Windhorst, A. D., 2017, In : PLoS ONE. 12, 11, p. e0187767

Research output: Contribution to journalArticleAcademicpeer-review

Parametric methods for dynamic 11C-phenytoin PET studies

Mansor, S., Yaqub, M., Boellaard, R., Froklage, F. E., De Vries, A., Bakker, E. D. M., Voskuyl, R. A., Eriksson, J., Schwarte, L. A., Verbeek, J., Windhorst, A. D. & Lammertsma, A. A., 1 Mar 2017, In : Journal of Nuclear Medicine. 58, 3, p. 479-483 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist

Wilkinson, S. M., Barron, M. L., O'Brien-Brown, J., Janssen, B., Stokes, L., Werry, E. L., Chishty, M., Skarratt, K. K., Ong, J. A., Hibbs, D. E., Vugts, D. J., Fuller, S., Windhorst, A. D. & Kassiou, M., 15 Nov 2017, In : ACS Chemical Neuroscience. 8, 11, p. 2374-2380 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Position statement on radiopharmaceutical production for clinical trials

Bormans, G., Buck, A., Chiti, A., Cooper, M., Croasdale, J., Desruet, M., Kumar, V., Liu, Y., Penuelas, I., Rossetti, C., Schiavo, R., Schwarz, S. W. & Windhorst, A. D., 29 Dec 2017, In : EJNMMI radiopharmacy and chemistry. 2, 1, p. 12 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles

Keinänen, O., Mäkilä, E. M., Lindgren, R., Virtanen, H., Liljenbäck, H., Oikonen, V., Sarparanta, M., Molthoff, C., Windhorst, A. D., Roivainen, A., Salonen, J. J. & Airaksinen, A. J., 31 Jan 2017, In : ACS Omega. 2, 1, p. 62-69 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

Beaino, W., Janssen, B., Kooij, G., van der Pol, S. M. A., van Het Hof, B., van Horssen, J., Windhorst, A. D. & de Vries, H. E., 22 Dec 2017, In : Journal of Neuroinflammation. 14, 1, p. 259

Research output: Contribution to journalArticleAcademicpeer-review

Quantification of Tau Load Using [18F]AV1451 PET

Golla, S. S. V., Timmers, T., Ossenkoppele, R., Groot, C., Verfaillie, S., Scheltens, P., van der Flier, W. M., Schwarte, L., Mintun, M. A., Devous, M., Schuit, R. C., Windhorst, A. D., Lammertsma, A. A., Boellaard, R., van Berckel, B. N. M. & Yaqub, M., 1 Dec 2017, In : Molecular Imaging and Biology. 19, 6, p. 963-971 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation

Hugenberg, V., Wagner, S., Kopka, K., Schäfers, M., Schuit, R. C., Windhorst, A. D. & Hermann, S., 12 Jan 2017, In : Journal of Medicinal Chemistry. 60, 1, p. 307-321 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Radiosynthesis of 1-iodo-2-[11C]methylpropane and 2-methyl-1-[11C]propanol and its application for alkylation reactions and C―C bond formation

Rotteveel, L., Poot, A. J., Funke, U., Pekošak, A., Filp, U., Lammertsma, A. A. & Windhorst, A. D., 1 Oct 2017, In : Journal of Labelled Compounds and Radiopharmaceuticals. 60, 12, p. 566-576 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stereocontrolled [11C]Alkylation of N-Terminal Glycine Schiff Bases To Obtain Dipeptides

Filp, U., Pekošak, A., Poot, A. J. & Windhorst, A. D., 10 Oct 2017, In : European Journal of Organic Chemistry. 2017, 37, p. 5592-5596 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stereoselective 11C Labeling of a “Native” Tetrapeptide by Using Asymmetric Phase-Transfer Catalyzed Alkylation Reactions

Pekošak, A., Rotstein, B. H., Collier, T. L., Windhorst, A. D., Vasdev, N. & Poot, A. J., 3 Feb 2017, In : European Journal of Organic Chemistry. 2017, 5, p. 1019-1024 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Strategies towards in vivo imaging of active transglutaminase type 2 using positron emission tomography

van der Wildt, B., Lammertsma, A. A., Drukarch, B. & Windhorst, A. D., 1 Mar 2017, In : Amino Acids. 49, 3, p. 585-595 11 p.

Research output: Contribution to journalArticleAcademicpeer-review