Betty Tijms

DR.

20092020

Research output per year

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Personal profile

Research interests

I am fascinated by the brain’s capability to learn and adjust itself in health and disease. In the past years I have focussed on studying the relationship of changes in brain networks and cognitive decline in AD. For this I use my own invention of single-subject grey matter networks that can explain more variance in cognitive decline than simpler volumetric measures of structural MRI scans. My team has contributed several papers over the years to show that grey matter network breakdown is key to predict decline over the cognitive spectrum of AD, demonstrating its great prognostic potential. Currently, I am further developing multimodal methodologies to advance our understanding of the biological process that explain loss of grey matter connectivity, using cerebrospinal fluid proteomics.

 

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Research Output

Similarity-Based Extraction of Individual Networks from Gray Matter

Tijms, B. M., Series, P., Willshaw, D. J. & Lawrie, S. M., 2012, In : Cerebral Cortex. 22, 7, p. 1530-1541

Research output: Contribution to journalArticleAcademicpeer-review

Atrophy subtypes in prodromal Alzheimer's disease are associated with cognitive decline

ten Kate, M., Dicks, E., van der Flier, W. M., Teunissen, C. E., Barkhof, F., Scheltens, P., Tijms, B. M. & Alzheimer’s Disease Neuroimaging Initiative, 2018, In : Brain : a journal of neurology. 141, 12, p. 3443-3456 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gray matter network disruptions and regional amyloid beta in cognitively normal adults

ten Kate, M., Visser, P. J., Bakardjian, H., Barkhof, F., Sikkes, S. A. M., van der Flier, W. M., Scheltens, P., Hampel, H., Habert, M. O., Dubois, B., Tijms, B. M., Audrain, C., Auffret, A., Bakardjian, H., Baldacci, F., Batrancourt, B., Benakki, I., Benali, H., Bertin, H., Bertrand, A. & 31 others, Boukadida, L., Cacciamani, F., Causse, V., Cavedo, E., Cherif Touil, S., Chiesa, P. A., Colliot, O., Dalla Barba, G., Depaulis, M., Dos Santos, A., Dubois, B., Dubois, M., Epelbaum, S., Fontaine, B., Francisque, H., Gagliardi, G., Genin, A., Genthon, R., Glasman, P., Gombert, F., Habert, M. O., Hampel, H., Hewa, H., Houot, M., Jungalee, N., Kas, A., Kilani, M., La Corte, V., Le Roy, F., Lehericy, S. & INSIGHT-preAD study group, 15 Mar 2018, In : Frontiers in Aging Neuroscience. 10, FEB, 67.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid

Alzheimer's Disease Neuroimaging Initiative, 24 Mar 2020, In : Neurobiology of Aging. 93

Research output: Contribution to journalArticleAcademicpeer-review

Press / Media

Debatavond: De netwerken van het brein, welke rol spelen ze bij hersenziektes?

BM Tijms & MM Schoonheim

26/04/2018

1 Media contribution

Press/Media: Public Engagement Activities