19992020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 46 Article
  • 12 Review article
  • 2 Comment/Letter to the editor
  • 1 Inaugural speech
2020

Oral geranylgeranylacetone treatment increases heat shock protein expression in human atrial tissue

van Marion, D. M. S., Dorsch, L., Hoogstra-Berends, F., Kakuchaya, T., Bockeria, L., de Groot, N. M. S. & Brundel, B. J. J. M., Jan 2020, In : Heart Rhythm. 17, 1, p. 115-122 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Role of HDACs in cardiac electropathology: Therapeutic implications for atrial fibrillation

Brundel, B. J. J. M., Li, J. & Zhang, D., Mar 2020, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1867, 3, 118459.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2019

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

Zhang, D., Hu, X., Li, J., Liu, J., Baks-Te Bulte, L., Wiersma, M., Malik, N-U-A., van Marion, D. M. S., Tolouee, M., Hoogstra-Berends, F., Lanters, E. A. H., van Roon, A. M., de Vries, A. A. F., Pijnappels, D. A., de Groot, N. M. S., Henning, R. H. & Brundel, B. J. J. M., 1 Dec 2019, In : Nature Communications. 10, 1, 1307.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Heat shock protein inducer GGA*-59 reverses contractile and structural remodeling via restoration of the microtubule network in experimental Atrial Fibrillation

Hu, X., Li, J., van Marion, D. M. S., Zhang, D. & Brundel, B. J. J. M., 1 Sep 2019, In : Journal of Molecular and Cellular Cardiology. 134, p. 86-97

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Imbalance of ER and Mitochondria Interactions: Prelude to Cardiac Ageing and Disease?

Li, J., Zhang, D., Brundel, B. J. J. M. & Wiersma, M., 12 Dec 2019, In : Cells. 8, 12, 1617.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation

Wiersma, M., van Marion, D. M. S., Wüst, R. C. I., Houtkooper, R. H., Zhang, D., Groot, N. M. S. D., Henning, R. H. & Brundel, B. J. J. M., 5 Oct 2019, In : Cells. 8, 10, 1202.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

Dorsch, L. M., Schuldt, M., dos Remedios, C. G., Schinkel, A. F. L., de Jong, P. L., Michels, M., Kuster, D. W. D., Brundel, B. J. J. M. & van der Velden, J., 18 Jul 2019, In : Cells. 8, 7, 741.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

van Marion, D. M. S., Hu, X., Zhang, D., Hoogstra-Berends, F., Seerden, J-P. G., Loen, L., Heeres, A., Steen, H., Henning, R. H. & Brundel, B. J. J. M., 1 Jan 2019, In : DRUG DESIGN DEVELOPMENT AND THERAPY. 13, p. 345-364

Research output: Contribution to journalArticleAcademicpeer-review

Untying the knot: protein quality control in inherited cardiomyopathies

Dorsch, L. M., Schuldt, M., Knežević, D., Wiersma, M., Kuster, D. W. D., van der Velden, J. & Brundel, B. J. J. M., 1 May 2019, In : Pflugers Archiv European Journal of Physiology. 471, 5, p. 795-806 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling

Meijering, R. A. M., Wiersma, M., Zhang, D., Lanters, E. A. H., Hoogstra-Berends, F., Scholma, J., Diks, S., Qi, X. Y., de Groot, N. M. S., Nattel, S., Henning, R. H. & Brundel, B. J. J. M., 1 Nov 2018, In : Heart Rhythm. 15, 11, p. 1708-1716 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Converse role of class I and class IIa HDACs in the progression of atrial fibrillation

Zhang, D., Hu, X., Li, J., Hoogstra-Berends, F., Zhuang, Q., Esteban, M. A., de Groot, N., Henning, R. H. & Brundel, B. J. J. M., 1 Dec 2018, In : Journal of Molecular and Cellular Cardiology. 125, p. 39-49 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy

Iuso, A., Wiersma, M., Schüller, H. J., Pode-Shakked, B., Marek-Yagel, D., Grigat, M., Schwarzmayr, T., Berutti, R., Alhaddad, B., Kanon, B., Grzeschik, N. A., Okun, J. G., Perles, Z., Salem, Y., Barel, O., Vardi, A., Rubinshtein, M., Tirosh, T., Dubnov-Raz, G., Messias, A. C. & 18 others, Terrile, C., Barshack, I., Volkov, A., Avivi, C., Eyal, E., Mastantuono, E., Kumbar, M., Abudi, S., Braunisch, M., Strom, T. M., Meitinger, T., Hoffmann, G. F., Prokisch, H., Haack, T. B., Brundel, B. J. J. M., Haas, D., Sibon, O. C. M. & Anikster, Y., 7 Jun 2018, In : American journal of human genetics. 102, 6, p. 1018-1030 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases

Li, J., Zhang, D., Wiersma, M. & Brundel, B. J. J. M., Dec 2018, In : Cells. 7, 12, 279.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system

Wiersma, M., Beuren, T. M. A., de Vrij, E. L., Reitsema, V. A., Bruintjes, J. J., Bouma, H. R., Brundel, B. J. J. M. & Henning, R. H., 1 Sep 2018, In : Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology. 223, p. 23-28 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Endoplasmic reticulum stress is associated with autophagy and cardiomyocyte remodeling in experimental and human atrial fibrillation

Wiersma, M., Meijering, R. A. M., Qi, X. Y., Zhang, D., Liu, T., Hoogstra-Berends, F., Sibon, O. C. M., Henning, R. H., Nattel, S. & Brundel, B. J. J. M., 1 Oct 2017, In : Journal of the American Heart Association. 6, 10, e006458.

Research output: Contribution to journalArticleAcademicpeer-review

Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Nolte, I. M., Munoz, M. L., Tragante, V., Amare, A. T., Jansen, R., Vaez, A., von der Heyde, B., Avery, C. L., Bis, J. C., Dierckx, B., van Dongen, J., Gogarten, S. M., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S. J., Jaju, D., Kerr, K. F., Kluttig, A., Krijthe, B. P. & 144 others, Kumar, J., van der Laan, S. W., Lyytikäinen, L. P., Maihofer, A. X., Minassian, A., van der Most, P. J., Müller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J. D., Thayer, J. F., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M. H., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D. G., de Bakker, P. I. W., Barcella, M., Bayoumi, R., Bieringa, R. J., Boomsma, D., Boucher, G., Britton, A. R., Christophersen, I., Dietrich, A., Ehret, G. B., Ellinor, P. T., Eskola, M., Felix, J. F., Floras, J. S., Franco, O. H., Friberg, P., Gademan, M. G. J., Geyer, M. A., Giedraitis, V., Hartman, C. A., Hemerich, D., Hofman, A., Hottenga, J. J., Huikuri, H., Hutri-Kähönen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A. M., Kors, J. A., Kumari, M., Kuznetsova, T., Laurie, C. C., Lefrandt, J. D., Li, Y., Li, Y., Liao, D., Limacher, M. C., Lin, H. J., Lindgren, C. M., Lubitz, S. A., Mahajan, A., McKnight, B., Zu Schwabedissen, H. M., Milaneschi, Y., Mononen, N., Morris, A. P., Nalls, M. A., Navis, G., Neijts, M., Nikus, K., North, K. E., O'Connor, D. T., Ormel, J., Perz, S., Peters, A., Psaty, B. M., Raitakari, O. T., Risbrough, V. B., Sinner, M. F., Siscovick, D., Smit, J. H., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Staessen, J. A., Stein, P. K., Stilp, A. M., Stolarz-Skrzypek, K., Strauch, K., Sundström, J., Swenne, C. A., Syvänen, A. C., Tardif, J. C., Taylor, K. D., Teumer, A., Thornton, T. A., Tinker, L. E., Uitterlinden, A. G., van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K. C., Willemsen, G., Wong, Q., Zhang, Z. M., Zonderman, A. B., Cusi, D., Evans, M. K., Greiser, H. K., van der Harst, P., Hassan, M., Ingelsson, E., Järvelin, M. R., Kääb, S., Kähönen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimäki, T., Lind, L., Nievergelt, C. M., O'Donnell, C. J., Oldehinkel, A. J., Penninx, B., Reiner, A. P., Riese, H., van Roon, A. M., Rioux, J. D., Rotter, J. I., Sofer, T., Stricker, B. H., Tiemeier, H., Vrijkotte, T. G. M., Asselbergs, F. W., Brundel, B. J. J. M., Heckbert, S. R., Whitsel, E. A., den Hoed, M., Snieder, H. & de Geus, E. J. C., 2 Aug 2017, In : Nature Communications. 8, 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Nolte, I. M., Munoz, M. L., Tragante, V., Amare, A. T., Jansen, R., Vaez, A., Von Der Heyde, B., Avery, C. L., Bis, J. C., Dierckx, B., Van Dongen, J., Gogarten, S. M., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S. J., Jaju, D., Kerr, K. F., Kluttig, A., Krijthe, B. P. & 144 others, Kumar, J., Van Der Laan, S. W., Lyytikäinen, L. P., Maihofer, A. X., Minassian, A., Van Der Most, P. J., Müller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J. D., Thayer, J. F., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M. H., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D. G., De Bakker, P. I. W., Barcella, M., Bayoumi, R., Bieringa, R. J., Boomsma, D., Boucher, G., Britton, A. R., Christophersen, I. E., Dietrich, A., Ehret, G. B., Ellinor, P. T., Eskola, M., Felix, J. F., Floras, J. S., Franco, O. H., Friberg, P., Gademan, M. G. J., Geyer, M. A., Giedraitis, V., Hartman, C. A., Hemerich, D., Hofman, A., Hottenga, J. J., Huikuri, H., Hutri-Kähönen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A. M., Kors, J. A., Kumari, M., Kuznetsova, T., Laurie, C. C., Lefrandt, J. D., Li, Y., Li, Y., Liao, D., Limacher, M. C., Lin, H. J., Lindgren, C. M., Lubitz, S. A., Mahajan, A., McKnight, B., Meyer Zu Schwabedissen, H., Milaneschi, Y., Mononen, N., Morris, A. P., Nalls, M. A., Navis, G., Neijts, M., Nikus, K., North, K. E., O'Connor, D. T., Ormel, J., Perz, S., Peters, A., Psaty, B. M., Raitakari, O. T., Risbrough, V. B., Sinner, M. F., Siscovick, D., Smit, J. H., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Staessen, J. A., Stein, P. K., Stilp, A. M., Stolarz-Skrzypek, K., Strauch, K., Sundström, J., Swenne, C. A., Syvänen, A. C., Tardif, J. C., Taylor, K. D., Teumer, A., Thornton, T. A., Tinker, L. E., Uitterlinden, A. G., Van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K. C., Willemsen, G., Wong, Q., Zhang, Z. M., Zonderman, A. B., Cusi, D., Evans, M. K., Greiser, H. K., Van Der Harst, P., Hassan, M., Ingelsson, E., Järvelin, M. R., Kääb, S., Kähönen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimäki, T., Lind, L., Nievergelt, C. M., O'Donnell, C. J., Oldehinkel, A. J., Penninx, B., Reiner, A. P., Riese, H., Van Roon, A. M., Rioux, J. D., Rotter, J. I., Sofer, T., Stricker, B. H., Tiemeier, H., Vrijkotte, T. G. M., Asselbergs, F. W., Brundel, B. J. J. M., Heckbert, S. R., Whitsel, E. A., Den Hoed, M., Snieder, H. & De Geus, E. J. C., 14 Jun 2017, In : Nature Communications. 8, 15805.

Research output: Contribution to journalArticleAcademicpeer-review

Proteostasis in cardiac health and disease

Henning, R. H. & Brundel, B. J. J. M., 1 Nov 2017, In : Nature Reviews Cardiology. 14, 11, p. 637-653 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Spatial distribution of conduction disorders during sinus rhythm

Lanters, E. A. H., Yaksh, A., Teuwen, C. P., van der Does, L. J. M. E., Kik, C., Knops, P., van Marion, D. M. S., Brundel, B. J. J. M., Bogers, A. J. J. C., Allessie, M. A. & de Groot, N. M. S., 15 Dec 2017, In : International Journal of Cardiology. 249, p. 220-225 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The growing world of small heat shock proteins: from structure to functions

Carra, S., Alberti, S., Arrigo, P. A., Benesch, J. L., Benjamin, I. J., Boelens, W., Bartelt-Kirbach, B., Brundel, B. J. J. M., Buchner, J., Bukau, B., Carver, J. A., Ecroyd, H., Emanuelsson, C., Finet, S., Golenhofen, N., Goloubinoff, P., Gusev, N., Haslbeck, M., Hightower, L. E., Kampinga, H. H. & 10 others, Klevit, R. E., Liberek, K., Mchaourab, H. S., McMenimen, K. A., Poletti, A., Quinlan, R., Strelkov, S. V., Toth, M. E., Vierling, E. & Tanguay, R. M., 1 Jul 2017, In : Cell Stress and Chaperones. 22, 4, p. 601-611 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The protective role of small heat shock proteins in cardiac diseases: key role in atrial fibrillation

Hu, X., Van Marion, D. M. S., Wiersma, M., Zhang, D. & Brundel, B. J. J. M., 1 Jul 2017, In : Cell Stress and Chaperones. 22, 4, p. 665-674 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Derailed Proteostasis as a Determinant of Cardiac Aging

Wiersma, M., Henning, R. H. & Brundel, B. J. J. M., Sep 2016, In : The Canadian journal of cardiology. 32, 9, p. 1166.e11–1166.e20

Research output: Contribution to journalArticleAcademicpeer-review

Erratum to: Tachyarrhythmia in patients with congenital heart disease: inevitable destiny

Teuwen, C. P., Taverne, Y. J. H. J., Houck, C., Götte, M., Brundel, B. J. J. M., Evertz, R., Witsenburg, M., Roos-Hesselink, J. W., Bogers, A. J. J. C., de Groot, N. M. S. & DaNaRa Study Investigators, Apr 2016, In : Netherlands Heart Journal. 24, 4, p. 301-2 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation

Zhang, D., Hu, X., Henning, R. H. & Brundel, B. J. J. M., 1 Apr 2016, In : Cardiovascular Research. 109, 4, p. 519-526

Research output: Contribution to journalArticleAcademicpeer-review

Non-sustained ventricular tachycardia in patients with congenital heart disease: An important sign?

Teuwen, C. P., Ramdjan, T. T. T. K., Gotte, M., Brundel, B. J. J. M., Evertz, R., Vriend, J. W. J., Molhoek, S. G., Dorman, H. G. R., van Opstal, J. M., Konings, T. C., van der Voort, P., Delacretaz, E., Wolfhagen, N. J., van Gastel, V., de Klerk, P., Theuns, D. A., Witsenburg, M., Roos-Hesselink, J. W., Triedman, J. K., Bogers, A. J. J. C. & 1 others, de Groot, N. M. S., 1 Mar 2016, In : International Journal of Cardiology. 206, p. 158-163

Research output: Contribution to journalArticleAcademicpeer-review

Restart your heart

Brundel, B. J. J. M., 2016, Amsterdam: Vrije Universiteit Amsterdam. 21 p.

Research output: Book/ReportInaugural speechOther research output

File
83 Downloads (Pure)

Tachyarrhythmia in patients with congenital heart disease: inevitable destiny

Teuwen, C. P., Taverne, Y. J. H. J., Houck, C., Gotte, M., Brundel, B. J. J. M., Evertz, R., Witsenburg, M., Roos-Hesselink, J. W., Bogers, A. J. J. C. & de Groot, N. M. S., Apr 2016, In : Netherlands Heart Journal. 24, 4, p. 161-170

Research output: Contribution to journalArticleAcademicpeer-review

2015

Animal and in silico models for the study of sarcomeric cardiomyopathies

Duncker, D. J., Bakkers, J., Brundel, B. J. J. M., Robbins, J., Tardiff, J. C. & Carrier, L., 2015, In : Cardiovascular Research. 105, 4, p. 439-448

Research output: Contribution to journalArticleAcademicpeer-review

Diagnosis and therapy of atrial fibrillation: The past, the present and the future

Van Marion, D. M. S., Lanters, E. A. H., Wiersma, M., Allessie, M. A., Brundel, B. B. J. J. M. & De Groot, N. M. S., 1 Jan 2015, In : Journal of Atrial Fibrillation. 8, 2, p. 51-60 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

HALT & REVERSE: Hsf1 activators lower cardiomyocyt damage; towards a novel approach to REVERSE atrial fibrillation

Lanters, E. A. H., van Marion, D. M. S., Kik, C., Steen, H., Bogers, A. J. J. C., Allessie, M. A., Brundel, B. J. J. M. & de Groot, N. M. S., 2015, In : Journal of Translational Medicine. 13, p. 347

Research output: Contribution to journalArticleAcademicpeer-review

Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on theTreatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013

Van Wagoner, D. R., Piccini, J. P., Albert, C. M., Anderson, M. E., Benjamin, E. J., Brundel, B., Califf, R. M., Calkins, H., Chen, P-S., Chiamvimonvat, N., Darbar, D., Eckhardt, L. L., Ellinor, P. T., Exner, D. V., Fogel, R. I., Gillis, A. M., Healey, J., Hohnloser, S. H., Kamel, H., Lathrop, D. A. & 10 others, Lip, G. Y. H., Mehra, R., Narayan, S. M., Olgin, J., Packer, D., Peters, N. S., Roden, D. M., Ross, H. M., Sheldon, R. & Wehrens, X. H. T., Jan 2015, In : Heart Rhythm. 12, 1, p. E5-E29

Research output: Contribution to journalArticleAcademicpeer-review

Reviving the protein quality control system: Therapeutic target for cardiac disease in the elderly

Meijering, R. A. M., Henning, R. H. & Brundel, B. J. J. M., Apr 2015, In : Trends in cardiovascular medicine. 25, 3, p. 243-247

Research output: Contribution to journalArticleAcademicpeer-review

RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response

Meijering, R. A. M., Wiersma, M., van Marion, D. M. S., Zhang, D., Hoogstra-Berends, F., Dijkhuis, A. J., Schmidt, M., Wieland, T., Kampinga, H. H., Henning, R. H. & Brundel, B. J. J. M., 2015, In : PLoS ONE. 10, 7, e0133553.

Research output: Contribution to journalArticleAcademicpeer-review

The future of atrial fibrillation therapy: intervention on heat shock proteins influencing electropathology is the next in line

Lanters, E. A. H., van Marion, D. M. S., Steen, H., de Groot, N. M. S. & Brundel, B. J. J. M., 2015, In : Netherlands Heart Journal. 23, 6, p. 327-333

Research output: Contribution to journalArticleAcademicpeer-review

Time Course of Atrial Fibrillation in Patients With Congenital Heart Defects

Teuwen, C. P., Ramdjan, T. T. T. K., Gotte, M., Brundel, B. J. J. M., Evertz, R., Vriend, J. W. J., Molhoek, S. G., Dorman, H. G. R., van Opstal, J. M., Konings, T. C., van der Voort, P., Delacretaz, E., Houck, C., Yaksh, A., Jansz, L. J., Witsenburg, M., Roos-Hesselink, J. W., Triedman, J. K., Bogers, A. J. J. C. & de Groot, N. M. S., 2015, In : Circulation. Arrhythmia and Electrophysiology. 8, 5, p. 1065-1072

Research output: Contribution to journalArticleAcademicpeer-review

2014

Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation

Zhang, D., Wu, C-T., Qi, X., Meijering, R. A. M., Hoogstra-Berends, F., Tadevosyan, A., Cubukcuoglu Deniz, G., Durdu, S., Akar, A. R., Sibon, O. C. M., Nattel, S., Henning, R. H. & Brundel, B. J. J. M., 21 Jan 2014, In : Circulation. 129, 3, p. 346-58 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog

Qi, X-Y., Diness, J. G., Brundel, B. J. J. M., Zhou, X-B., Naud, P., Wu, C-T., Huang, H., Harada, M., Aflaki, M., Dobrev, D., Grunnet, M. & Nattel, S., 28 Jan 2014, In : Circulation. 129, 4, p. 430-40 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

den Hoed, M. A. H., Eijgelsheim, M., Esko, T., Brundel, B. J., Peal, D. S., Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E., Westra, H. J., Johnson, T., Isaacs, A., Yang, L., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., Bochud, M. & 248 others, Boucher, G., Cornelis, M. C., Gudbjartsson, D. F., Hadley, D., van der Harst, P., Hayward, C., den Heijer, M., Igl, W., Jackson, A. U., Kutalik, Z., Luan, J., Kemp, J. P., Kristiansson, K., Ladenvall, C., Lorentzon, M., Montasser, M. E., Njajou, O. T., O'Reilly, P. F., Padmanabhan, S., St Pourcain, B., Rankinen, T., Salo, P., Tanaka, T., Timpson, N. J., Vitart, V., Waite, L., Wheeler, W., Zhang, W., Draisma, H. H. M., Feitosa, M. F., Kerr, K. F., Lind, P. A., Mihailov, E., Onland-Moret, N. C., Song, C., Weedon, M. N., Xie, W., Yengo, L., Absher, D., Albert, C. M., Alonso, A., Arking, D. E., de Bakker, P. I., Balkau, B., Barlassina, C., Benaglio, P., Bis, J. C., Bouatia-Naji, N., Brage, S., Chanock, S. J., Chines, P. S., Chung, M., Darbar, D., Dina, C., Dörr, M., Elliott, P., Felix, S. B., Fischer, K., Fuchsberger, C., de Geus, E. J. C., Goyette, P., Gudnason, V., Harris, T. B., Hartikainen, A. L., Havulinna, A. S., Heckbert, S. R., Hicks, A. A., Hofman, A., Holewijn, S., Hoogstra-Berends, F., Hottenga, J. J., Jensen, M. K., Johansson, A., Junttila, J., Kääb, S., Kanon, B., Ketkar, S., Khaw, K. T., Knowles, J. W., Kooner, A. S., Kors, J. A., Kumari, M., Milani, L., Laiho, P., Lakatta, E. G., Langenberg, C., Leusink, M., Liu, Y., Luben, R. N., Lunetta, K. L., Lynch, S. N., Markus, M. R., Marques-Vidal, P., Mateo Leach, I., McArdle, W. L., McCarroll, S. A., Medland, S. E., Miller, K. A., Montgomery, G. W., Morrison, A. C., Müller-Nurasyid, M., Navarro, P., Nelis, M., O'Connell, J. R., O'Donnell, C. J., Ong, K. K., Newman, A. B., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Psaty, B. M., Rao, D. C., Ring, S. M., Rossin, E. J., Rudan, D., Sanna, S., Scott, R. A., Sehmi, J. S., Sharp, S., Shin, J. T., Singleton, A. B., Smith, A. V., Soranzo, N., Spector, T. D., Stewart, C., Stringham, H. M., Tarasov, K. V., Uitterlinden, A. G., Vandenput, L., Hwang, S. J., Whitfield, J. B., Wijmenga, C., Wild, S. H., Willemsen, G., Wilson, J. F., Witteman, J. C., Wong, A., Wong, Q., Jamshidi, Y., Zitting, P., Boer, J. M., Boomsma, D. I., Borecki, I. B., van Duijn, C. M., Ekelund, U., Forouhi, N. G., Froguel, P., Hingorani, A. D., Ingelsson, E., Kivimaki, M., Kronmal, R. A., Kuh, D., Lind, L., Martin, N. G., Oostra, B. A., Pedersen, N. L., Quertermous, T., Rotter, J. I., van der Schouw, Y. T., Verschuren, W. M., Walker, M., Albanes, D., Arnar, D. O., Assimes, T. L., Bandinelli, S., Boehnke, M., de Boer, R. A., Bouchard, C., Caulfield, W. L., Chambers, J. C., Curhan, G., Cusi, D., Eriksson, J., Ferrucci, L., van Gilst, W. H., Glorioso, N., de Graaf, J., Groop, L., Gyllensten, U., Hsueh, W. C., Hu, F. B., Huikuri, H. V., Hunter, D. J., Iribarren, C., Isomaa, B., Järvelin, M. R., Jula, A., Kähönen, M., Kiemeney, L. A., van der Klauw, M. M., Kooner, J. S., Kraft, P., Iacoviello, L., Lehtimäki, T., Lokki, M. L., Mitchell, B. D., Navis, G., Nieminen, M. S., Ohlsson, C., Poulter, N. R., Qi, L., Raitakari, O. T., Rimm, E. B., Rioux, J. D., Rizzi, F., Rudan, I., Salomaa, V., Sever, P. S., Shields, D. C., Shuldiner, A. R., Sinisalo, J., Stanton, A. V., Stolk, R. P., Strachan, D. P., Tardif, J. C., Thorsteinsdottir, U., Tuomilehto, J., van Veldhuisen, D. J., Virtamo, J., Viikari, J., Vollenweider, P., Waeber, G., Widen, E., Cho, Y. S., Olsen, J. V., Visscher, P. M., Willer, C. J., Franke, L., Erdmann, J., Thompson, J. R., Pfeufer, A., Sotoodehnia, N., Newton-Cheh, C., Ellinor, P. T., Stricker, B. H. C., Metspalu, A., Perola, M., Beckmann, J. S., Smith, G. D., Stefansson, K., Wareham, N. J., Munroe, P. B., Sibon, O. C. M., Milan, D. J., Snieder, H., Samani, N. J. & Loos, R. J., 2013, In : Nature Genetics. 45, 6, p. 621-631

Research output: Contribution to journalArticleAcademicpeer-review

2012

Heat Shock Protein-Inducing Compounds as Therapeutics to Restore Proteostasis in Atrial Fibrillation

Hoogstra-Berends, F., Meijering, R. A. M., Zhang, D., Heeres, A., Loen, L., Seerden, J-P., Kuipers, I., Kampinga, H. H., Henning, R. H. & Brundel, B. J. J. M., Apr 2012, In : Trends in cardiovascular medicine. 22, 3, p. 62-68

Research output: Contribution to journalReview articleAcademicpeer-review

Loss of proteostatic control as a substrate for atrial fibrillation: a novel target for upstream therapy by heat shock proteins

Meijering, R. A. M., Zhang, D., Hoogstra-Berends, F., Henning, R. H. & Brundel, B. J. J. M., 2012, In : Frontiers in Physiology. 3

Research output: Contribution to journalReview articleAcademicpeer-review

2011

Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation

Zhang, D., Ke, L., Mackovicova, K., Van Der Want, J. J. L., Sibon, O. C. M., Tanguay, R. M., Morrow, G., Henning, R. H., Kampinga, H. H. & Brundel, B. J. J. M., Sep 2011, In : Journal of Molecular and Cellular Cardiology. 51, 3, p. 381-389

Research output: Contribution to journalArticleAcademicpeer-review

HSPB1, HSPB6, HSPB7 and HSPB8 Protect against RhoA GTPase-Induced Remodeling in Tachypaced Atrial Myocytes

Ke, L., Meijering, R. A. M., Hoogstra-Berends, F., Mackovicova, K., Vos, M. J., Van Gelder, I. C., Henning, R. H., Kampinga, H. H. & Brundel, B. J. J. M., 24 Jun 2011, In : PLoS ONE. 6, 6

Research output: Contribution to journalArticleAcademicpeer-review

2009

The Calcium/Calmodulin/Kinase System and Arrhythmogenic Afterdepolarizations in Bradycardia-Related Acquired Long-QT Syndrome

Qi, X., Yeh, Y-H., Chartier, D., Xiao, L., Tsuji, Y., Brundel, B. J. J. M., Kodama, I. & Nattel, S., Jun 2009, In : Circulation. Arrhythmia and Electrophysiology. 2, 3, p. 295-304

Research output: Contribution to journalArticleAcademicpeer-review

2008

Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation

Ke, L., Qi, X. Y., Dijkhuis, A-J., Chartier, D., Nattel, S., Henning, R. H., Kampinga, H. H. & Brundel, B. J. M., Nov 2008, In : Journal of Molecular and Cellular Cardiology. 45, 5, p. 685-693

Research output: Contribution to journalArticleAcademicpeer-review

Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current

Qi, X. Y., Yeh, Y-H., Xiao, L., Burstein, B., Maguy, A., Chartier, D., Villeneuve, L. R., Brundel, B. J. J. M., Dobrev, D. & Nattel, S., 10 Oct 2008, In : Circulation Research. 103, 8, p. 845-54 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia

Sakabe, M., Shiroshita-Takeshita, A., Maguy, A., Brundel, B. J. J. M., Fujiki, A., Inoue, H. & Nattel, S., 1 Apr 2008, In : Cardiovascular Research. 78, 1, p. 63-70

Research output: Contribution to journalArticleAcademicpeer-review

Heat shock proteins as molecular targets for intervention in atrial fibrillation

Brundel, B. J. J. M., Ke, L., Dijkhuis, A-J., Qi, X., Shiroshita-Takeshita, A., Nattel, S., Henning, R. H. & Kampinga, H. H., 1 Jun 2008, In : Cardiovascular Research. 78, 3, p. 422-428

Research output: Contribution to journalReview articleAcademicpeer-review

2007

Beat shock proteins and atrial fibrillation

Kampinga, H. H., Henning, R. H., van Gelder, I. C. & Brundel, B. J. J. M., Jan 2007, In : Cell Stress and Chaperones. 12, 2, p. 97-100

Research output: Contribution to journalReview articleAcademicpeer-review

Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure

Shiroshita-Takeshita, A., Brundel, B. J. J. M., Burstein, B., Leung, T-K., Mitamura, H., Ogawa, S. & Nattel, S., Apr 2007, In : Cardiovascular Research. 74, 1, p. 75-84

Research output: Contribution to journalArticleAcademicpeer-review

2006

Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation

Brundel, B. J. J. M., Henning, R. H., Ke, L., van Gelder, I. C., Crijns, H. J. G. M. & Kampinga, H. H., Sep 2006, In : Journal of Molecular and Cellular Cardiology. 41, 3, p. 555-562

Research output: Contribution to journalArticleAcademicpeer-review