20052019
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Research Output 2005 2019

2019

Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal

Alzheimer's Disease Neuroimaging Initiative, 2019, In : Neurology. 92, 23, p. e2699-e2705

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Associations of AD biomarkers and cognitive performance with nutritional status: The NUDAD project

Doorduijn, A. S., Visser, M., van de Rest, O., Kester, M. I., de Leeuw, F. A., Boesveldt, S., Fieldhouse, J. L. P., van den Heuvel, E. G. H. M., Teunissen, C. E., Scheltens, P., van der Flier, W. M. & de van der Schueren, M. A. E., 2019, In : Nutrients. 11, 5, 1161.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

Liebsch, F., Kulic, L., Teunissen, C., Shobo, A., Ulku, I., Engelschalt, V., Hancock, M. A., van der Flier, W. M., Kunach, P., Rosa-Neto, P., Scheltens, P., Poirier, J., Saftig, P., Bateman, R. J., Breitner, J., Hock, C. & Multhaup, G., 2019, In : Nature Communications. 10, 1, 2240.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

Alzheimer's Disease Neuroimaging Initiative, 2019, In : Lancet Neurology. 18, 11, p. 1034-1044

Research output: Contribution to journalArticleAcademicpeer-review

Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions

TRACE-VCI study group, 2019, In : Neurobiology of Aging.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Bos, I., Vos, S., Verhey, F., Scheltens, P., Teunissen, C., Engelborghs, S., Sleegers, K., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R. G., Tsolaki, M., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Lleó, A., Johannsen, P., Freund-Levi, Y., Frölich, L. & 12 othersVandenberghe, R., Westwood, S., Dobricic, V., Barkhof, F., Legido-Quigley, C., Bertram, L., Lovestone, S., Streffer, J., Andreasson, U., Blennow, K., Zetterberg, H. & Visser, P. J., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia

Meeter, L. H. H., Steketee, R. M. E., Salkovic, D., Vos, M. E., Grossman, M., McMillan, C. T., Irwin, D. J., Boxer, A. L., Rojas, J. C., Olney, N. T., Karydas, A., Miller, B. L., Pijnenburg, Y. A. L., Barkhof, F., Sánchez-Valle, R., Lladó, A., Borrego-Ecija, S., Diehl-Schmid, J., Grimmer, T., Goldhardt, O. & 27 othersSantillo, A. F., Hansson, O., Vestberg, S., Borroni, B., Padovani, A., Galimberti, D., Scarpini, E., Rohrer, J. D., Woollacott, I. O. C., Synofzik, M., Wilke, C., de Mendonca, A., Vandenberghe, R., Benussi, L., Ghidoni, R., Binetti, G., Niessen, W. J., Papma, J. M., Seelaar, H., Jiskoot, L. C., de Jong, F. J., Donker Kaat, L., del Campo, M., Teunissen, C. E., Bron, E. E., van den Berg, E. & van Swieten, J. C., 2019, In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Contactins in the central nervous system: role in health and disease

Chatterjee, M., Schild, D. & Teunissen, C., 2019, In : Neural regeneration research. 14, 2, p. 206-216 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

CSF alpha-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease (vol 22, pg 87, 2010)

van Steenoven, I., Majbour, N. K., Vaikath, N. N., Berendse, H. W., van der Flier, W. M., van de Berg, W. D. J., Teunissen, C. E., Lemstra, A. W. & El-Agnaf, O. M. A., Jan 2019, In : Movement Disorders. 34, 1, p. 159-159

Research output: Contribution to journalArticleAcademicpeer-review

Decision tree supports the interpretation of CSF biomarkers in Alzheimer's disease

Babapour Mofrad, R., Schoonenboom, N. S. M., Tijms, B. M., Scheltens, P., Visser, P. J., van der Flier, W. M. & Teunissen, C. E., 1 Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 1-9 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

Bridel, C., van Wieringen, W. N., Zetterberg, H., Tijms, B. M., Teunissen, C. E., Alvarez-Cermeño, J. C., Andreasson, U., Axelsson, M., Bäckström, D. C., Bartos, A., Bjerke, M., Blennow, K., Boxer, A., Brundin, L., Burman, J., Christensen, T., Fialová, L., Forsgren, L., Frederiksen, J. L., Gisslén, M. & 57 othersGray, E., Gunnarsson, M., Hall, S., Hansson, O., Herbert, M. K., Jakobsson, J., Jessen-Krut, J., Janelidze, S., Johannsson, G., Jonsson, M., Kappos, L., Khademi, M., Khalil, M., Kuhle, J., Landén, M., Leinonen, V., Logroscino, G., Lu, C-H., Lycke, J., Magdalinou, N. K., Malaspina, A., Mattsson, N., Meeter, L. H., Mehta, S. R., Modvig, S., Olsson, T., Paterson, R. W., Pérez-Santiago, J., Piehl, F., Pijnenburg, Y. A. L., Pyykkö, O. T., Ragnarsson, O., Rojas, J. C., Romme Christensen, J., Sandberg, L., Scherling, C. S., Schott, J. M., Sellebjerg, F. T., Simone, I. L., Skillbäck, T., Stilund, M., Sundström, P., Svenningsson, A., Tortelli, R., Tortorella, C., Trentini, A., Troiano, M., Turner, M. R., van Swieten, J. C., Vågberg, M., Verbeek, M. M., Villar, L. M., Visser, P. J., Wallin, A., Weiss, A., Wikkelsø, C. & Wild, E. J., 2019, In : JAMA Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Shi, L., Westwood, S., Baird, A. L., Winchester, L., Dobricic, V., Kilpert, F., Hong, S., Franke, A., Hye, A., Ashton, N. J., Morgan, A. R., Bos, I., Vos, S. J. B., Buckley, N. J., Kate, M. T., Scheltens, P., Vandenberghe, R., Gabel, S., Meersmans, K., Engelborghs, S. & 33 othersde Roeck, E. E., Sleegers, K., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R. G., Molinuevo, J. L., Rami, L., Wallin, A., Kettunen, P., Tsolaki, M., Verhey, F., Lleó, A., Alcolea, D., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Johannsen, P., Teunissen, C. E., Freund-Levi, Y., Frölich, L., Legido-Quigley, C., Barkhof, F., Blennow, K., Zetterberg, H., Baker, S., Morgan, B. P., Streffer, J., Visser, P. J., Bertram, L., Lovestone, S. & Nevado-Holgado, A. J., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Guidelines for CSF processing and biobanking: impact on the identification and development of optimal CSF protein biomarkers

Hok-A-Hin, Y. S., Willemse, E. A. J., Teunissen, C. E. & del Campo, M., 2019, Methods in Molecular Biology. Humana Press Inc., Vol. 2044. p. 27-50 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Inflammatory biomarkers in Alzheimer's disease plasma

Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease & NIMA Consortium, 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study

Leurs, C. E., Twaalfhoven, H. A. M., Lissenberg-Witte, B. I., van Pesch, V., Dujmovic, I., Drulovic, J., Castellazzi, M., Bellini, T., Pugliatti, M., Kuhle, J., Villar, L. M., Alvarez-Cermeño, J. C., Alvarez-Lafuente, R., Hegen, H., Deisenhammer, F., Walchhofer, L. M., Thouvenot, E., Comabella, M., Montalban, X., Vécsei, L. & 19 othersRajda, C., Galimberti, D., Scarpini, E., Altintas, A., Rejdak, K., Frederiksen, J. L., Pihl-Jensen, G., Jensen, P. E. H., Khalil, M., Voortman, M. M., Fazekas, F., Saiz, A., la Puma, D., Vercammen, M., Vanopdenbosch, L., Uitdehaag, B. M. J., Killestein, J., Bridel, C. & Teunissen, C., 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study

Lleó, A., Alcolea, D., Martínez-Lage, P., Scheltens, P., Parnetti, L., Poirier, J., Simonsen, A. H., Verbeek, M. M., Rosa-Neto, P., Slot, R. E. R., Tainta, M., Izaguirre, A., Reijs, B. L. R., Farotti, L., Tsolaki, M., Vandenbergue, R., Freund-Levi, Y., Verhey, F. R. J., Clarimón, J., Fortea, J. & 8 othersFrolich, L., Santana, I., Molinuevo, J. L., Lehmann, S., Visser, P. J., Teunissen, C. E., Zetterberg, H. & Blennow, K., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, 1 Feb 2019, In : Alzheimer's and Dementia. 15, 12, p. 292-312 21 p.

Research output: Contribution to journalArticleAcademicpeer-review

Plasma proteome in multiple sclerosis disease progression

Malekzadeh, A., Leurs, C., van Wieringen, W., Steenwijk, M. D., Schoonheim, M. M., Amann, M., Naegelin, Y., Kuhle, J., Killestein, J. & Teunissen, C. E., 31 Jul 2019, In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Pre-analytical stability of novel cerebrospinal fluid biomarkers

Willemse, E. A. J., Vermeiren, Y., Garcia-Ayllon, M-S., Bridel, C., De Deyn, P. P., Engelborghs, S., van der Flier, W. M., Jansen, E. E. W., Lopez-Font, I. B., Mendes, V., Manadas, B., de Roeck, N., Saez-Valero, J., Struys, E. A., Vanmechelen, E., Andreasson, U. & Teunissen, C. E., 23 Jul 2019, In : Clinica Chimica Acta.

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: Cross-sectional comparison of three European memory clinic samples Jose Luis Molinuevo (jlmolinuevo@barcelonabeta.org); Frank Jessen (frank.jessen@uk-koeln.de); Wiesje Van der Flier (WM.vdFlier@vumc.nl)

Wolfsgruber, S., Molinuevo, J. L., Wagner, M., Teunissen, C. E., Rami, L., Coll-Padrós, N., Bouwman, F. H., Slot, R. E. R., Wesselman, L. M. P., Peters, O., Luther, K., Buerger, K., Priller, J., Laske, C., Teipel, S., Spottke, A., Heneka, M. T., Düzel, E., Drzezga, A., Wiltfang, J. & 3 othersSikkes, S. A. M., van der Flier, W. M. & Jessen, F., 2019, In : Alzheimer's Research and Therapy. 11, 1, 8.

Research output: Contribution to journalArticleAcademicpeer-review

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

Kim, M., Snowden, S., Suvitaival, T., Ali, A., Merkler, D. J., Ahmad, T., Westwood, S., Baird, A., Proitsi, P., Nevado-Holgado, A., Hye, A., Bos, I., Vos, S., Vandenberghe, R., Teunissen, C., ten Kate, M., Scheltens, P., Gabel, S., Meersmans, K., Blin, O. & 31 othersRichardson, J., de Roeck, E., Sleegers, K., Bordet, R. G., Rami, L., Kettunen, P., Tsolaki, M., Verhey, F., Sala, I., Lléo, A., Peyratout, G., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Engelborghs, S., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Popp, J., Martinez-Lage, P., Bertram, L., Barkhof, F., Ashton, N., Blennow, K., Zetterberg, H., Streffer, J., Visser, P. J., Lovestone, S. & Legido-Quigley, C., 2019, In : Alzheimer's and Dementia. 15, 6, p. 817-827

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prognostic value of Alzheimer's biomarkers in mild cognitive impairment: the effect of age at onset

Alzheimer’s Disease Neuroimaging Initiative, 2019, In : Journal of Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Serum Neurofilament light correlates with CADASIL disease severity and survival

Gravesteijn, G., Rutten, J. W., Verberk, I. M. W., Böhringer, S., Liem, M. K., van der Grond, J., Aartsma-Rus, A., Teunissen, C. E. & Lesnik Oberstein, S. A. J., 1 Jan 2019, In : Annals of Clinical and Translational Neurology. 6, 1, p. 46-56 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease—Data from three memory clinic studies

Hu, X., Teunissen, C. E., Spottke, A., Heneka, M. T., Düzel, E., Peters, O., Li, S., Priller, J., Buerger, K., Teipel, S., Laske, C., Verfaillie, S. C. J., Barkhof, F., Coll-Padrós, N., Rami, L., Molinuevo, J. L., van der Flier, W. M. & Jessen, F., Feb 2019, In : Alzheimers & Dementia. 15, 2, p. 185-193

Research output: Contribution to journalArticleAcademicpeer-review

Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV

Blokhuis, C., Peeters, C. F. W., Cohen, S., Scherpbier, H. J., Kuijpers, T. W., Reiss, P., Kootstra, N. A., Teunissen, C. E. & Pajkrt, D., 2019, In : Scientific Reports. 9, 1, 8004.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies

van Steenoven, I., Noli, B., Cocco, C., Ferri, G-L., Oeckl, P., Otto, M., Koel-Simmelink, M. J. A., Bridel, C., van der Flier, W. M., Lemstra, A. W. & Teunissen, C. E., 2019, In : International Journal of Molecular Sciences. 20, 19

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy

Chakraborty, A., Kamermans, A., van Het Hof, B., Castricum, K., Aanhane, E., van Horssen, J., Thijssen, V. L., Scheltens, P., Teunissen, C. E., Fontijn, R. D., van der Flier, W. M. & de Vries, H. E., 2018, In : Brain : a journal of neurology. 141, 12, p. 3377-3388 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid – method comparison and round robin study

Mollenhauer, B., Bowman, F. D., Drake, D., Duong, J., Blennow, K., el-Agnaf, O., Shaw, L. M., Masucci, J., Taylor, P., Umek, R. M., Dunty, J. M., Smith, C. L., Stoops, E., Vanderstichele, H., Schmid, A. W., Moniatte, M., Zhang, J., Kruse, N., Lashuel, H. A., Teunissen, C. & 4 othersSchubert, T., Dave, K. D., Hutten, S. J. & Zetterberg, H., 2018, In : Journal of Neurochemistry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

Amyloid Biomarker Study Group, 1 Jan 2018, In : JAMA Psychiatry. 75, 1, p. 84-95 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Atrophy subtypes in prodromal Alzheimer's disease are associated with cognitive decline

ten Kate, M., Dicks, E., van der Flier, W. M., Teunissen, C. E., Barkhof, F., Scheltens, P., Tijms, B. M. & Alzheimer’s Disease Neuroimaging Initiative, 2018, In : Brain : a journal of neurology. 141, 12, p. 3443-3456 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

Lewczuk, P., O’Bryant, S. E., Verbeek, M. M., Dubois, B., Visser, P. J., Jellinger, K. A., Engelborghs, S., Ramirez, A., Parnetti, L., Jack, C. R., Teunissen, C. E., Hampel, H., Lleó, A., Jessen, F., Glodzik, L., de Leon, M. J., Fagan, A. M., Molinuevo, J. L., Jansen, W. J., Winblad, B. & 28 othersShaw, L. M., Andreasson, U., Otto, M., Mollenhauer, B., Wiltfang, J., Turner, M. R., Zerr, I., Handels, R., Thompson, A. G., Johansson, G., Ermann, N., Trojanowski, J. Q., Karaca, I., Wagner, H., Oeckl, P., van Waalwijk van Doorn, L., Bjerke, M., Kuiperij, H. B., Farotti, L., Li, Y., Gordon, B. A., Epelbaum, S., Vos, S. J. B., Klijn, C. J. M., Van Nostrand, W. E., Minguillon, C., Schmitz, M. & on Behalf of the Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut, 19 May 2018, In : World Journal of Biological Psychiatry. 19, 4, p. 244-328 85 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

Leurs, C. E., Podlesniy, P., Trullas, R., Balk, L., Steenwijk, M. D., Malekzadeh, A., Piehl, F., Uitdehaag, B. M., Killestein, J., van Horssen, J. & Teunissen, C. E., 1 Apr 2018, In : Multiple Sclerosis. 24, 4, p. 472-480 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., Haller, T., Singh-Manoux, A., Verhoeven, A., Willemsen, G., de Leeuw, F. A., Wagner, H., van Dongen, J., Hertel, J., Budde, K., Willems van Dijk, K. & 28 othersWeinhold, L., Ikram, M. A., Pietzner, M., Perola, M., Wagner, M., Friedrich, N., Slagboom, P. E., Scheltens, P., Yang, Q., Gertzen, R. E., Egert, S., Li, S., Hankemeier, T., van Beijsterveldt, C. E. M., Vasan, R. S., Maier, W., Peeters, C. F. W., Jörgen Grabe, H., Ramirez, A., Seshadri, S., Metspalu, A., Kivimäki, M., Salomaa, V., Demirkan, A., Boomsma, D. I., van der Flier, W. M., Amin, N. & van Duijn, C. M., 1 Jun 2018, In : Alzheimer's and Dementia. 14, 6, p. 707-722 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease

Groot, C., Sudre, C. H., Barkhof, F., Teunissen, C. E., van Berckel, B. N. M., Seo, S. W., Ourselin, S., Scheltens, P., Cardoso, M. J., van der Flier, W. M. & Ossenkoppele, R., 13 Nov 2018, In : Neurology. 91, 20, p. e1851-e1859

Research output: Contribution to journalArticleAcademicpeer-review

CNS penetration of ART in HIV-infected children

van den Hof, M., Blokhuis, C., Cohen, S., Scherpbier, H. J., Wit, F. W. N. M., Pistorius, M. C. M., Kootstra, N. A., Teunissen, C. E., Mathot, R. A. A. & Pajkrt, D., 2018, In : The Journal of antimicrobial chemotherapy. 73, 2, p. 484-489

Research output: Contribution to journalArticleAcademicpeer-review