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Research Output 2005 2019

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Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

Liebsch, F., Kulic, L., Teunissen, C., Shobo, A., Ulku, I., Engelschalt, V., Hancock, M. A., van der Flier, W. M., Kunach, P., Rosa-Neto, P., Scheltens, P., Poirier, J., Saftig, P., Bateman, R. J., Breitner, J., Hock, C. & Multhaup, G., 2019, In : Nature Communications. 10, 1, 2240.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Bos, I., Vos, S., Verhey, F., Scheltens, P., Teunissen, C., Engelborghs, S., Sleegers, K., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R. G., Tsolaki, M., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Lleó, A., Johannsen, P., Freund-Levi, Y., Frölich, L. & 12 othersVandenberghe, R., Westwood, S., Dobricic, V., Barkhof, F., Legido-Quigley, C., Bertram, L., Lovestone, S., Streffer, J., Andreasson, U., Blennow, K., Zetterberg, H. & Visser, P. J., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia

Meeter, L. H. H., Steketee, R. M. E., Salkovic, D., Vos, M. E., Grossman, M., McMillan, C. T., Irwin, D. J., Boxer, A. L., Rojas, J. C., Olney, N. T., Karydas, A., Miller, B. L., Pijnenburg, Y. A. L., Barkhof, F., Sánchez-Valle, R., Lladó, A., Borrego-Ecija, S., Diehl-Schmid, J., Grimmer, T., Goldhardt, O. & 27 othersSantillo, A. F., Hansson, O., Vestberg, S., Borroni, B., Padovani, A., Galimberti, D., Scarpini, E., Rohrer, J. D., Woollacott, I. O. C., Synofzik, M., Wilke, C., de Mendonca, A., Vandenberghe, R., Benussi, L., Ghidoni, R., Binetti, G., Niessen, W. J., Papma, J. M., Seelaar, H., Jiskoot, L. C., de Jong, F. J., Donker Kaat, L., del Campo, M., Teunissen, C. E., Bron, E. E., van den Berg, E. & van Swieten, J. C., 2019, In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CSF alpha-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease (vol 22, pg 87, 2010)

van Steenoven, I., Majbour, N. K., Vaikath, N. N., Berendse, H. W., van der Flier, W. M., van de Berg, W. D. J., Teunissen, C. E., Lemstra, A. W. & El-Agnaf, O. M. A., Jan 2019, In : Movement Disorders. 34, 1, p. 159-159

Research output: Contribution to journalArticleAcademicpeer-review

Inflammatory biomarkers in Alzheimer's disease plasma

Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease & NIMA Consortium, 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study

Leurs, C. E., Twaalfhoven, H. A. M., Lissenberg-Witte, B. I., van Pesch, V., Dujmovic, I., Drulovic, J., Castellazzi, M., Bellini, T., Pugliatti, M., Kuhle, J., Villar, L. M., Alvarez-Cermeño, J. C., Alvarez-Lafuente, R., Hegen, H., Deisenhammer, F., Walchhofer, L. M., Thouvenot, E., Comabella, M., Montalban, X., Vécsei, L. & 19 othersRajda, C., Galimberti, D., Scarpini, E., Altintas, A., Rejdak, K., Frederiksen, J. L., Pihl-Jensen, G., Jensen, P. E. H., Khalil, M., Voortman, M. M., Fazekas, F., Saiz, A., la Puma, D., Vercammen, M., Vanopdenbosch, L., Uitdehaag, B. M. J., Killestein, J., Bridel, C. & Teunissen, C., 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study

Lleó, A., Alcolea, D., Martínez-Lage, P., Scheltens, P., Parnetti, L., Poirier, J., Simonsen, A. H., Verbeek, M. M., Rosa-Neto, P., Slot, R. E. R., Tainta, M., Izaguirre, A., Reijs, B. L. R., Farotti, L., Tsolaki, M., Vandenbergue, R., Freund-Levi, Y., Verhey, F. R. J., Clarimón, J., Fortea, J. & 8 othersFrolich, L., Santana, I., Molinuevo, J. L., Lehmann, S., Visser, P. J., Teunissen, C. E., Zetterberg, H. & Blennow, K., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, 1 Feb 2019, In : Alzheimer's and Dementia. 15, 12, p. 292-312 21 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: Cross-sectional comparison of three European memory clinic samples Jose Luis Molinuevo (jlmolinuevo@barcelonabeta.org); Frank Jessen (frank.jessen@uk-koeln.de); Wiesje Van der Flier (WM.vdFlier@vumc.nl)

Wolfsgruber, S., Molinuevo, J. L., Wagner, M., Teunissen, C. E., Rami, L., Coll-Padrós, N., Bouwman, F. H., Slot, R. E. R., Wesselman, L. M. P., Peters, O., Luther, K., Buerger, K., Priller, J., Laske, C., Teipel, S., Spottke, A., Heneka, M. T., Düzel, E., Drzezga, A., Wiltfang, J. & 3 othersSikkes, S. A. M., van der Flier, W. M. & Jessen, F., 2019, In : Alzheimer's Research and Therapy. 11, 1, 8.

Research output: Contribution to journalArticleAcademicpeer-review

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

Kim, M., Snowden, S., Suvitaival, T., Ali, A., Merkler, D. J., Ahmad, T., Westwood, S., Baird, A., Proitsi, P., Nevado-Holgado, A., Hye, A., Bos, I., Vos, S., Vandenberghe, R., Teunissen, C., ten Kate, M., Scheltens, P., Gabel, S., Meersmans, K., Blin, O. & 31 othersRichardson, J., de Roeck, E., Sleegers, K., Bordet, R. G., Rami, L., Kettunen, P., Tsolaki, M., Verhey, F., Sala, I., Lléo, A., Peyratout, G., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Engelborghs, S., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Popp, J., Martinez-Lage, P., Bertram, L., Barkhof, F., Ashton, N., Blennow, K., Zetterberg, H., Streffer, J., Visser, P. J., Lovestone, S. & Legido-Quigley, C., 2019, In : Alzheimer's and Dementia. 15, 6, p. 817-827

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Serum Neurofilament light correlates with CADASIL disease severity and survival

Gravesteijn, G., Rutten, J. W., Verberk, I. M. W., Böhringer, S., Liem, M. K., van der Grond, J., Aartsma-Rus, A., Teunissen, C. E. & Lesnik Oberstein, S. A. J., 1 Jan 2019, In : Annals of Clinical and Translational Neurology. 6, 1, p. 46-56 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease—Data from three memory clinic studies

Hu, X., Teunissen, C. E., Spottke, A., Heneka, M. T., Düzel, E., Peters, O., Li, S., Priller, J., Buerger, K., Teipel, S., Laske, C., Verfaillie, S. C. J., Barkhof, F., Coll-Padrós, N., Rami, L., Molinuevo, J. L., van der Flier, W. M. & Jessen, F., Feb 2019, In : Alzheimers & Dementia. 15, 2, p. 185-193

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy

Chakraborty, A., Kamermans, A., van Het Hof, B., Castricum, K., Aanhane, E., van Horssen, J., Thijssen, V. L., Scheltens, P., Teunissen, C. E., Fontijn, R. D., van der Flier, W. M. & de Vries, H. E., 2018, In : Brain : a journal of neurology. 141, 12, p. 3377-3388 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid – method comparison and round robin study

Mollenhauer, B., Bowman, F. D., Drake, D., Duong, J., Blennow, K., el-Agnaf, O., Shaw, L. M., Masucci, J., Taylor, P., Umek, R. M., Dunty, J. M., Smith, C. L., Stoops, E., Vanderstichele, H., Schmid, A. W., Moniatte, M., Zhang, J., Kruse, N., Lashuel, H. A., Teunissen, C. & 4 othersSchubert, T., Dave, K. D., Hutten, S. J. & Zetterberg, H., 2018, In : Journal of Neurochemistry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Atrophy subtypes in prodromal Alzheimer's disease are associated with cognitive decline

ten Kate, M., Dicks, E., van der Flier, W. M., Teunissen, C. E., Barkhof, F., Scheltens, P., Tijms, B. M. & Alzheimer’s Disease Neuroimaging Initiative, 2018, In : Brain : a journal of neurology. 141, 12, p. 3443-3456 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

Leurs, C. E., Podlesniy, P., Trullas, R., Balk, L., Steenwijk, M. D., Malekzadeh, A., Piehl, F., Uitdehaag, B. M., Killestein, J., van Horssen, J. & Teunissen, C. E., 1 Apr 2018, In : Multiple Sclerosis. 24, 4, p. 472-480 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., Haller, T., Singh-Manoux, A., Verhoeven, A., Willemsen, G., de Leeuw, F. A., Wagner, H., van Dongen, J., Hertel, J., Budde, K., Willems van Dijk, K. & 28 othersWeinhold, L., Ikram, M. A., Pietzner, M., Perola, M., Wagner, M., Friedrich, N., Slagboom, P. E., Scheltens, P., Yang, Q., Gertzen, R. E., Egert, S., Li, S., Hankemeier, T., van Beijsterveldt, C. E. M., Vasan, R. S., Maier, W., Peeters, C. F. W., Jörgen Grabe, H., Ramirez, A., Seshadri, S., Metspalu, A., Kivimäki, M., Salomaa, V., Demirkan, A., Boomsma, D. I., van der Flier, W. M., Amin, N. & van Duijn, C. M., 1 Jun 2018, In : Alzheimer's and Dementia. 14, 6, p. 707-722 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease

Groot, C., Sudre, C. H., Barkhof, F., Teunissen, C. E., van Berckel, B. N. M., Seo, S. W., Ourselin, S., Scheltens, P., Cardoso, M. J., van der Flier, W. M. & Ossenkoppele, R., 13 Nov 2018, In : Neurology. 91, 20, p. e1851-e1859

Research output: Contribution to journalArticleAcademicpeer-review

CNS penetration of ART in HIV-infected children

van den Hof, M., Blokhuis, C., Cohen, S., Scherpbier, H. J., Wit, F. W. N. M., Pistorius, M. C. M., Kootstra, N. A., Teunissen, C. E., Mathot, R. A. A. & Pajkrt, D., 2018, In : The Journal of antimicrobial chemotherapy. 73, 2, p. 484-489

Research output: Contribution to journalArticleAcademicpeer-review

Computer-assisted prediction of clinical progression in the earliest stages of AD

Rhodius-Meester, H. F. M., Liedes, H., Koikkalainen, J., Wolfsgruber, S., Coll-Padros, N., Kornhuber, J., Peters, O., Jessen, F., Kleineidam, L., Molinuevo, J. L., Rami, L., Teunissen, C. E., Barkhof, F., Sikkes, S. A. M., Wesselman, L. M. P., Slot, R. E. R., Verfaillie, S. C. J., Scheltens, P., Tijms, B. M., Lötjönen, J. & 1 othersvan der Flier, W. M., 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 726-736

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease

Chatterjee, M., Del Campo, M., Morrema, T. H. J., de Waal, M., van der Flier, W. M., Hoozemans, J. J. M. & Teunissen, C. E., 1 Jun 2018, In : Alzheimer's Research & Therapy. 10, 1, p. 52

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Data-driven differential diagnosis of dementia using multiclass disease state index classifier

Tolonen, A., Rhodius-Meester, H. F. M., Bruun, M., Koikkalainen, J., Barkhof, F., Lemstra, A. W., Koene, T., Scheltens, P., Teunissen, C. E., Tong, T., Guerrero, R., Schuh, A., Ledig, C., Baroni, M., Rueckert, D., Soininen, H., Remes, A. M., Waldemar, G., Hasselbalch, S. G., Mecocci, P. & 2 othersvan der Flier, W. M. & Lötjönen, J., 25 Apr 2018, In : Frontiers in Aging Neuroscience. 10, APR, 111.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Disease-related determinants are associated with mortality in dementia due to Alzheimer's disease

Rhodius-Meester, H. F. M., Liedes, H., Koene, T., Lemstra, A. W., Teunissen, C. E., Barkhof, F., Scheltens, P., Van Gils, M., Lötjönen, J. & Van Der Flier, W. M., 20 Feb 2018, In : Alzheimer's Research and Therapy. 10, 1, 23.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

gMS-Classifier1 does not predict disability progression in multiple sclerosis

van Rossum, J. A., Killestein, J., Villar, L. M., Riskind, P. N., Freedman, M. S. & Teunissen, C., 2018, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Gray matter network measures are associated with cognitive decline in mild cognitive impairment

Dicks, E., Tijms, B. M., ten Kate, M., Gouw, A. A., Benedictus, M. R., Teunissen, C. E., Barkhof, F., Scheltens, P. & van der Flier, W. M., 1 Jan 2018, In : Neurobiology of Aging. 61, p. 198-206 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease

Scheltens, N. M. E., van der Weijden, K., Adriaanse, S. M., van Assema, D., Oomen, P. P., Krudop, W. A., Lammertsma, A. A., Barkhof, F., Koene, T., Teunissen, C. E., Scheltens, P., van der Flier, W. M., Pijnenburg, Y. A. L., Yaqub, M., Ossenkoppele, R. & van Berckel, B. N. M., 1 Jan 2018, In : NeuroImage: Clinical. 19, p. 625-632 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Interlaboratory proficiency processing scheme in CSF aliquoting: Implementation and assessment based on biomarkers of Alzheimer's disease

Lewczuk, P., Gaignaux, A., Kofanova, O., Ermann, N., Betsou, F., Brandner, S., Mroczko, B., Blennow, K., Strapagiel, D., Paciotti, S., Vogelgsang, J., Roehrl, M. H., Mendoza, S., Kornhuber, J. & Teunissen, C., 2018, In : Alzheimer's Research and Therapy. 10, 1, 87.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Interlaboratory validation of cerebrospinal fluid α-synuclein quantification in the diagnosis of sporadic Creutzfeldt-Jakob disease

Kruse, N., Heslegrave, A., Gupta, V., Foiani, M., Villar-Piqué, A., Schmitz, M., Lehmann, S., Teunissen, C., Blennow, K., Zetterberg, H., Mollenhauer, B., Zerr, I. & Llorens, F., 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 461-470

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neurogranin as cerebrospinal fluid biomarker for Alzheimer disease: An assay comparison study

Willemse, E. A. J., De Vos, A., Herries, E. M., Andreasson, U., Engelborghs, S., Van Der Flier, W. M., Scheltens, P., Crimmins, D., Ladenson, J. H., Vanmechelen, E., Zetterberg, H., Fagan, A. M., Blennow, K., Bjerke, M. & Teunissen, C. E., 1 Jun 2018, In : Clinical Chemistry. 64, 6, p. 927-937 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Novel CSF biomarkers to discriminate FTLD and its pathological subtypes

del Campo, M., Galimberti, D., Elias, N., Boonkamp, L., Pijnenburg, Y. A., van Swieten, J. C., Watts, K., Paciotti, S., Beccari, T., Hu, W. & Teunissen, C. E., 2018, In : Annals of Clinical and Translational Neurology. 5, 10, p. 1163-1175

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Oncolytic virotherapy in glioblastoma patients induces a tumor macrophage phenotypic shift leading to an altered glioblastoma microenvironment

van den Bossche, W. B. L., Kleijn, A., Teunissen, C. E., Voerman, J. S. A., Teodosio, C., Noske, D. P., van Dongen, J. J. M., Dirven, C. M. F. & Lamfers, M. L. M., 2018, In : Neuro-Oncology. 20, 11, p. 1494-1504

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Physical behavior is weakly associated with physical fatigue in persons with multiple sclerosis-related fatigue

TREFAMS-ACE study group, Blikman, L. J. M., Van Meeteren, J., Rizopoulos, D., De Groot, V., Beckerman, H., Stam, H. J. & Bussmann, J. B. J., 1 Oct 2018, In : Journal of Rehabilitation Medicine. 50, 9, p. 821-827 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Plasma Amyloid-β (Aβ42) Correlates with Cerebrospinal Fluid Aβ42 in Alzheimer's Disease

Teunissen, C. E., Chiu, M-J., Yang, C-C., Yang, S-Y., Scheltens, P., Zetterberg, H. & Blennow, K., 2018, In : Journal of Alzheimer's Disease. 62, 4, p. 1857-1863

Research output: Contribution to journalArticleAcademicpeer-review

Poly(GP), neurofilament and grey matter deficits in C9orf72 expansion carriers

Meeter, L. H. H., Gendron, T. F., Sias, A. C., Jiskoot, L. C., Russo, S. P., Donker Kaat, L., Papma, J. M., Panman, J. L., van der Ende, E. L., Dopper, E. G., Franzen, S., Graff, C., Boxer, A. L., Rosen, H. J., Sanchez-Valle, R., Galimberti, D., Pijnenburg, Y. A. L., Benussi, L., Ghidoni, R., Borroni, B. & 21 othersLaforce, R., del Campo, M., Teunissen, C. E., van Minkelen, R., Rojas, J. C., Coppola, G., Geschwind, D. H., Rademakers, R., Karydas, A. M., Öijerstedt, L., Scarpini, E., Binetti, G., Padovani, A., Cash, D. M., Dick, K. M., Bocchetta, M., Miller, B. L., Rohrer, J. D., Petrucelli, L., van Swieten, J. C. & Lee, S. E., 2018, In : Annals of Clinical and Translational Neurology. 5, 5, p. 583-597

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pre-amyloid stage of Alzheimer's disease in cognitively normal individuals

for ADNI, 1 Sep 2018, In : Annals of Clinical and Translational Neurology. 5, 9, p. 1037-1047 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access