Christiaan Vinkers

DR.MR., (Principal Investigator)


Research output per year

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Personal profile

Research interests

My overall research objective is to investigate the neurobiological background of stress resilience and vulnerability including (epi)genetic, neuroendocrine, and brain circuitry factors. I have obtained degrees in Pharmacy, Medicine and Law. My preclinical research during my  PhD training concerned the genetic and molecular basis of stress reactivity using pharmacological, genetic and molecular techniques. With over 15 peer-reviewed publications and several international collaborations, this led to a cum laude PhD thesis in 2009.  During my study of Pharmacy, subsequent PhD training, and my study of Medicine, I saw a great unmet need for effective treatment options in psychiatric patients which convinced me to start my psychiatry residencies. In daily practice, I diagnose and treat patients with psychiatric disorders (including depression, psychosis, and bipolar disorder) which directly links my fundamental research activities to a clinical setting.


It is my drive is to look for solutions in both fundamental preclinical and applied clinical research and promote the exchange of ideas between those two research approaches. My research has contributed how (traumatic) stress increases the risk for psychiatric disorders and helped to identify who is (not) at risk. I am currently leading epidemiological and experimental studies examining both genetic and neuroimaging parameters, to furtherdisentangle and integrate the biological and psychological determinants of stress resilience.

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Research Output

At-risk individuals display altered brain activity following stress

van Leeuwen, J. M. C., Vink, M., Fernández, G., Hermans, E. J., Joëls, M., Kahn, R. S. & Vinkers, C. H., Aug 2018, In : Neuropsychopharmacology. 43, 9, p. 1954-1960 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glucocorticoid receptor exon 1F methylation and the cortisol stress response in health and disease

Schür, R. R., van Leeuwen, J. M. C., Houtepen, L. C., Joëls, M., Kahn, R. S., Boks, M. P. & Vinkers, C. H., Nov 2018, In : Psychoneuroendocrinology. 97, p. 182-189 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans

Houtepen, L. C., Vinkers, C. H., Carrillo-Roa, T., Hiemstra, M., van Lier, P. A., Meeus, W., Branje, S., Heim, C. M., Nemeroff, C. B., Mill, J., Schalkwyk, L. C., Creyghton, M. P., Kahn, R. S., Joëls, M., Binder, E. B. & Boks, M. P. M., 21 Mar 2016, In : Nature Communications. 7, p. 10967

Research output: Contribution to journalArticleAcademicpeer-review

Early-life blockade of 5-HT(1A) receptors alters adult anxiety behavior and benzodiazepine sensitivity

Vinkers, C. H., Oosting, R. S., van Bogaert, M. J. V., Olivier, B. & Groenink, L., 15 Feb 2010, In : Biological Psychiatry. 67, 4, p. 309-16 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Increased responses of the reward circuitry to positive task feedback following acute stress in healthy controls but not in siblings of schizophrenia patients

van Leeuwen, J. M. C., Vink, M., Joëls, M., Kahn, R. S., Hermans, E. J. & Vinkers, C. H., 1 Jan 2019, In : NeuroImage. 184, p. 547-554 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Press / Media

KennisCafé: Depressie Dossier.

Brenda Penninx & CH Vinkers


1 item of Media coverage

Press/Media: Research

Burn-out ontbeert wetenschappelijke basis

Christiaan Vinkers


1 Media contribution

Press/Media: Public Engagement Activities