Coen Ottenheijm

PROF.DR., (Principal Investigator)

20052020
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Research Output 2005 2020

2020

KBTBD13 is an actin-binding protein that modulates muscle kinetics

de Winter, J. M., Molenaar, J. P., Yuen, M., van der Pijl, R., Shen, S., Conijn, S., van de Locht, M., Willigenburg, M., Bogaards, S. J. P., van Kleef, E. S., Lassche, S., Persson, M., Rassier, D. E., Sztal, T. E., Ruparelia, A. A., Oorschot, V., Ramm, G., Hall, T. E., Xiong, Z., Johnson, C. N. & 21 othersLi, F., Kiss, B., Lozano-Vidal, N., Boon, R. A., Marabita, M., Nogara, L., Blaauw, B., Rodenburg, R. J., Küsters, B., Doorduin, J., Beggs, A. H., Granzier, H., Campbell, K., Ma, W., Irving, T., Malfatti, E., Romero, N. B., Bryson-Richardson, R. J., van Engelen, B. G. M., Voermans, N. C. & Ottenheijm, C. A. C., 3 Feb 2020, In : Journal of Clinical Investigation. 130, 2, p. 754-767 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nebulin: big protein with big responsibilities

Yuen, M. & Ottenheijm, C. A. C., 25 Jan 2020, In : Journal of Muscle Research and Cell Motility.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Laitila, J. M., McNamara, E. L., Wingate, C. D., Goullee, H., Ross, J. A., Taylor, R. L., van der Pijl, R., Griffiths, L. M., Harries, R., Ravenscroft, G., Clayton, J. S., Sewry, C., Lawlor, M. W., Ottenheijm, C. A. C., Bakker, A. J., Ochala, J., Laing, N. G., Wallgren-Pettersson, C., Pelin, K. & Nowak, K. J., 17 Feb 2020, In : Acta neuropathologica communications. 8, 1, 18.

Research output: Contribution to journalArticleAcademicpeer-review

Preserved single muscle fiber specific force in facioscapulohumeral muscular dystrophy

Lassche, S., Voermans, N. C., van der Pijl, R., van den Berg, M., Heerschap, A., van Hees, H., Kusters, B., van der Maarel, S. M., Ottenheijm, C. A. C. & van Engelen, B. G. M., 21 Jan 2020, In : Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Diaphragm contractile weakness due to reduced mechanical loading: Role of titin

van der Pijl, R. J., Granzier, H. L. & Ottenheijm, C. A. C., 1 Aug 2019, In : American Journal of Physiology: Cell Physiology. 317, 2, p. C167-C176

Research output: Contribution to journalArticleAcademicpeer-review

Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation

Roesthuis, L., van der Hoeven, H., Sinderby, C., Frenzel, T., Ottenheijm, C., Brochard, L., Doorduin, J. & Heunks, L., Oct 2019, In : Intensive Care Medicine. 45, 10, p. 1372-1381 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

End-diastolic force pre-activates cardiomyocytes and determines contractile force: role of titin and calcium

Najafi, A., van de Locht, M., Schuldt, M., Schönleitner, P., van Willigenburg, M., Bollen, I., Goebel, M., Ottenheijm, C. A. C., van der Velden, J., Helmes, M. & Kuster, D. W. D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4521-4531

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Expiratory muscle dysfunction in critically ill patients: towards improved understanding

Shi, Z-H., Jonkman, A., de Vries, H., Jansen, D., Ottenheijm, C., Girbes, A., Spoelstra-de Man, A., Zhou, J-X., Brochard, L. & Heunks, L., 1 Aug 2019, In : Intensive Care Medicine. 45, 8, p. 1061-1071 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Late Breaking Abstract - Effects of levosimendan on diaphragm contractile efficiency in patients weaning from mechanical ventilation

Roesthuis, L., Van Der Hoeven, H., Sinderby, C., Frenzel, T., Ottenheijm, C., Brochard, L., Doorduin, J. & Heunks, L., 28 Sep 2019.

Research output: Contribution to conferencePaperAcademic

Mechanisms leading to muscle weakness in Nemaline myopathy

Joureau, B., 2019, 204 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

Muscle fiber dysfunction contributes to weakness in inclusion body myositis

Lassche, S., Rietveld, A., Heerschap, A., van Hees, H. W., Hopman, M. T. E., Voermans, N. C., Saris, C. G. J., van Engelen, B. G. M. & Ottenheijm, C. A. C., 1 Jun 2019, In : Neuromuscular Disorders. 29, 6, p. 468-476 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Muscle weakness in a S. pneumoniae sepsis mouse model

Witteveen, E., Wieske, L., Manders, E., Verhamme, C., Ottenheijm, C. A. C., Schultz, M. J., van Schaik, I. N. & Horn, J., Jan 2019, In : Annals of Translational Medicine. 7, 1, 9.

Research output: Contribution to journalArticleAcademicpeer-review

Recessive MYH7-related myopathy in two families

Beecroft, S. J., van de Locht, M., de Winter, J. M., Ottenheijm, C. A., Sewry, C. A., Mohammed, S., Ryan, M. M., Woodcock, I. R., Sanders, L., Gooding, R., Davis, M. R., Oates, E. C., Laing, N. G., Ravenscroft, G., McLean, C. A. & Jungbluth, H., 1 Jun 2019, In : Neuromuscular Disorders. 29, 6, p. 456-467 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength

Greising, S. M., Ottenheijm, C. A. C., O’Halloran, K. D. & Barreiro, E., 1 Aug 2018, In : Journal of Applied Physiology. 125, 2, p. 243-253 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Diaphragm Protective Mechanical Ventilation to Improve Outcome in ICU Patients?

Heunks, L. & Ottenheijm, C., 15 Jan 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 1, p. 150-152

Research output: Contribution to journalEditorialAcademicpeer-review

Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

Brynnel, A., Hernandez, Y., Kiss, B., Lindqvist, J., Adler, M., Kolb, J., van der Pijl, R., Gohlke, J., Strom, J., Smith, J., Ottenheijm, C. & Granzier, H. L., 19 Dec 2018, In : eLife. 7, e40532.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3)

Joureau, B., de Winter, J. M., Conijn, S., Bogaards, S. J. P., Kovacevic, I., Kalganov, A., Persson, M., Lindqvist, J., Stienen, G. J. M., Irving, T. C., Ma, W., Yuen, M., Clarke, N. F., Rassier, D. E., Malfatti, E., Romero, N. B., Beggs, A. H. & Ottenheijm, C. A. C., 1 Feb 2018, In : Annals of Neurology. 83, 2, p. 269-282 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

Lindqvist, J., van den Berg, M., van der Pijl, R., Hooijman, P. E., Beishuizen, A., Elshof, J., de Waard, M., Girbes, A., Spoelstra-de Man, A., Shi, Z-H., van den Brom, C., Bogaards, S., Shen, S., Strom, J., Granzier, H., Kole, J., Musters, R. J. P., Paul, M. A., Heunks, L. M. A. & Ottenheijm, C. A. C., 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. 472-485 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Titin-based mechanosensing modulates muscle hypertrophy

van der Pijl, R., Strom, J., Conijn, S., Lindqvist, J., Labeit, S., Granzier, H. & Ottenheijm, C. A. C., 2018, In : Journal of Cachexia, Sarcopenia and Muscle. 9, 5, p. 947-961 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill

van den Berg, M., Hooijman, P. E., Beishuizen, A., de Waard, M. C., Paul, M. A., Hartemink, K. J., van Hees, H. W. H., Lawlor, M. W., Brocca, L., Bottinelli, R., Pellegrino, M. A., Stienen, G. J. M., Heunks, L. M. A., Wüst, R. C. I. & Ottenheijm, C. A., 15 Dec 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 12, p. 1544-1558 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy

Joureau, B., de Winter, J. M., Stam, K., Granzier, H. & Ottenheijm, C. A. C., Jan 2017, In : Neuromuscular Disorders. 27, 1, p. 83-89 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nemaline myopathy: pathophysiology and therapeutic targets

de Winter, JM., 2017, 232 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

Sarcomere Dysfunction in Nemaline Myopathy

de Winter, J. M. & Ottenheijm, C. A. C., 2017, In : Neuromuscular Disorders. 4, 2, p. 99-113 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

Mutation-Specific Effects on Thin Filament Length in Thin Filament Myopathy

de Winter, J. M., Joureau, B., Lee, E-J., Kiss, B., Yuen, M., Gupta, V. A., Pappas, C. T., Gregorio, C. C., Stienen, G. J. M., Edvardson, S., Wallgren-Pettersson, C., Lehtokari, V-L., Pelin, K., Malfatti, E., Romero, N. B., van Engelen, B. G., Voermans, N. C., Donkervoort, S., Bonnemann, C. G., Clarke, N. F. & 3 othersBeggs, A. H., Granzier, H. & Ottenheijm, C. A. C., Jun 2016, In : Annals of Neurology. 79, 6, p. 959-969

Research output: Contribution to journalArticleAcademicpeer-review

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension

Manders, E., Bonta, P. I., Kloek, J. J., Symersky, P., Bogaard, H-J., Hooijman, P. E., Jasper, J. R., Malik, F. I., Stienen, G., Vonk-Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 1 Jul 2016, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 311, 1, p. L20-L28

Research output: Contribution to journalArticleAcademicpeer-review

Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension Relative Contribution of Fibrosis and Myofibril Stiffness

Rain, S., Andersen, S., Najafi, A., Schultz, J. G., Bos, D. D. S. G., Handoko, M. L., Bogaard, H-J., Vonk-Noordegraaf, A., Andersen, A., van der Velden, J., Ottenheijm, C. A. C. & de Man, F. S., Jul 2016, In : Circulation. Heart failure. 9, 7, e002636.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

Hooijman, P. E., Beishuizen, A., Witt, C. C., de Waard, M. C., Girbes, A. R. J., Spoelstra-de Man, A. M. E., Niessen, H. W., Manders, E., van Hees, H. W. H., van den Brom, C. E., Silderhuis, V., Lawlor, M. W., Labeit, S., Stienen, G. J. M., Hartemink, K. J., Paul, M. A., Heunks, L. M. A. & Ottenheijm, C. A. C., 15 May 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 10, p. 1126-1138 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

37 Downloads (Pure)

Diaphragm muscle fiber weakness in mechanically ventilated patients

Hooijman, P. E., 2015

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene

de Winter, J. M., Joureau, B., Sequeira Oliveira, V., Clarke, N. F., van der Velden, J., Stienen, G. J. M., Granzier, H., Beggs, A. H. & Ottenheijm, C. A. C., 2015, In : Skeletal Muscle. 5, 12.

Research output: Contribution to journalArticleAcademicpeer-review

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy: corrigendum

Yuen, M., Sandaradura, S. A., Dowling, J. J., Kostyukova, A. S., Moroz, N., Quinlan, K. G., Lehtokari, V-L., Ravenscroft, G., Todd, E. J., Ceyhan-Birsoy, O., Gokhin, D. S., Maluenda, J., Lek, M., Nolent, F., Pappas, C. T., Novak, S. M., D'Amico, A., Malfatti, E., Thomas, B. P., Gabriel, S. B. & 37 othersGupta, N., Daly, M. J., Ilkovski, B., Houweling, P. J., Davidson, A. E., Swanson, L. C., Brownstein, C. A., Gupta, V. A., Medne, L., Shannon, P., Martin, N., Bick, D. P., Flisberg, A., Holmberg, E., Van den Bergh, P., Lapunzina, P., Waddell, L. B., Sloboda, D. D., Bertini, E., Chitayat, D., Telfer, W. R., Laquerrière, A., Gregorio, C. C., Ottenheijm, C. A. C., Bönnemann, C. G., Pelin, K., Beggs, A. H., Hayashi, Y. K., Romero, N. B., Laing, N. G., Nishino, I., Wallgren-Pettersson, C., Melki, J., Fowler, V. M., MacArthur, D. G., North, K. N. & Clarke, N. F., Jan 2015, In : Journal of Clinical Investigation. 125, 1, p. 456-7 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Muscle weakness in TPM3-myopathy is due to reduced Ca2+-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres

Yuen, M., Cooper, S. T., Marston, S. B., Nowak, K. J., McNamara, E., Mokbel, N., Ilkovski, B., Ravenscroft, G., Rendu, J., de Winter, J. M., Klinge, L., Beggs, A. H., North, K. N., Ottenheijm, C. A. C. & Clarke, N. F., 2015, In : Human Molecular Genetics. 24, 22, p. 6278-6292

Research output: Contribution to journalArticleAcademicpeer-review

Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy

Li, F., Buck, D., de Winter, J. M., Kolb, J., Meng, H., Birch, C., Slater, R., Escobar, Y. N., Smith, J. E., Yang, L., Konhilas, J., Lawlor, M. W., Ottenheijm, C. A. C. & Granzier, H. L., 2015, In : Human Molecular Genetics. 24, 18, p. 5219-5233

Research output: Contribution to journalArticleAcademicpeer-review

Quadriceps muscle fibre dysfunction in patients with pulmonary arterial hypertension

Manders, E., Ruiter, G., Bogaard, H. J., Stienen, G. J. M., Vonk Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 2015, In : European Respiratory Journal. 45, 6, p. 1737-1740

Research output: Contribution to journalArticleAcademicpeer-review

160 Downloads (Pure)

Striated muscle dysfunction in Pulmonary Arterial Hypertension

Manders, E., 2015

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

The striated muscles in pulmonary arterial hypertension: adaptations beyond the right ventricle

Manders, E., Rain, S., Bogaard, H. J., Handoko, M. L., Stienen, G. J. M., Vonk Noordegraaf, A., Ottenheijm, C. A. C. & de Man, F. S., 2015, In : European Respiratory Journal. 46, 3, p. 832-842

Research output: Contribution to journalArticleAcademicpeer-review

TPM3 Deletions Cause a Hypercontractile Congenital Muscle Stiffness Phenotype

Donkervoort, S., Papadaki, M., de Winter, J. M., Neu, M. B., Kirschner, J., Bolduc, V., Yang, M. L., Gibbons, M. A., Hu, Y., Dastgir, J., Leach, M. E., Rutkowski, A., Foley, A., Krueger, M., Wartchow, E. P., McNamara, E., Ong, R., Nowak, K. J., Laing, N. G., Clarke, N. F. & 3 othersOttenheijm, C. A. C., Marston, S. B. & Boennemann, C. G., 2015, In : Annals of Neurology. 78, 6, p. 982-994

Research output: Contribution to journalArticleAcademicpeer-review

2014

Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy

Gineste, C., Ottenheijm, C. A. C., Le Fur, Y., Banzet, S., Pecchi, E., Vilmen, C., Cozzone, P. J., Koulmann, N., Hardeman, E. C., Bendahan, D. & Gondin, J., 2014, In : PLoS ONE. 9, 9, e109066.

Research output: Contribution to journalArticleAcademicpeer-review

Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension

Manders, E., Bogaard, H. J., Handoko, M. L., van de Veerdonk, M. C., Keogh, A., Westerhof, N., Stienen, G. J. M., dos Remedios, C. G., Humbert, M., Dorfmuller, P., Fadel, E., Guignabert, C., van der Velden, J., Vonk-Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 2014, In : Journal of the American College of Cardiology. 64, 1, p. 28-37

Research output: Contribution to journalArticleAcademicpeer-review

Diaphragm Fiber Strength Is Reduced in Critically III Patients and Restored by a Troponin Activator

Hooijman, P. E., Beishuizen, A., de Waard, M. C., de Man, F. S., Vermeijden, J. W., Steenvoorde, P., Bouwman, R. A., Lommen, W., van Hees, H. W. H., Heunks, L. M. A., Dickhoff, C., van der Peet, D. L., Girbes, A. R. J., Jasper, J. R., Malik, F. I., Stienen, G. J. M., Hartemink, K. J., Paul, M. A. & Ottenheijm, C. A. C., 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 7, p. 863-865

Research output: Contribution to journalArticleAcademicpeer-review

Diaphragm fiber strength is reduced in critically Ill patients and restored by a troponin activator

Hooijman, P. E., Beishuizen, A., De Waard, M. C., De Man, F. S., Vermeijden, J. W., Steenvoorde, P., Bouwman, R. A., Lommen, W., Van Hees, H. W. H., Heunks, L. M. A., Dickhoff, C., Van Der Peet, D. L., Girbes, A. R. J., Jasper, J. R., Malik, F. I., Stienen, G. J. M., Hartemink, K. J., Paul, M. A. & Ottenheijm, C. A. C., 1 Apr 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 7, p. 863-865 3 p.

Research output: Contribution to journalLetterAcademicpeer-review

Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole

Methawasin, M., Hutchinson, K. R., Lee, E. J., Smith, J. E., Saripalli, C., Hidalgo, C. G., Ottenheijm, C. A. C. & Granzier, H., 2014, In : Circulation. 129, 19, p. 1924-1936

Research output: Contribution to journalArticleAcademicpeer-review

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy

Yuen, M., Sandaradura, S. A., Dowling, J. J., Kostyukova, A. S., Moroz, N., Quinlan, K. G., Lehtokari, V. L., Ravenscroft, G., Todd, E. J., Ceyhan-Birsoy, O., Gokhin, D. S., Maluenda, J., Lek, M., Nolent, F., Pappas, C. T., Novak, S. M., D'Amico, A., Malfatti, E., Thomas, B. P., Gabriel, S. B. & 37 othersGupta, N., Daly, M. J., Ilkovski, B., Houweling, P. J., Davidson, A. E., Swanson, L. C., Brownstein, C. A., Gupta, V. A., Medne, L., Shannon, P., Martin, N., Bick, D. P., Flisberg, A., Holmberg, E., van den Bergh, P., Lapunzina, P., Waddell, L. B., Sioboda, D. D., Bertini, E., Chitayat, D., Telfer, W. R., Laquerriere, A., Gregorio, C. C., Ottenheijm, C. A. C., Bonnemann, C. G., Pelin, K., Beggs, A. H., Hayashi, Y. K., Romero, N. B., Laing, N. G., Nishino, I., Wallgren-Pettersson, C., Melki, J., Fowler, V. M., MacArthur, D. G., North, K. N. & Clarke, N. F., 2014, In : Journal of Clinical Investigation. 124, 11, p. 4693-4708

Research output: Contribution to journalArticleAcademicpeer-review

Mitochondrial Respiration and Passive Stretch of the Diaphragm During Unilateral Phrenic Nerve Stimulation

Hooijman, P. E. & Ottenheijm, C. A. C., 2014, In : Critical Care Medicine. 42, 9, p. E633-E634

Research output: Contribution to journalArticleAcademicpeer-review

Muscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype

Malfatti, E., Lehtokari, V. L., Bohm, J., de Winter, J. M., Schaffer, U., Estournet, B., Quijano-Roy, S., Monges, S., Lubieniecki, F., Bellance, R., Viou, M. T., Madelaine, A., Wu, B., Taratuto, A. L., Eymard, B., Pelin, K., Fardeau, M., Ottenheijm, C. A. C., Wallgren-Pettersson, C., Laporte, J. & 1 othersRomero, N. B., 2014, In : Acta Neuropathologica Communinications. 2, a44.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle physiology: move to translation

Ottenheijm, C. A. C., Jaspers, R. T., Wüst, R. C. I. & van der Velden, J., 2014, In : Journal of Muscle Research and Cell Motility. 35, 1, p. 1-2 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Passive stretch of the diaphragm following unilateral phrenic nerve stimulation

Hooijman, P. E. & Ottenheijm, C. A. C., 2014, In : European Respiratory Journal. 43, 5, p. 1533-1534

Research output: Contribution to journalArticleAcademicpeer-review

Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension

Rain, S., da Silva Goncalves Bos, D., Handoko, M. L., Westerhof, N., Stienen, G. J. M., Ottenheijm, C. A. C., Goebel, M., Dorfmuller, P., Guignabert, C., Humbert, M., Bogaard, H. J., dos Remedios, C., Saripalli, C., Hidalgo, C. G., Granzier, H. L., Vonk-Noordegraaf, A., van der Velden, J. & de Man, F. S., 2014, In : Journal of American Heart Association. 3, 3, e000716.

Research output: Contribution to journalArticleAcademicpeer-review

Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation

Hooijman, P. E., Paul, M. A., Stienen, G. J. M., Beishuizen, A., van Hees, H. W. H., Singhal, S., Bashir, M., Budak, M. T., Morgen, J., Barsotti, R. J., Levine, S. & Ottenheijm, C. A. C., 2014, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 307, 6, p. L460-L470

Research output: Contribution to journalArticleAcademicpeer-review

2013

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

Ottenheijm, C. A. C., Buck, D., de Winter, J. M., Ferrara, C., Piroddi, N., Tesi, C., Jasper, J. R., Malik, F. I., Meng, H., Stienen, G. J. M., Beggs, A. H., Labeit, S., Poggesi, C., Lawlor, M. W. & Granzier, H., 2013, In : Brain. 136, p. 1718-1731

Research output: Contribution to journalArticleAcademicpeer-review