Coen Ottenheijm

PROF.DR., (Principal Investigator)

20052020
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Research Output 2005 2020

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Article
2020

KBTBD13 is an actin-binding protein that modulates muscle kinetics

de Winter, J. M., Molenaar, J. P., Yuen, M., van der Pijl, R., Shen, S., Conijn, S., van de Locht, M., Willigenburg, M., Bogaards, S. J. P., van Kleef, E. S., Lassche, S., Persson, M., Rassier, D. E., Sztal, T. E., Ruparelia, A. A., Oorschot, V., Ramm, G., Hall, T. E., Xiong, Z., Johnson, C. N. & 21 othersLi, F., Kiss, B., Lozano-Vidal, N., Boon, R. A., Marabita, M., Nogara, L., Blaauw, B., Rodenburg, R. J., Küsters, B., Doorduin, J., Beggs, A. H., Granzier, H., Campbell, K., Ma, W., Irving, T., Malfatti, E., Romero, N. B., Bryson-Richardson, R. J., van Engelen, B. G. M., Voermans, N. C. & Ottenheijm, C. A. C., 3 Feb 2020, In : Journal of Clinical Investigation. 130, 2, p. 754-767 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nebulin: big protein with big responsibilities

Yuen, M. & Ottenheijm, C. A. C., 25 Jan 2020, In : Journal of Muscle Research and Cell Motility.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Laitila, J. M., McNamara, E. L., Wingate, C. D., Goullee, H., Ross, J. A., Taylor, R. L., van der Pijl, R., Griffiths, L. M., Harries, R., Ravenscroft, G., Clayton, J. S., Sewry, C., Lawlor, M. W., Ottenheijm, C. A. C., Bakker, A. J., Ochala, J., Laing, N. G., Wallgren-Pettersson, C., Pelin, K. & Nowak, K. J., 17 Feb 2020, In : Acta neuropathologica communications. 8, 1, 18.

Research output: Contribution to journalArticleAcademicpeer-review

Preserved single muscle fiber specific force in facioscapulohumeral muscular dystrophy

Lassche, S., Voermans, N. C., van der Pijl, R., van den Berg, M., Heerschap, A., van Hees, H., Kusters, B., van der Maarel, S. M., Ottenheijm, C. A. C. & van Engelen, B. G. M., 21 Jan 2020, In : Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Diaphragm contractile weakness due to reduced mechanical loading: Role of titin

van der Pijl, R. J., Granzier, H. L. & Ottenheijm, C. A. C., 1 Aug 2019, In : American Journal of Physiology: Cell Physiology. 317, 2, p. C167-C176

Research output: Contribution to journalArticleAcademicpeer-review

Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation

Roesthuis, L., van der Hoeven, H., Sinderby, C., Frenzel, T., Ottenheijm, C., Brochard, L., Doorduin, J. & Heunks, L., Oct 2019, In : Intensive Care Medicine. 45, 10, p. 1372-1381 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

End-diastolic force pre-activates cardiomyocytes and determines contractile force: role of titin and calcium

Najafi, A., van de Locht, M., Schuldt, M., Schönleitner, P., van Willigenburg, M., Bollen, I., Goebel, M., Ottenheijm, C. A. C., van der Velden, J., Helmes, M. & Kuster, D. W. D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4521-4531

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Muscle fiber dysfunction contributes to weakness in inclusion body myositis

Lassche, S., Rietveld, A., Heerschap, A., van Hees, H. W., Hopman, M. T. E., Voermans, N. C., Saris, C. G. J., van Engelen, B. G. M. & Ottenheijm, C. A. C., 1 Jun 2019, In : Neuromuscular Disorders. 29, 6, p. 468-476 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Muscle weakness in a S. pneumoniae sepsis mouse model

Witteveen, E., Wieske, L., Manders, E., Verhamme, C., Ottenheijm, C. A. C., Schultz, M. J., van Schaik, I. N. & Horn, J., Jan 2019, In : Annals of Translational Medicine. 7, 1, 9.

Research output: Contribution to journalArticleAcademicpeer-review

Recessive MYH7-related myopathy in two families

Beecroft, S. J., van de Locht, M., de Winter, J. M., Ottenheijm, C. A., Sewry, C. A., Mohammed, S., Ryan, M. M., Woodcock, I. R., Sanders, L., Gooding, R., Davis, M. R., Oates, E. C., Laing, N. G., Ravenscroft, G., McLean, C. A. & Jungbluth, H., 1 Jun 2019, In : Neuromuscular Disorders. 29, 6, p. 456-467 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

Brynnel, A., Hernandez, Y., Kiss, B., Lindqvist, J., Adler, M., Kolb, J., van der Pijl, R., Gohlke, J., Strom, J., Smith, J., Ottenheijm, C. & Granzier, H. L., 19 Dec 2018, In : eLife. 7, e40532.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3)

Joureau, B., de Winter, J. M., Conijn, S., Bogaards, S. J. P., Kovacevic, I., Kalganov, A., Persson, M., Lindqvist, J., Stienen, G. J. M., Irving, T. C., Ma, W., Yuen, M., Clarke, N. F., Rassier, D. E., Malfatti, E., Romero, N. B., Beggs, A. H. & Ottenheijm, C. A. C., 1 Feb 2018, In : Annals of Neurology. 83, 2, p. 269-282 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

Lindqvist, J., van den Berg, M., van der Pijl, R., Hooijman, P. E., Beishuizen, A., Elshof, J., de Waard, M., Girbes, A., Spoelstra-de Man, A., Shi, Z-H., van den Brom, C., Bogaards, S., Shen, S., Strom, J., Granzier, H., Kole, J., Musters, R. J. P., Paul, M. A., Heunks, L. M. A. & Ottenheijm, C. A. C., 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. 472-485 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Titin-based mechanosensing modulates muscle hypertrophy

van der Pijl, R., Strom, J., Conijn, S., Lindqvist, J., Labeit, S., Granzier, H. & Ottenheijm, C. A. C., 2018, In : Journal of Cachexia, Sarcopenia and Muscle. 9, 5, p. 947-961 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill

van den Berg, M., Hooijman, P. E., Beishuizen, A., de Waard, M. C., Paul, M. A., Hartemink, K. J., van Hees, H. W. H., Lawlor, M. W., Brocca, L., Bottinelli, R., Pellegrino, M. A., Stienen, G. J. M., Heunks, L. M. A., Wüst, R. C. I. & Ottenheijm, C. A., 15 Dec 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 12, p. 1544-1558 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy

Joureau, B., de Winter, J. M., Stam, K., Granzier, H. & Ottenheijm, C. A. C., Jan 2017, In : Neuromuscular Disorders. 27, 1, p. 83-89 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Mutation-Specific Effects on Thin Filament Length in Thin Filament Myopathy

de Winter, J. M., Joureau, B., Lee, E-J., Kiss, B., Yuen, M., Gupta, V. A., Pappas, C. T., Gregorio, C. C., Stienen, G. J. M., Edvardson, S., Wallgren-Pettersson, C., Lehtokari, V-L., Pelin, K., Malfatti, E., Romero, N. B., van Engelen, B. G., Voermans, N. C., Donkervoort, S., Bonnemann, C. G., Clarke, N. F. & 3 othersBeggs, A. H., Granzier, H. & Ottenheijm, C. A. C., Jun 2016, In : Annals of Neurology. 79, 6, p. 959-969

Research output: Contribution to journalArticleAcademicpeer-review

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension

Manders, E., Bonta, P. I., Kloek, J. J., Symersky, P., Bogaard, H-J., Hooijman, P. E., Jasper, J. R., Malik, F. I., Stienen, G., Vonk-Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 1 Jul 2016, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 311, 1, p. L20-L28

Research output: Contribution to journalArticleAcademicpeer-review

Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension Relative Contribution of Fibrosis and Myofibril Stiffness

Rain, S., Andersen, S., Najafi, A., Schultz, J. G., Bos, D. D. S. G., Handoko, M. L., Bogaard, H-J., Vonk-Noordegraaf, A., Andersen, A., van der Velden, J., Ottenheijm, C. A. C. & de Man, F. S., Jul 2016, In : Circulation. Heart failure. 9, 7, e002636.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

Hooijman, P. E., Beishuizen, A., Witt, C. C., de Waard, M. C., Girbes, A. R. J., Spoelstra-de Man, A. M. E., Niessen, H. W., Manders, E., van Hees, H. W. H., van den Brom, C. E., Silderhuis, V., Lawlor, M. W., Labeit, S., Stienen, G. J. M., Hartemink, K. J., Paul, M. A., Heunks, L. M. A. & Ottenheijm, C. A. C., 15 May 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 10, p. 1126-1138 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene

de Winter, J. M., Joureau, B., Sequeira Oliveira, V., Clarke, N. F., van der Velden, J., Stienen, G. J. M., Granzier, H., Beggs, A. H. & Ottenheijm, C. A. C., 2015, In : Skeletal Muscle. 5, 12.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle weakness in TPM3-myopathy is due to reduced Ca2+-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres

Yuen, M., Cooper, S. T., Marston, S. B., Nowak, K. J., McNamara, E., Mokbel, N., Ilkovski, B., Ravenscroft, G., Rendu, J., de Winter, J. M., Klinge, L., Beggs, A. H., North, K. N., Ottenheijm, C. A. C. & Clarke, N. F., 2015, In : Human Molecular Genetics. 24, 22, p. 6278-6292

Research output: Contribution to journalArticleAcademicpeer-review

Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy

Li, F., Buck, D., de Winter, J. M., Kolb, J., Meng, H., Birch, C., Slater, R., Escobar, Y. N., Smith, J. E., Yang, L., Konhilas, J., Lawlor, M. W., Ottenheijm, C. A. C. & Granzier, H. L., 2015, In : Human Molecular Genetics. 24, 18, p. 5219-5233

Research output: Contribution to journalArticleAcademicpeer-review

Quadriceps muscle fibre dysfunction in patients with pulmonary arterial hypertension

Manders, E., Ruiter, G., Bogaard, H. J., Stienen, G. J. M., Vonk Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 2015, In : European Respiratory Journal. 45, 6, p. 1737-1740

Research output: Contribution to journalArticleAcademicpeer-review

The striated muscles in pulmonary arterial hypertension: adaptations beyond the right ventricle

Manders, E., Rain, S., Bogaard, H. J., Handoko, M. L., Stienen, G. J. M., Vonk Noordegraaf, A., Ottenheijm, C. A. C. & de Man, F. S., 2015, In : European Respiratory Journal. 46, 3, p. 832-842

Research output: Contribution to journalArticleAcademicpeer-review

TPM3 Deletions Cause a Hypercontractile Congenital Muscle Stiffness Phenotype

Donkervoort, S., Papadaki, M., de Winter, J. M., Neu, M. B., Kirschner, J., Bolduc, V., Yang, M. L., Gibbons, M. A., Hu, Y., Dastgir, J., Leach, M. E., Rutkowski, A., Foley, A., Krueger, M., Wartchow, E. P., McNamara, E., Ong, R., Nowak, K. J., Laing, N. G., Clarke, N. F. & 3 othersOttenheijm, C. A. C., Marston, S. B. & Boennemann, C. G., 2015, In : Annals of Neurology. 78, 6, p. 982-994

Research output: Contribution to journalArticleAcademicpeer-review

2014

Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy

Gineste, C., Ottenheijm, C. A. C., Le Fur, Y., Banzet, S., Pecchi, E., Vilmen, C., Cozzone, P. J., Koulmann, N., Hardeman, E. C., Bendahan, D. & Gondin, J., 2014, In : PLoS ONE. 9, 9, e109066.

Research output: Contribution to journalArticleAcademicpeer-review

Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension

Manders, E., Bogaard, H. J., Handoko, M. L., van de Veerdonk, M. C., Keogh, A., Westerhof, N., Stienen, G. J. M., dos Remedios, C. G., Humbert, M., Dorfmuller, P., Fadel, E., Guignabert, C., van der Velden, J., Vonk-Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 2014, In : Journal of the American College of Cardiology. 64, 1, p. 28-37

Research output: Contribution to journalArticleAcademicpeer-review

Diaphragm Fiber Strength Is Reduced in Critically III Patients and Restored by a Troponin Activator

Hooijman, P. E., Beishuizen, A., de Waard, M. C., de Man, F. S., Vermeijden, J. W., Steenvoorde, P., Bouwman, R. A., Lommen, W., van Hees, H. W. H., Heunks, L. M. A., Dickhoff, C., van der Peet, D. L., Girbes, A. R. J., Jasper, J. R., Malik, F. I., Stienen, G. J. M., Hartemink, K. J., Paul, M. A. & Ottenheijm, C. A. C., 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 7, p. 863-865

Research output: Contribution to journalArticleAcademicpeer-review

Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole

Methawasin, M., Hutchinson, K. R., Lee, E. J., Smith, J. E., Saripalli, C., Hidalgo, C. G., Ottenheijm, C. A. C. & Granzier, H., 2014, In : Circulation. 129, 19, p. 1924-1936

Research output: Contribution to journalArticleAcademicpeer-review

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy

Yuen, M., Sandaradura, S. A., Dowling, J. J., Kostyukova, A. S., Moroz, N., Quinlan, K. G., Lehtokari, V. L., Ravenscroft, G., Todd, E. J., Ceyhan-Birsoy, O., Gokhin, D. S., Maluenda, J., Lek, M., Nolent, F., Pappas, C. T., Novak, S. M., D'Amico, A., Malfatti, E., Thomas, B. P., Gabriel, S. B. & 37 othersGupta, N., Daly, M. J., Ilkovski, B., Houweling, P. J., Davidson, A. E., Swanson, L. C., Brownstein, C. A., Gupta, V. A., Medne, L., Shannon, P., Martin, N., Bick, D. P., Flisberg, A., Holmberg, E., van den Bergh, P., Lapunzina, P., Waddell, L. B., Sioboda, D. D., Bertini, E., Chitayat, D., Telfer, W. R., Laquerriere, A., Gregorio, C. C., Ottenheijm, C. A. C., Bonnemann, C. G., Pelin, K., Beggs, A. H., Hayashi, Y. K., Romero, N. B., Laing, N. G., Nishino, I., Wallgren-Pettersson, C., Melki, J., Fowler, V. M., MacArthur, D. G., North, K. N. & Clarke, N. F., 2014, In : Journal of Clinical Investigation. 124, 11, p. 4693-4708

Research output: Contribution to journalArticleAcademicpeer-review

Mitochondrial Respiration and Passive Stretch of the Diaphragm During Unilateral Phrenic Nerve Stimulation

Hooijman, P. E. & Ottenheijm, C. A. C., 2014, In : Critical Care Medicine. 42, 9, p. E633-E634

Research output: Contribution to journalArticleAcademicpeer-review

Muscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype

Malfatti, E., Lehtokari, V. L., Bohm, J., de Winter, J. M., Schaffer, U., Estournet, B., Quijano-Roy, S., Monges, S., Lubieniecki, F., Bellance, R., Viou, M. T., Madelaine, A., Wu, B., Taratuto, A. L., Eymard, B., Pelin, K., Fardeau, M., Ottenheijm, C. A. C., Wallgren-Pettersson, C., Laporte, J. & 1 othersRomero, N. B., 2014, In : Acta Neuropathologica Communinications. 2, a44.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle physiology: move to translation

Ottenheijm, C. A. C., Jaspers, R. T., Wüst, R. C. I. & van der Velden, J., 2014, In : Journal of Muscle Research and Cell Motility. 35, 1, p. 1-2 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Passive stretch of the diaphragm following unilateral phrenic nerve stimulation

Hooijman, P. E. & Ottenheijm, C. A. C., 2014, In : European Respiratory Journal. 43, 5, p. 1533-1534

Research output: Contribution to journalArticleAcademicpeer-review

Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension

Rain, S., da Silva Goncalves Bos, D., Handoko, M. L., Westerhof, N., Stienen, G. J. M., Ottenheijm, C. A. C., Goebel, M., Dorfmuller, P., Guignabert, C., Humbert, M., Bogaard, H. J., dos Remedios, C., Saripalli, C., Hidalgo, C. G., Granzier, H. L., Vonk-Noordegraaf, A., van der Velden, J. & de Man, F. S., 2014, In : Journal of American Heart Association. 3, 3, e000716.

Research output: Contribution to journalArticleAcademicpeer-review

Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation

Hooijman, P. E., Paul, M. A., Stienen, G. J. M., Beishuizen, A., van Hees, H. W. H., Singhal, S., Bashir, M., Budak, M. T., Morgen, J., Barsotti, R. J., Levine, S. & Ottenheijm, C. A. C., 2014, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 307, 6, p. L460-L470

Research output: Contribution to journalArticleAcademicpeer-review

2013

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

Ottenheijm, C. A. C., Buck, D., de Winter, J. M., Ferrara, C., Piroddi, N., Tesi, C., Jasper, J. R., Malik, F. I., Meng, H., Stienen, G. J. M., Beggs, A. H., Labeit, S., Poggesi, C., Lawlor, M. W. & Granzier, H., 2013, In : Brain. 136, p. 1718-1731

Research output: Contribution to journalArticleAcademicpeer-review

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol

Lassche, S., Ottenheijm, C. A. C., Voermans, N. C., Westeneng, H. J., Janssen, B. H., van der Maarel, S. M., Hopman, M. T., Padberg, G. W., Stienen, G. J. M. & van Engelen, B. G. M., 2013, In : BMC Neurology. 13, 144.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of diaphragm plication on pulmonary function and cardiopulmonary exercise parameters

Welvaart, W. N., Jak, P. M. C., van de Veerdonk, M. C., Marcus, J. T., Ottenheijm, C. A. C., Paul, M. A. & Vonk-Noordegraaf, A., 2013, In : European Journal of Cardio-thoracic Surgery. 44, 4, p. 643-647

Research output: Contribution to journalArticleAcademicpeer-review

Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency

Lee, E. J., de Winter, J. M., Buck, D., Jasper, J. R., Malik, F. I., Labeit, S., Ottenheijm, C. A. C. & Granzier, H., 2013, In : PLoS ONE. 8, 2, e55861.

Research output: Contribution to journalArticleAcademicpeer-review

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype

Gineste, C., de Winter, J. M., Kohl, C., Witt, C. C., Giannesini, B., Brohm, K., Le Fur, Y., Gretz, N., Vilmen, C., Pecchi, E., Jubeau, M., Cozzone, P. J., Stienen, G. J. M., Granzier, H., Labeit, S., Ottenheijm, C. A. C., Bendahan, D. & Gondin, J., 2013, In : Neuromuscular Disorders. 23, 4, p. 357-369

Research output: Contribution to journalArticleAcademicpeer-review

K7del is a common TPM2 gene mutation associated with nemaline myopathy and raised myofibre calcium sensitivity

Mokbel, N., Ilkovski, B., Kreissl, M., Memo, M., Jeffries, C. M., Marttila, M., Lehtokari, V. L., Lemola, E., Gronholm, M., Yang, N., Menard, D., Marcorelles, P., Echaniz-Laguna, A., Reimann, J., Vainzof, M., Monnier, N., Ravenscroft, G., McNamara, E., Nowak, K. J., Laing, N. G. & 6 othersWallgren-Pettersson, C., Trewhella, J., Marston, S., Ottenheijm, C. A. C., North, K. N. & Clarke, N. F., 2013, In : Brain. 136, p. 494-507

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial titin hypophosphorylation importantly contributes to heart failure with preserved ejection fraction in a rat metabolic risk model

Hamdani, N., Franssen, C. P. M., Lourenco, A., Falcao-Pires, I., Fontoura, D., Leite, S., Plettig, L., Lopez, B., Ottenheijm, C. A. C., Becher, P. M., Gonzalez, A., Tschope, C., Diez, J., Linke, W. A., Leite-Moreira, A. F. & Paulus, W. J., 2013, In : Circulation. Heart failure. 6, 6, p. 1239-1249

Research output: Contribution to journalArticleAcademicpeer-review

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

Rain, S., Handoko, M. L., Trip, P., Gan, C. T., Westerhof, N., Stienen, G. J. M., Paulus, W. J., Ottenheijm, C. A. C., Marcus, J. T., Dorfmuller, P., Guignabert, C., Humbert, M., Macdonald, P., dos Remedios, C., Postmus, P. E., Saripalli, C., Hidalgo, C. G., Granzier, H. L., Vonk-Noordegraaf, A., van der Velden, J. & 1 othersde Man, F. S., 2013, In : Circulation. 128, 18, p. 2016-2025

Research output: Contribution to journalArticleAcademicpeer-review

Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy

Lassche, S., Stienen, G. J. M., Irving, T. C., van der Maarel, S. M., Voermans, N. C., Padberg, G. W., Granzier, H., van Engelen, B. G. M. & Ottenheijm, C. A. C., 2013, In : Neurology. 80, 8, p. 733-737

Research output: Contribution to journalArticleAcademicpeer-review

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations

de Winter, J. M., Buck, D., Hidalgo, C., Jasper, J. R., Malik, F. I., Clarke, N. F., Stienen, G. J. M., Lawlor, M. W., Beggs, A. H., Ottenheijm, C. A. C. & Granzier, H., 2013, In : Journal of Medical Genetics. 50, 6, p. 383-392

Research output: Contribution to journalArticleAcademicpeer-review

2012

Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction

Manders, E., de Man, F. S., Handoko, M. L., Westerhof, N., van Hees, H. W. H., Stienen, G. J. M., Vonk Noordegraaf, A. & Ottenheijm, C. A. C., 2012, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 303, 12, p. L1070-L1078

Research output: Contribution to journalArticleAcademicpeer-review

47 Downloads (Pure)

The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization

Ottenheijm, C. A. C., Granzier, H. & Labeit, S., 2012, In : Frontiers in Physiology. 3, 37.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Titin and diaphragm dysfunction in mechanically ventilated rats

van Hees, H. W. H., Schellekens, W. J. M., Acuna, G. L. A., Linkels, M., Hafmans, T., Ottenheijm, C. A. C., Granzier, H. L., Scheffer, G. J., van der Hoeven, J. G., Dekhuijzen, P. N. R. & Heunks, L. M. A., 2012, In : Intensive Care Medicine. 38, 4, p. 702-709

Research output: Contribution to journalArticleAcademicpeer-review