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Research Output

Elective neck dissection or sentinel lymph node biopsy in early stage oral cavity cancer patients: The dutch experience

Den Toom, I. J., Boeve, K., Lobeek, D., Bloemena, E., Donswijk, M. L., de Keizer, B., Klop, W. M. C., Leemans, C. R., Willems, S. M., Takes, R. P., Witjes, M. J. H. & de Bree, R., Jul 2020, In : Cancers. 12, 7, p. 1-13 13 p., 1783.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Epithelial-to-mesenchymal transition is a prognostic marker for patient outcome in advanced stage HNSCC patients treated with chemoradiotherapy

van der Heijden, M., Essers, P. B. M., Verhagen, C. V. M., Willems, S. M., Sanders, J., de Roest, R. H., Vossen, D. M., Leemans, C. R., Verheij, M., Brakenhoff, R. H., van den Brekel, M. W. M. & Vens, C., Jun 2020, In : Radiotherapy and Oncology. 147, p. 186-194 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Health-related and cancer-related Internet use by patients treated with total laryngectomy

van Uden-Kraan, C. F., Jansen, F., Lissenberg-Witte, B. I., Eerenstein, S. E. J., Leemans, C. R. & Verdonck-de Leeuw, I. M., Jan 2020, In : Supportive Care in Cancer. 28, 1, p. 131-140 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Outcome prediction of head and neck squamous cell carcinoma by MRI radiomic signatures

Mes, S. W., van Velden, F. H. P., Peltenburg, B., Peeters, C. F. W., Te Beest, D. E., van de Wiel, M. A., Mekke, J., Mulder, D. C., Martens, R. M., Castelijns, J. A., Pameijer, F. A., de Bree, R., Boellaard, R., Leemans, C. R., Brakenhoff, R. H. & de Graaf, P., 4 Jun 2020, In : European Radiology.

Research output: Contribution to journalArticleAcademicpeer-review

Predictive value of quantitative 18F-FDG-PET radiomics analysis in patients with head and neck squamous cell carcinoma

Martens, R. M., Koopman, T., Noij, D. P., Pfaehler, E., Übelhör, C., Sharma, S., Vergeer, M. R., Leemans, C. R., Hoekstra, O. S., Yaqub, M., Zwezerijnen, G. J., Heymans, M. W., Peeters, C. F. W., de Bree, R., de Graaf, P., Castelijns, J. A. & Boellaard, R., 7 Sep 2020, In : EJNMMI Research. 10, 1, p. 102 102.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Acute hypoxia profile is a stronger prognostic factor than chronic hypoxia in advanced stage head and neck cancer patients

van der Heijden, M., de Jong, M. C., Verhagen, C. V. M., de Roest, R. H., Sanduleanu, S., Hoebers, F., Leemans, C. R., Brakenhoff, R. H., Vens, C., Verheij, M. & van den Brekel, M. W. M., 1 Apr 2019, In : Cancers. 11, 4, 583.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: The NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank

Verdonck-de Leeuw, I. M., Jansen, F., Brakenhoff, R. H., Langendijk, J. A., Takes, R., Terhaard, C. H. J., de Jong, R. J. B., Smit, J. H. & Leemans, C. R., 2019, In : BMC Cancer. 19, 1, 765.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessment of Neurocognitive Impairment and Speech Functioning before Head and Neck Cancer Treatment

Piai, V., Prins, J. B., Verdonck-de Leeuw, I. M., Leemans, C. R., Terhaard, C. H. J., Langendijk, J. A., Baatenburg de Jong, R. J., Smit, J. H., Takes, R. P. & Kessels, R. P. C., 1 Mar 2019, In : JAMA Otolaryngology - Head and Neck Surgery. 145, 3, p. 251-257

Research output: Contribution to journalArticleAcademicpeer-review

Biochemically Silent Sympathetic Paraganglioma, Pheochromocytoma, or Metastatic Disease in SDHD Mutation Carriers

Dreijerink, K. M. A., Rijken, J. A., Compaijen, C. J., Timmers, H. J. L. M., van der Horst-Schrivers, A. N. A., van Leeuwaarde, R. S., van Dam, P. S., Leemans, C. R., van Dam, E. W. C. M., Dickhoff, C., Dommering, C. J., de Graaf, P., Zwezerijnen, G. J. C., van der Valk, P., Menke-van der Houven van Oordt, C. W., Hensen, E. F., Corssmit, E. P. M. & Eekhoff, E. M. W., 1 Nov 2019, In : The Journal of clinical endocrinology and metabolism. 104, 11, p. 5421-5426 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients (CheckMate 141 and KEYNOTE 040)

Pai, S. I., Faivre, S., Licitra, L., Machiels, J-P., Vermorken, J. B., Bruzzi, P., Gruenwald, V., Giglio, R. E., Leemans, C. R., Seiwert, T. Y. & Soulieres, D., 2019, In : Journal for Immunotherapy of Cancer. 7, 1, 96.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

Douma, J. A. J., Verdonck-de Leeuw, I. M., Leemans, C. R., Jansen, F., Langendijk, J. A., Baatenburg de Jong, R. J., Terhaard, C. H. J., Takes, R. P., Chinapaw, M. J., Altenburg, T. M. & Buffart, L. M., 1 Jan 2019, In : Acta Oncologica.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Depth of invasion in patients with early stage oral cancer staged by sentinel node biopsy

den Toom, I. J., Janssen, L. M., van Es, R. J. J., Karagozoglu, K. H., de Keizer, B., van Weert, S., Willems, S. M., Bloemena, E., Leemans, C. R. & de Bree, R., 1 Jul 2019, In : Head & Neck. 41, 7, p. 2100-2106 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Drug sensitivity prediction models reveal a link between DNA repair defects and poor prognosis in HNSCC

Essers, P. B. M., van der Heijden, M., Verhagen, C. V. M., Ploeg, E. M., de Roest, R. H., Leemans, C. R., Brakenhoff, R. H., van den Brekel, M. W. M., Bartelink, H., Verheij, M. & Vens, C., 1 Nov 2019, In : Cancer Research. 79, 21, p. 5597-5611 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Establishment and Genetic Landscape of Precancer Cell Model Systems from the Head and Neck Mucosal Lining

de Boer, D. V., Brink, A., Buijze, M., Stigter-van Walsum, M., Hunter, K. D., Ylstra, B., Bloemena, E., Leemans, C. R. & Brakenhoff, R. H., 1 Jan 2019, In : Molecular Cancer Research. 17, 1, p. 120-130 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Factors associated with depression over time in head and neck cancer patients: A systematic review

Korsten, L. H. A., Jansen, F., de Haan, B. J. F., Sent, D., Cuijpers, P., Leemans, C. R. & Verdonck-de Leeuw, I. M., 1 Jun 2019, In : Psycho-Oncology. 28, 6, p. 1159-1183 25 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Fifteen-year history of the European head and neck society

Hoşal, Ş., Golusiński, W., Andry, G., Leemans, C. R. & LeFebvre, J. L., 1 Oct 2019, In : Oral Oncology. 97, p. 112-114

Research output: Contribution to journalEditorialAcademicpeer-review

Functional imaging early during (chemo)radiotherapy for response prediction in head and neck squamous cell carcinoma; a systematic review

Martens, R. M., Noij, D. P., Ali, M., Koopman, T., Marcus, J. T., Vergeer, M. R., de Vet, H., de Jong, M. C., Leemans, C. R., Hoekstra, O. S., de Bree, R., de Graaf, P., Boellaard, R. & Castelijns, J. A., 1 Jan 2019, In : Oral Oncology. 88, p. 75-83 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

High rate of unexpected lymphatic drainage patterns and a high accuracy of the sentinel lymph node biopsy in oral cancer after previous neck treatment

den Toom, I. J., Boeve, K., van Weert, S., Bloemena, E., Brouwers, A. H., Hoekstra, O. S., de Keizer, B., van der Vegt, B., Willems, S. M., Leemans, C. R., Witjes, M. J. H. & de Bree, R., 1 Jul 2019, In : Oral Oncology. 94, p. 68-72

Research output: Contribution to journalArticleAcademicpeer-review

Increased mortality in SDHB but not in SDHD pathogenic variant carriers

Rijken, J. A., van Hulsteijn, L. T., Dekkers, O. M., Niemeijer, N. D., Leemans, C. R., Eijkelenkamp, K., van der Horst-Schrivers, A. N. A., Kerstens, M. N., van Berkel, A., Timmers, H. J. L. M., Kunst, H., Bisschop, P. H. L. T., Dreijerink, K. M. A., van Dooren, M. F., Hes, F. J., Jansen, J. C., Corssmit, E. P. M. & Hensen, E. F., 1 Jan 2019, In : Cancers. 11, 1, 103.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Molecular characterization of locally relapsed head and neck cancer after concomitant chemoradiotherapy

De Roest, R. H., Mes, S. W., Poell, J. B., Brink, A., Van De Wiel, M. A., Bloemena, E., Thai, E., Poli, T., Leemans, C. R. & Brakenhoff, R. H., 1 Dec 2019, In : Clinical Cancer Research. 25, 23, p. 7256-7265 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

46 Downloads (Pure)

Prevalence and clinical and psychological correlates of high fear of cancer recurrence in patients newly diagnosed with head and neck cancer

Mirosevic, S., Thewes, B., van Herpen, C., Kaanders, J., Merkx, T., Humphris, G., Baatenburg de Jong, R. J., Langendijk, J. A., Leemans, C. R., Terhaard, C. H. J., Verdonck-de Leeuw, I. M., Takes, R., Prins, J. & the NET-QUBIC Consortium, 1 Jan 2019, In : Head and Neck. 41, 9, p. 3187-3200 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prevalence of sleep disturbances among head and neck cancer patients: A systematic review and meta-analysis

Santoso, A. M. M., Jansen, F., de Vries, R., Leemans, C. R., van Straten, A. & Verdonck-de Leeuw, I. M., 1 Oct 2019, In : Sleep Medicine Reviews. 47, p. 62-73

Research output: Contribution to journalReview articleAcademicpeer-review

Quality assurance in head and neck cancer surgery: where are we, and where are we going?

Simon, C., Dietz, A. & Leemans, C. R., 1 Apr 2019, In : Current Opinion in Otolaryngology and Head and Neck Surgery. 27, 2, p. 151-156 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial

Mehanna, H., Robinson, M., Hartley, A., Kong, A., Foran, B., Fulton-Lieuw, T., Dalby, M., Mistry, P., Sen, M., O'Toole, L., Al Booz, H., Dyker, K., Moleron, R., Whitaker, S., Brennan, S., Cook, A., Griffin, M., Aynsley, E., Rolles, M., de Winton, E. & 31 others, Chan, A., Srinivasan, D., Nixon, I., Grumett, J., Leemans, C. R., Buter, J., Henderson, J., Harrington, K., McConkey, C., Gray, A., Dunn, J., Moleron, R., McArdle, O., Dyker, K., Al Booz, H., O'Toole, L., Cook, A., Husband, D., Loo, V., Soe, W., Aynsley, E., Sridhar, T., Jankowska, P., Joseph, M., Geropantas, K., Vaidya, D., Griffin, M., Hartley, A., Vijayan, R., Buter, J. & De-ESCALaTE HPV Trial Group, 5 Jan 2019, In : Lancet. 393, 10166, p. 51-60 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Referrals for head and neck cancer in England and The Netherlands: an international qualitative study of the views of secondary-care surgical specialists

Langton, S., Rijken, J. A., Bankhead, C. R., Plüddemann, A. & Leemans, C. R., 1 Feb 2019, In : British Journal of Oral and Maxillofacial Surgery. 57, 2, p. 116-124

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

A novel succinate dehydrogenase subunit B germline variant associated with head and neck paraganglioma in a Dutch kindred: A family-based study

de Vos, B., Rijken, J. A., Adank, M. A., Hoksbergen, A. W. J., Bayley, J. P., Leemans, C. R. & Hensen, E. F., 1 Jun 2018, In : Clinical Otolaryngology. 43, 3, p. 841-845 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical value of FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma

Deurvorst, S. E., Hoekstra, O. S., Castelijns, J. A., Witte, B. I., Leemans, C. R. & de Bree, R., Jun 2018, In : Clinical Otolaryngology. 43, 3, p. 875-881 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Combining deep learning and radiomics to predict HPV status in oropharyngeal squamous cell carcinoma

Jochems, A., Leijenaar, R. T. H., Bogowicz, M., Hoebers, F. J. P., Wesseling, F., Huang, S. H., Chan, B., Waldron, J. N., O'Sullivan, B., Rietveld, D., Leemans, C. R., Riesterer, O., Tanadini-Lang, S., Guckenberger, M., Ikenberg, K. & Lambin, P., Apr 2018, In : Radiotherapy and Oncology. 127, p. S504-S505

Research output: Contribution to journalMeeting AbstractAcademic

Depressive symptoms in relation to overall survival in people with head and neck cancer: A longitudinal cohort study

Jansen, F., Verdonck-de Leeuw, I. M., Cuijpers, P., Leemans, C. R., Waterboer, T., Pawlita, M., Penfold, C., Thomas, S. J., Waylen, A. & Ness, A. R., 1 Sep 2018, In : Psycho-Oncology. 27, 9, p. 2245-2256 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Detection of Distant Metastases in Head and Neck Cancer: Changing Landscape

de Bree, R., Senft, A., Coca-Pelaz, A., Kowalski, L., Lopez, F., Mendenhall, W., Quer, M., Rinaldo, A., Shaha, A. R., Strojan, P., Takes, R. P., Silver, C. E., Leemans, C. R. & Ferlito, A., 2018, In : Advances in therapy. 35, 2, p. 161-172

Research output: Contribution to journalReview articleAcademicpeer-review

Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study

Leijenaar, R. T. H., Bogowicz, M., Jochems, A., Hoebers, F. J. P., Wesseling, F. W. R., Huang, S. H., Chan, B., Waldron, J. N., O'Sullivan, B., Rietveld, D., Leemans, C. R., Brakenhoff, R. H., Riesterer, O., Tanadini-Lang, S., Guckenberger, M., Ikenberg, K. & Lambin, P., 2018, In : British Journal of Radiology. 91, 1086

Research output: Contribution to journalArticleAcademicpeer-review

Epidemiologic associations of HPV-positive oropharyngeal cancer and (pre)cancerous cervical lesions

Rietbergen, M. M., van Bokhoven, A. A. J. D., Lissenberg-Witte, B. I., Heideman, D. A. M., Leemans, C. R., Brakenhoff, R. H. & Bloemena, E., 15 Jul 2018, In : International Journal of Cancer. 143, 2, p. 283-288 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Erratum to: The molecular landscape of head and neck cancer (Nature Reviews Cancer, (2018), 18, 5, (269-282), 10.1038/nrc.2018.11)

Leemans, C. R., Snijders, P. J. F. & Brakenhoff, R. H., 2018, In : Nature Reviews Cancer. 18, 10, p. 662

Research output: Contribution to journalErratumAcademicpeer-review

Evaluation of the eighth TNM classification on p16-positive oropharyngeal squamous cell carcinomas in the Netherlands and the importance of additional HPV DNA testing

Nauta, I. H., Rietbergen, M. M., van Bokhoven, A. A. J. D., Bloemena, E., Lissenberg-Witte, B. I., Heideman, D. A. M., Baatenburg de Jong, R. J., Brakenhoff, R. H. & Leemans, C. R., 1 May 2018, In : Annals of Oncology. 29, 5, p. 1273-1279 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of vascular features of vocal cords proposed by the European Laryngological Society

Šifrer, R., Rijken, J. A., Leemans, C. R., Eerenstein, S. E. J., van Weert, S., Hendrickx, J. J., Bloemena, E., Heuveling, D. A. & Rinkel, R. N. P. M., 1 Jan 2018, In : European Archives of Oto-Rhino-Laryngology. 275, 1, p. 147-151 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Highlights from the Second International Symposium on HPV infection in head and neck cancer

Wiegand, S., Wichmann, G., Golusinski, W., Leemans, C. R., Klussmann, J. P. & Dietz, A., 2018, In : European Archives of Oto-Rhino-Laryngology. 275, 6, p. 1365-1373

Research output: Contribution to journalReview articleAcademicpeer-review