Cyra Leurs

DRS.

20162019
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Research Output 2016 2019

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Article
2019

Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis

Leurs, C. E., Lopes Pinheiro, M. A., Wierts, L., den Hoedt, S., Mulder, M. T., Eijlers, A. J. C., Schoonheim, M. M., Balk, L. J., Uitdehaag, B. M. J., Killestein, J. & de Vries, H. E., 1 Feb 2019, In : Multiple Sclerosis and Related Disorders. 28, p. 44-49 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study

Leurs, C. E., Twaalfhoven, H. A. M., Lissenberg-Witte, B. I., van Pesch, V., Dujmovic, I., Drulovic, J., Castellazzi, M., Bellini, T., Pugliatti, M., Kuhle, J., Villar, L. M., Alvarez-Cermeño, J. C., Alvarez-Lafuente, R., Hegen, H., Deisenhammer, F., Walchhofer, L. M., Thouvenot, E., Comabella, M., Montalban, X., Vécsei, L. & 19 othersRajda, C., Galimberti, D., Scarpini, E., Altintas, A., Rejdak, K., Frederiksen, J. L., Pihl-Jensen, G., Jensen, P. E. H., Khalil, M., Voortman, M. M., Fazekas, F., Saiz, A., la Puma, D., Vercammen, M., Vanopdenbosch, L., Uitdehaag, B. M. J., Killestein, J., Bridel, C. & Teunissen, C., 8 May 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Plasma proteome in multiple sclerosis disease progression

Malekzadeh, A., Leurs, C., van Wieringen, W., Steenwijk, M. D., Schoonheim, M. M., Amann, M., Naegelin, Y., Kuhle, J., Killestein, J. & Teunissen, C. E., 1 Sep 2019, In : Annals of Clinical and Translational Neurology. 6, 9, p. 1582-1594 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

Leurs, C. E., Podlesniy, P., Trullas, R., Balk, L., Steenwijk, M. D., Malekzadeh, A., Piehl, F., Uitdehaag, B. M., Killestein, J., van Horssen, J. & Teunissen, C. E., 1 Apr 2018, In : Multiple Sclerosis. 24, 4, p. 472-480 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Deep gray matter volume loss drives disability worsening in multiple sclerosis

Eshaghi, A., Prados, F., Brownlee, W. J., Altmann, D. R., Tur, C., Cardoso, M. J., De Angelis, F., van de Pavert, S. H., Cawley, N., De Stefano, N., Stromillo, M. L., Battaglini, M., Ruggieri, S., Gasperini, C., Filippi, M., Rocca, M. A., Rovira, A., Sastre-Garriga, J., Vrenken, H., Leurs, C. E. & 11 othersKillestein, J., Pirpamer, L., Enzinger, C., Ourselin, S., Wheeler-Kingshott, C. A. M. G., Chard, D., Thompson, A. J., Alexander, D. C., Barkhof, F., Ciccarelli, O. & MAGNIMS Study Group, 1 Feb 2018, In : Annals of Neurology. 83, 2, p. 210-222 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Information processing speed in multiple sclerosis: Relevance of default mode network dynamics

van Geest, Q., Douw, L., van ‘t Klooster, S., Leurs, C. E., Genova, H. M., Wylie, G. R., Steenwijk, M. D., Killestein, J., Geurts, J. J. G. & Hulst, H. E., 2018, In : NeuroImage: Clinical. 19, p. 507-515

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Progression of regional grey matter atrophy in multiple sclerosis

Eshaghi, A., Marinescu, R. V., Young, A. L., Firth, N. C., Prados, F., Jorge Cardoso, M., Tur, C., De Angelis, F., Cawley, N., Brownlee, W. J., De Stefano, N., Laura Stromillo, M., Battaglini, M., Ruggieri, S., Gasperini, C., Filippi, M., Rocca, M. A., Rovira, A., Sastre-Garriga, J., Geurts, J. J. G. & 13 othersVrenken, H., Wottschel, V., Leurs, C. E., Uitdehaag, B., Pirpamer, L., Enzinger, C., Ourselin, S., Gandini Wheeler-Kingshott, C. A., Chard, D., Thompson, A. J., Barkhof, F., Alexander, D. C. & Ciccarelli, O., 1 Jun 2018, In : Brain. 141, 6, p. 1665-1677 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Switching natalizumab to fingolimod within 6 weeks reduces recurrence of disease activity in MS patients

Leurs, C. E., van Kempen, Z. LE., Dekker, I., Balk, L. J., Wattjes, M. P., Rispens, T., Uitdehaag, B. M. & Killestein, J., Oct 2018, In : Multiple Sclerosis. 24, 11, p. 1453-1460

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing

van Kempen, Z. LE., Leurs, C. E., Witte, B. I., de Vries, A., Wattjes, M. P., Rispens, T. & Killestein, J., May 2018, In : Multiple Sclerosis. 24, 6, p. 805-810

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

John Cunningham virus conversion in relation to natalizumab concentration in multiple sclerosis patients

van Kempen, Z. L. E., Leurs, C. E., de Vries, A., Vennegoor, A., Rispens, T., Wattjes, M. P. & Killestein, J., 1 Sep 2017, In : European Journal of Neurology. 24, 9, p. 1196-1199 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets

Best, M. G., Sol, N., In ‘t Veld, S. G. J. G., Vancura, A., Muller, M., Niemeijer, A. L. N., Fejes, A. V., Tjon Kon Fat, L. A., Huis In ‘t Veld, A. E., Leurs, C., Le Large, T. Y., Meijer, L. L., Kooi, I. E., Rustenburg, F., Schellen, P., Verschueren, H., Post, E., Wedekind, L. E., Bracht, J., Esenkbrink, M. & 33 othersWils, L., Favaro, F., Schoonhoven, J. D., Tannous, J., Meijers-Heijboer, H., Kazemier, G., Giovannetti, E., Reijneveld, J. C., Idema, S., Killestein, J., Heger, M., de Jager, S. C., Urbanus, R. T., Hoefer, I. E., Pasterkamp, G., Mannhalter, C., Gomez-Arroyo, J., Bogaard, H. J., Noske, D. P., Vandertop, W. P., van den Broek, D., Ylstra, B., Nilsson, R. J. A., Wesseling, P., Karachaliou, N., Rosell, R., Lee-Lewandrowski, E., Lewandrowski, K. B., Tannous, B. A., de Langen, A. J., Smit, E. F., van den Heuvel, M. M. & Wurdinger, T., 14 Aug 2017, In : Cancer Cell. 32, 2, p. 238-252.e9

Research output: Contribution to journalArticleAcademicpeer-review

2016

High cumulative JC virus seroconversion rate during long-term use of natalizumab

Vennegoor, A., van Rossum, J. A., Leurs, C., Wattjes, M. P., Rispens, T., Murk, J. L. A. N., Uitdehaag, B. M. J. & Killestein, J., Jun 2016, In : European Journal of Neurology. 23, 6, p. 1079-1085

Research output: Contribution to journalArticleAcademicpeer-review

Physiological evidence for diversification of IFN alpha- and IFN beta-mediated response programs in different autoimmune diseases

de Jong, T. D., Vosslamber, S., Mantel, E., de Ridder, S., Wesseling, J. G., van der Pouw Kraan, T., Leurs, C., Hegen, H., Deisenhammer, F., Killestein, J., Lundberg, I. E., Vencovsky, J., Nurmohamed, M. T., van Schaardenburg, D., Bultink, I. E. M., Voskuyl, AE., Pegtel, DM., van der Laken, C. J., Bijlsma, J. W. J. & Verweij, C. L., 17 Feb 2016, In : Arthritis Research & Therapy. 18, 49.

Research output: Contribution to journalArticleAcademicpeer-review