Daniëlle Vugts

DR., (Principal Investigator)

  • De Boelelaan 1085C, W&N Building

    1081 HV Amsterdam

    Netherlands

20112020

Research output per year

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Research Output

Correction: Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source (Chemical Communications (2018) 54 (10179-10182) DOI: 10.1039/c8cc03206h)

Pees, A., Sewing, C., Vosjan, M. J. W. D., Tadino, V., Herscheid, J. D. M., Windhorst, A. D. & Vugts, D. J., 1 Jan 2019, In : Chemical Communications. 55, 38, p. 5523

Research output: Contribution to journalErratumAcademicpeer-review

Open Access

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach

Bruijnen, S. T. G., Chandrupatla, D. M. S. H., Giovanonni, L., Neri, D., Vugts, D. J., Huisman, M. C., Hoekstra, O. S., Musters, R. J. P., Lammertsma, A. A., van Dongen, G. A. M. S., Jansen, G., Molthoff, C. F. M. & van der Laken, C. J., 7 Jan 2019, In : Molecular Pharmaceutics. 16, 1, p. 273-281

Research output: Contribution to journalArticleAcademicpeer-review

Fully Automated 89 Zr Labeling and Purification of Antibodies

Poot, A. J., Adamzek, K. W. A., Windhorst, A. D., Vosjan, M. J. W. D., Kropf, S., Wester, H-J., van Dongen, G. A. M. S. & Vugts, D. J., 2019, In : Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60, 5, p. 691-695

Research output: Contribution to journalArticleAcademicpeer-review

Immuno-PET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors

Willemien Menke-van der Houven van Oordt, C., McGeoch, A., Bergstrom, M., McSherry, I., Smith, D. A., Cleveland, M., Al-Azzam, W., Chen, L., Verheul, H., Hoekstra, O. S., Vugts, D. J., Freedman, I., Huisman, M., Matheny, C., van Dongen, G. & Zhang, S., 1 Jan 2019, In : Journal of Nuclear Medicine. 60, 7, p. 902-909 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

Thorneloe, K. S., Sepp, A., Zhang, S., Galinanes-Garcia, L., Galette, P., Al-Azzam, W., Vugts, D. J., van Dongen, G., Elsinga, P., Wiegers, J., Glaudemans, A. W. J. M., Vincent, V., Renaux, J., Szapacs, M., Birchler, M., Cleveland, M., Bergstrom, M. & Davies, M., 2019, In : EJNMMI Research. 9, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

89Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding

van Brummelen, E. M. J., Huisman, M. C., de Wit-van der Veen, L. J., Nayak, T. K., Stokkel, M. P. M., Mulder, E. R., Hoekstra, O. S., Vugts, D. J., Van Dongen, G. A. M. S., Verheul, H. M., Evers, S., Tessier, J. J. L., Saro, J., Schellens, J. H. M. & Menke-van der Houven van Oordt, C. W., 15 May 2018, In : Oncotarget. 9, 37, p. 24737-24749 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A dual-labeled cRGD-based PET/optical tracer for pre-operative staging and intraoperative treatment of colorectal cancer

Sibinga Mulder, B. G., Handgraaf, H. J., Vugts, D. J., Sewing, C., Windhorst, A. D., Stammes, M., de Geus-Oei, L-F., Bordo, M. W., Mieog, J. S. D., van de Velde, C. J., Frangioni, J. V. & Vahrmeijer, A. L., 20 Oct 2018, In : American journal of nuclear medicine and molecular imaging. 8, 5, p. 282-291 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody

Jauw, Y. W. S., Huisman, M. C., Nayak, T. K., Vugts, D. J., Christen, R., Naegelen, V. M., Ruettinger, D., Heil, F., Lammertsma, A. A., Verheul, H. M. W., Hoekstra, O. S., van Dongen, G. A. M. S. & van Oordt, C. W. M. D. H., 22 Jan 2018, In : EJNMMI Research. 8, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

Pees, A., Sewing, C., Vosjan, M. J. W. D., Tadino, V., Herscheid, J. D. M., Windhorst, A. D. & Vugts, D. J., 6 Sep 2018, In : Chemical Communications. 54, 72, p. 10179-10182 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Feasibility of PET/CT system performance harmonisation for quantitative multicentre 89Zr studies

Huisman, M., Sera, T., Vugts, D., Boellaard, R. & on behalf of EARL, 2018, In : EJNMMI PHYSICS. 5, 1, 26.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

High resolution combined molecular and structural optical imaging of colorectal cancer in a xenograft mouse model

Feroldi, F., Verlaan, M., Knaus, H., Davidoiu, V., Vugts, D. J., van Dongen, G. A. M. S., Molthoff, C. F. M. & de Boer, J. F., 1 Dec 2018, In : Biomedical Optics Express. 9, 12, p. 6186-6204

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state

Villa, A., Klein, B., Janssen, B., Pedragosa, J., Pepe, G., Zinnhardt, B., Vugts, D. J., Gelosa, P., Sironi, L., Beaino, W., Damont, A., Dollé, F., Jego, B., Winkeler, A., Ory, D., Solin, O., Vercouillie, J., Funke, U., Laner-Plamberger, S., Blomster, L. V. & 7 others, Christophersen, P., Vegeto, E., Aigner, L., Jacobs, A., Planas, A. M., Maggi, A. & Windhorst, A. D., 2018, In : Theranostics. 8, 19, p. 5400-5418 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of the allosteric P2X receptor antagonist [C]SMW139 as a PET tracer of microglial activation

Janssen, B., Vugts, D. J., Wilkinson, S. M., Ory, D., Chalon, S., Hoozemans, J. J. M., Schuit, R. C., Beaino, W., Kooijman, E. J. M., van den Hoek, J., Chishty, M., Doméné, A., Van der Perren, A., Villa, A., Maggi, A., Molenaar, G. T., Funke, U., Shevchenko, R. V., Baekelandt, V., Bormans, G. & 3 others, Lammertsma, A. A., Kassiou, M. & Windhorst, A. D., 26 Apr 2018, In : Scientific Reports. 8, 1, p. 6580

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

PET imaging of microglial activation - Beyond targeting TSPO

Janssen, B., Vugts, D. J., Windhorst, A. D. & Mach, R. H., 2018, In : Molecules. 23, 3, 607.

Research output: Contribution to journalReview articleAcademicpeer-review

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M. & 3 others, de Gruijl, T. D., Smit, E. F. & de Langen, A. J., 1 Dec 2018, In : Nature Communications. 9, 1, 4664.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A PET imaging study to investigate the biodistribution and clearance of an albumin binding domain antibody (AlbudAb (TM)) in healthy subjects

Thorneloe, K., Bergstrom, M., Galinanes-Garcia, L., Galette, P., Al-Azzam, W., Vincent, V., Vugts, D., van Dongen, G., Elsinga, P., Wiegers, J., Glaudemans, A., Renaux, J., Cleveland, M., Davies, M. & Zhang, S., Oct 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, p. S148-S149

Research output: Contribution to journalMeeting AbstractAcademic

Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines

Klein, C., Waldhauer, I., Nicolini, V. G., Freimoser-Grundschober, A., Nayak, T., Vugts, D. J., Dunn, C., Bolijn, M., Benz, J., Stihle, M., Lang, S., Roemmele, M., Hofer, T., van Puijenbroek, E., Wittig, D., Moser, S., Ast, O., Brünker, P., Gorr, I. H., Neumann, S. & 10 others, de Vera Mudry, M. C., Hinton, H., Crameri, F., Saro, J., Evers, S., Gerdes, C., Bacac, M., van Dongen, G., Moessner, E. & Umaña, P., 4 Mar 2017, In : OncoImmunology. 6, 3, e1277306.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET

Vugts, D. J., Klaver, C., Sewing, C., Poot, A. J., Adamzek, K., Huegli, S., Mari, C., Visser, G. W. M., Valverde, I. E., Gasser, G., Mindt, T. L. & van Dongen, G. A. M. S., 1 Feb 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, 2, p. 286-295 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

ESPMIS: Helping Young Scientists Navigate the Molecular Imaging Landscape

Zeglis, B. M. & Vugts, D. J., Jun 2017, In : Molecular Imaging and Biology. 19, 3, p. 325-327 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fluorine-18 labelled building blocks for PET tracer synthesis

Van Der Born, D., Pees, A., Poot, A. J., Orru, R. V. A., Windhorst, A. D. & Vugts, D. J., 7 Aug 2017, In : Chemical Society Reviews. 46, 15, p. 4709-4773 65 p.

Research output: Contribution to journalReview articleAcademicpeer-review

ImmunoPET imaging to assess target engagement: Experience from Zr-89-anti-HER3 mAb (GSK2849330) in patients with solid tumors

Mcgeoch, A., van Oordt, C. M. D. H., Bergstrom, M., McSherry, I., Smith, D., Cleveland, M., Hoekstra, O., Vugts, D., Weber, A., Freedman, I., Huisman, M., Matheny, C., van Dongen, G. & Zhang, S., Oct 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, p. S314-S315

Research output: Contribution to journalMeeting AbstractAcademic

Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice

Alsaid, H., Skedzielewski, T., Rambo, M. V., Hunsinger, K., Hoang, B., Fieles, W., Long, E. R., Tunstead, J., Vugts, D. J., Cleveland, M., Clarke, N., Matheny, C. & Jucker, B. M., 2017, In : PLoS ONE. 12, 4, p. e0176075

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist

Wilkinson, S. M., Barron, M. L., O'Brien-Brown, J., Janssen, B., Stokes, L., Werry, E. L., Chishty, M., Skarratt, K. K., Ong, J. A., Hibbs, D. E., Vugts, D. J., Fuller, S., Windhorst, A. D. & Kassiou, M., 15 Nov 2017, In : ACS Chemical Neuroscience. 8, 11, p. 2374-2380 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: A theragnostic approach

Even, A. J. G., Hamming-Vrieze, O., van Elmpt, W., Winnepenninckx, V. J. L., Heukelom, J., Tesselaar, M. E. T., Vogel, W. V., Hoeben, A., Zegers, C. M. L., Vugts, D. J., van Dongen, G. A. M. S., Bartelink, H., Mottaghy, F. M., Hoebers, F. & Lambin, P., 2017, In : Oncotarget. 8, 3, p. 3870-3880 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Whole body PD-1 and PD-L1 PET in pts with NSCLC

Niemeijer, A-L., Smit, E., Bahce, I., Hoekstra, O., Huisman, M., van Dongen, G. A., Windhorst, B., Hendrikse, N., Poot, A. J., Vugts, D., Leung, D. K., Hayes, W., Smith, R. A., Wilson, L. M., Thunnissen, E. & de langen, J., Sep 2017, In : Annals of Oncology. 28

Research output: Contribution to journalMeeting AbstractAcademic

Whole Body PD-1 and PD-L1 PET in Pts with NSCLC

Niemeijer, A., Smit, E., Van Dongen, G., Windhorst, A. D., Huisman, M., Hendrikse, N., Bahce, I., Lueng, D., Smith, R., Hayes, W., Wilson, L., Bonacorsi, S., Donnelly, D., Morin, P., Poot, A., Vugts, D., Thunnissen, E. & De Langen, J., Nov 2017, In : Journal of Thoracic Oncology. 12, 11, p. S1817-S1817

Research output: Contribution to journalMeeting AbstractAcademic

Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models

Jansen, M. H. A., Lagerweij, T., Sewing, A. C. P., Vugts, D. J., van Vuurden, D. G., Molthoff, C. F. M., Caretti, V., Veringa, S. J. E., Petersen, N., Carcaboso, A. M., Noske, D. P., Vandertop, W. P., Wesseling, P., van Dongen, G. A. M. S., Kaspers, G. J. L. & Hulleman, E., 1 Sep 2016, In : Molecular Cancer Therapeutics. 15, 9, p. 2166-2174 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

HDL mimetic CER-001 targets atherosclerotic plaques in patients

Zheng, K. H., van der Valk, F. M., Smits, L. P., Sandberg, M., Dasseux, J-L., Baron, R., Barbaras, R., Keyserling, C., Coolen, B. F., Nederveen, A. J., Verberne, H. J., Nell, T. E., Vugts, D. J., Duivenvoorden, R., Fayad, Z. A., Mulder, W. J. M., van Dongen, G. A. M. S. & Stroes, E. S. G., Aug 2016, In : Atherosclerosis. 251, p. 381-388

Research output: Contribution to journalArticleAcademicpeer-review

Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography

Janssen, B., Vugts, D. J., Funke, U., Molenaar, G. T., Kruijer, P. S., van Berckel, B. N. M., Lammertsma, A. A. & Windhorst, A. D., Mar 2016, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1862, 3, p. 425-441

Research output: Contribution to journalArticleAcademicpeer-review

Molecular imaging as a tool to investigate heterogeneity of advanced HER2-positive breast cancer and to predict patient outcome under trastuzumab emtansine (T-DM1): the ZEPHIR trial

Gebhart, G., Lamberts, L. E., Wimana, Z., Garcia, C., Emonts, P., Ameye, L., Stroobants, S., Huizing, M., Aftimos, P., Tol, J., Oyen, W. J. G., Vugts, D. J., Hoekstra, O. S., Schroder, C. P., van Oordt, C. W. M. D. H., Guiot, T., Brouwers, A. H., Awada, A., de Vries, E. G. E. & Flamen, P., Apr 2016, In : Annals of Oncology. 27, 4, p. 619-624

Research output: Contribution to journalArticleAcademicpeer-review

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer

van Loon, J., Even, A. J. G., Aerts, H. J. W. L., Öllers, M., Hoebers, F., van Elmpt, W., Dubois, L., Dingemans, A-M. C., Lalisang, R. I., Kempers, P., Brans, B., Winnepenninckx, V., Speel, E-J., Thunnissen, E., Smits, K. M., Boellaard, R., Vugts, D. J., De Ruysscher, D. & Lambin, P., 21 Dec 2016, In : Radiotherapy and Oncology.

Research output: Contribution to journalArticleAcademicpeer-review

Zr-89-cetuximab PET imaging in patients with advanced colorectal cancer

van der Houven van Oordt, C. W., Gootjes, E. C., Huisman, M. C., Vugts, D. J., Roth, C., Luik, A. M., Mulder, E. R., Schuit, R. C., Boellaard, R., Hoekstra, O. S., van Dongen, G. A. M. S. & Verheul, H. M. W., 2015, In : Oncotarget. 6, 30, p. 30384-30393

Research output: Contribution to journalArticleAcademicpeer-review

2014

A Universal Procedure for the [F-18]Trifluoromethylation of Aryl Iodides and Aryl Boronic Acids with Highly Improved Specific Activity

van der Born, D., Sewing, C., Herscheid, J. D. M., Windhorst, A. D., Orru, R. V. A. & Vugts, D. J., 2014, In : Angewandte Chemie International Edition in English. 53, 41, p. 11046-11050

Research output: Contribution to journalArticleAcademicpeer-review

Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling

Cohen, R., Vugts, D. J., Visser, G. W. M., Stigter-van Walsum, M., Bolijn, M., Spiga, M., Lazzari, P., Shankar, S., Sani, M., Zanda, M. & van Dongen, G. A. M. S., 2014, In : Cancer Research. 74, 20, p. 5700-5710

Research output: Contribution to journalArticleAcademicpeer-review