Diederik Kuster

DR.

20112019
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Research Output 2011 2019

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Article
2019

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W. D., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., Varró, A., Dobrev, D., Ai, X., Janssen, P. M. L., Kass, D. A., Jones, W. K., Gilbert, R. J. & Sadayappan, S., 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 236-246

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Untying the knot: protein quality control in inherited cardiomyopathies

Dorsch, L. M., Schuldt, M., Knežević, D., Wiersma, M., Kuster, D. W. D., van der Velden, J. & Brundel, B. J. J. M., 1 May 2019, In : Pflugers Archiv European Journal of Physiology. 471, 5, p. 795-806

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S. & 1 othersHandoko, M. L., 1 Jan 2018, In : Circulation. 137, 9, p. 910-924 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes

the NIGRAM consortium, Verkaik, M., Oranje, M., Abdurrachim, D., Goebel, M., Gam, Z., Prompers, J. J., Helmes, M., ter Wee, P. M., van der Velden, J., Kuster, D. W., Vervloet, M. G. & Eringa, E. C., 1 Apr 2018, In : Physiological Reports. 6, 7, e13591.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy

Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Krueger, M., Poggesi, C., Ho, C. Y., Kuster, D. W. D., Michels, M. & van der Velden, J., Jun 2018, In : Circulation. Heart failure. 11, 6, e004133.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy

Parbhudayal, R. Y., Garra, A. R., Götte, M. J. W., Michels, M., Pei, J., Harakalova, M., Asselbergs, F. W., van Rossum, A. C., van der Velden, J. & Kuster, D. W. D., Oct 2018, In : Journal of Molecular and Cellular Cardiology. 123, p. 59-63 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy

Bollen, I. A. E., van der Meulen, M., de Goede, K., Kuster, D. W. D., Dalinghaus, M. & van der Velden, J., 22 Dec 2017, In : Frontiers in Physiology. 8, 01103.

Research output: Contribution to journalArticleAcademicpeer-review

Genotype-specific pathogenic effects in human dilated cardiomyopathy

Bollen, I. A. E., Schuldt, M., Harakalova, M., Vink, A., Asselbergs, F. W., Pinto, J. R., Krueger, M., Kuster, D. W. D. & van der Velden, J., 15 Jul 2017, In : Journal of Physiology - London. 595, 14, p. 4677-4693

Research output: Contribution to journalArticleAcademicpeer-review

Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease

Bollen, I. A. E., Ehler, E., Fleischanderl, K., Bouwman, F., Kempers, L., Ricke-Hoch, M., Hilfiker-Kleiner, D., dos Remedios, C. G., Krüger, M., Vink, A., Asselbergs, F. W., van Spaendonck-Zwarts, K. Y., Pinto, Y. M., Kuster, D. W. D. & van der Velden, J., 1 Dec 2017, In : American Journal of Pathology. 187, 12, p. 2645-2658 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

beta-adrenergic receptor signalling and its functional consequences in the diseased heart

Najafi, A., Sequeira Oliveira, V., Kuster, D. W. D. & van der Velden, J., Apr 2016, In : European Journal of Clinical Investigation. 46, 4, p. 362-374

Research output: Contribution to journalArticleAcademicpeer-review

Selective phosphorylation of PKA targets after beta-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model

Najafi, A., Sequeira Oliveira, V., Helmes, M., Bollen, I. A. E., Goebel, M., Regan, J. A., Carrier, L., Kuster, D. W. D. & Van der Velden, J., 15 May 2016, In : Cardiovascular Research. 110, 2, p. 200-214

Research output: Contribution to journalArticleAcademicpeer-review

2015

ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease

Sequeira Oliveira, V., Najafi, A., Wijnker, P. J. M., dos Remedios, C. G., Michels, M., Kuster, D. W. D. & van der Velden, J., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. E7003-E7012

Research output: Contribution to journalArticleAcademicpeer-review

Peripartum cardiomyopathy and dilated cardiomyopathy: different at heart

Bollen, A. E., van Deel, E. D., Kuster, D. W. D. & van der Velden, J., 2015, In : Frontiers in Physiology. 5, 531.

Research output: Contribution to journalArticleAcademicpeer-review

Sex-dependent pathophysiological mechanisms in hypertrophic cardiomyopathy: Implications for rhythm disorders

Nijenkamp, L. A. M., Guclu, A., Appelman, J. E. A., van der Velden, J. & Kuster, D. W. D., 2015, In : Heart Rhythm. 12, 2, p. 433-439

Research output: Contribution to journalArticleAcademicpeer-review

Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice

Najafi, A., Schlossarek, S., van Deel, E. D., van den Heuvel, N., Guclu, A., Goebel, M., Kuster, D. W. D., Carrier, L. & van der Velden, J., 2015, In : Pflügers Archiv European Journal of Physiology. 467, 6, p. 1303-1317

Research output: Contribution to journalArticleAcademicpeer-review

Synergistic role of ADP and Ca2+ in diastolic myocardial stiffness

Sequeira Oliveira, V., Najafi, A., McConnell, M., Fowler, E. D., Bollen, A. E., Wüst, R. C. I., dos Remedios, C., Helmes, M. H. B., White, E., Stienen, G. J. M., Tardiff, J., Kuster, D. W. D. & van der Velden, J., 2015, In : Journal of Physiology - London. 593, 17, p. 3899-3916

Research output: Contribution to journalArticleAcademicpeer-review

2014

Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships

Sequeira Oliveira, V., Witjas-Paalberends, E. R., Kuster, D. W. D. & van der Velden, J., 2014, In : Pflügers Archiv European Journal of Physiology. 466, 2, p. 201-206

Research output: Contribution to journalArticleAcademicpeer-review

MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation

Kuster, D. W. D. & Sadayappan, S., 2014, In : Pflügers Archiv European Journal of Physiology. 466, 2, p. 207-213

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C ( cMyBP-C) Impairs Myofilament Function in Human Myocardium

Witayavanitkul, N., Mou, Y. A., Kuster, D. W. D., Khairallah, R. J., Sarkey, J., Govindan, S., Chen, X., Ge, Y., Rajan, S., Wieczorek, D. F., Irving, T., Westfall, M. V., de Tombe, P. P. & Sadayappan, S., 2014, In : Journal of Biological Chemistry. 289, 13, p. 8818-8827

Research output: Contribution to journalArticleAcademicpeer-review

Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury

Kuster, D. W. D., Cardenas-Ospina, A., Miller, L., Liebetrau, C., Troidl, C., Nef, H. M., Moellmann, H., Hamm, C. W., Pieper, K. S., Mahaffey, K. W., Kleiman, N. S., Stuyvers, B. D., Marian, A. J. & Sadayappan, S., 2014, In : American Journal of Physiology. Heart and Circulatory Physiology. 306, 4, p. H547-H556

Research output: Contribution to journalArticleAcademicpeer-review

Thyroid hormone-regulated cardiac microRNAs are predicted to suppress pathological hypertrophic signaling

Janssen, R., Zuidwijk, M. J., Kuster, D. W. D., Muller, A. & Simonides, W. S., 2014, In : Frontiers in Endocrinology. 5, OCT, 171.

Research output: Contribution to journalArticleAcademicpeer-review

2013

GSK3 beta Phosphorylates Newly Identified Site in the Proline-Alanine-Rich Region of Cardiac Myosin-Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human

Kuster, D. W. D., Sequeira Oliveira, V., Najafi, A., Boontje, N., Wijnker, P. J. M., Witjas-Paalberends, E. R., Marston, S. B., dos Remedios, C. G., Carrier, L., Demmers, J. A. A., Redwood, C., Sadayappan, S. & van der Velden, J., 2013, In : Circulation Research. 112, 4, p. 633-639

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations

Kuster, D. W. D., Mulders, J., ten Cate, F. J., Michels, M., dos Remedios, C. G., da Costa Martins, P. A., van der Velden, J. & Oudejans, C. B. M., 2013, In : Journal of Molecular and Cellular Cardiology. 65, p. 59-66

Research output: Contribution to journalArticleAcademicpeer-review

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

Sequeira Oliveira, V., Wijnker, P. J. M., Nijenkamp, L. L. A. M., Kuster, D. W. D., Najafi, A., Witjas-Paalberends, E. R., Regan, J. A., Boontje, N., ten Cate, F. J., Germans, T., Carrier, L., Sadayappan, S., van Slegtenhorst, M. A., Zaremba, R., Foster, D. B., Murphy, A. M., Poggesi, C., dos Remedios, C., Stienen, G. J. M., Ho, C. Y. & 2 othersMichels, M. & van der Velden, J., 2013, In : Circulation Research. 112, 11, p. 1491-1505

Research output: Contribution to journalArticleAcademicpeer-review

2012

Cardiac myosin binding protein C phosphorylation in cardiac disease

Kuster, D. W. D., Bawazeer, A. C., Zaremba, R., Goebel, M., Boontje, N. & van der Velden, J., 2012, In : Journal of Muscle Research and Cell Motility. 33, 1, p. 43-52

Research output: Contribution to journalArticleAcademicpeer-review

27 Downloads (Pure)

Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy With Normal Systolic Function

van Dijk, S. J., Paalberends, E. R., Najafi, A., Michels, M., Sadayappan, S., Carrier, L., Boontje, N. M., Kuster, D. W. D., van Slegtenhorst, M., Dooijes, D., dos Remedios, C., ten Cate, F. J., Stienen, G. J. M. & van der Velden, J., 2012, In : Circulation. Heart failure. 5, 1, p. 36-U126

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2011

Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis

van Deel, E. D., de Boer, M., Kuster, D. W. D., Boontje, N. M., Holemans, P., Sipido, K. R., van der Velden, J. & Duncker, D. J., 2011, In : Journal of Molecular and Cellular Cardiology. 50, 6, p. 1017-1025

Research output: Contribution to journalArticleAcademicpeer-review

6 Downloads (Pure)

Gene expression profile in the diaphragm following contractile inactivity during thoracic surgery

Welvaart, W. N., Paul, M. A., Kuster, D. W. D., van Wieringen, W. N., Rustenburg, F., Stienen, G. J. M., Vonk Noordegraaf, A. & Ottenheijm, C. A. C., 2011, In : International Journal of Physiology, Pathophysiology and Pharmacology. 3, 3, p. 167-175

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

'Integrative Physiology 2.0': integration of systems biology into physiology and its application to cardiovascular homeostasis

Kuster, D. W. D., Merkus, D., van der Velden, J., Verhoeven, A. J. M. & Duncker, D. J., 2011, In : Journal of Physiology - London. 589, 5, p. 1037-1045

Research output: Contribution to journalArticleAcademicpeer-review

21 Downloads (Pure)

Left ventricular remodeling in swine after myocardial infarction: a transcriptional genomics approach

Kuster, D. W. D., Merkus, D., Kremer, A., van Ijcken, W. F. J., de Beer, V. J., Verhoeven, A. J. M. & Duncker, D. J., 2011, In : Basic Research in Cardiology. 106, 6, p. 1269-1281

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
34 Downloads (Pure)

Nuclear protein extraction from frozen porcine myocardium

Kuster, D. W. D., Merkus, D., Jorna, H. J. J., Dekkers, D. H. W., Duncker, D. J. & Verhoeven, A. J. M., 2011, In : Journal of physiology and biochemistry. 67, 2, p. 165-173

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Prostanoids suppress the coronary vasoconstrictor influence of endothelin after myocardial infarction

de Beer, V. J., Taverne, Y. J., Kuster, D. W. D., Najafi, A., Duncker, D. J. & Merkus, D., 2011, In : American Journal of Physiology. Heart and Circulatory Physiology. 301, 3, p. H1080-H1089

Research output: Contribution to journalArticleAcademicpeer-review