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Research Output

2020

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

van Olst, L., Verhaege, D., Franssen, M., Kamermans, A., Roucourt, B., Carmans, S., Ytebrouck, E., van der Pol, S. M. A., Wever, D., Popovic, M., Vandenbroucke, R. E., Sobrino, T., Schouten, M. & de Vries, H. E., 31 Jan 2020, In : Neurobiology of Aging. 89, 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in glioma

Bikhezar, F., de Kruijff, R. M., van der Meer, A. J. G. M., Torrelo Villa, G., van der Pol, S. M. A., Becerril Aragon, G., Gasol Garcia, A., Narayan, R. S., de Vries, H. E., Slotman, B. J., Denkova, A. G. & Sminia, P., 1 Jan 2020, In : Journal of Neuro-Oncology. 146, 2, p. 239-246 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis

Leurs, C. E., Lopes Pinheiro, M. A., Wierts, L., den Hoedt, S., Mulder, M. T., Eijlers, A. J. C., Schoonheim, M. M., Balk, L. J., Uitdehaag, B. M. J., Killestein, J. & de Vries, H. E., 1 Feb 2019, In : Multiple Sclerosis and Related Disorders. 28, p. 44-49 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Astrocytic ceramide as possible indicator of neuroinflammation

de Wit, N. M., den Hoedt, S., Martinez-Martinez, P., Rozemuller, A. J., Mulder, M. T. & de Vries, H. E., 25 Feb 2019, In : Journal of Neuroinflammation. 16, 1, 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain

Schouten, M., Bielefeld, P., Garcia-Corzo, L., Passchier, E. M. J., Gradari, S., Jungenitz, T., Pons-Espinal, M., Gebara, E., Martín-Suárez, S., Lucassen, P. J., de Vries, H. E., Trejo, J. L., Schwarzacher, S. W., de Pietri Tonelli, D., Toni, N., Mira, H., Encinas, J. M. & Fitzsimons, C. P., 20 Jun 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro

Broekaart, D. W. M., van Scheppingen, J., Anink, J. J., Wierts, L., van het Hof, B., Jansen, F. E., Spliet, W. G., van Rijen, P. C., Kamphuis, W. W., de Vries, H. E., Aronica, E. & van Vliet, E. A., 1 Jan 2019, In : Neuropathology and Applied Neurobiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Induction of brain-infiltrating T-bet–expressing B cells in multiple sclerosis

van Langelaar, J., Rijvers, L., Janssen, M., Wierenga-Wolf, A. F., Melief, M-J., Siepman, T. A., de Vries, H. E., Unger, P-P. A., van Ham, S. M., Hintzen, R. Q. & van Luijn, M. M., 1 Aug 2019, In : Annals of Neurology. 86, 2, p. 264-278

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology

Derada Troletti, C., Fontijn, R. D., Gowing, E., Charabati, M., van Het Hof, B., Didouh, I., van der Pol, S. M. A., Geerts, D., Prat, A., van Horssen, J., Kooij, G. & de Vries, H. E., 1 Feb 2019, In : Cell Death and Disease. 10, 2, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

Wouters, E., de Wit, N. M., Vanmol, J., van der Pol, S. M. A., van Het Hof, B., Sommer, D., Loix, M., Geerts, D., Gustafsson, J. A., Steffensen, K. R., Vanmierlo, T., Bogie, J. F. J., Hendriks, J. J. A. & de Vries, H. E., 1 Jan 2019, In : Frontiers in Immunology. 10, p. 1811

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Profiling the unique protective properties of intracranial arterial endothelial cells

Hermkens, D. M. A., Stam, O. C. G., de Wit, N. M., Fontijn, R. D., Jongejan, A., Moerland, P. D., Mackaaij, C., Waas, I. S. E., Daemen, M. J. A. P. & de Vries, H. E., 14 Oct 2019, In : Acta Neuropathologica Communinications. 7, 1, p. 151

Research output: Contribution to journalArticleAcademicpeer-review

Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production

Kamermans, A., Planting, K. E., Jalink, K., van Horssen, J. & de Vries, H. E., 1 Jan 2019, In : GLIA. 67, 1, p. 68-77 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype

Kamermans, A., Verhoeven, T., van het Hof, B., Koning, J. J., Borghuis, L., Witte, M., van Horssen, J., de Vries, H. E. & Rijnsburger, M., 4 Oct 2019, In : Frontiers in Immunology. 10, 2312.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

Kooij, G., Derada Troletti, C., Leuti, A., Norris, P. C., Riley, I., Albanese, M., Ruggieri, S., Libreros, S., van der Pol, S. M. A., van Het Hof, B., Schell, Y., Guerrera, G., Buttari, F., Mercuri, N. B., Centonze, D., Gasperini, C., Battistini, L., de Vries, H. E., Serhan, C. N. & Chiurchiù, V., 28 Nov 2019, In : Haematologica.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The P4-ATPase ATP9A is a novel determinant of exosome release

Naik, J., Hau, C. M., Bloemendaal, L. T., Mok, K. S., Hajji, N., Wehman, A. M., Meisner, S., Muncan, V., Paauw, N. J., de Vries, H. E., Nieuwland, R., Paulusma, C. C. & Bosma, P. J., 2019, In : PLoS ONE. 14, 4, e0213069.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Activation of the innate immune system is evident throughout epileptogenesis and is associated with blood-brain barrier dysfunction and seizure progression

Broekaart, D. W. M., Anink, J. J., Baayen, J. C., Idema, S., de Vries, H. E., Aronica, E., Gorter, J. A. & van Vliet, E. A., 1 Oct 2018, In : Epilepsia. 59, 10, p. 1931-1944 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy

Chakraborty, A., Kamermans, A., van Het Hof, B., Castricum, K., Aanhane, E., van Horssen, J., Thijssen, V. L., Scheltens, P., Teunissen, C. E., Fontijn, R. D., van der Flier, W. M. & de Vries, H. E., 2018, In : Brain : a journal of neurology. 141, 12, p. 3377-3388 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia

van Olst, L., Bielefeld, P., Fitzsimons, C. P., de Vries, H. E. & Schouten, M., 1 Aug 2018, In : Aging Cell. 17, 4, e12790.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mycobacteria employ two different mechanisms to cross the blood-brain barrier

van Leeuwen, L. M., Boot, M., Kuijl, C., Picavet, D. I., van Stempvoort, G., van der Pol, S. M. A., de Vries, H. E., van der Wel, N. N., van der Kuip, M., van Furth, A. M., van der Sar, A. M. & Bitter, W., 1 Sep 2018, In : Cellular Microbiology. 20, 9, e1285820.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner

Derada Troletti, C., Lopes Pinheiro, M. A., Charabati, M., Gowing, E., van het Hof, B., van der Pol, S. M. A., Geerts, D., Prat, A., Fontijn, R. D., Unger, W. W. & de Vries, H. E., 1 Mar 2018, In : Brain, Behavior, and Immunity. 69, p. 48-56 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Studying the blood–brain barrier will provide new insights into neurodegeneration – Yes

Kamphuis, W. W. & de Vries, H. E., 2018, In : Multiple Sclerosis Journal. 24, 8, p. 1023-1024

Research output: Contribution to journalComment/Letter to the editorAcademic

T helper 17.1 cells associate with multiple sclerosis disease activity: Perspectives for early intervention

van Langelaar, J., van der Vuurst de Vries, R. M., Janssen, M., Wierenga-Wolf, A. F., Spilt, I. M., Siepman, T. A., Dankers, W., Verjans, G. M. G. M., de Vries, H. E., Lubberts, E., Hintzen, R. Q. & van Luijn, M. M., 2018, In : Brain. 141, 5, p. 1334-1349

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2017

Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy

de Wit, N. M., Snkhchyan, H., den Hoedt, S., Wattimena, D., de Vos, R., Mulder, M. T., Walter, J., Martinez-Martinez, P., Hoozemans, J. J., Rozemuller, A. J. & de Vries, H. E., 2017, In : Journal of Alzheimer's Disease. 60, 3, p. 795-807 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation at the blood-brain barrier: The role of liver X receptors

de Wit, N. M., Vanmol, J., Kamermans, A., Hendriks, J. J. A. & de Vries, H. E., 1 Nov 2017, In : Neurobiology of Disease. 107, p. 57-65 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van der Pol, S. M. A., Zarzycka, B., Heijnen, P. D. A. M., Beckers, L., den Toom, M., Gijbels, M. J. J., Boon, L., Weber, C., de Vries, H. E., Nicolaes, G. A. F., Dijkstra, C. D., Kooij, G. & Lutgens, E., 12 May 2017, In : Journal of Neuroinflammation. 14, 1, 105.

Research output: Contribution to journalArticleAcademicpeer-review

In Vivo Molecular MRI of ICAM-1 Expression on Endothelium and Leukocytes from Subacute to Chronic Stages After Experimental Stroke

Deddens, L. H., van Tilborg, G. A. F., van der Marel, K., Hunt, H., van der Toorn, A., Viergever, M. A., de Vries, H. E. & Dijkhuizen, R. M., 1 Oct 2017, In : Translational Stroke Research. 8, 5, p. 440-448 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

MiR-126 and miR-126∗ regulate shear-resistant firm leukocyte adhesion to human brain endothelium

Cerutti, C., Edwards, L. J., De Vries, H. E., Sharrack, B., Male, D. K. & Romero, I. A., 30 Mar 2017, In : Scientific Reports. 7, 45284.

Research output: Contribution to journalArticleAcademicpeer-review

Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment

Lagerweij, T., Dusoswa, S. A., Negrean, A., Hendrikx, E. M. L., de Vries, H. E., Kole, J., Garcia-Vallejo, J. J., Mansvelder, H. D., Vandertop, W. P., Noske, D. P., Tannous, B. A., Musters, R. J. P., van Kooyk, Y., Wesseling, P., Zhao, X. W. & Wurdinger, T., 1 Nov 2017, In : Angiogenesis. 20, 4, p. 533-546 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels

Den Hoedt, S., Janssen, C. I. F., Astarita, G., Piomelli, D., Leijten, F. P. J., Crivelli, S. M., Verhoeven, A. J. M., De Vries, H. E., Walter, J., Martinez-Martinez, P., Sijbrands, E. J. G., Kiliaan, A. J. & Mulder, M. T., 2017, In : Journal of Alzheimer's Disease. 60, 3, p. 769-781 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Purinergic receptor P2Y12: a potential target for PET imaging of neuroinflammation in multiple sclerosis and EAE

Beaino, W., Janssen, B., Kooij, G., van der Pol, S., Windhorst, A. D. & de Vries, H. E., Jun 2017, In : GLIA. 65, p. E478-E479

Research output: Contribution to journalMeeting AbstractAcademic

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

Beaino, W., Janssen, B., Kooij, G., van der Pol, S. M. A., van Het Hof, B., van Horssen, J., Windhorst, A. D. & de Vries, H. E., 22 Dec 2017, In : Journal of Neuroinflammation. 14, 1, p. 259

Research output: Contribution to journalArticleAcademicpeer-review

Serotonin: A mediator of the gut-brain axis in multiple sclerosis

Malinova, T. S., Dijkstra, C. D. & de Vries, H. E., 1 Nov 2017, In : Multiple Sclerosis. 1352458517739975.

Research output: Contribution to journalReview articleAcademicpeer-review

Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications

Crivelli, S. M., Paulus, A., Markus, J., Bauwens, M., Berkes, D., De Vries, H. E., Mulder, M. T., Walter, J., Mottaghy, F. M., Losen, M. & Martinez-Martinez, P., 2017, In : Journal of Alzheimer's Disease. 60, 3, p. 783-794 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The blood brain barrier in Alzheimer's disease

Chakraborty, A., de Wit, N. M., van der Flier, W. M. & de Vries, E., 1 Feb 2017, In : Vascular Pharmacology. 89, p. 12-18 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

Acid sphingomyelinase: a new biomarker for multiple sclerosis?

Leurs, C. E., Pinheiro, M. A. L., Wierts, L., Eijlers, A. J. C., Balk, L., Wattjes, M. P., Uitdehaag, B. M. J., Killestein, J. & de Vries, E., Sep 2016, In : Multiple Sclerosis. 22, p. 770-770

Research output: Contribution to journalMeeting AbstractOther research output

Acid Sphingomyelinase-Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells

Lopes Pinheiro, M., Kroon, J., Hoogenboezem, M., Geerts, D., van het Hof, B., van der Pol, S. M. A., van Buul, J. D. & de Vries, H. E., 1 Jan 2016, In : Journal of Immunology. 196, 1, p. 72-79

Research output: Contribution to journalArticleAcademicpeer-review

Altered blood–brain barrier transport in neuro-inflammatory disorders

Schenk, G. J. & de Vries, H. E., 1 Jun 2016, In : Drug Discovery Today: Technologies. 20, p. 5-11 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats I: Magnetic resonance imaging

van Vliet, E. A., Otte, W. M., Wadman, W. J., Aronica, E., Kooij, G., de Vries, H. E., Dijkhuizen, R. M. & Gorter, J. A., Jan 2016, In : Epilepsia. 57, 1, p. 59-69

Research output: Contribution to journalArticleAcademicpeer-review

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms

van Vliet, E. A., Otte, W. M., Wadman, W. J., Aronica, E., Kooij, G., de Vries, H. E., Dijkhuizen, R. M. & Gorter, J. A., Jan 2016, In : Epilepsia. 57, 1, p. 70-78

Research output: Contribution to journalArticleAcademicpeer-review

Correction: Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., Van Nieuw Amerongen, G. P., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 2016, In : PLoS ONE. 11, 11, p. e0166809

Research output: Contribution to journalArticleAcademicpeer-review

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., van Nieuw Amerongen, G., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 15 Nov 2016, In : PLoS ONE. 11, 11, e0157233.

Research output: Contribution to journalArticleAcademicpeer-review

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., Van Nieuw-Amerongen, G. P., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 2016, In : PLoS ONE. 11, 7, p. e0157233

Research output: Contribution to journalArticleAcademicpeer-review

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke

Lopes Pinheiro, M., Kooij, G., Mizee, M. R., Kamermans, A., Enzmann, G., Lyck, R., Schwaninger, M., Engelhardt, B. & de Vries, H. E., Mar 2016, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1862, 3, p. 461-471

Research output: Contribution to journalArticleAcademicpeer-review

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

Lopes Pinheiro, M., Kamermans, A., Garcia-Vallejo, J. J., Hof, B. V. H., Wierts, L., O'Toole, T., Boeve, D., Verstege, M., van der Pol, S. M. A., Van Kooyk, Y., de Vries, H. E. & Unger, W. W. J., 23 Jun 2016, In : eLife. 5, e13149.

Research output: Contribution to journalArticleAcademicpeer-review

In Vitro and Ex Vivo Model Systems to Measure ABC Transporter Activity at the Blood-Brain Barrier

de Wit, N. M., Kooij, G. & de Vries, H. E., 2016, In : Current Pharmaceutical Design. 22, 38, p. 5768-5773

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro

Cerutti, C., Soblechero-Martin, P., Wu, D., Lopez-Ramirez, M. A., de Vries, H., Sharrack, B., Male, D. K. & Romero, I. A., 31 May 2016, In : FLUIDS AND BARRIERS OF THE CNS. 13, 8.

Research output: Contribution to journalArticleAcademicpeer-review