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Research Output 2008 2019

2019

2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors

Cascioferro, S., Parrino, B., Petri, G. L., Cusimano, M. G., Schillaci, D., di Sarno, V., Musella, S., Giovannetti, E., Cirrincione, G. & Diana, P., 2019, In : European Journal of Medicinal Chemistry. 167, p. 200-210

Research output: Contribution to journalArticleAcademicpeer-review

Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression (Nature Communications, (2018), 9, 1, (1845), 10.1038/s41467-018-03962-x)

Ottaviani, S., Stebbing, J., Frampton, A. E., Zagorac, S., Krell, J., de Giorgio, A., Trabulo, S. M., Nguyen, V. T. M., Magnani, L., Feng, H., Giovannetti, E., Funel, N., Gress, T. M., Jiao, L. R., Lombardo, Y., Lemoine, N. R., Heeschen, C. & Castellano, L., 2019, In : Nature Communications. 10, 1, 3738.

Research output: Contribution to journalErratumAcademicpeer-review

Open Access

Breastfeeding during R-CHOP chemotherapy: please abstain!

Codacci-Pisanelli, G., Honeywell, R. J., Asselin, N., Bellettini, G., Peters, G. J., Giovannetti, E. & Peccatori, F. A., 2019, In : European Journal of Cancer. 119, p. 107-111

Research output: Contribution to journalComment/Letter to the editorAcademic

Can circulating tumor and exosomal nucleic acids act as biomarkers for pancreatic ductal adenocarcinoma?

Liu, D. S. K., Mato Prado, M., Giovannetti, E., Jiao, L. R., Krell, J. & Frampton, A. E., 2019, In : Expert review of molecular diagnostics. 19, 7, p. 553-558

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Can cytidine deaminase be used as predictive biomarker for gemcitabine toxicity and response?

Peters, G. J., Giovannetti, E., Honeywell, R. J. & Ciccolini, J., 2019, In : British Journal of Clinical Pharmacology.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line

van der Steen, N., Leonetti, A., Keller, K., Dekker, H., Funel, N., Lardon, F., Ruijtenbeek, R., Tiseo, M., Rolfo, C., Pauwels, P., Peters, G. J. & Giovannetti, E., 2019, In : Biochemical Pharmacology. 166, p. 128-138

Research output: Contribution to journalArticleAcademicpeer-review

HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers

Moosavi, F., Giovannetti, E., Saso, L. & Firuzi, O., 2019, In : Critical Reviews in Clinical Laboratory Sciences. 56, 8, p. 533-566

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Modification of Drug Response in Cancer by MicroRNAs

Meijer, L. L., Puik, J. R., Vivaldi, C., Capula, M., Vasile, E., Kazemier, G. & Giovannetti, E., 2019, RSC Drug Discovery Series. Royal Society of Chemistry, Vol. 2019-January. p. 416-451 (RSC Drug Discovery Series).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer

Leonetti, A., Wever, B., Mazzaschi, G., Assaraf, Y. G., Rolfo, C., Quaini, F., Tiseo, M. & Giovannetti, E., 17 Sep 2019, In : Drug Resistance Updates. 46, p. 100644

Research output: Contribution to journalArticleAcademicpeer-review

Notch pathway in small-cell lung cancer: from preclinical evidence to therapeutic challenges

Leonetti, A., Facchinetti, F., Minari, R., Cortellini, A., Rolfo, C. D., Giovannetti, E. & Tiseo, M., 2019, In : Cellular Oncology.

Research output: Contribution to journalReview articleAcademicpeer-review

Novel targeted strategies to overcome resistance in small-cell lung cancer: focus on PARP inhibitors and rovalpituzumab tesirine

van den Borg, R., Leonetti, A., Tiseo, M., Giovannetti, E. & Peters, G. J., 2019, In : Expert Review of Anticancer Therapy. 19, 6, p. 461-471

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pharmacogenetics of treatments for pancreatic cancer

el Hassouni, B., Li Petri, G., Liu, D. S. K., Cascioferro, S., Parrino, B., Hassan, W., Diana, P., Ali, A., Frampton, A. E. & Giovannetti, E., 2019, In : Expert Opinion on Drug Metabolism and Toxicology. 15, 6, p. 437-447

Research output: Contribution to journalArticleAcademicpeer-review

Role of c-MET inhibitors in overcoming drug resistance in spheroid models of primary human pancreatic cancer and stellate cells

Firuzi, O., Che, P. P., el Hassouni, B., Buijs, M., Coppola, S., Löhr, M., Funel, N., Heuchel, R., Carnevale, I., Schmidt, T., Mantini, G., Avan, A., Saso, L., Peters, G. J. & Giovannetti, E., 2019, In : Cancers. 11, 5, 638.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment

Balboni, B., el Hassouni, B., Honeywell, R. J., Sarkisjan, D., Giovannetti, E., Poore, J., Heaton, C., Peterson, C., Benaim, E., Lee, Y. B., Kim, D. J. & Peters, G. J., 2019, In : Expert Opinion on Investigational Drugs. 28, 4, p. 311-322

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

Sciarrillo, R., Wojtuszkiewicz, A., El Hassouni, B., Funel, N., Gandellini, P., Lagerweij, T., Buonamici, S., Blijlevens, M., Zeeuw van der Laan, E. A., Zaffaroni, N., Deraco, M., Kusamura, S., Würdinger, T., Peters, G. J., Molthoff, C. F. M., Jansen, G., Kaspers, G. J. L., Cloos, J. & Giovannetti, E., Jan 2019, In : EBioMedicine. 39, p. 215-225

Research output: Contribution to journalArticleAcademicpeer-review

Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance

Parrino, B., Schillaci, D., Carnevale, I., Giovannetti, E., Diana, P., Cirrincione, G. & Cascioferro, S., 2019, In : European Journal of Medicinal Chemistry. 161, p. 154-178 25 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

el Hassouni, B., Granchi, C., Vallés-Martí, A., Supadmanaba, I. G. P., Bononi, G., Tuccinardi, T., Funel, N., Jimenez, C. R., Peters, G. J., Giovannetti, E. & Minutolo, F., 2019, In : Seminars in Cancer Biology.

Research output: Contribution to journalReview articleAcademicpeer-review

To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology

EORTC PAMM Group, Jul 2019, In : Anticancer Research. 39, 7, p. 3303-3309 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Uridine cytidine kinase 2 as a potential biomarker for treatment with RX-3117 in pancreatic cancer*

Hassouni, B. E. L., Infante, J., Mantini, G., Ricci, C., Funel, N., Giovannetti, E. & Peters, G. J., 2019, In : Anticancer Research. 39, 7, p. 3609-3614

Research output: Contribution to journalArticleAcademicpeer-review

2018

5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer

Toffalorio, F., Santarpia, M., Radice, D., Jaramillo, C. A., Spitaleri, G., Manzotti, M., Catania, C., Jordheim, L. P., Pelosi, G., Peters, G. J., Tibaldi, C., Funel, N., Spaggiari, L., de Braud, F., de Pas, T. & Giovannetti, E., 2018, In : Oncotarget. 9, 23, p. 16437-16450 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Aminopeptidase antibodies in mesothelioma: new wine deserves new sacks: new wine deserves new sacks

van Meerbeeck, J. P., Jansen, G., Giovannetti, E. & Peters, G. J., 2018, In : European Respiratory Journal. 51, 5, p. pii: 1800807 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

A synthetic lethal bullet

Rolfo, C. & Giovannetti, E., 1 Jan 2018, In : Nature Nanotechnology. 13, 1, p. 6-7 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Combined exosomal RNA and circulating tumor DNA for epidermal growth factor mutation detection in non-small cell lung cancer

Lazzari, C., Gregorc, V., Cangi, M. G., Giovannetti, E., Bulotta, A. & Santarpia, M., 2018, In : Journal of Thoracic Disease. 10, p. S4023-S4027

Research output: Contribution to journalReview articleAcademicpeer-review

Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer: a prospective validation study

Italian Oncological Group of Clinical Research (GOIRC), Tibaldi, C., Camerini, A., Tiseo, M., Mazzoni, F., Barbieri, F., Vittimberga, I., Brighenti, M., Boni, L., Baldini, E., Gilli, A., Honeywell, R., Chartoire, M., Peters, G. J. & Giovannetti, E., 27 Nov 2018, In : British Journal of Cancer. 119, 11, p. 1326-1331 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC

Van Der Steen, N., Mentens, Y., Ramael, M., Leon, L. G., Germonpré, P., Ferri, J., Gandara, D. R., Giovannetti, E., Peters, G. J., Pauwels, P. & Rolfo, C., Jan 2018, In : Clinical Lung Cancer. 19, 1, p. 35-41

Research output: Contribution to journalArticleAcademicpeer-review

Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden

Frampton, A. E., Prado, M. M., López-Jiménez, E., Fajardo-Puerta, A. B., Jawad, Z. A. R., Lawton, P., Giovannetti, E., Habib, N. A., Castellano, L., Stebbing, J., Krell, J. & Jiao, L. R., 2018, In : Oncotarget. 9, 27, p. 19006-19013 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Liquid biopsies to optimize therapeutic efficacy in unresponsive lung cancer patients

Santarpia, M., Funel, N., Ali, A. & Giovannetti, E., 2018, In : Expert Opinion on Drug Metabolism and Toxicology. 14, 8, p. 761-763 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Multidrug-resistant transporter expression does not always result in drug resistance

le Large, T. Y. S., el Hassouni, B., Kazemier, G., Piersma, S. R., van Laarhoven, H. W. M., Bijlsma, M. F., Jimenez, C. R. & Giovannetti, E., 2018, In : Cancer Science. 109, 10, p. 3360-3362 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Noncoding RNAs emerging as novel biomarkers in pancreatic cancer

Garajová, I., Balsano, R., Tommasi, C. & Giovannetti, E., 2018, In : Current pharmaceutical design. 24, 39, p. 4601-4604

Research output: Contribution to journalReview articleAcademicpeer-review

Plasma miR-181a-5p Downregulation Predicts Response and Improved Survival After FOLFIRINOX in Pancreatic Ductal Adenocarcinoma

Meijer, L. L., Garajová, I., Caparello, C., Le Large, T. Y. S., Frampton, A. E., Vasile, E., Funel, N., Kazemier, G. & Giovannetti, E., 1 Nov 2018, In : Annals of Surgery.

Research output: Contribution to journalArticleAcademicpeer-review

Primary and metastatic brain cancer genomics and emerging biomarkers for immunomodulatory cancer treatment

Passiglia, F., Caglevic, C., Giovannetti, E., Pinto, J. A., Manca, P., Taverna, S., Listì, A., Gil-Bazo, I., Raez, L. E., Russo, A. & Rolfo, C., 2018, In : Seminars in Cancer Biology. 52, Pt 2, p. 259-268 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma

Petri, G. L., Cascioferro, S., Parrino, B., Peters, G. J., Diana, P. & Giovannetti, E., 2018, In : Pharmacogenomics. 19, 10, p. 811-814 4 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance

El Hassouni, B., Sarkisjan, D., Vos, J. C., Giovannetti, E. & Peters, G. J., 3 Dec 2018, In : Current Medicinal Chemistry.

Research output: Contribution to journalArticleAcademicpeer-review

TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression

Ottaviani, S., Stebbing, J., Frampton, A. E., Zagorac, S., Krell, J., de Giorgio, A., Trabulo, S. M., Nguyen, V. T. M., Magnani, L., Feng, H., Giovannetti, E., Funel, N., Gress, T. M., Jiao, L. R., Lombardo, Y., Lemoine, N. R., Heeschen, C. & Castellano, L., 2018, In : Nature Communications. 9, 1, 1845.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The microbiome of pancreatic cancer: from molecular diagnostics to new therapeutic approaches to overcome chemoresistance caused by metabolic inactivation of gemcitabine

Choy, A. T. F., Carnevale, I., Coppola, S., Meijer, L. L., Kazemier, G., Zaura, E., Deng, D. & Giovannetti, E., 2018, In : Expert review of molecular diagnostics. 18, 12, p. 1005-1009

Research output: Contribution to journalArticleAcademicpeer-review

WDR48 (WD repeat domain 48)

Olazabal-Herrero, A., Peters, G. J., Giovannetti, E. & Rodriguez, J. A., 2018, In : Atlas of Genetics and Cytogenetics in Oncology and Haematology. 22, 2, p. 44-50

Research output: Contribution to journalReview articleAcademicpeer-review

2017

A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer

Coppola, S., Carnevale, I., Danen, E. H. J., Peters, G. J., Schmidt, T., Assaraf, Y. G. & Giovannetti, E., 1 Mar 2017, In : Drug Resistance Updates. 31, p. 43-51 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Anaplastic lymphoma kinase inhibition in metastatic non-small cell lung cancer: Clinical impact of alectinib

Muller, I. B., De Langen, A. J., Giovannetti, E. & Peters, G. J., 13 Sep 2017, In : OncoTargets and Therapy. 10, p. 4535-4541 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Development of bioluminescent chick chorioallantoic membrane (CAM) models for primary pancreatic cancer cells: A platform for drug testing

Rovithi, M., Avan, A., Funel, N., Leon, L. G., Gomez, V. E., Wurdinger, T., Griffioen, A. W., Verheul, H. M. W. & Giovannetti, E., 17 Mar 2017, In : Scientific Reports. 7, 44686.

Research output: Contribution to journalArticleAcademicpeer-review

Drug resistance in pancreatic cancer: Impact of altered energy metabolism

Grasso, C., Jansen, G. & Giovannetti, E., 1 Jun 2017, In : Critical Reviews in Oncology/Hematology. 114, p. 139-152 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN

Cavazzoni, A., La Monica, S., Alfieri, R., Ravelli, A., Van Der Steen, N., Sciarrillo, R., Madeddu, D., Lagrasta, C. A. M., Quaini, F., Bonelli, M., Fumarola, C., Cretella, D., Digiacomo, G., Tiseo, M., Peters, G. J., Ardizzoni, A., Petronini, P. G. & Giovannetti, E., 8 Aug 2017, In : Oncotarget. 8, 32, p. 53068-53083 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Epidermal growth factor receptor tyrosine kinase inhibitors and chemotherapy: A glimmer of hope?

Van Der Steen, N., Rolfo, C. D., Pauwels, P., Peters, G. J. & Giovannetti, E., 20 Feb 2017, In : Journal of Clinical Oncology. 35, 6, p. 692-693 2 p.

Research output: Contribution to journalLetterAcademicpeer-review

Erratum to: miRNAs: micro-managers of anticancer combination therapies (Angiogenesis, (2017), 20, (269–285), 10.1007/s10456-017-9545-x)

van Beijnum, J. R., Giovannetti, E., Poel, D., Nowak-Sliwinska, P. & Griffioen, A. W., 1 Nov 2017, In : Angiogenesis. 20, 4, p. 673 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Immunotherapy in NSCLC: A Promising and Revolutionary Weapon

Giovannetti, E., 2017, Advances in Experimental Medicine and Biology Series. Springer

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies

Le Large, T. Y. S., Bijlsma, M. F., Kazemier, G., van Laarhoven, H. W. M., Giovannetti, E. & Jimenez, C. R., 1 Jun 2017, In : Seminars in Cancer Biology. 44, p. 153-169 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Liquid Biopsies in Esophageal, Gastric and Pancreatic Cancers

Giovannetti, E., 2017, Current Clinical Pathology Series. Humana Press

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

MiRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma

Puik, J. R., Meijer, L. L., Le Large, T. Y. S., Prado, M. M., Frampton, A. E., Kazemier, G. & Giovannetti, E., 1 Sep 2017, In : Pharmacogenomics. 18, 14, p. 1343-1358 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

miRNAs: micro-managers of anticancer combination therapies

van Beijnum, J. R., Giovannetti, E., Poel, D., Nowak-Sliwinska, P. & Griffioen, A. W., May 2017, In : Angiogenesis. 20, 2, p. 269-285 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review