Elisa Giovannetti

, (Principal Investigator)

20082019
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Research Output 2008 2019

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2016

Role of Akt signaling in resistance to DNA-targeted therapy

Avan, A., Narayan, R., Giovannetti, E. & Peters, G. J., 2016, In : World journal of clinical oncology. 7, 5, p. 352-369 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy-Letter

Leon, L. G., Funel, N., Peters, G. J., Avan, A., Vistoli, F., Boggi, U. & Giovannetti, E., 15 May 2016, In : Clinical Cancer Research. 22, 10, p. 2594-2594

Research output: Contribution to journalArticleAcademicpeer-review

The potential of neurotrophic tyrosine kinase (NTRK) inhibitors for treating lung cancer

Passiglia, F., Caparica, R., Giovannetti, E., Giallombardo, M., Listi, A., Diana, P., Cirrincione, G., Caglevic, C., Raez, L. E., Russo, A. & Rolfo, C., 2 Apr 2016, In : Expert Opinion on Investigational Drugs. 25, 4, p. 385-392

Research output: Contribution to journalArticleAcademicpeer-review

Tissue distribution of Crizotinib and Gemcitabine combination in a patient-derived orthotopic mouse model of pancreatic cancer

Honeywell, RJ., Avan, A., Giovannetti, E. & Peters, GJ., 2016, In : ADMET & DMPK. 4, p. 327-334

Research output: Contribution to journalArticleAcademicpeer-review

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Sciarrillo, R., Wojtuszkiewicz, A., Kooi, I. E., Gómez, V. E., Boggi, U., Jansen, G., Kaspers, G-J., Cloos, J. & Giovannetti, E., 9 Dec 2016, In : Journal of Visualized Experiments. 118

Research output: Contribution to journalArticleAcademic

2015

Circulating microRNAs as diagnostic biomarkers for pancreatic cancer

Le Large, T. Y. S., Meijer, L. L., Prado, M. M., Kazemier, G., Frampton, A. E. & Giovannetti, E., 2015, In : Expert review of molecular diagnostics. 15, 12, p. 1525-1529

Research output: Contribution to journalArticleAcademicpeer-review

C-MET as a target for personalized therapy

Garajova, I., Giovannetti, E., Biasco, G. & Peters, G. J., 2015, In : Translational Oncogenomics. 7, Suppl 1, p. 13-21

Research output: Contribution to journalArticleAcademicpeer-review

Cytochrome P450 1B1 (CYP1B1) polymorphisms are associated with clinical outcome of docetaxel in non-small cell lung cancer (NSCLC) patients

Vasile, E., Tibaldi, C., Leon, G. L., D'Incecco, A. & Giovannetti, E., 2015, In : Journal of Cancer Research and Clinical Oncology. 141, 7, p. 1189-1194

Research output: Contribution to journalArticleAcademicpeer-review

Entrectinib: a potent new TRK, ROS1, and ALK inhibitor

Rolfo, C., Ruiz, R., Giovannetti, E., Gil-Bazo, I., Russo, A., Passiglia, F., Giallombardo, M., Peeters, M. & Raez, L., 2015, In : Expert Opinion on Investigational Drugs. 24, 11, p. 1493-1500

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients

De Mattos-Arruda, L., Bottai, G., Nuciforo, P. G., Di Tommaso, L., Giovannetti, E., Peg, V., Losurdo, A., Perez-Garcia, J., Masci, G., Corsi, F., Cortes, J., Seoane, J., Calin, G. A. & Santarpia, L., 2015, In : Oncotarget. 6, 35, p. 37269-37280

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA profiling of primary pulmonary enteric adenocarcinoma in members from the same family reveals some similarities to pancreatic adenocarcinoma-a step towards personalized therapy

Garajova, I., Funel, N., Fiorentino, M., Agostini, V., Ferracin, M., Negrini, M., Frassineti, G. L., Gavelli, G., Frampton, A. E., Biasco, G. & Giovannetti, E., 2015, In : Clinical epigenetics. 7, 129.

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNAs in Cancer Management: Big Challenges for Small Molecules

Gandellini, P., Giovannetti, E. & Nicassio, F., 2015, In : BioMed Research International. 2015, 982156.

Research output: Contribution to journalArticleAcademicpeer-review

microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis

Frampton, A. E., Krell, J., Jamieson, N. B., Gall, T. M. H., Giovannetti, E., Funel, N., Prado, M. M., Krell, D., Habib, N. A., Castellano, L., Jiao, L. R. & Stebbing, J., 2015, In : European Journal of Cancer. 51, 11, p. 1389-1404

Research output: Contribution to journalArticleAcademicpeer-review

MiRNAs and Their Interference with the Main Molecular Mechanisms Responsible for Drug Resistance in Pancreatic Cancer

Garajova, I., Giovannetti, E., Caponi, S., van Zweeden, A. A. & Peters, G. J., 2015, In : Current Pharmacology Reports. 1, 4, p. 223-233

Research output: Contribution to journalArticleAcademicpeer-review

NF-kappaB drives acquired resistance to a novel mutant-selective EGFR inhibitor

Galvani, E., Sun, J., Leon, L. G., Sciarrillo, R., Narayan, R. S., Tjin Tham Sjin, R., Lee, K., Ohashi, K., Heideman, D. A. M., Alfieri, R. R., Heynen, G. J., Bernards, R., Smit, E. F., Pao, W., Peters, G. J. & Giovannetti, E., 2015, In : Oncotarget. 6, 40, p. 42717-42732

Research output: Contribution to journalArticleAcademicpeer-review

Platinum-Induced Neurotoxicity and Preventive Strategies: Past, Present, and Future

Avan, A., Postma, T. J., Ceresa, C., Avan, A., Cavaletti, G., Giovannetti, E. & Peters, G. J., 2015, In : The Oncologist. 20, 4, p. 411-432

Research output: Contribution to journalArticleAcademicpeer-review

Unraveling the complexity of autophagy: Potential therapeutic applications in Pancreatic Ductal Adenocarcinoma

Gomez, V. E., Giovannetti, E. & Peters, G. J., 2015, In : Seminars in Cancer Biology. 35, p. 11-19

Research output: Contribution to journalArticleAcademicpeer-review

Usefulness of Measuring microRNAs in Bile and Plasma for Pancreatic Ductal Adenocarcinoma Diagnosis

Le Large, T. Y. S., Frampton, A. E., Meijer, L. L., Stebbing, J., Kazemier, G. & Giovannetti, E., 2015, In : American Journal of Gastroenterology. 110, 5, p. 768-769

Research output: Contribution to journalArticleAcademicpeer-review

2014

AKT1 and SELP Polymorphisms Predict the Risk of Developing Cachexia in Pancreatic Cancer Patients

Avan, A., Avan, A., Le Large, T. Y. S., Mambrini, A., Funel, N., Maftouh, M., Ghayour-Mobarhan, M., Cantore, M., Boggi, U., Peters, G. J., Pacetti, P. & Giovannetti, E., 2014, In : PLoS ONE. 9, 9, e108057.

Research output: Contribution to journalArticleAcademicpeer-review

A microRNA meta-signature for pancreatic ductal adenocarcinoma

Frampton, A. E., Giovannetti, E., Jamieson, N. B., Krell, J., Gall, T. M. H., Stebbing, J., Jiao, L. R. & Castellano, L., 2014, In : Expert review of molecular diagnostics. 14, 3, p. 267-271

Research output: Contribution to journalArticleAcademicpeer-review

A polymorphism in the promoter is associated with EZH2 expression but not with outcome in advanced pancreatic cancer patients

Maftouh, M., Avan, A., Funel, N., Paolicchi, E., Vasile, E., Pacetti, P., Vaccaro, V., Faviana, P., Campani, D., Caponi, S., Mambrini, A., Boggi, U., Cantore, M., Milella, M., Peters, G. J., Reni, M. & Giovannetti, E., 2014, In : Pharmacogenomics. 15, 5, p. 609-618

Research output: Contribution to journalArticleAcademicpeer-review

Are erlotinib and gefitinib interchangeable, opposite or complementary for non-small cell lung cancer treatment? Biological, pharmacological and clinical aspects

Bronte, G., Rolfo, C., Giovannetti, E., Cicero, G., Pauwels, P., Passiglia, F., Castiglia, M., Rizzo, S., Lo Vullo, F., Fiorentino, E., van Meerbeeck, J. & Russo, A., 2014, In : Critical Reviews in Oncology / Hematology. 89, 2, p. 300-313

Research output: Contribution to journalArticleAcademicpeer-review

Calcium/Magnesium Infusion for Oxaliplatin-Induced Neuropathy: Protective or Not?

Avan, A., Avan, A., Giovannetti, E. & Peters, G. J., 2014, In : Journal of Clinical Oncology. 32, 29, p. 3341-3341

Research output: Contribution to journalArticleAcademicpeer-review

Characterization of and Protection from Neurotoxicity Induced by Oxaliplatin, Bortezomib and Epothilone-B

Ceresa, C., Avan, A., Giovannetti, E., Geldof, A. A., Avan, A., Cavaletti, G. & Peters, G. J., 2014, In : Anticancer Research. 34, 1B, p. 517-523

Research output: Contribution to journalArticleAcademicpeer-review

CYB5A and autophagy-mediated cell death in pancreatic cancer

Giovannetti, E. & Giaccone, G., 2014, In : Autophagy. 10, 4, p. 697-698

Research output: Contribution to journalArticleAcademicpeer-review

EZH2 (enhancer of zeste homolog 2 (Drosophila))

Avan, A., Maftouh, M., Fiuji, H., Giovannetti, E. & Peters, G. J., 2014, In : Atlas of Genetics and Cytogenetics in Oncology and Haematology. 18, 12, p. 900-906

Research output: Contribution to journalArticleAcademicpeer-review

Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/beta-catenin signalling in pancreatic adenocarcinoma

Maftouh, M., Da Silva Aresta Belo van Wijk, A. I., Avan, A., Funel, N., Peters, G. J., Giovannetti, E. & van Die, I., 2014, In : Oncotarget. 5, 14, p. 5335-5349

Research output: Contribution to journalArticleAcademicpeer-review

Genetic variation: effect on prostate cancer

Sissung, T. M., Price, D. K., Del Re, M., Ley, A. M., Giovannetti, E., Figg, W. D. & Danesi, R., 2014, In : Biochimica et Biophysica Acta. Reviews on Cancer. 1846, 2, p. 446-456

Research output: Contribution to journalArticleAcademicpeer-review

Impact of microRNAs in Resistance to Chemotherapy and Novel Targeted Agents in Non-Small Cell Lung Cancer

Rolfo, C., Fanale, D., Hong, D. S., Tsimberidou, A. M., Piha-Paul, S. A., Pauwels, P., van Meerbeeck, JP., Caruso, S., Bazan, V., Cicero, G., Russo, A. & Giovannetti, E., 2014, In : Current Pharmaceutical Biotechnology. 15, 5, p. 475-485

Research output: Contribution to journalArticleAcademicpeer-review

MET As a Potential Target for the Treatment of Upper Gastrointestinal Cancers: Characterization of Novel c-Met Inhibitors from Bench to Bed-side

Avan, A., Maftouh, M., Funel, N., Ghayour-Mobarhan, M., Boggi, U., Peters, G. J. & Giovannetti, E., 2014, In : Current Medicinal Chemistry. 21, 8, p. 975-989

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression

Frampton, A. E., Castellano, L., Colombo, T., Giovannetti, E., Krell, J., Jacob, J., Pellegrino, L., Roca-Alonso, L., Funel, N., Gall, T. M. H., Giorgio, A., Pinho, F. G., Fulci, V., Britton, D. J., Ahmad, R., Habib, N. A., Coombes, R. C., Harding, V., Knosel, T., Stebbing, J. & 1 othersJiao, L. R., 2014, In : Gastroenterology. 146, 1, p. 268-277

Research output: Contribution to journalArticleAcademicpeer-review

Mir-211 Modulates Gemcitabine Activity Through Downregulation of Ribonucleotide Reductase and Inhibits the Invasive Behavior of Pancreatic Cancer Cells

Maftouh, M., Avan, A., Funel, N., Frampton, A. E., Fiuji, H., Pelliccioni, S., Castellano, L., Galla, V., Peters, G. J. & Giovannetti, E., 2014, In : Nucleosides, Nucleotides and Nucleic Acids. 33, 4-6, p. 384-393

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Mechanisms Underlying the Role of MicroRNAs in the Chemoresistance of Pancreatic Cancer

Garajova, I., Le Large, T. Y. S., Frampton, A. E., Rolfo, C., Voortman, J. & Giovannetti, E., 2014, In : BioMed Research International. 2014, 678401.

Research output: Contribution to journalArticleAcademicpeer-review

New Strategies and Applications for Drugs Targeting EGFR and c-Met

Giovannetti, E. & Leon, L. G., 2014, In : Current Drug Targets. 15, 14, p. 1261-1262

Research output: Contribution to journalArticleAcademicpeer-review

Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors

Rolfo, C., Giovannetti, E., Hong, D. S., Bivona, T., Raez, L. E., Bronte, G., Buffoni, L., Reguart, N., Santos, E. S., Germonpre, P., Taron, M., Passiglia, F., van Meerbeeck, JP., Russo, A., Peeters, M., Gil-Bazo, I., Pauwels, P. & Rosell, R., 2014, In : Cancer Treatment Reviews. 40, 8, p. 990-1004

Research output: Contribution to journalArticleAcademicpeer-review

On the use of pharmacogenetics in cancer treatment and clinical trials

Robert, J., Le Morvan, V., Giovannetti, E. & Peters, G. J., 2014, In : European Journal of Cancer. 50, 15, p. 2532-2543

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacogenetics of Non-small Cell Lung Cancer (NSCLC): Time to "Work it Out"?

Galvani, E., Toffalorio, F., Peters, G. J., De Pas, T. & Giovannetti, E., 2014, In : Current Pharmaceutical Design. 20, 24, p. 3863-3874

Research output: Contribution to journalArticleAcademicpeer-review

Predictive Role of Repair Enzymes in the Efficacy of Cisplatin Combinations in Pancreatic and Lung Cancer

Peters, G. J., Avan, A., Gallegos-Ruiz, M. I., Orsini, V., Avan, A., Giovannetti, E. & Smit, E. F., 2014, In : Anticancer Research. 34, 1, p. 435-442

Research output: Contribution to journalArticleAcademicpeer-review

Role of CYB5A in Pancreatic Cancer Prognosis and Autophagy Modulation

Giovannetti, E., Wang, Q. Y., Avan, A., Funel, N., Lagerweij, T., Lee, J., Caretti, V., van der Velde, A., Boggi, U., Wang, Y. S., Vasile, E., Peters, G. J., Wurdinger, T. & Giaccone, G., 2014, In : Journal of the National Cancer Institute. 106, 1, djt346.

Research output: Contribution to journalArticleAcademicpeer-review

Selection of the Best Blood Compartment to Measure Cytidine Deaminase Activity to Stratify for Optimal Gemcitabine Or Cytarabine Treatment

Peters, G. J., Honeywell, R. J., Maulandi, M., Giovannetti, E., Losekoot, N., Etienne-Grimaldi, M. C., Milano, G., Serdjebi, C. & Ciccolini, J., 2014, In : Nucleosides, Nucleotides and Nucleic Acids. 33, 4-6, p. 403-412

Research output: Contribution to journalArticleAcademicpeer-review

SNPs in PI3K-PTEN-mTOR and Brain Metastases in NSCLC-Letter

Avan, A., Maftouh, M., Avan, A., Tibaldi, C., Zucali, P. A. & Giovannetti, E., 2014, In : Clinical Cancer Research. 20, 13, p. 3623-3624

Research output: Contribution to journalArticleAcademicpeer-review

Synergistic Activity of the c-Met and Tubulin Inhibitor Tivantinib (ARQ197) with Pemetrexed in Mesothelioma Cells

Leon, L. G., Gemelli, M., Sciarrillo, R., Avan, A., Funel, N. & Giovannetti, E., 2014, In : Current Drug Targets. 15, 14, p. 1331-1340

Research output: Contribution to journalArticleAcademicpeer-review

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

Maftouh, M., Avan, A., Sciarrillo, R., Granchi, C., Leon, L. G., Rani, R., Funel, N., Smid, K., Honeywell, R. J., Boggi, U., Minutolo, F., Peters, G. J. & Giovannetti, E., 2014, In : British Journal of Cancer. 110, 1, p. 172-182

Research output: Contribution to journalArticleAcademicpeer-review

The EGFR Pathway Regulates BCRP Expression in NSCLC Cells: Role of Erlotinib

Porcelli, L., Giovannetti, E., Assaraf, Y. G., Jansen, G., Scheffer, G. L., Kathman, I., Azzariti, A., Paradiso, A. & Peters, G. J., 2014, In : Current Drug Targets. 15, 14, p. 1322-1330

Research output: Contribution to journalArticleAcademicpeer-review

A single nucleotide polymorphism in EZH2 predicts overall survival rate in patients with cholangiocarcinoma

Paolicchi, E., Pacetti, P., Giovannetti, E., Mambrini, A., Orlandi, M., Crea, F., Romani, A. A., Tartarini, R., Danesi, R., Peters, G. J. & Cantore, M., 2013, In : Oncology Letters. 6, 5, p. 1487-1491

Research output: Contribution to journalArticleAcademicpeer-review

Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding?

Pistilli, B., Bellettini, G., Giovannetti, E., Codacci-Pisanelli, G., Azim, H. A., Benedetti, G., Sarno, M. A. & Peccatori, F. A., 2013, In : Cancer Treatment Reviews. 39, 3, p. 207-211

Research output: Contribution to journalArticleAcademicpeer-review