Elisa Giovannetti

, (Principal Investigator)

20082019
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Research Output 2008 2019

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2013

Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met-driven Pancreatic Carcinoma

Avan, A., Caretti, V., Funel, N., Galvani, E., Maftouh, M., Honeywell, R. J., Lagerweij, T., van Tellingen, O., Campani, D., Fuchs, D., Verheul, H. M., Schuurhuis, G. J., Boggi, U., Peters, G. J., Wurdinger, T. & Giovannetti, E., 2013, In : Cancer Research. 73, 22, p. 6745-6756

Research output: Contribution to journalArticleAcademicpeer-review

Development of New Molecular Agents Targeting Key Signalling Pathways Activated by Growth Factors in Human Cancer

Giovannetti, E. & Peters, G. J., 2013, In : Current Pharmaceutical Design. 19, 5, p. 807-807

Research output: Contribution to journalArticleAcademicpeer-review

Distinct miRNA profiles are associated with malignant transformation of pancreatic cystic tumors revealing potential biomarkers for clinical use

Frampton, A. E., Gall, T. M. H., Giovannetti, E., Stebbing, J., Castellano, L., Jiao, L. R. & Krell, J., 2013, In : Expert review of molecular diagnostics. 13, 4, p. 325-329

Research output: Contribution to journalArticleAcademicpeer-review

Enhancement of the Antiproliferative Activity of Gemcitabine by Modulation of c-Met Pathway in Pancreatic Cancer

Avan, A., Quint, K., Nicolini, F., Funel, N., Frampton, A. E., Maftouh, M., Pelliccioni, S., Schuurhuis, G. J., Peters, G. J. & Giovannetti, E., 2013, In : Current Pharmaceutical Design. 19, 5, p. 940-950

Research output: Contribution to journalArticleAcademicpeer-review

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Current Status and Future Perspectives in the Development of Novel Irreversible Inhibitors for the Treatment of Mutant Non-small Cell Lung Cancer

Galvani, E., Alfieri, R., Giovannetti, E., Cavazzoni, A., La Monica, S., Galetti, M., Fumarola, C., Bonelli, M., Mor, M., Tiseo, M., Peters, G. J., Petronini, P. G. & Ardizzoni, A., 2013, In : Current Pharmaceutical Design. 19, 5, p. 818-832

Research output: Contribution to journalArticleAcademicpeer-review

Gefitinib Inhibits Invasive Phenotype and Epithelial-Mesenchymal Transition in Drug-Resistant NSCLC Cells with MET Amplification

La Monica, S., Caffarra, C., Saccani, F., Galvani, E., Galetti, M., Fumarola, C., Bonelli, M., Cavazzoni, A., Cretella, D., Sirangelo, R., Gatti, R., Tiseo, M., Ardizzoni, A., Giovannetti, E., Petronini, P. G. & Alfieri, R. R., 2013, In : PLoS ONE. 8, 10, e78656.

Research output: Contribution to journalArticleAcademicpeer-review

Gender, Cytidine Deaminase, and 5-Aza/Decitabine-Letter

Ciccolini, J., Peters, G. J. & Giovannetti, E., 2013, In : Clinical Cancer Research. 19, 11, p. 3105-3105

Research output: Contribution to journalArticleAcademicpeer-review

MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1

Azijli, K., Yuvaraj, S., van Roosmalen, I., Flach, K., Giovannetti, E., Peters, G. J., de Jong, S. & Kruyt, F. A. E., 2013, In : Apoptosis. 18, 7, p. 851-860

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Mechanisms Underlying the Antitumor Activity of 3-Aminopropanamide Irreversible Inhibitors of the Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer

Galvani, E., Giovannetti, E., Saccani, F., Cavazzoni, A., Leon, L. G., Dekker, H., Alfieri, R., Carmi, C., Mor, M., Ardizzoni, A., Petronini, P. G. & Peters, G. J., 2013, In : Neoplasia. 15, 1, p. 61-72

Research output: Contribution to journalArticleAcademicpeer-review

38 Downloads (Pure)

Pemetrexed Induced Thymidylate Synthase Inhibition in Non-Small Cell Lung Cancer Patients: A Pilot Study with 3 '-Deoxy-3 '-[F-18]fluorothymidine Positron Emission Tomography

Frings, V., van der Veldt, A. A. M., Boellaard, R., Herder, G. J. M., Giovannetti, E., Honeywell, R. J., Peters, G. J., Thunnissen, E., Hoekstra, O. S. & Smit, E. F., 2013, In : PLoS ONE. 8, 5, e63705.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Polymorphisms correlated with the clinical outcome of locally advanced or metastatic colorectal cancer patients treated with ALIRI vs. FOLFIRI

Barcelos, A., Giovannetti, E., de Jonge, R., Maftouh, M., Griffioen, P., Hanauske, A. R. & Peters, G. J., 2013, In : Pteridines. 24, 1, p. 69-79

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic factors in gemcitabine-cisplatin polychemotherapy regimens in pancreatic cancer: XPD-Lys751Gln polymorphism strikes back

Avan, A., Pacetti, P., Reni, M., Milella, M., Vasile, E., Mambrini, A., Vaccaro, V., Caponi, S., Cereda, S., Peters, G. J., Cantore, M. & Giovannetti, E., 2013, In : International Journal of Cancer. 133, 4, p. 1016-1022

Research output: Contribution to journalArticleAcademicpeer-review

Serum miR-1290 as a Marker of Pancreatic Cancer-Letter

Frampton, A. E., Krell, J., Kazemier, G. & Giovannetti, E., 2013, In : Clinical Cancer Research. 19, 18, p. 5250-5251

Research output: Contribution to journalArticleAcademicpeer-review

The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms

Caponi, S., Funel, N., Frampton, A. E., Mosca, F., Santarpia, L., van der Velde, A. G., Jiao, L. R., De Lio, N., Falcone, A., Kazemier, G., Meijer, G. A., Verheul, H. M. W., Vasile, E., Peters, G. J., Boggi, U. & Giovannetti, E., 2013, In : Annals of Oncology. 24, 3, p. 734-741

Research output: Contribution to journalArticleAcademicpeer-review

Thymidylate synthase inhibitors for thoracic tumors

Peters, G. J., Galvani, E., Jansen, G., Assaraf, Y. & Giovannetti, E., 2013, In : Pteridines. 24, 1, p. 57-67

Research output: Contribution to journalArticleAcademicpeer-review

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy

Garcia-Santisteban, I., Peters, G. J., Giovannetti, E. & Rodriguez, J. A., 2013, In : Molecular Cancer. 12, 91.

Research output: Contribution to journalArticleAcademicpeer-review

2012

Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients

Tibaldi, C., Giovannetti, E., Tiseo, M., Leon, L. G., D'Incecco, A., Losekoot, N., Bartolotti, M., Honeywell, R. J., Cappuzzo, F., Ardizzoni, A. & Peters, G. J., 2012, In : Annals of Oncology. 23, 3, p. 670-677

Research output: Contribution to journalArticleAcademicpeer-review

Defining a prognostic molecular profile for ductal adenocarcinoma of the pancreas highlights known key signaling pathways

Frampton, A. E., Krell, J., Giovannetti, E., Krell, D., Stebbing, J., Castellano, L. & Jiao, L. R., 2012, In : Expert Review of Anticancer Therapy. 12, 10, p. 1275-1278

Research output: Contribution to journalArticleAcademicpeer-review

EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity

Galvani, E., Peters, G. J. & Giovannetti, E., 2012, In : Future Oncology. 8, 8, p. 1015-1029

Research output: Contribution to journalArticleAcademicpeer-review

First genome-wide association study to identify novel genes related to irinotecan toxicity

Peters, G. J. & Giovannetti, E., 2012, In : Pharmacogenomics. 13, 13, p. 1445-1446

Research output: Contribution to journalArticleAcademicpeer-review

37 Downloads (Pure)

High-Throughput MicroRNA (miRNAs) Arrays Unravel the Prognostic Role of MiR-211 in Pancreatic Cancer

Giovannetti, E., te Velde, A., Funel, N., Vasile, E., Perrone, V., Leon, L. G., De Lio, N., Avan, A., Caponi, S., Pollina, L. E., Galla, V., Sudo, H., Falcone, A., Campani, D., Boggi, U. & Peters, G. J., 2012, In : PLoS ONE. 7, 11, p. e49145-e49145

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Loss of 18q22.3 Involving the Carboxypeptidase of Glutamate-like Gene Is Associated with Poor Prognosis in Resected Pancreatic Cancer

Lee, J., Giovannetti, E., Hwang, J. H., Petrini, I., Wang, Q. Y., Voortman, J., Wang, Y. H., Steinberg, S. M., Funel, N., Meltzer, P. S., Wang, Y. S. & Giaccone, G., 2012, In : Clinical Cancer Research. 18, 2, p. 524-533

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells

Avan, A., Crea, F., Paolicchi, E., Funel, N., Galvani, E., Marquez, V. E., Honeywell, R. J., Danesi, R., Peters, G. J. & Giovannetti, E., 2012, In : Molecular Cancer Therapeutics. 11, 8, p. 1735-1746

Research output: Contribution to journalArticleAcademicpeer-review

Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice

Giovannetti, E., Erozenci, A., Smit, J., Danesi, R. & Peters, G. J., 2012, In : Critical Reviews in Oncology / Hematology. 81, 2, p. 103-122

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Targets of Gemcitabine Action: Rationale for Development of Novel Drugs and Drug Combinations

Elnaggar, M., Giovannetti, E. & Peters, G. J., 2012, In : Current Pharmaceutical Design. 18, 19, p. 2811-2829

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacogenetics of conventional chemotherapy in non-small-cell lung cancer: a changing landscape?

Giovannetti, E., Toffalorio, F., De Pas, T. & Peters, G. J., 2012, In : Pharmacogenomics. 13, 9, p. 1073-1086

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin

Tiseo, M., Giovannetti, E., Tibaldi, C., Camerini, A., Di Costanzo, F., Barbieri, F., Burgers, J. A., Vincent, A. D., Peters, G. J., Smit, E. F. & Ardizzoni, A., 2012, In : Lung Cancer. 78, 1, p. 92-99

Research output: Contribution to journalArticleAcademicpeer-review

Polymorphisms to Predict Outcome to the Tyrosine Kinase Inhibitors Gefitinib, Erlotinib, Sorafenib and Sunitinib

Erdem, L., Giovannetti, E., Leon, L. G., Honeywell, R. & Peters, G. J., 2012, In : Current Topics in Medicinal Chemistry. 12, 15, p. 1649-1659

Research output: Contribution to journalArticleAcademicpeer-review

Role of miRNAs in the response to anticancer therapy

Frampton, A. L., Krell, J., Giovannetti, E., Jiao, L. R. & Stebbing, J., 2012, In : Pharmacogenomics. 13, 15, p. 1663-1666

Research output: Contribution to journalArticleAcademicpeer-review

96 Downloads (Pure)

TFAP2E-DKK4 and Chemoresistance in Colorectal Cancer

Giovannetti, E., Codacci-Pisanelli, G. & Peters, G. J., 2012, In : New England Journal of Medicine. 366, 10, p. 966-966

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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"The only thing I know is that I know nothing": 5-fluorouracil in human milk

Peccatori, F. A., Giovannetti, E., Pistilli, B., Bellettini, G., Codacci-Pisanelli, G., Losekoot, N., Curigliano, G., Peccatori, H. A., Azim, G. A. & Peters, G. J., 2012, In : Annals of Oncology. 23, 2, p. 543-544

Research output: Contribution to journalArticleAcademicpeer-review

2011

Analysis of drug interactions

Bijnsdorp, I. V., Giovannetti, E. & Peters, G. J., 2011, In : Methods in Molecular Biology. 731, p. 421-434

Research output: Contribution to journalArticleAcademic

Antiproliferative Effects of Novel Aliphatic Acetogenin Analogs Against Aggressive Solid Tumor Cell Lines

Leon, L. G., Giovannetti, E., Alecci, C., Giancola, F., Funel, N., Zucali, P., Peters, G. J. & Padron, J. M., 2011, In : In vivo. 25, 2, p. 203-207

Research output: Contribution to journalArticleAcademicpeer-review

Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy

Giovannetti, E., Pacetti, P., Reni, M., Leon, L. G., Mambrini, A., Vasile, E., Ghidini, M., Funel, N., Lucchesi, M., Cereda, S., Peters, G. J. & Cantore, M., 2011, In : Pharmacogenomics. 12, 12, p. 1641-1652

Research output: Contribution to journalArticleAcademicpeer-review

Correlation of basal EGFR expression with pancreatic cancer grading but not with clinical outcome after gemcitabine-based treatment

Funel, N., Vasile, E., Del Chiaro, M., Boggi, U., Falcone, A., Campani, D., Scarpa, A. & Giovannetti, E., 2011, In : Annals of Oncology. 22, 2, p. 482-484

Research output: Contribution to journalArticleAcademicpeer-review

Critical role of laser microdissection for genetic, epigenetic and proteomic analyses in pancreatic cancer

Funel, N., Giovannetti, E., Pollina, L. E., Del Chiaro, M., Mosca, F., Boggi, U. & Campani, D., 2011, In : Expert review of molecular diagnostics. 11, 7, p. 695-701

Research output: Contribution to journalArticleAcademicpeer-review

Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

Granchi, C., Roy, S., Giacomelli, C., Macchia, M., Tuccinardi, T., Martinelli, A., Lanza, M., Betti, L., Giannaccini, G., Lucacchini, A., Funel, N., Leon, L. G., Giovannetti, E., Peters, G. J., Palchaudhuri, R., Calvaresi, E. C., Hergenrother, P. J. & Minutolo, F., 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1599-1612

Research output: Contribution to journalArticleAcademicpeer-review

DNA Copy Number Profiles Correlate with Outcome in Colorectal Cancer Patients Treated with Fluoropyrimidine/Antifolate-based Regimens

Leon, L. G., Giovannetti, E., Smid, K., van Houte, B. P. P., Hanauske, A. R., Giaccone, G. & Peters, G. J., 2011, In : Current Drug Metabolism. 12, 10, p. 956-965

Research output: Contribution to journalArticleAcademic

Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients

Lemos, C., Giovannetti, E., Zucali, P. A., Assaraf, Y. G., Scheffer, G. L., van der Straaten, T., D'Incecco, A., Falcone, A., Guchelaar, H. J., Danesi, R., Santoro, A., Giaccone, G., Tibaldi, C. & Peters, G. J., 2011, In : Pharmacogenomics. 12, 2, p. 159-170

Research output: Contribution to journalArticleAcademicpeer-review

Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer

Giovannetti, E., Erdem, L., Olcay, E., Leon, L. G. & Peters, G. J., 2011, In : Frontiers in Bioscience. 16, p. 116-130

Research output: Contribution to journalArticleAcademicpeer-review

Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Patients

Tibaldi, C., Giovannetti, E., Vasile, E., Boldrini, L., Gallegos-Ruiz, M. I., Bernardini, I., Incensati, R., Danesi, R., Cappuzzo, F., Peters, G. J. & Fontanini, G., 2011, In : Journal of Thoracic Oncology. 6, 2, p. 395-396

Research output: Contribution to journalArticleAcademicpeer-review

Loss of Heterozygosity Status of D9S105 Marker Is Associated with Downregulation of Kruppel-Like Factor 4 Expression in Pancreatic Ductal Adenocarcinoma and Pancreatic Intraepithelial Lesions

Funel, N., Morelli, M., Giovannetti, E., Del Chiaro, M., Pollina, L. E., Mosca, F., Boggi, U., Cavazzana, A. & Campani, D., 2011, In : Pancreatology. 11, 1, p. 30-42

Research output: Contribution to journalArticleAcademicpeer-review

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

Granchi, C., Roy, S., De Simone, A., Salvetti, I., Tuccinardi, T., Martinelli, A., Macchia, M., Lanza, M., Betti, L., Giannaccini, G., Lucacchini, A., Giovannetti, E., Sciarrillo, R., Peters, G. J. & Minutolo, F., Nov 2011, In : European Journal of Medicinal Chemistry. 46, 11, p. 5398-5407 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

35 Downloads (Pure)

Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin

Giovannetti, E., Zucali, P. A., Assaraf, Y. G., Leon, L. G., Smid, K., Alecci, C., Giancola, F., Destro, A., Gianoncelli, L., Lorenzi, E., Roncalli, M., Santoro, A. & Peters, G. J., 2011, In : British Journal of Cancer. 105, 10, p. 1542-1553

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Regulation of Deoxycytidine Kinase Expression and Sensitivity to Gemcitabine by Micro-RNA 330 and Promoter Methylation in Cancer Cells

Hodzic, J., Giovannetti, E., Calvo, B. D., Adema, A. D. & Peters, G. J., 2011, In : Nucleosides, Nucleotides and Nucleic Acids. 30, 12, p. 1214-1222

Research output: Contribution to journalArticleAcademicpeer-review