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Research Output 2008 2019

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2008

Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples

Giovannetti, E., Laan, A. C., Vasile, E., Tibaldi, C., Nannizzi, S., Ricciardi, S., Falcone, A., Danesi, R. & Peters, G. J., 2008, In : Nucleosides, Nucleotides and Nucleic Acids. 27, 6-7, p. 720-725

Research output: Contribution to journalArticleAcademicpeer-review

Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients

Tibaldi, C., Giovannetti, E., Vasile, E., Mey, V., Laan, A. C., Nannizzi, S., Di Marsico, R., Antonuzzo, A., Orlandini, C., Ricciardi, S., Del Tacca, M., Peters, G. J., Falcone, A. & Danesi, R., 2008, In : Clinical Cancer Research. 14, 6, p. 1797-1803

Research output: Contribution to journalArticleAcademicpeer-review

Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells

Lemos, C., Kathmann, I., Giovannetti, E., Dekker, H., Scheffer, G. L., Calhau, C., Jansen, G. & Peters, G. J., 2008, In : International Journal of Cancer. 123, 7, p. 1712-1720

Research output: Contribution to journalArticleAcademicpeer-review

Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples

Hubeek, I., Giovannetti, E., Broekhuizen, AJ., Pastor-Anglada, M., Kaspers, G. J. L. & Peters, G. J., 2008, In : Nucleosides, Nucleotides and Nucleic Acids. 27, 6-7, p. 787-793

Research output: Contribution to journalArticleAcademicpeer-review

Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma

Funel, N., Giovannetti, E., Del Chiaro, M., Mey, V., Pollina, L. E., Nannizzi, S., Boggi, U., Ricciardi, S., Del Tacca, M., Bevilacqua, G., Mosca, F., Danesi, R. & Campani, D., 2008, In : Laboratory Investigation. 88, 7, p. 773-784

Research output: Contribution to journalArticleAcademicpeer-review

Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

Giovannetti, E., Ugrasena, D. G., Supriyadi, E., Vroling, L., Azzarello, A., de Lange, D., Peters, G. J., Veerman, A. J. P. & Cloos, J., 2008, In : Leukemia Research. 32, 1, p. 19-24

Research output: Contribution to journalArticleAcademicpeer-review

Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells

Giovannetti, E., Lemos, C., Tekle, C., Smid, K., Nannizzi, S., Rodriguez, J. A., Ricciardi, S., Danesi, R., Giaccone, G. & Peters, G. J., 2008, In : Molecular Pharmacology. 73, 4, p. 1290-1300

Research output: Contribution to journalArticleAcademicpeer-review

Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells

Tekle, C., Giovannetti, E., Sigmond, J., Graff, J. R., Smid, K. & Peters, G. J., 2008, In : British Journal of Cancer. 99, 5, p. 750-759

Research output: Contribution to journalArticleAcademicpeer-review

Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors

Zucali, P. A., Ruiz, M. G., Giovannetti, E., Destro, A., Varella-Garcia, M., Floor, K., Ceresoli, G. L., Rodriguez, J. A., Garassino, I., Comoglio, P., Roncalli, M., Santoro, A. & Giaccone, G., 2008, In : Annals of Oncology. 19, 9, p. 1605-1612

Research output: Contribution to journalArticleAcademicpeer-review

Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins

Lemos, C., Kathmann, L., Giovannetti, E., Belien, J. A. M., Scheffer, G. L., Calhau, C., Jansen, G. & Peters, G. J., 2009, In : Molecular Cancer Therapeutics. 8, 3, p. 655-664

Research output: Contribution to journalArticleAcademicpeer-review

Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines

Crea, F., Giovannetti, E., Cortesi, F., Mey, V., Nannizzi, S., Ruiz, M., Ricciardi, S., Del Tacca, M., Peters, G. J. & Danesi, R., 2009, In : Molecular Cancer Therapeutics. 8, 7, p. 1964-1973

Research output: Contribution to journalArticleAcademicpeer-review

Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib

Lemos, C., Kathmann, I., Giovannetti, E., Calhau, C., Jansen, G. & Peters, G. J., 2009, In : British Journal of Cancer. 100, 7, p. 1120-1127

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacogenomics in non-small-cell lung cancer chemotherapy

Danesi, R., Pasqualetti, G., Giovannetti, E., Crea, F., Altavilla, G., Del Tacca, M. & Rosell, R., 2009, In : Advanced Drug Delivery Reviews. 61, 5, p. 408-417

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacogenomics of gemcitabine in non-small-cell lung cancer and other solid tumors

Danesi, R., Altavilla, G., Giovannetti, E. & Rosell, R., 2009, In : Pharmacogenomics. 10, 1, p. 69-80

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacologic rationale for early G-CSF prophylaxis in cancer patients and role of pharmacogenetics in treatment optimization

Crea, F., Giovannetti, E., Zinzani, P. L. & Danesi, R., 2009, In : Critical Reviews in Oncology / Hematology. 72, 1, p. 21-44

Research output: Contribution to journalArticleAcademicpeer-review

Polymorphisms in the Enhancer Region of the Thymidylate Synthase Gene Are Associated with Thymidylate Synthase Levels in Normal Tissues but Not in Malignant Tissues of Patients with Colorectal Cancer

Mauritz, R., Giovannetti, E., Beumer, I. J., Smid, K., van Groeningen, C. J., Pinedo, H. M. & Peters, G. J., 2009, In : Clinical Colorectal Cancer. 8, 3, p. 146-154

Research output: Contribution to journalArticleAcademicpeer-review

Role of pharmacodynamic, pharmacogenetic and pharmacogenomic biomarkers of cancer chemotherapy with antifolates

Peters, G. J., Honeywell, R. J., Leon, L. G., van Groeningen, C. J., Jansen, G., Ijlstra, B., Meijer, G. A. & Giovannetti, E., 2009, In : Pteridines. 20, p. 115-127

Research output: Contribution to journalArticleAcademic

Single Nucleotide Polymorphisms and Clinical Outcome in Patients with Biliary Tract Carcinoma Treated with Epirubicin, Cisplatin and Capecitabine

Pacetti, P., Giovannetti, E., Mambrini, A., Nannizzi, S., Orlandi, M., Tartarini, R., Del Freo, A., Del Tacca, M., Danesi, R. & Cantore, M., 2009, In : Anticancer Research. 29, 5, p. 1835-1840

Research output: Contribution to journalArticleAcademicpeer-review

2010

A Multicenter Phase II Study of Erlotinib and Sorafenib in Chemotherapy-Naive Patients with Advanced Non-Small Cell Lung Cancer

Lind, J. S. W., Dingemans, A. M. C., Groen, H. J. M., Thunnissen, F. B. J. M., Bekers, O., Heideman, D. A. M., Honeywell, R. J., Giovannetti, E., Peters, G. J., Postmus, P. E., van Suylen, R. J. & Smit, E. F., 2010, In : Clinical Cancer Research. 16, 11, p. 3078-3087

Research output: Contribution to journalArticleAcademicpeer-review

Association of Polymorphisms in AKT1 and EGFR with Clinical Outcome and Toxicity in Non-Small Cell Lung Cancer Patients Treated with Gefitinib

Giovannetti, E., Zucali, P. A., Peters, G. J., Cortesi, F., D'Incecco, A., Smit, E. F., Falcone, A., Burgers, J. A., Santoro, A., Danesi, R., Giaccone, G. & Tibaldi, C., 2010, In : Molecular Cancer Therapeutics. 9, 3, p. 581-593

Research output: Contribution to journalArticleAcademicpeer-review

21 Downloads (Pure)

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines

Nannizzi, S., Veal, G. J., Giovannetti, E., Mey, V., Ricciardi, S., Ottley, C. J., Tacca, M. D. & Danesi, R., 2010, In : Cancer Chemotherapy and Pharmacology. 66, 3, p. 547-558

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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24 Downloads (Pure)

Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients

Pastina, I., Giovannetti, E., Chioni, A., Sissung, T. M., Crea, F., Orlandini, C., Price, D. K., Cianci, C., Figg, W. D., Ricci, S. & Danesi, R., 2010, In : BMC Cancer. 10, p. 511 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Differences of Gene Expression in Non-small Cell Lung Cancer Are Histology, Tumor Site, and Methodology Relevant?

Toffalorio, F., De Pas, T. & Giovannetti, E., 2010, In : Journal of Thoracic Oncology. 5, 8, p. 1310-1311

Research output: Contribution to journalArticleAcademicpeer-review

3 Downloads (Pure)

Drug delivery and drug resistance: EGFR-tyrosine kinase inhibitors in non-small cell lung cancer

Olcay, E., Giovannetti, E. & Peters, G. J., 2010, In : The Open Lung Cancer Journal. 3, p. 25-32 8 p.

Research output: Contribution to journalArticleAcademic

Open Access
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Expression of gemcitabine- and cisplatin-related genes in non-small-cell lung cancer

Toffalorio, F., Giovannetti, E., De Pas, T., Radice, D., Pelosi, G., Manzotti, M., Minocci, D., Spaggiari, L., Spitaleri, G., Noberasco, C., Catania, C., Boselli, S., Danesi, R. & de Braud, F., 2010, In : Pharmacogenomics Journal. 10, 3, p. 180-190

Research output: Contribution to journalArticleAcademicpeer-review

30 Downloads (Pure)

Identification of MicroRNA-21 as a Biomarker for Chemoresistance and Clinical Outcome Following Adjuvant Therapy in Resectable Pancreatic Cancer

Hwang, J. H., Voortman, J., Giovannetti, E., Steinberg, S. M., Leon, L. G., Kim, Y. T., Funel, N., Park, J. K., Kim, M. A., Kang, G. H., Kim, S. W., Del Chiaro, M., Peters, G. J. & Giaccone, G., 2010, In : PLoS ONE. 5, 5, p. e10630 12 p., e10630.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Impact of Cytidine Deaminase Polymorphisms on Toxicity After Gemcitabine: The Question Is Still Ongoing

Giovannetti, E., Tibaldi, C., Falcone, A., Danesi, R. & Peters, G. J., 2010, In : Journal of Clinical Oncology. 28, 14, p. E221-E222

Research output: Contribution to journalArticleAcademicpeer-review

Methylation Specific PCR to Characterize Methylation of the Promoter of Deoxycytidine Kinase

Peters, G. J., Hodzic, J., Ortega, B., Giovannetti, E., Adema, A. D., Broekhuizen, R., Kaspers, G. J. L. & Hubeek, I., 2010, In : Nucleosides, Nucleotides and Nucleic Acids. 29, 4-6, p. 408-413

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

Giovannetti, E., Funel, N., Peters, G. J., Del Chiaro, M., Erozenci, L. A., Vasile, E., Leon, L. G., Pollina, L. E., Groen, A., Falcone, A., Danesi, R., Campani, D., Verheul, H. M. W. & Boggi, U., 2010, In : Cancer Research. 70, 11, p. 4528-4538

Research output: Contribution to journalArticleAcademicpeer-review

New tricks for old biomarkers: thymidylate synthase expression as a predictor of pemetrexed activity in malignant mesothelioma

Zucali, P. A., Giovannetti, E., Assaraf, Y. G., Ceresoli, G. L., Peters, G. J. & Santoro, A., 2010, In : Annals of Oncology. 21, 7, p. 1560-1561

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological Aspects of the Enzastaurin-Pemetrexed Combination in Non-Small Cell Lung Cancer (NSCLC)

Giovannetti, E., Honeywell, R. J., Hanauske, A. R., Tekle, C., Kuenen, B., Sigmond, J., Giaccone, G. & Peters, G. J., 2010, In : Current Drug Targets. 11, 1, p. 12-28

Research output: Contribution to journalArticleAcademicpeer-review

Simple and selective method for the determination of various tyrosine kinase inhibitors used in the clinical setting by liquid chromatography tandem mass spectrometry

Honeywell, R. J., Yarzadah, K., Giovannetti, E., Losekoot, N., Smit, E. F., Walraven, M., Lind, J. S. W., Tibaldi, C., Verheul, H. M. W. & Peters, G. J., 2010, In : Journal of Chromatography B. 878, 15-16, p. 1059-1068

Research output: Contribution to journalArticleAcademicpeer-review

Study of Apoptosis Induction and Deoxycytidine Kinase/Cytidine Deaminase Modulation in the Synergistic Interaction of a Novel Ceramide Analog and Gemcitabine in Pancreatic Cancer Cells

Giovannetti, E., Leon, L. G., Bertini, S., Macchia, M., Minutolo, F., Funel, N., Alecci, C., Giancola, F., Danesi, R. & Peters, G. J., 2010, In : Nucleosides, Nucleotides and Nucleic Acids. 29, 4-6, p. 419-426

Research output: Contribution to journalArticleAcademicpeer-review

2011

Analysis of drug interactions

Bijnsdorp, I. V., Giovannetti, E. & Peters, G. J., 2011, In : Methods in Molecular Biology. 731, p. 421-434

Research output: Contribution to journalArticleAcademic

Antiproliferative Effects of Novel Aliphatic Acetogenin Analogs Against Aggressive Solid Tumor Cell Lines

Leon, L. G., Giovannetti, E., Alecci, C., Giancola, F., Funel, N., Zucali, P., Peters, G. J. & Padron, J. M., 2011, In : In vivo. 25, 2, p. 203-207

Research output: Contribution to journalArticleAcademicpeer-review

Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy

Giovannetti, E., Pacetti, P., Reni, M., Leon, L. G., Mambrini, A., Vasile, E., Ghidini, M., Funel, N., Lucchesi, M., Cereda, S., Peters, G. J. & Cantore, M., 2011, In : Pharmacogenomics. 12, 12, p. 1641-1652

Research output: Contribution to journalArticleAcademicpeer-review

Correlation of basal EGFR expression with pancreatic cancer grading but not with clinical outcome after gemcitabine-based treatment

Funel, N., Vasile, E., Del Chiaro, M., Boggi, U., Falcone, A., Campani, D., Scarpa, A. & Giovannetti, E., 2011, In : Annals of Oncology. 22, 2, p. 482-484

Research output: Contribution to journalArticleAcademicpeer-review

Critical role of laser microdissection for genetic, epigenetic and proteomic analyses in pancreatic cancer

Funel, N., Giovannetti, E., Pollina, L. E., Del Chiaro, M., Mosca, F., Boggi, U. & Campani, D., 2011, In : Expert review of molecular diagnostics. 11, 7, p. 695-701

Research output: Contribution to journalArticleAcademicpeer-review

Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

Granchi, C., Roy, S., Giacomelli, C., Macchia, M., Tuccinardi, T., Martinelli, A., Lanza, M., Betti, L., Giannaccini, G., Lucacchini, A., Funel, N., Leon, L. G., Giovannetti, E., Peters, G. J., Palchaudhuri, R., Calvaresi, E. C., Hergenrother, P. J. & Minutolo, F., 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1599-1612

Research output: Contribution to journalArticleAcademicpeer-review

DNA Copy Number Profiles Correlate with Outcome in Colorectal Cancer Patients Treated with Fluoropyrimidine/Antifolate-based Regimens

Leon, L. G., Giovannetti, E., Smid, K., van Houte, B. P. P., Hanauske, A. R., Giaccone, G. & Peters, G. J., 2011, In : Current Drug Metabolism. 12, 10, p. 956-965

Research output: Contribution to journalArticleAcademic

Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients

Lemos, C., Giovannetti, E., Zucali, P. A., Assaraf, Y. G., Scheffer, G. L., van der Straaten, T., D'Incecco, A., Falcone, A., Guchelaar, H. J., Danesi, R., Santoro, A., Giaccone, G., Tibaldi, C. & Peters, G. J., 2011, In : Pharmacogenomics. 12, 2, p. 159-170

Research output: Contribution to journalArticleAcademicpeer-review

Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer

Giovannetti, E., Erdem, L., Olcay, E., Leon, L. G. & Peters, G. J., 2011, In : Frontiers in Bioscience. 16, p. 116-130

Research output: Contribution to journalArticleAcademicpeer-review

Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Patients

Tibaldi, C., Giovannetti, E., Vasile, E., Boldrini, L., Gallegos-Ruiz, M. I., Bernardini, I., Incensati, R., Danesi, R., Cappuzzo, F., Peters, G. J. & Fontanini, G., 2011, In : Journal of Thoracic Oncology. 6, 2, p. 395-396

Research output: Contribution to journalArticleAcademicpeer-review

Loss of Heterozygosity Status of D9S105 Marker Is Associated with Downregulation of Kruppel-Like Factor 4 Expression in Pancreatic Ductal Adenocarcinoma and Pancreatic Intraepithelial Lesions

Funel, N., Morelli, M., Giovannetti, E., Del Chiaro, M., Pollina, L. E., Mosca, F., Boggi, U., Cavazzana, A. & Campani, D., 2011, In : Pancreatology. 11, 1, p. 30-42

Research output: Contribution to journalArticleAcademicpeer-review

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

Granchi, C., Roy, S., De Simone, A., Salvetti, I., Tuccinardi, T., Martinelli, A., Macchia, M., Lanza, M., Betti, L., Giannaccini, G., Lucacchini, A., Giovannetti, E., Sciarrillo, R., Peters, G. J. & Minutolo, F., Nov 2011, In : European Journal of Medicinal Chemistry. 46, 11, p. 5398-5407 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

22 Downloads (Pure)

Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin

Giovannetti, E., Zucali, P. A., Assaraf, Y. G., Leon, L. G., Smid, K., Alecci, C., Giancola, F., Destro, A., Gianoncelli, L., Lorenzi, E., Roncalli, M., Santoro, A. & Peters, G. J., 2011, In : British Journal of Cancer. 105, 10, p. 1542-1553

Research output: Contribution to journalArticleAcademicpeer-review

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Regulation of Deoxycytidine Kinase Expression and Sensitivity to Gemcitabine by Micro-RNA 330 and Promoter Methylation in Cancer Cells

Hodzic, J., Giovannetti, E., Calvo, B. D., Adema, A. D. & Peters, G. J., 2011, In : Nucleosides, Nucleotides and Nucleic Acids. 30, 12, p. 1214-1222

Research output: Contribution to journalArticleAcademicpeer-review