20022019

Research output per year

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Research Output

2019

HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer

Cioni, B., Jordanova, E. S., Hooijberg, E., van der Linden, R., de Menezes, R. X., Tan, K., Willems, S., Elbers, J. B. W., Broeks, A., Bergman, A. M., Zuur, C. L. & de Boer, J. P., 1 Feb 2019, In : Head and Neck. 41, 2, p. 463-478 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs

Chondronasiou, D., Eisden, T-J. T. H. D., Stam, A. G. M., Matthews, Q. L., Icyuz, M., Hooijberg, E., Dmitriev, I., Curiel, D. T., de Gruijl, T. D. & van de Ven, R., 18 Jul 2018, In : Vaccines. 6, 3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells

de Bruin, R. C. G., Veluchamy, J. P., Lougheed, S. M., Schneiders, F. L., Lopez-Lastra, S., Lameris, R., Stam, A. G., Sebestyen, Z., Kuball, J., Molthoff, C. F. M., Hooijberg, E., Roovers, R. C., Santo, J. P. D., van Bergen en Henegouwen, P. M. P., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., 17 Oct 2017, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Extent and Location of Tumor-Infiltrating Lymphocytes in Microsatellite-Stable Colon Cancer Predict Outcome to Adjuvant Active Specific Immunotherapy

Turksma, A. W., Coupe, V. M. H., Shamier, M. C., Lam, K. L. H., de Weger, V. A., Belien, J. A. M., van den Eertwegh, A. J., Meijer, G. A., Meijer, C. J. L. M. & Hooijberg, E., 15 Jan 2016, In : Clinical Cancer Research. 22, 2, p. 346-356

Research output: Contribution to journalArticleAcademicpeer-review

Highly specific and potently activating V gamma 9V delta 2-T cell specific nanobodies for diagnostic and therapeutic applications

de Bruin, R. C. G., Lougheed, S. M., van der Kruk, L., Stam, A. G., Hooijberg, E., Roovers, R. C., Henegouwen, P. M. P. V. B. E., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., Aug 2016, In : Clinical Immunology. 169, p. 128-138

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic value of BRAF and KRAS mutation status in stage II and III microsatellite instable colon cancers

de Cuba, E. M. V., Snaebjornsson, P., Heideman, D. A. M., van Grieken, N. C. T., Bosch, L. J. W., Fijneman, R. J. A., Belt, E., Bril, H., Stockmann, H. B. A. C., Hooijberg, E., Punt, C. J. A., Koopman, M., Nagtegaal, I. D., Coupe, V. H. M., Carvalho, B. & Meijer, G. A., 1 Mar 2016, In : International Journal of Cancer. 138, 5, p. 1139-1145

Research output: Contribution to journalArticleAcademicpeer-review

Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression

de Groen, F. L. M., Timmer, L. M., Menezes, R. X., Diosdado, B., Hooijberg, E., Meijer, G. A., Steenbergen, R. D. M. & Carvalho, B., 2015, In : PLoS ONE. 10, 7, e0132495.

Research output: Contribution to journalArticleAcademicpeer-review

Gene-Dosage Dependent Overexpression at the 13q Amplicon Identifies DIS3 as Candidate Oncogene in Colorectal Cancer Progression

de Groen, F. L. M., Krijgsman, O., Tijssen, M., Vriend, L. E. M., Ylstra, B., Hooijberg, E., Meijer, G. A., Steenbergen, R. D. M. & Carvalho, B., 2014, In : Genes, Chromosomes and Cancer. 53, 4, p. 339-348

Research output: Contribution to journalArticleAcademicpeer-review

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8(+) T-cell cross-priming

Fehres, C. M., Bruijns, S. C. M., van Beelen, A. J., Kalay, H., Ambrosini, M., Hooijberg, E., Unger, W. W. J., de Gruijl, T. D. & van Kooyk, Y., 2014, In : European Journal of Immunology. 44, 8, p. 2415-2424

Research output: Contribution to journalArticleAcademicpeer-review

2013

Effector memory T-cell frequencies in relation to tumour stage, location and HPV status in HNSCC patients

Turksma, A. W., Bontkes, H. J., van den Heuvel, H., de Gruijl, T. D., von Blomberg, B. M. E., Braakhuis, B. J. M., Leemans, C. R., Bloemena, E., Meijer, C. J. L. M. & Hooijberg, E., 2013, In : Oral Diseases. 19, 6, p. 577-584

Research output: Contribution to journalArticleAcademicpeer-review

Exploring dendritic cell based vaccines targeting survivin for the treatment of head and neck cancer patients

Turksma, A. W., Bontkes, H. J., Ruizendaal, J. J., Scholten, K. B. J., Akershoek, J., Rampersad, S., Moesbergen, L. M., Cillessen, S. A. G. M., Santegoets, S. J. A. M., de Gruijl, T. D., Leemans, C. R., Meijer, C. J. L. M. & Hooijberg, E., 2013, In : Journal of Translational Medicine. 11, 152.

Research output: Contribution to journalArticleAcademicpeer-review

Functional characterization of a STAT3-dependent dendritic cell-derived CD14(+) cell population arising upon IL-10-driven maturation

Lindenberg, J. J., van de Ven, R., Lougheed, S. M., Zomer, A., Santegoets, S. J. A. M., Griffioen, A. W., Hooijberg, E., van den Eertwegh, A. J. M., Thijssen, V. L., Scheper, R. J., Oosterhoff, D. & de Gruijl, T. D., 2013, In : OncoImmunology. 2, 4, e23837.

Research output: Contribution to journalArticleAcademicpeer-review

IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation

Lindenberg, J. J., Oosterhoff, D., Sombroek, C. C., Lougheed, S. M., Hooijberg, E., Stam, A. G. M., Santegoets, S. J. A. M., Tijssen, H. J., Buter, J., Pinedo, H. M., van den Eertwegh, A. J. M., Scheper, R. J., Koenen, H. J. P. M., van de Ven, R. & de Gruijl, T. D., 2013, In : PLoS ONE. 8, 7, e70237.

Research output: Contribution to journalArticleAcademicpeer-review

IL-21 in cancer immunotherapy: At the right place at the right time

Santegoets, S. J. A. M., Turksma, A. W., Powell, D. J., Hooijberg, E. & de Gruijl, T. D., 2013, In : OncoImmunology. 2, 6, e24522.

Research output: Contribution to journalArticleAcademicpeer-review

IL-21 promotes the expansion of CD27+CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells

Santegoets, S. J. A. M., Turksma, A. W., Suhoski, M. M., Stam, A. G. M., Albelda, S. M., Hooijberg, E., Scheper, R. J., van den Eertwegh, A. J. M., Gerritsen, W. R., Powell, D. J. J., June, C. H. & de Gruijl, T. D., 2013, In : Journal of Translational Medicine. 11, p. 37-37

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
69 Downloads (Pure)

Immunotherapy for head and neck cancer patients: shifting the balance

Turksma, A. W., Braakhuis, B. J. M., Bloemena, E., Meijer, C. J. L. M., Leemans, C. R. & Hooijberg, E., 2013, In : Immunotherapy. 5, 1, p. 49-61

Research output: Contribution to journalArticleAcademicpeer-review

Increased cytotoxic capacity of tumor antigen specific human T cells after in vitro stimulation with IL21 producing dendritic cells

Turksma, A. W., Bontkes, H. J., Ruizendaal, J. J., van den Heuvel, H., Scholten, K. B. J., Santegoets, S. J. A. M., de Gruijl, T. D., Meijer, C. J. L. M. & Hooijberg, E., 2013, In : Human Immunology. 74, 5, p. 506-513

Research output: Contribution to journalArticleAcademicpeer-review

Notch controls generation and function of human effector CD8+ T cells

Kuijk, L. M., Verstege, M. I., Rekers, N. V., Bruijns, S. C. M., Hooijberg, E., Roep, B. O., de Gruijl, T. D., van Kooyk, Y. & Unger, W. W. J., 2013, In : Blood. 121, 14, p. 2638-2646

Research output: Contribution to journalArticleAcademicpeer-review

2012

Clinical effects of Adjuvant Active Specific Immunotherapy differ between Patients with Microsatellite Stable and Microsatellite Instable Colon Cancer

de Weger, V. A., Turksma, A. W., Voorham, Q. J. M., Euler, Z., Bril, H., van den Eertwegh, A. J. M., Bloemena, E., Pinedo, H. M., Vermorken, J. B., van Tinteren, H., Meijer, G. A. & Hooijberg, E., 2012, In : Clinical Cancer Research. 18, 3, p. 882-889

Research output: Contribution to journalArticleAcademicpeer-review

Exposure of CD34(+) precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy

van de Ven, R., Reurs, A. W., Wijnands, P. G. J. T. B., van Wetering, S., Kruisbeek, A. M., Hooijberg, E., Scheffer, G. L., Scheper, R. J. & de Gruijl, T. D., 2012, In : Cancer Immunology and Immunotherapy. 61, 2, p. 181-191

Research output: Contribution to journalArticleAcademicpeer-review

Glycan-modified liposomes boost CD4(+) and CD8(+) T-cell responses by targeting DC-SIGN on dendritic cells

Unger, W. W. J., van Beelen, A. J., Bruijns, S. C. M., Joshi, M., Fehres, C. M., van Bloois, L., Verstege, M. I., Ambrosini, M., Kalay, H., Nazmi, K., Bolscher, J. G., Hooijberg, E., de Gruijl, T. D., Storm, G. & van Kooyk, Y., 2012, In : Journal of Controlled Release. 160, 1, p. 88-95

Research output: Contribution to journalArticleAcademicpeer-review

Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7

Henken, F. E., Oosterhuis, K., Ohlschlager, P., Bosch, L., Hooijberg, E., Haanen, J. B. A. G. & Steenbergen, R. D. M., 2012, In : Vaccine. 30, 28, p. 4259-4266

Research output: Contribution to journalArticleAcademicpeer-review

2011

Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer.

Scholten, K. B. J., Turksma, A. W., Ruizendaal, JJ., van den Hende, M., van der Burg, S. H., Heemskerk, M. H. M., Meijer, C. J. L. M. & Hooijberg, E., 2011, In : Journal of Translational Medicine. 9, 1, p. 147

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
72 Downloads (Pure)
43 Downloads (Pure)
2010

Promiscuous behavior of HPV16E6 specific T cell receptor beta chains hampers functional expression in TCR transgenic T cells, which can be restored in part by genetic modification

Scholten, K. B. J., Ruizendaal, JJ., Graf, M., Schoedl, T., Kramer, D., Meijer, C. J. L. M., Man, S. & Hooijberg, E., 2010, In : Cellular Oncology. 32, 1-2, p. 43-56

Research output: Contribution to journalArticleAcademicpeer-review

Selective Transduction of Dendritic Cells in Human Lymph Nodes and Superior Induction of High-avidity Melanoma-reactive Cytotoxic T Cells by a CD40-targeted Adenovirus

Hangalapura, B. N., Oosterhoff, D., Agarwal, S., Wijnands, P. G. J. T. B., van de Ven, R., Santegoets, S. J. A. M., van den Tol, M. P., Hooijberg, E., Pereboev, A., van den Eertwegh, A. J. M., Curiel, D. T., Scheper, R. J. & de Gruijl, T. D., 2010, In : Journal of Immunotherapy. 33, 7, p. 706-715

Research output: Contribution to journalArticleAcademicpeer-review

2009

Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis

van Houdt, I. S., Sluijter, B. J. R., van Leeuwen, P. A. M., Moesbergen, L. M., Hooijberg, E., Meijer, C. J. L. M., de Gruijl, T. D., Oudejans, J. J. & Boven, E., 2009, In : Cellular Oncology. 31, 5, p. 407-413

Research output: Contribution to journalArticleAcademicpeer-review

Reduced human leukocyte antigen expression in advanced-stage Ewing sarcoma: implications for immune recognition

Berghuis, D., de Hooge, A. S. K., Santos, S., Horst, D. R., Wertz, E. J., van Eggermond, M. C., van den Elsen, P. J., Taminiau, A. H. M., Ottaviano, L., Schaefer, K. L., Dirksen, U., Hooijberg, E., Mulder, A. B., Melief, C. J., Egeler, R. M., Schilham, M. W., Jordanova, E. S., Hogendoorn, P. C. W. & Lankester, A., 2009, In : Journal of Pathology. 218, 2, p. 222-231

Research output: Contribution to journalArticleAcademicpeer-review

2008

Favorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T-lymphocytes and preserved MHC class I antigen expression

van Houdt, I. S., Sluijter, B. J. R., Moesbergen, L. M., Vos, W., de Gruijl, T. D., Molenkamp, B. G., van den Eertwegh, A. J. M., Hooijberg, E., van Leeuwen, P. A. M., Meijer, C. J. L. M. & Oudejans, J. J., 2008, In : International Journal of Cancer. 123, 3, p. 609-615

Research output: Contribution to journalArticleAcademicpeer-review

IFN-gamma-producing human invariant NKT cells promote tumor-associated antigen-specific cytotoxic T cell responses

Moreno, M., Molling, J. W., von Mensdorff-Pouilly, S., Verheijen, R. H. M., Hooijberg, E., Kramer, D., Reurs, A. W., van den Eertwegh, A. J. M., von Blomberg, B. M. E., Scheper, R. J. & Bontkes, H. J., 2008, In : Journal of Immunology. 181, 4, p. 2446-2454

Research output: Contribution to journalArticleAcademicpeer-review

Inducing antitumor T cell immunity: comparative functional analysis of interstitial versus Langerhans dendritic cells in a human cell line model

Santegoets, S. J. A. M., Bontkes, H. J., Stam, A. G., Bhoelan, F., Ruizendaal, JJ., van den Eertwegh, A. J. M., Hooijberg, E., Scheper, R. J. & de Gruijl, T. D., 2008, In : Journal of Immunology. 180, 7, p. 4540-4549

Research output: Contribution to journalArticleAcademicpeer-review

Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity

Joseph, A., Zheng, J. H., Follenzi, A., Dilorenzo, T., Sango, K., Hyman, J., Chen, K., Piechocka-Trocha, A., Brander, C., Hooijberg, E., Vignali, D. A., Walker, B. D. & Goldstein, H., 2008, In : Journal of Virology. 82, 6, p. 3078-3089

Research output: Contribution to journalArticleAcademicpeer-review

Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells

Cillessen, S. A. G. M., Reed, J. C., Welsh, K., Pinilla, C., Houghten, R., Hooijberg, E., Deurhof, J., Castricum, K. C., Kortman, P., Hess, C. J., Ossenkoppele, G. J., Meijer, C. J. L. M. & Oudejans, J. J., 2008, In : Blood. 111, 1, p. 369-375

Research output: Contribution to journalArticleAcademicpeer-review

2007

Dendritic cells transfected with interleukin-12 and tumor-associated antigen messenger RNA induce high avidity cytotoxic T cells

Bontkes, H. J., Kramer, D., Ruizendaal, J. J., Kueter, E. W. M., van Tendeloo, V. F. I., Meijer, C. J. L. M. & Hooijberg, E., 1 Feb 2007, In : Gene Therapy. 14, 4, p. 366-375 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2006

Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation.

van de Ven, R., de Jong, M. C., Reurs, A. W., Schoonderwoerd, A., Jansen, G., Hooijberg, E., Scheffer, GL., de Gruijl, TD. & Scheper, RJ., 2006, In : Journal of Immunology. 176, 9, p. 5191 5198 p., 16621983.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2005

Antigen gene transfer to human plasmacytoid dendritic cells using recombinant adenovirus and vaccinia virus vectors

Bontkes, H. J., Ruizendaal, J. J., Schreurs, M. W. J., Kramer, D., Meijer, C. J. L. M. & Hooijberg, E., 3 Aug 2005, In : Cellular Oncology. 27, 3, p. 175-182 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes

Schreurs, M. W. J., Hermsen, M. A. J. A., Geltink, R. I. K., Scholten, K. B. J., Brink, A. A. T. P., Kueter, E. W. M., Tijssen, M., Meijer, C. J. L. M., Ylstra, B., Meijer, G. A. & Hooijberg, E., 1 Oct 2005, In : Blood. 106, 8, p. 2663-2670 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Plasmacytoid dendritic cells are present in cervical carcinoma and become activated by human papillomavirus type 16 virus-like particles

Bontkes, H. J., Ruizendaal, J. J., Kramer, D., Meijer, C. J. L. M. & Hooijberg, E., 1 Jan 2005, In : Gynecologic Oncology. 96, 3, p. 897-901 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium

de Vries, H. E., Hendriks, J. J. A., Honing, H., De Lavalette, C. R., van der Pol, S. M. A., Hooijberg, E., Dijkstra, C. D. & van den Berg, T. K., 1 Jun 2002, In : Journal of Immunology. 168, 11, p. 5832-9 8 p.

Research output: Contribution to journalArticleAcademicpeer-review