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Research Output 2009 2019

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2019

Effects of combined angiotensin II receptor antagonism and neprilysin inhibition in experimental pulmonary hypertension and right ventricular failure

Andersen, S., Axelsen, J. B., Ringgaard, S., Nyengaard, J. R., Hyldebrandt, J. A., Bogaard, H. J., de Man, F. S., Nielsen-Kudsk, J. E. & Andersen, A., 1 Jan 2019, In : International Journal of Cardiology.

Research output: Contribution to journalArticleAcademicpeer-review

ERS statement on exercise training and rehabilitation in patients with severe chronic pulmonary hypertension

Grünig, E., Eichstaedt, C., Barberà, J-A., Benjamin, N., Blanco, I., Bossone, E., Cittadini, A., Coghlan, G., Corris, P., D'Alto, M., D'Andrea, A., Delcroix, M., de Man, F., Gaine, S., Ghio, S., Gibbs, S., Gumbiene, L., Howard, L. S., Johnson, M., Jurevičienė, E. & 16 othersKiely, D. G., Kovacs, G., MacKenzie, A., Marra, A. M., McCaffrey, N., McCaughey, P., Naeije, R., Olschewski, H., Pepke-Zaba, J., Reis, A., Santos, M., Saxer, S., Tulloh, R. M., Ulrich, S., Vonk Noordegraaf, A. & Peacock, A. J., Feb 2019, In : The European respiratory journal. 53, 2

Research output: Contribution to journalArticleAcademicpeer-review

Highlights from the ERS International Congress 2018: Assembly 13 - Pulmonary Vascular Diseases

Ramjug, S., Adão, R., Lewis, R., Coste, F., de Man, F., Jimenez, D., Sitbon, O., Delcroix, M. & Vonk-Noordegraaf, A., 2019, In : ERS Monograph. 5, 1, 00202-2018.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

Rol, N., de Raaf, M. A., Sun, X. Q., Kuiper, V. P., da Silva Gonçalves Bos, D., Happé, C., Kurakula, K., Dickhoff, C., Thuillet, R., Tu, L., Guignabert, C., Schalij, I., Lodder, K., Pan, X., Herrmann, F. E., van Nieuw Amerongen, G. P., Koolwijk, P., Vonk-Noordegraaf, A., de Man, F. S., Wollin, L. & 3 othersGoumans, M-J., Szulcek, R. & Bogaard, H. J., 2019, In : Cardiovascular Research. 115, 2, p. 432-439

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone

Andersen, S., Birkmose Axelsen, J., Ringgaard, S., Randel Nyengaard, J., Holm Nielsen, S., Genovese, F., Asser Karsdal, M., Adler Hyldebrandt, J., Brandt Sørensen, C., de Man, F. S., Jan Bogaard, H., Erik Nielsen-Kudsk, J. & Andersen, A., Apr 2019, In : Pulmonary Circulation. 9, 2, p. 204589401984865

Research output: Contribution to journalArticleAcademicpeer-review

Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling

Kurakula, K., Sun, X-Q., Happé, C., da Silva Goncalves Bos, D., Szulcek, R., Schalij, I., Wiesmeijer, K. C., Lodder, K., Tu, L., Guignabert, C., de Vries, C. J. M., de Man, F. S., Vonk Noordegraaf, A., ten Dijke, P., Goumans, M-J. & Bogaard, H. J., 2019, In : The European respiratory journal. 54, 3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Right Ventricular Fibrosis

Andersen, S., Nielsen-Kudsk, J. E., Vonk Noordegraaf, A. & de Man, F. S., 8 Jan 2019, In : Circulation. 139, 2, p. 269-285 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

The right treatment for the right ventricle

Groeneveldt, J. A., de Man, F. S. & Westerhof, B. E., Sep 2019, In : Current opinion in pulmonary medicine. 25, 5, p. 410-417 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

3'-Deoxy-3'-[18F]Fluorothymidine Positron Emission Tomography Depicts Heterogeneous Proliferation Pathology in Idiopathic Pulmonary Arterial Hypertension Patient Lung

Ashek, A., Spruijt, O. A., Harms, H. J., Lammertsma, A. A., Cupitt, J., Dubois, O., Wharton, J., Dabral, S., Pullamsetti, S. S., Huisman, M. C., Frings, V., Boellaard, R., de Man, F. S., Botros, L., Jansen, S., Vonk Noordegraaf, A., Wilkins, M. R., Bogaard, H. J. & Zhao, L., 2018, In : Circulation. Cardiovascular imaging. 11, 8, p. e007402

Research output: Contribution to journalArticleAcademicpeer-review

Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S. & 1 othersHandoko, M. L., 1 Jan 2018, In : Circulation. 137, 9, p. 910-924 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

da Silva Gonçalves Bos, D., Happé, C., Schalij, I., Pijacka, W., Paton, J. F. R., Guignabert, C., Tu, L., Thuillet, R., Bogaard, H. J., van Rossum, A. C., Vonk-Noordegraaf, A., de Man, F. S. & Handoko, M. L., 2017, In : JACC: Basic to Translational Science. 2, 1, p. 22-35 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

RV pressure overload: from hypertrophy to failure

van der Bruggen, C. E. E., Tedford, R. J., Handoko, M. L., van der Velden, J. & de Man, F. S., 1 Oct 2017, In : Cardiovascular Research. 113, 12, p. 1423-1432

Research output: Contribution to journalArticleAcademicpeer-review

Vascular remodelling in the pulmonary circulation after major lung resection

Rol, N., Happe, C., Belien, J. A. M., de Man, F. S., Westerhof, N., Vonk-Noordegraaf, A., Grunberg, K. & Bogaard, H. J., 1 Aug 2017, In : European Respiratory Journal. 50, 2, 1700806.

Research output: Contribution to journalArticleAcademicpeer-review

2016

A critical appraisal of transpulmonary and diastolic pressure gradients

Handoko, M. L., De Man, F. S., Oosterveer, F. P. T., Bogaard, H-J., Vonk-Noordegraaf, A. & Westerhof, N., Sep 2016, In : Physiological Reports. 4, 17, e12910.

Research output: Contribution to journalArticleAcademicpeer-review

Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension A View on the Right Ventricle

van der Bruggen, C. E., Happe, C. M., Dorfmueller, P., Trip, P., Spruijt, O. A., Rol, N., Hoevenaars, F. P., Houweling, A. C., Girerd, B., Marcus, J. T., Mercier, O., Humbert, M., Handoko, M. L., van der Velden, J., Noordegraaf, A. V., Bogaard, H. J., Goumans, M-J. & de Man, F. S., 3 May 2016, In : Circulation. 133, 18, p. 1747-1760

Research output: Contribution to journalArticleAcademicpeer-review

Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage

Szulcek, R., Happe, C. M., Rol, N., Fontijn, R. D., Dickhoff, C., Hartemink, K. J., Grunberg, K., Tu, L., Timens, W., Nossent, G. D., Paul, M. A., Leyen, T. A., Horrevoets, A. J., de Man, F. S., Guignabert, C., Yu, P. B., Vonk-Noordegraaf, A., van Nieuw Amerongen, G. & Bogaard, H. J., 15 Jun 2016, In : American Journal of Respiratory and Critical Care Medicine. 193, 12, p. 1410-1420

Research output: Contribution to journalArticleAcademicpeer-review

Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats

Happe, C. M., de Raaf, M. A., Rol, N., Schalij, I., Vonk Noordegraaf, A., Westerhof, N., Voelkel, N. F., de Man, F. S. & Bogaard, H. J., 1 Jun 2016, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 310, 11, p. L1088-L1097

Research output: Contribution to journalArticleAcademicpeer-review

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension

Manders, E., Bonta, P. I., Kloek, J. J., Symersky, P., Bogaard, H-J., Hooijman, P. E., Jasper, J. R., Malik, F. I., Stienen, G., Vonk-Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 1 Jul 2016, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 311, 1, p. L20-L28

Research output: Contribution to journalArticleAcademicpeer-review

Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension Relative Contribution of Fibrosis and Myofibril Stiffness

Rain, S., Andersen, S., Najafi, A., Schultz, J. G., Bos, D. D. S. G., Handoko, M. L., Bogaard, H-J., Vonk-Noordegraaf, A., Andersen, A., van der Velden, J., Ottenheijm, C. A. C. & de Man, F. S., Jul 2016, In : Circulation. Heart failure. 9, 7, e002636.

Research output: Contribution to journalArticleAcademicpeer-review

The effect of perioperative insulin treatment on cardiodepression in mild adiposity in mice

Boly, C. A., Eringa, E. C., Bouwman, R. A., van den Akker, R. F. P., de Man, F. S., Schalij, I., Loer, S. A., Boer, C. & van den Brom, C. E., 20 Sep 2016, In : Cardiovascular Diabetology. 15, 135.

Research output: Contribution to journalArticleAcademicpeer-review

Tyrosine kinase inhibitor BIBF1000 does not hamper right ventricular pressure adaptation in rats

de Raaf, M. A., Herrmann, F. E., Schalij, I., de Man, F. S., Vonk-Noordegraaf, A., Guignabert, C., Wollin, L. & Bogaard, H. J., Sep 2016, In : American Journal of Physiology. Heart and Circulatory Physiology. 311, 3, p. H604-H612

Research output: Contribution to journalArticleAcademicpeer-review

2015

beta-blockers in pulmonary arterial hypertension: evolving concepts of right heart failure

de Man, F. S. & Handoko, M. L., 2015, In : European Respiratory Journal. 46, 3, p. 619-621

Research output: Contribution to journalArticleAcademicpeer-review

Characteristics of Pulmonary Arterial Hypertension in Affected Carriers of a Mutation Located in the Cytoplasmic Tail of Bone Morphogenetic Protein Receptor Type 2

Girerd, B., Coulet, F., Jais, X., Eyries, M., van der Bruggen, C. E. E., de Man, F. S., Houweling, A. C., Dorfmueller, P., Savale, L., Sitbon, O., Vonk-Noordegraaf, A., Soubrier, F., Simonneau, G., Humbert, M. & Montani, D., 2015, In : Chest. 147, 5, p. 1385-1394

Research output: Contribution to journalArticleAcademicpeer-review

Intravenous iron therapy in patients with idiopathic pulmonary arterial hypertension and iron deficiency

Ruiter, G., Manders, E., Happe, C. M., Schalij, I., Groepenhoff, H., Howard, L. S., Wilkins, M. R., Bogaard, H. J., Westerhof, N., van der Laarse, W. J., de Man, F. S. & Vonk-Noordegraaf, A., 2015, In : Pulmonary Circulation. 5, 3, p. 466-472

Research output: Contribution to journalArticleAcademicpeer-review

Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension Role of the Macrophage Migration Inhibitory Factor/CD74 Complex

Le Hiress, M., Tu, L., Ricard, N., Phan, C., Thuillet, R., Fadel, E., Dorfmuller, P., Montani, D., de Man, F. S., Humbert, M., Huertas, A. & Guignabert, C., 2015, In : American Journal of Respiratory and Critical Care Medicine. 192, 8, p. 983-997

Research output: Contribution to journalArticleAcademicpeer-review

Quadriceps muscle fibre dysfunction in patients with pulmonary arterial hypertension

Manders, E., Ruiter, G., Bogaard, H. J., Stienen, G. J. M., Vonk Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 2015, In : European Respiratory Journal. 45, 6, p. 1737-1740

Research output: Contribution to journalArticleAcademicpeer-review

Risk-stratification in normotensive acute pulmonary embolism

Handoko, M. L. & de Man, F. S., 2015, In : Netherlands Heart Journal. 23, 1, p. 52-54

Research output: Contribution to journalArticleAcademicpeer-review

Serotonin transporter is not required for the development of severe pulmonary hypertension in the Sugen hypoxia rat model

de Raaf, M. A., Kroeze, Y., Middelman, A., de Man, F. S., de Jong, H., Vonk-Noordegraaf, A., de Korte, C., Voelkel, N. F., Homberg, J. & Bogaard, H. J., 2015, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 309, 10, p. L1164-L1173

Research output: Contribution to journalArticleAcademicpeer-review

Sympathetic nervous system activation and beta-adrenoceptor blockade in right heart failure

Andersen, S., Andersen, A., de Man, F. S. & Nielsen-Kudsk, J. E., 2015, In : European Journal of Heart Failure. 17, 4, p. 358-366

Research output: Contribution to journalArticleAcademicpeer-review

The striated muscles in pulmonary arterial hypertension: adaptations beyond the right ventricle

Manders, E., Rain, S., Bogaard, H. J., Handoko, M. L., Stienen, G. J. M., Vonk Noordegraaf, A., Ottenheijm, C. A. C. & de Man, F. S., 2015, In : European Respiratory Journal. 46, 3, p. 832-842

Research output: Contribution to journalArticleAcademicpeer-review

2014

Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension

Manders, E., Bogaard, H. J., Handoko, M. L., van de Veerdonk, M. C., Keogh, A., Westerhof, N., Stienen, G. J. M., dos Remedios, C. G., Humbert, M., Dorfmuller, P., Fadel, E., Guignabert, C., van der Velden, J., Vonk-Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 2014, In : Journal of the American College of Cardiology. 64, 1, p. 28-37

Research output: Contribution to journalArticleAcademicpeer-review

Diaphragm Fiber Strength Is Reduced in Critically III Patients and Restored by a Troponin Activator

Hooijman, P. E., Beishuizen, A., de Waard, M. C., de Man, F. S., Vermeijden, J. W., Steenvoorde, P., Bouwman, R. A., Lommen, W., van Hees, H. W. H., Heunks, L. M. A., Dickhoff, C., van der Peet, D. L., Girbes, A. R. J., Jasper, J. R., Malik, F. I., Stienen, G. J. M., Hartemink, K. J., Paul, M. A. & Ottenheijm, C. A. C., 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 7, p. 863-865

Research output: Contribution to journalArticleAcademicpeer-review

Diffusion capacity and BMPR2 mutations in pulmonary arterial hypertension

Trip, P., Girerd, B., Bogaard, H. J., de Man, F. S., Boonstra, A., Garcia, G., Humbert, M., Montani, D. & Vonk-Noordegraaf, A., 2014, In : European Respiratory Journal. 43, 4, p. 1195-1198

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Bisoprolol and Losartan Treatment in the Hypertrophic and Failing Right Heart

Andersen, S., Schultz, J. G., Andersen, A., Ringgaard, S., Nielsen, J. M., Holmboe, S., Vildbrad, M. D., de Man, F. S., Bogaard, H. J., Vonk-Noordegraaf, A. & Nielsen-Kudsk, J. E., 2014, In : Journal of Cardiac Failure. 20, 11, p. 864-873

Research output: Contribution to journalArticleAcademicpeer-review

Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension

Ruiter, G., Lanser, I. J., de Man, F. S., van der Laarse, W. J., Wharton, J., Wilkins, M. R., Howard, L. S., Vonk-Noordegraaf, A. & Voskuyl, A. E., 2014, In : Rheumatology. 53, 2, p. 285-292

Research output: Contribution to journalArticleAcademicpeer-review

Lung Cancer Patients Benefit from Second Opinions by Improvement of Diagnosis and Therapy

Schook, R. M., ter Avest, M. J., van Setten, C. H., de Man, F. S., Smit, E. F. & Postmus, P. E., 2014, In : Cancer and Clinical Oncology. 3, 1, p. 43-57

Research output: Contribution to journalArticleAcademicpeer-review

Pressure-overload-induced right heart failure

Rain, S., Handoko, M. L., Vonk-Noordegraaf, A., Bogaard, H. J., van der Velden, J. & de Man, F. S., 2014, In : Pflügers Archiv European Journal of Physiology. 466, 6, p. 1055-1063

Research output: Contribution to journalArticleAcademicpeer-review

Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension

Rain, S., da Silva Goncalves Bos, D., Handoko, M. L., Westerhof, N., Stienen, G. J. M., Ottenheijm, C. A. C., Goebel, M., Dorfmuller, P., Guignabert, C., Humbert, M., Bogaard, H. J., dos Remedios, C., Saripalli, C., Hidalgo, C. G., Granzier, H. L., Vonk-Noordegraaf, A., van der Velden, J. & de Man, F. S., 2014, In : Journal of American Heart Association. 3, 3, e000716.

Research output: Contribution to journalArticleAcademicpeer-review

SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction

de Raaf, M. A., Schalij, I., Gomez-Arroyo, J., Rol, N., Happé, C. M., de Man, F. S., Vonk-Noordegraaf, A., Westerhof, N., Voelkel, N. F. & Bogaard, H. J., 2014, In : European Respiratory Journal. 44, 1, p. 160-168

Research output: Contribution to journalArticleAcademicpeer-review

The Right Ventricle Explains Sex Differences in Survival in Idiopathic Pulmonary Arterial Hypertension

Jacobs, W., van de Veerdonk, M. C., Trip, P., de Man, F. S., Heymans, M. W., Marcus, J. T., Kawut, S. M., Bogaard, H. J., Boonstra, A. & Vonk-Noordegraaf, A., 2014, In : Chest. 145, 6, p. 1230-1236

Research output: Contribution to journalArticleAcademicpeer-review