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Research Output 1993 2019

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2019

A multi-shell multi-tissue diffusion study of brain connectivity in early multiple sclerosis

Tur, C., Grussu, F., Prados, F., Charalambous, T., Collorone, S., Kanber, B., Cawley, N., Altmann, D. R., Ourselin, S. B., Barkhof, F., Clayden, J. D., Toosy, A. T., Wheeler-Kingshott, C. A. M. G. & Ciccarelli, O., 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

AMYPAD Diagnostic and Patient Management Study: Rationale and design

Frisoni, G. B., Barkhof, F., Altomare, D., Berkhof, J., Boccardi, M., Canzoneri, E., Collij, L., Drzezga, A., Farrar, G., Garibotto, V., Gismondi, R., Gispert, J-D., Jessen, F., Kivipelto, M., Lopes Alves, I., Molinuevo, J-L., Nordberg, A., Payoux, P., Ritchie, C., Savicheva, I. & 8 othersScheltens, P., Schmidt, M. E., Schott, J., Stephens, A., van Berckel, B., Vellas, B., Walker, Z. & Raffa, N., Mar 2019, In : Alzheimers & Dementia. 15, 3, p. 388-399

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

APOE and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms

Charidimou, A., Zonneveld, H. I., Shams, S., Kantarci, K., Shoamanesh, A., Hilal, S., Yates, P. A., Boulouis, G., Na, H. K., Pasi, M., Biffi, A., Chai, Y. L., Chong, J. R., Wahlund, L-O., Clifford, J. R., Chen, C., Gurol, M. E., Goldstein, J. N., Na, D. L., Barkhof, F. & 4 othersSeo, S. W., Rosand, J., Greenberg, S. M. & Viswanathan, A., 2019, In : Neurology. 93, 4, p. e358-e371

Research output: Contribution to journalArticleAcademicpeer-review

Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis

Eshaghi, A., Kievit, R. A., Prados, F., Sudre, C. H., Nicholas, J., Cardoso, M. J., Chan, D., Nicholas, R., Ourselin, S., Greenwood, J., Thompson, A. J., Alexander, D. C., Barkhof, F., Chataway, J. & Ciccarelli, O., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 11020-11027

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines

Filippi, M., Preziosa, P., Banwell, B. L., Barkhof, F., Ciccarelli, O., De Stefano, N., Geurts, J. J. G., Paul, F., Reich, D. S., Toosy, A. T., Traboulsee, A., Wattjes, M. P., Yousry, T. A., Gass, A., Lubetzki, C., Weinshenker, B. G. & Rocca, M. A., Jul 2019, In : Brain : a journal of neurology. 142, 7, p. 1858-1875

Research output: Contribution to journalArticleAcademicpeer-review

Association between tumor location and neurocognitive functioning using tumor localization maps

Habets, E. J. J., Hendriks, E. J., Taphoorn, M. J. B., Douw, L., Zwinderman, A. H., Vandertop, W. P., Barkhof, F., de Witt Hamer, P. C. & Klein, M., 2019, In : Journal of Neuro-Oncology. 144, 3, p. 573-582

Research output: Contribution to journalArticleAcademicpeer-review

Automated fiber tract reconstruction for surgery planning: Extensive validation in language-related white matter tracts

Mancini, M., Vos, S. B., Vakharia, V. N., O'Keeffe, A. G., Trimmel, K., Barkhof, F., Dorfer, C., Soman, S., Winston, G. P., Wu, C., Duncan, J. S., Sparks, R. & Ourselin, S., 2019, In : NeuroImage: Clinical. 23, 101883.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Automatically computed rating scales from MRI for patients with cognitive disorders

Alzheimer’s Disease Neuroimaging Initiative, 2019, In : European Radiology.

Research output: Contribution to journalArticleAcademicpeer-review

Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

van Maurik, I. S., Vos, S. J., Bos, I., Bouwman, F. H., Teunissen, C. E., Scheltens, P., Barkhof, F., Frolich, L., Kornhuber, J., Wiltfang, J., Maier, W., Peters, O., Rüther, E., Nobili, F., Frisoni, G. B., Spiru, L., Freund-Levi, Y., Wallin, A. K., Hampel, H., Soininen, H. & 20 othersTsolaki, M., Verhey, F., Kłoszewska, I., Mecocci, P., Vellas, B., Lovestone, S., Galluzzi, S., Herukka, S-K., Santana, I., Baldeiras, I., de Mendonça, A., Silva, D., Chetelat, G., Egret, S., Palmqvist, S., Hansson, O., Visser, P. J., Berkhof, J., van der Flier, W. M. & Alzheimer's Disease Neuroimaging Initiative, 2019, In : Lancet Neurology. 18, 11, p. 1034-1044

Research output: Contribution to journalArticleAcademicpeer-review

Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions

Weaver, N. A., Doeven, T., Barkhof, F., Biesbroek, J. M., Groeneveld, O. N., Kuijf, H. J., Prins, N. D., Scheltens, P., Teunissen, C. E., van der Flier, W. M., Biessels, G. J. & TRACE-VCI study group, 2019, (Accepted/In press) In : Neurobiology of Aging.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Bos, I., Vos, S., Verhey, F., Scheltens, P., Teunissen, C., Engelborghs, S., Sleegers, K., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R. G., Tsolaki, M., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Lleó, A., Johannsen, P., Freund-Levi, Y., Frölich, L. & 12 othersVandenberghe, R., Westwood, S., Dobricic, V., Barkhof, F., Legido-Quigley, C., Bertram, L., Lovestone, S., Streffer, J., Andreasson, U., Blennow, K., Zetterberg, H. & Visser, P. J., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis

Elliott, C., Belachew, S., Wolinsky, J. S., Hauser, S. L., Kappos, L., Barkhof, F., Bernasconi, C., Fecker, J., Model, F., Wei, W. & Arnold, D. L., 2019, In : Brain. 142, 9, p. 2787-2799

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical relevance of acute cerebral microinfarcts in vascular cognitive impairment

Ferro, D. A., van den Brink, H., Exalto, L. G., Boomsma, J. M. F., Barkhof, F., Prins, N. D., van der Flier, W. M., Biessels, G. J. & TRACE-VCI study group, 2 Apr 2019, In : Neurology. 92, 14, p. e1558-e1566

Research output: Contribution to journalArticleAcademicpeer-review

Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia

Meeter, L. H. H., Steketee, R. M. E., Salkovic, D., Vos, M. E., Grossman, M., McMillan, C. T., Irwin, D. J., Boxer, A. L., Rojas, J. C., Olney, N. T., Karydas, A., Miller, B. L., Pijnenburg, Y. A. L., Barkhof, F., Sánchez-Valle, R., Lladó, A., Borrego-Ecija, S., Diehl-Schmid, J., Grimmer, T., Goldhardt, O. & 27 othersSantillo, A. F., Hansson, O., Vestberg, S., Borroni, B., Padovani, A., Galimberti, D., Scarpini, E., Rohrer, J. D., Woollacott, I. O. C., Synofzik, M., Wilke, C., de Mendonca, A., Vandenberghe, R., Benussi, L., Ghidoni, R., Binetti, G., Niessen, W. J., Papma, J. M., Seelaar, H., Jiskoot, L. C., de Jong, F. J., Donker Kaat, L., del Campo, M., Teunissen, C. E., Bron, E. E., van den Berg, E. & van Swieten, J. C., 2019, In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship

van Loenhoud, A. C., van der Flier, W. M., Wink, A. M., Dicks, E., Groot, C., Twisk, J., Barkhof, F., Scheltens, P., Ossenkoppele, R. & Alzheimer's Disease Neuroimaging Initiative, 23 Jul 2019, In : Neurology. 93, 4, p. e334-e346

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparing Glioblastoma Surgery Decisions Between Teams Using Brain Maps of Tumor Locations, Biopsies, and Resections

Mueller, D. M. J., Robe, P. A. J. T., Eijgelaar, R. S., Witte, M. G., Visser, M., de Munck, J. C., Broekman, M. L. D., Seute, T., Hendrikse, J., Noske, D. P., Vandertop, W. P., Barkhof, F., Kouwenhoven, M. C. M., Mandonnet, E., Berger, M. S. & Hamer, P. C. D. W., Jan 2019, In : JCO clinical cancer informatics. 3, p. 1-12 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cortical atrophy accelerates as cognitive decline worsens in multiple sclerosis

Eijlers, A. J. C., Dekker, I., Steenwijk, M. D., Meijer, K. A., Hulst, H. E., Pouwels, P. J. W., Uitdehaag, B. M. J., Barkhof, F., Vrenken, H., Schoonheim, M. M. & Geurts, J. J. G., 2019, In : Neurology. 93, 14, p. e1348-e1359

Research output: Contribution to journalArticleAcademicpeer-review

Cortical cerebral blood flow in ageing: effects of haematocrit, sex, ethnicity and diabetes

Smith, L. A., Melbourne, A., Owen, D., Cardoso, M. J., Sudre, C. H., Tillin, T., Sokolska, M., Atkinson, D., Chaturvedi, N., Ourselin, S., Hughes, A. D., Barkhof, F. & Jäger, H. R., 2019, In : European Radiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dementia imaging in clinical practice: a European-wide survey of 193 centres and conclusions by the ESNR working group

Vernooij, M. W., Pizzini, F. B., Schmidt, R., Smits, M., Yousry, T. A., Bargallo, N., Frisoni, G. B., Haller, S. & Barkhof, F., 2019, In : Neuroradiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Detecting frontotemporal dementia syndromes using MRI biomarkers

Bruun, M., Koikkalainen, J., Rhodius-Meester, H. F. M., Baroni, M., Gjerum, L., van Gils, M., Soininen, H., Remes, A. M., Hartikainen, P. I., Waldemar, G., Mecocci, P., Barkhof, F., Pijnenburg, Y., van der Flier, W. M., Hasselbalch, S. G., Lötjönen, J. & Frederiksen, K. S., 2019, In : NeuroImage: Clinical. 22, 101711.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Shi, L., Westwood, S., Baird, A. L., Winchester, L., Dobricic, V., Kilpert, F., Hong, S., Franke, A., Hye, A., Ashton, N. J., Morgan, A. R., Bos, I., Vos, S. J. B., Buckley, N. J., Kate, M. T., Scheltens, P., Vandenberghe, R., Gabel, S., Meersmans, K., Engelborghs, S. & 33 othersde Roeck, E. E., Sleegers, K., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R. G., Molinuevo, J. L., Rami, L., Wallin, A., Kettunen, P., Tsolaki, M., Verhey, F., Lleó, A., Alcolea, D., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Johannsen, P., Teunissen, C. E., Freund-Levi, Y., Frölich, L., Legido-Quigley, C., Barkhof, F., Blennow, K., Zetterberg, H., Baker, S., Morgan, B. P., Streffer, J., Visser, P. J., Bertram, L., Lovestone, S. & Nevado-Holgado, A. J., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis

Beltrán, E., Gerdes, L. A., Hansen, J., Flierl-Hecht, A., Krebs, S., Blum, H., Ertl-Wagner, B., Barkhof, F., Kümpfel, T., Hohlfeld, R. & Dornmair, K., 2019, In : Journal of Clinical Investigation. 129, 11, p. 4758-4768

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Early imaging predictors of long-term outcomes in relapse-onset multiple sclerosis

Brownlee, W. J., Altmann, D. R., Prados, F., Miszkiel, K. A., Eshaghi, A., Gandini Wheeler-Kingshott, C. A. M., Barkhof, F. & Ciccarelli, O., 2019, In : Brain. 142, 8, p. 2276-2287

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of HLA-DRB1 alleles and genetic variants on the development of neutralizing antibodies to interferon beta in the BEYOND and BENEFIT trials

Buck, D., Andlauer, T. F., Igl, W., Wicklein, E-M., Mühlau, M., Weber, F., Köchert, K., Pohl, C., Arnason, B., Comi, G., Cook, S., Filippi, M., Hartung, H-P., Jeffery, D., Kappos, L., Barkhof, F., Edan, G., Freedman, M. S., Montalbán, X., Müller-Myhsok, B. & 2 othersHemmer, B. & BEYOND and BENEFIT Study Groups, 1 Apr 2019, In : Multiple Sclerosis. 25, 4, p. 565-573

Research output: Contribution to journalArticleAcademicpeer-review

Exploring resting state connectivity in patients with psychotic depression

Oudega, M. L., van der Werf, Y. D., Dols, A., Wattjes, M. P., Barkhof, F., Bouckaert, F., Vandenbulcke, M., de Winter, F-L., Sienaert, P., Eikelenboom, P., Stek, M. L., van den Heuvel, O. A., Emsell, L., Rhebergen, D. & van Exel, E., 2019, In : PLoS ONE. 14, 1, e0209908.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gray matter networks and cognitive impairment in multiple sclerosis

Rimkus, C. M., Schoonheim, M. M., Steenwijk, M. D., Vrenken, H., Eijlers, A. J., Killestein, J., Wattjes, M. P., Leite, C. C., Barkhof, F. & Tijms, B. M., 1 Mar 2019, In : Multiple Sclerosis. 25, 3, p. 382-391

Research output: Contribution to journalArticleAcademicpeer-review

Gray matter T1-w/T2-w ratios are higher in Alzheimer's disease

Pelkmans, W., Dicks, E., Barkhof, F., Vrenken, H., Scheltens, P., van der Flier, W. M. & Tijms, B. M., 2019, In : Human Brain Mapping. 40, 13, p. 3900-3909

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Harmonization of neuroimaging biomarkers for neurodegenerative diseases: A survey in the imaging community of perceived barriers and suggested actions

Jovicich, J., Barkhof, F., Babiloni, C., Herholz, K., Mulert, C., van Berckel, B. N. M., Frisoni, G. B. & SRA-NED JPND Working Group, Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 69-73

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

High-dimensional detection of imaging response to treatment in multiple sclerosis

Kanber, B., Nachev, P., Barkhof, F., Calvi, A., Cardoso, J., Cortese, R., Prados, F., Sudre, C. H., Tur, C., Ourselin, S. & Ciccarelli, O., 2019, In : NPJ digital medicine. 2, p. 49

Research output: Contribution to journalArticleAcademicpeer-review

How Do Different Forms of Vascular Brain Injury Relate to Cognition in a Memory Clinic Population: The TRACE-VCI Study

Boomsma, J. M. F., Exalto, L. G., Barkhof, F., van den Berg, E., de Bresser, J., Heinen, R., Leeuwis, A. E., Prins, N. D., Scheltens, P., Weinstein, H. C., van der Flier, W. M. & Biessels, G. J., 2019, In : Journal of Alzheimer's Disease. 68, 3, p. 1273-1286

Research output: Contribution to journalArticleAcademicpeer-review

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

Leeuwis, A. E., Weaver, N. A., Biesbroek, J. M., Exalto, L. G., Kuijf, H. J., Hooghiemstra, A. M., Prins, N. D., Scheltens, P., Barkhof, F., van der Flier, W. M., Biessels, G. J. & TRACE-VCI study group, 25 Apr 2019, In : Journal of Psychiatry and Neuroscience. 44, 4, p. 1-10 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Improved performance of the 2017 McDonald criteria for diagnosis of multiple sclerosis in children in a real-life cohort

Hacohen, Y., Brownlee, W., Mankad, K., Chong, W. K. K., Thompson, A., Lim, M., Wassmer, E., Hemingway, C., Barkhof, F. & Ciccarelli, O., 2019, In : Multiple Sclerosis.

Research output: Contribution to journalArticleAcademicpeer-review

Inflammatory biomarkers in Alzheimer's disease plasma

Morgan, A. R., Touchard, S., Leckey, C., O'Hagan, C., Nevado-Holgado, A. J., Barkhof, F., Bertram, L., Blin, O., Bos, I., Dobricic, V., Engelborghs, S., Frisoni, G., Frölich, L., Gabel, S., Johannsen, P., Kettunen, P., Kłoszewska, I., Legido-Quigley, C., Lleó, A., Martinez-Lage, P. & 32 othersMecocci, P., Meersmans, K., Molinuevo, J. L., Peyratout, G., Popp, J., Richardson, J., Sala, I., Scheltens, P., Streffer, J., Soininen, H., Tainta-Cuezva, M., Teunissen, C., Tsolaki, M., Vandenberghe, R., Visser, P. J., Vos, S., Wahlund, L-O., Wallin, A., Westwood, S., Zetterberg, H., Lovestone, S., Morgan, B. P., Bullmore, E. T., Bhatti, J., Chamberlain, S. J., Correia, M. M., Crofts, A. L., Dickinson, A., Foster, A. C., Kitzbichler, M. G., NIMA Consortium & Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease, Jun 2019, In : Alzheimer's and Dementia. 15, 6, p. 776-787

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Inter-rater agreement in glioma segmentations on longitudinal MRI

Visser, M., Müller, D. M. J., van Duijn, R. J. M., Smits, M., Verburg, N., Hendriks, E. J., Nabuurs, R. J. A., Bot, J. C. J., Eijgelaar, R. S., Witte, M., van Herk, M. B., Barkhof, F., de Witt Hamer, P. C. & de Munck, J. C., 2019, In : NeuroImage: Clinical. 22, 101727.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Lifespan normative data on rates of brain volume changes

Battaglini, M., Gentile, G., Luchetti, L., Giorgio, A., Vrenken, H., Barkhof, F., Cover, K. S., Bakshi, R., Chu, R., Sormani, M. P., Enzinger, C., Ropele, S., Ciccarelli, O., Wheeler-Kingshott, C., Yiannakas, M., Filippi, M., Rocca, M. A., Preziosa, P., Gallo, A., Bisecco, A. & 8 othersPalace, J., Kong, Y., Horakova, D., Vaneckova, M., Gasperini, C., Ruggeri, S., de Stefano, N. & MAGNIMS Study Group, Sep 2019, In : Neurobiology of Aging. 81, p. 30-37

Research output: Contribution to journalArticleAcademicpeer-review

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Moccia, M., Prados, F., Filippi, M., Rocca, M. A., Valsasina, P., Brownlee, W. J., Zecca, C., Gallo, A., Rovira, A., Gass, A., Palace, J., Lukas, C., Vrenken, H., Ourselin, S., Gandini Wheeler-Kingshott, C. A. M., Ciccarelli, O., Barkhof, F. & MAGNIMS Study Group, 1 Nov 2019, In : Annals of Neurology. 86, 5, p. 704-713

Research output: Contribution to journalArticleAcademicpeer-review

Medial temporal lobe atrophy and posterior atrophy scales normative values

Cotta Ramusino, M., Altomare, D., Bacchin, R., Ingala, S., Bnà, C., Bonetti, M., Costa, A., Barkhof, F., Nicolosi, V., Festari, C., Frisoni, G. B. & Boccardi, M., 15 Jul 2019, In : NeuroImage: Clinical. 24, p. 101936

Research output: Contribution to journalArticleAcademicpeer-review

Modeling grey matter atrophy as a function of time, aging or cognitive decline show different anatomical patterns in Alzheimer's disease

Dicks, E., Vermunt, L., van der Flier, W. M., Visser, P. J., Barkhof, F., Scheltens, P., Tijms, B. M. & Alzheimer's Disease Neuroimaging Initiative, 19 Mar 2019, In : NeuroImage: Clinical. 22

Research output: Contribution to journalArticleAcademicpeer-review