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2014

Brain volume and white matter hyperintensities as determinants of cerebral blood flow in Alzheimer's disease.

Benedictus, M. R., Binnewijzend, M. A. A., Kuijer, J. P. A., Steenwijk, M. D., Versteeg, A., Vrenken, H., Scheltens, P., Barkhof, F., van der Flier, W. M. & Prins, N. D., 2014, In : Neurobiology of Aging. 35, 12, p. 2665-2670

Research output: Contribution to journalArticleAcademicpeer-review

CD49d antisense drug ATL1102 reduces disease activity in patients with relapsing-remitting MS

Limmroth, V., Barkhof, F., Desem, N., Diamond, M. P. & Tachas, G., 2014, In : Neurology. 83, 20, p. 1780-1788

Research output: Contribution to journalArticleAcademicpeer-review

Cerebrospinal fluid levels of Alzheimer's disease biomarkers in middle-aged patients with type 1 diabetes

Ouwens, D. M., van Duinkerken, E., Schoonenboom, S. N. M., de Wiza, D. H., Klein, M., van Golen, L. W., Pouwels, P. J. W., Barkhof, F., Moll, A. C., Snoek, F. J., Teunissen, C. E., Scheltens, P. & Diamant, M., 2014, In : Diabetologia. 57, 10, p. 2208-2214

Research output: Contribution to journalArticleAcademicpeer-review

Changes in MEG resting-state networks are related to cognitive decline in type 1 diabetes mellitus patients

Demuru, M., van Duinkerken, E., Fraschini, M., Marrosu, F., Snoek, F. J., Barkhof, F., Klein, M., Diamant, M. & Hillebrand, A., 2014, In : NeuroImage: Clinical. 5, p. 69-76

Research output: Contribution to journalArticleAcademicpeer-review

Daclizumab in multiple sclerosis: a high-yield extension study

Barkhof, F. & Ciccarelli, O., 2014, In : Lancet Neurology. 13, 5, p. 443-444

Research output: Contribution to journalArticleAcademicpeer-review

Defining the clinical course of multiple sclerosis The 2013 revisions

Lublin, F. D., Reingold, S. C., Cohen, J. A., Cutter, G. R., Sorensen, P. S., Thompson, A. J., Wolinsky, J. S., Balcer, L. J., Banwell, B., Barkhof, F., Bebo, B., Calabresi, P. A., Clanet, M., Comi, G., Fox, R. J., Freedman, M. S., Goodman, A. D., Inglese, M., Kappos, L., Kieseier, B. C. & 12 others, Lincoln, J. A., Lubetzki, C., Miller, A. E., Montalban, X., O'Connor, P. W., Petkau, J., Pozzilli, C., Rudick, R. A., Sormani, M. P., Stuve, O., Waubant, E. & Polman, C. H., 2014, In : Neurology. 83, 3, p. 278-286

Research output: Contribution to journalArticleAcademicpeer-review

Determinants of iron accumulation in deep grey matter of multiple sclerosis patients

Ropele, S., Kilsdonk, I. D., Wattjes, M. P., Langkammer, C., de Graaf, W. L., Frederiksen, J. L., Larsson, H. B., Yiannakas, M., Wheeler-Kingshott, C. A. M., Enzinger, C., Khalil, M., Rocca, M. A., Sprenger, T., Amann, M., Kappos, L., Filippi, M., Rovira, A., Ciccarelli, O., Barkhof, F. & Fazekas, F., 2014, In : Multiple Sclerosis. 20, 13, p. 1692-1698

Research output: Contribution to journalArticleAcademicpeer-review

Diagnosis of asymptomatic natalizumab-associated PML: are we between a rock and a hard place?

Wattjes, M. P., Vennegoor, A., Mostert, J., van Oosten, B. W., Barkhof, F. & Killestein, J., 2014, In : Journal of Neurology. 261, 6, p. 1139-1143

Research output: Contribution to journalArticleAcademicpeer-review

Diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy using MRI

Wattjes, M. P. & Barkhof, F., 2014, In : Current Opinion in Neurology. 27, 3, p. 260-270

Research output: Contribution to journalArticleAcademicpeer-review

Diagnostic value of brain chronic black holes on T1-weighted MR images in clinically isolated syndromes

Mitjana, R., Tintore, M., Rocca, M. A., Auger, C., Barkhof, F., Filippi, M., Polman, C., Fazekas, F., Huerga, E., Montalban, X. & Rovira, A., 2014, In : Multiple Sclerosis. 20, 11, p. 1471-1477

Research output: Contribution to journalArticleAcademicpeer-review

Differential impact of subclinical carotid artery disease on cerebral structure and functioning in type 1 diabetes patients with versus those without proliferative retinopathy

van Duinkerken, E., IJzerman, R. G., van der Zijl, N. J., Barkhof, F., Pouwels, P. J. W., Schoonheim, M. M., Moll, A. C., Boerop, J., Wessels, A. M., Klein, M., Snoek, F. J. & Diamant, M., 2014, In : Cardiovascular Diabetology. 13, 58.

Research output: Contribution to journalArticleAcademicpeer-review

Distinctive structural and functional MRI footprint for cognitive dysfunction in pediatric MS?

Tedeschi, G., Gallo, A. & Barkhof, F., 2014, In : Neurology. 82, 15, p. 1296-1297

Research output: Contribution to journalArticleAcademicpeer-review

Distinct perfusion patterns in Alzheimer's disease, frontotemporal dementia and dementia with Lewy bodies

Binnewijzend, M. A. A., Kuijer, J. P. A., van der Flier, W. M., Benedictus, M. R., Moller, C. M., Pijnenburg, Y. A. L., Lemstra, A. W., Prins, N. D., Wattjes, M. P., van Berckel, B. N. M., Scheltens, P. & Barkhof, F., 2014, In : European Radiology. 24, 9, p. 2326-2333

Research output: Contribution to journalArticleAcademicpeer-review

Effect of prior treatment status and reasons for discontinuation on the efficacy and safety of fingolimod vs. interferon β-1a intramuscular: Subgroup analyses of the Trial Assessing Injectable Interferon vs. Fingolimod Oral in Relapsing–Remitting Multiple Sclerosis (TRANSFORMS)

Khatri, B. O., Pelletier, J., Kappos, L., Hartung, H. P., Comi, G., Barkhof, F., von Rosenstiel, P., Meng, X., Grinspan, A., Hashmonay, R. & Cohen, J. A., 2014, In : Multiple Sclerosis and Related Disorders. 3, 3, p. 355-363

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Insulin Detemir and NPH Insulin on Body Weight and Appetite-Regulating Brain Regions in Human Type 1 Diabetes: A Randomized Controlled Trial

van Golen, L. W., Veltman, D. J., IJzerman, R. G., Deijen, J. B., Heijboer, A. C., Barkhof, F., Drent, M. L. & Diamant, M., 2014, In : PLoS ONE. 9, 4, p. e94483 e94483.

Research output: Contribution to journalArticleAcademicpeer-review

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Efficacy of subcutaneous interferon beta-1a on MRI outcomes in a randomised controlled trial of patients with clinically isolated syndromes

De Stefano, N., Comi, G., Kappos, L., Freedman, M. S., Polman, C. H., Uitdehaag, B. M. J., Hennessy, B., Casset-Semanaz, F., Lehr, L., Stubinski, B., Jack, D. L. & Barkhof, F., 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 6, p. 647-653

Research output: Contribution to journalArticleAcademicpeer-review

Functional connectivity and cognitive decline over 3 years in Parkinson disease

Olde Dubbelink, K. T. E., Schoonheim, M. M., Deijen, J. B., Twisk, J. W. R., Barkhof, F. & Berendse, H. W., 2014, In : Neurology. 83, 22, p. 2046-2053

Research output: Contribution to journalArticleAcademicpeer-review

Functional Correlates of Cognitive Dysfunction in Multiple Sclerosis: A Multicenter fMRI Study

Rocca, M. A., Valsasina, P., Hulst, H. E., Abdel-Aziz, K., Enzinger, C., Gallo, A., Pareto, D., Riccitelli, G., Muhlert, N., Ciccarelli, O., Barkhof, F., Fazekas, F., Tedeschi, G., Arevalo, M. J. & Filippi, M., 2014, In : Human Brain Mapping. 35, 12, p. 5799-5814

Research output: Contribution to journalArticleAcademicpeer-review

GLP-1 Receptor Activation Modulates Appetite- and Reward-Related Brain Areas in Humans

van Bloemendaal, L., IJzerman, R. G., ten Kulve, J. S., Barkhof, F., Konrad, R. J., Drent, M. L., Veltman, D. J. & Diamant, M., 2014, In : Diabetes. 63, 12, p. 4186-4196

Research output: Contribution to journalArticleAcademicpeer-review

Head Motion Parameters in fMRI Differ Between Patients with Mild Cognitive Impairment and Alzheimer Disease Versus Elderly Control Subjects

Haller, S., Monsch, A. U., Richiardi, J., Barkhof, F., Kressig, R. W. & Radue, E. W., 2014, In : Brain Topography. 27, 6, p. 801-807

Research output: Contribution to journalArticleAcademicpeer-review

Hippocampal volume change measurement: Quantitative assessment of the reproducibility of expert manual outlining and the automated methods FreeSurfer and FIRST

Mulder, E. R., de Jong, R. A., Knol, D. L., van Schijndel, R. A., Cover, K. S., Visser, P. J., Barkhof, F. & Vrenken, H., 2014, In : NeuroImage. 92, p. 169-181

Research output: Contribution to journalArticleAcademicpeer-review

Improved differentiation between MS and vascular brain lesions using FLAIR* at 7 Tesla

Kilsdonk, I. D., Wattjes, M. P., Lopez-Soriano, A., Kuijer, J. P. A., de Jong, M. C., de Graaf, W. L., Conijn, M. M. A., Polman, C. H., Luijten, P. R., Geurts, J. J. G., Geerlings, M. I. & Barkhof, F., 2014, In : European Radiology. 24, 4, p. 841-849

Research output: Contribution to journalArticleAcademicpeer-review

Increased Number of Microinfarcts in Alzheimer Disease at 7-T MR Imaging

van Rooden, S., Goos, J. D. C., van Opstal, A. M., Versluis, M. J., Webb, A. G., Blauw, G. J., van der Flier, W. M., Scheltens, P., Barkhof, F., van Buchem, M. A. & van der Grond, J., 2014, In : Radiology. 270, 1, p. 205-211

Research output: Contribution to journalArticleAcademicpeer-review

Indicators for cognitive performance and subjective cognitive complaints in multiple sclerosis: a role for advanced MRI?

Hulst, H. E., Gehring, K., Uitdehaag, B. M. J., Visser, L. H., Polman, C. H., Barkhof, F., Sitskoorn, M. M. & Geurts, J. J. G., 2014, In : Multiple Sclerosis. 20, 8, p. 1131-1134

Research output: Contribution to journalArticleAcademicpeer-review

Interferon beta-1b reduces black holes in a randomised trial of clinically isolated syndrome

Nagtegaal, G. J. A., Pohl, C., Wattjes, M. P., Hulst, H. E., Freedman, M. S., Hartung, H. P., Miller, D., Montalban, X., Kappos, L., Edan, G., Pleimes, D., Beckman, K., Stemper, B., Polman, C. H., Sandbrink, R. & Barkhof, F., 2014, In : Multiple Sclerosis. 20, 2, p. 234-242

Research output: Contribution to journalArticleAcademicpeer-review

Longitudinal absolute metabolite quantification of white and gray matter regions in healthy controls using proton MR spectroscopic imaging

Wiebenga, O. T., Klauser, A. M., Nagtegaal, G. J. A., Schoonheim, M. M., Barkhof, F., Geurts, J. J. G. & Pouwels, P. J. W., 2014, In : NMR in Biomedicine. 27, 3, p. 304-311

Research output: Contribution to journalArticleAcademicpeer-review

Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions

Ossenkoppele, R., van der Flier, W. M., Verfaillie, S. C. J., Vrenken, H., Versteeg, A., van Schijndel, R. A., Sikkes, S. A., Twisk, J., Adriaanse, S. M., Zwan, M. D., Boellaard, R., Windhorst, A. D., Barkhof, F., Scheltens, P., Lammertsma, A. A. & van Berckel, B. N. M., 2014, In : Neurology. 82, 20, p. 1768-1775

Research output: Contribution to journalArticleAcademicpeer-review

Long-term impact of interferon beta-1b in patients with CIS: 8-year follow-up of BENEFIT

Edan, G., Kappos, L., Montalban, X., Polman, C. H., Freedman, M. S., Hartung, H. P., Miller, D., Barkhof, F., Herrmann, J., Lanius, V., Stemper, B., Pohl, C., Sandbrink, R. & Pleimes, D., 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 11, p. 1183-1189

Research output: Contribution to journalArticleAcademicpeer-review

Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration

Kearney, H., Rocca, M. A., Valsasina, P., Balk, L., Sastre-Garriga, J., Reinhardt, J., Ruggieri, S., Rovira, A., Stippich, C., Kappos, L., Sprenger, T., Tortorella, P., Rovaris, M., Gasperini, C., Montalban, X., Geurts, J. J. G., Polman, C. H., Barkhof, F., Filippi, M., Altmann, D. R. & 3 others, Ciccarelli, O., Miller, D. H. & Chard, D. T., 2014, In : Multiple Sclerosis. 20, 1, p. 72-80

Research output: Contribution to journalArticleAcademicpeer-review

Magnetic resonance imaging of the brain in adults with severe falciparum malaria

Maude, R. J., Barkhof, F., Hassan, M. U., Ghose, A., Hossain, A., Faiz, M. A., Choudhury, E., Rashid, R., bu Sayeed, A., Charunwatthana, P., Plewes, K., Kingston, H., Maude, R. R., Silamut, K., Day, N. P. J., White, N. J. & Dondorp, A. M., 2014, In : Malaria Journal. 13, 177.

Research output: Contribution to journalArticleAcademicpeer-review

Mean upper cervical cord area (MUCCA) measurement in long-standing multiple sclerosis: Relation to brain findings and clinical disability.

Daams, M., Weiler, F., Steenwijk, M. D., Hahn, H. K., Geurts, J. J. G., Vrenken, H., van Schijndel, R. A., Balk, L. J., Tewarie, P., Tillema, J. M., Killestein, J., Uitdehaag, B. M. J. & Barkhof, F., 2014, In : Multiple Sclerosis. 20, 14, p. 1860-1865

Research output: Contribution to journalArticleAcademicpeer-review

Molecular mechanism underlying the impact of vitamin D on disease activity of MS

Munger, K. L., Kochert, K., Simon, K. C., Kappos, L., Polman, C. H., Freedman, M. S., Hartung, H. P., Miller, D. H., Montalban, X., Edan, G., Barkhof, F., Pleimes, D., Sandbrink, R., Ascherio, A. & Pohl, C., 2014, In : Annals of Clinical and Translational Neurology. 1, 8, p. 605-617

Research output: Contribution to journalArticleAcademicpeer-review

Morphological features of MS lesions on FLAIR* at 7 T and their relation to patient characteristics

Kilsdonk, I. D., Lopez Soriano, A., Kuijer, J. P. A., de Graaf, W. L., Castelijns, J. A., Polman, C. H., Luijten, P. R., Geurts, J. J. G., Barkhof, F. & Wattjes, M. P., 2014, In : Journal of Neurology. 261, 7, p. 1356-1364

Research output: Contribution to journalArticleAcademicpeer-review

Moving toward earlier treatment of multiple sclerosis: Findings from a decade of clinical trials and implications for clinical practice

Freedman, M., Comi, G., De Stefano, N., Barkhof, F., Polman, C. H., Uitdehaag, B. M. J., Lehr, L., Stubinski, B. & Kappos, L., 2014, In : Multiple Sclerosis and Related Disorders. 3, 2, p. 147-155

Research output: Contribution to journalArticleAcademicpeer-review

MRI mimics of multiple sclerosis

Sanchez Aliaga, E. & Barkhof, F., 2014, In : Handbook of Clinical Neurology. 122, p. 291-316

Research output: Contribution to journalArticleAcademicpeer-review

Multicenter R-2* Mapping in the Healthy Brain

Ropele, S., Wattjes, M. P., Langkammer, C., Kilsdonk, I. D., de Graaf, W. L., Frederiksen, J. L., Fuglo, D., Yiannakas, M., Wheeler-Kingshott, C. A. M., Enzinger, C., Rocca, M. A., Sprenger, T., Amman, M., Kappos, L., Filippi, M., Rovira, A., Ciccarelli, O., Barkhof, F. & Fazekas, F., 2014, In : Magnetic Resonance in Medicine. 71, 3, p. 1103-1107

Research output: Contribution to journalArticleAcademicpeer-review

Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial

Confavreux, C., O'Connor, P., Comi, G., Freedman, M. S., Miller, A. E., Olsson, T. P., Wolinsky, J. S., Bagulho, T., Delhay, J. L., Dukovic, D., Barkhof, F., Truffinet, P. & Kappos, L., 2014, In : Lancet Neurology. 13, 3, p. 247-256

Research output: Contribution to journalArticleAcademicpeer-review

Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis

van de Kraats, C., Killestein, J., Popescu, V., rijkers, E., Vrenken, H., Lutjohann, D., Barkhof, F., Polman, C. H. & Teunissen, C. E., 2014, In : Multiple Sclerosis. 20, 4, p. 412-417

Research output: Contribution to journalArticleAcademicpeer-review

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

Ciccarelli, O., Barkhof, F., Bodini, B., De Stefano, N., Golay, X., Nicolay, K., Pelletier, D., Pouwels, P. J. W., Smith, S. A., Wheeler-Kingshott, C. A. M., Stankoff, B., Yousry, T. & Miller, D. H., 2014, In : Lancet Neurology. 13, 8, p. 807-822

Research output: Contribution to journalArticleAcademicpeer-review

Patient subgroup analyses of the treatment effect of subcutaneous interferon beta-1a on development of multiple sclerosis in the randomized controlled REFLEX study

Freedman, M. S., De Stefano, N., Barkhof, F., Polman, C. H., Comi, G., Uitdehaag, B. M. J., Casset-Semanaz, F., Hennessy, B., Lehr, L., Stubinski, B., Jack, D. L. & Kappos, L., 2014, In : Journal of Neurology. 261, 3, p. 490-499

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence of cortical superficial siderosis in a memory clinic population

Zonneveld, H. I., Goos, J. D. C., Wattjes, M. P., Prins, N. D., Scheltens, P., van der Flier, W. M., Kuijer, J. P. A., Muller, M. & Barkhof, F., 2014, In : Neurology. 82, 8, p. 698-704

Research output: Contribution to journalArticleAcademicpeer-review

Progression in disability and regional grey matter atrophy in relapsing-remitting multiple sclerosis

Hofstetter, L., Naegelin, Y., Filli, L., Kuster, P., Traud, S., Smieskova, R., Mueller-Lenke, N., Kappos, L., Gass, A., Sprenger, T., Penner, I. K., Nichols, T. E., Vrenken, H., Barkhof, F., Polman, C., Radue, E. W., Borgwardt, S. J. & Bendfeldt, K., 2014, In : Multiple Sclerosis. 20, 2, p. 202-213

Research output: Contribution to journalArticleAcademicpeer-review

Proliferative Retinopathy in Type 1 Diabetes Is Associated With Cerebral Microbleeds, Which Is Part of Generalized Microangiopathy

Woerdeman, J. P., van Duinkerken, E., Wattjes, M. P., Barkhof, F., Snoek, F. J., Moll, A. C., Klein, M., de Boer, M. P., IJzerman, R. G., Serne, E. H. & Diamant, M., 2014, In : Diabetes Care. 37, 4, p. 1165-1168

Research output: Contribution to journalArticleAcademicpeer-review