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Research Output 1993 2019

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2014

Increased Number of Microinfarcts in Alzheimer Disease at 7-T MR Imaging

van Rooden, S., Goos, J. D. C., van Opstal, A. M., Versluis, M. J., Webb, A. G., Blauw, G. J., van der Flier, W. M., Scheltens, P., Barkhof, F., van Buchem, M. A. & van der Grond, J., 2014, In : Radiology. 270, 1, p. 205-211

Research output: Contribution to journalArticleAcademicpeer-review

Indicators for cognitive performance and subjective cognitive complaints in multiple sclerosis: a role for advanced MRI?

Hulst, H. E., Gehring, K., Uitdehaag, B. M. J., Visser, L. H., Polman, C. H., Barkhof, F., Sitskoorn, M. M. & Geurts, J. J. G., 2014, In : Multiple Sclerosis. 20, 8, p. 1131-1134

Research output: Contribution to journalArticleAcademicpeer-review

Interferon beta-1b reduces black holes in a randomised trial of clinically isolated syndrome

Nagtegaal, G. J. A., Pohl, C., Wattjes, M. P., Hulst, H. E., Freedman, M. S., Hartung, H. P., Miller, D., Montalban, X., Kappos, L., Edan, G., Pleimes, D., Beckman, K., Stemper, B., Polman, C. H., Sandbrink, R. & Barkhof, F., 2014, In : Multiple Sclerosis. 20, 2, p. 234-242

Research output: Contribution to journalArticleAcademicpeer-review

Longitudinal absolute metabolite quantification of white and gray matter regions in healthy controls using proton MR spectroscopic imaging

Wiebenga, O. T., Klauser, A. M., Nagtegaal, G. J. A., Schoonheim, M. M., Barkhof, F., Geurts, J. J. G. & Pouwels, P. J. W., 2014, In : NMR in Biomedicine. 27, 3, p. 304-311

Research output: Contribution to journalArticleAcademicpeer-review

Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions

Ossenkoppele, R., van der Flier, W. M., Verfaillie, S. C. J., Vrenken, H., Versteeg, A., van Schijndel, R. A., Sikkes, S. A., Twisk, J., Adriaanse, S. M., Zwan, M. D., Boellaard, R., Windhorst, A. D., Barkhof, F., Scheltens, P., Lammertsma, A. A. & van Berckel, B. N. M., 2014, In : Neurology. 82, 20, p. 1768-1775

Research output: Contribution to journalArticleAcademicpeer-review

Long-term impact of interferon beta-1b in patients with CIS: 8-year follow-up of BENEFIT

Edan, G., Kappos, L., Montalban, X., Polman, C. H., Freedman, M. S., Hartung, H. P., Miller, D., Barkhof, F., Herrmann, J., Lanius, V., Stemper, B., Pohl, C., Sandbrink, R. & Pleimes, D., 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 11, p. 1183-1189

Research output: Contribution to journalArticleAcademicpeer-review

Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration

Kearney, H., Rocca, M. A., Valsasina, P., Balk, L., Sastre-Garriga, J., Reinhardt, J., Ruggieri, S., Rovira, A., Stippich, C., Kappos, L., Sprenger, T., Tortorella, P., Rovaris, M., Gasperini, C., Montalban, X., Geurts, J. J. G., Polman, C. H., Barkhof, F., Filippi, M., Altmann, D. R. & 3 othersCiccarelli, O., Miller, D. H. & Chard, D. T., 2014, In : Multiple Sclerosis. 20, 1, p. 72-80

Research output: Contribution to journalArticleAcademicpeer-review

Magnetic resonance imaging of the brain in adults with severe falciparum malaria

Maude, R. J., Barkhof, F., Hassan, M. U., Ghose, A., Hossain, A., Faiz, M. A., Choudhury, E., Rashid, R., bu Sayeed, A., Charunwatthana, P., Plewes, K., Kingston, H., Maude, R. R., Silamut, K., Day, N. P. J., White, N. J. & Dondorp, A. M., 2014, In : Malaria Journal. 13, 177.

Research output: Contribution to journalArticleAcademicpeer-review

Mean upper cervical cord area (MUCCA) measurement in long-standing multiple sclerosis: Relation to brain findings and clinical disability.

Daams, M., Weiler, F., Steenwijk, M. D., Hahn, H. K., Geurts, J. J. G., Vrenken, H., van Schijndel, R. A., Balk, L. J., Tewarie, P., Tillema, J. M., Killestein, J., Uitdehaag, B. M. J. & Barkhof, F., 2014, In : Multiple Sclerosis. 20, 14, p. 1860-1865

Research output: Contribution to journalArticleAcademicpeer-review

Molecular mechanism underlying the impact of vitamin D on disease activity of MS

Munger, K. L., Kochert, K., Simon, K. C., Kappos, L., Polman, C. H., Freedman, M. S., Hartung, H. P., Miller, D. H., Montalban, X., Edan, G., Barkhof, F., Pleimes, D., Sandbrink, R., Ascherio, A. & Pohl, C., 2014, In : Annals of Clinical and Translational Neurology. 1, 8, p. 605-617

Research output: Contribution to journalArticleAcademicpeer-review

Morphological features of MS lesions on FLAIR* at 7 T and their relation to patient characteristics

Kilsdonk, I. D., Lopez Soriano, A., Kuijer, J. P. A., de Graaf, W. L., Castelijns, J. A., Polman, C. H., Luijten, P. R., Geurts, J. J. G., Barkhof, F. & Wattjes, M. P., 2014, In : Journal of Neurology. 261, 7, p. 1356-1364

Research output: Contribution to journalArticleAcademicpeer-review

Moving toward earlier treatment of multiple sclerosis: Findings from a decade of clinical trials and implications for clinical practice

Freedman, M., Comi, G., De Stefano, N., Barkhof, F., Polman, C. H., Uitdehaag, B. M. J., Lehr, L., Stubinski, B. & Kappos, L., 2014, In : Multiple Sclerosis and Related Disorders. 3, 2, p. 147-155

Research output: Contribution to journalArticleAcademicpeer-review

MRI mimics of multiple sclerosis

Sanchez Aliaga, E. & Barkhof, F., 2014, In : Handbook of Clinical Neurology. 122, p. 291-316

Research output: Contribution to journalArticleAcademicpeer-review

Multicenter R-2* Mapping in the Healthy Brain

Ropele, S., Wattjes, M. P., Langkammer, C., Kilsdonk, I. D., de Graaf, W. L., Frederiksen, J. L., Fuglo, D., Yiannakas, M., Wheeler-Kingshott, C. A. M., Enzinger, C., Rocca, M. A., Sprenger, T., Amman, M., Kappos, L., Filippi, M., Rovira, A., Ciccarelli, O., Barkhof, F. & Fazekas, F., 2014, In : Magnetic Resonance in Medicine. 71, 3, p. 1103-1107

Research output: Contribution to journalArticleAcademicpeer-review

Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial

Confavreux, C., O'Connor, P., Comi, G., Freedman, M. S., Miller, A. E., Olsson, T. P., Wolinsky, J. S., Bagulho, T., Delhay, J. L., Dukovic, D., Barkhof, F., Truffinet, P. & Kappos, L., 2014, In : Lancet Neurology. 13, 3, p. 247-256

Research output: Contribution to journalArticleAcademicpeer-review

Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis

van de Kraats, C., Killestein, J., Popescu, V., rijkers, E., Vrenken, H., Lutjohann, D., Barkhof, F., Polman, C. H. & Teunissen, C. E., 2014, In : Multiple Sclerosis. 20, 4, p. 412-417

Research output: Contribution to journalArticleAcademicpeer-review

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

Ciccarelli, O., Barkhof, F., Bodini, B., De Stefano, N., Golay, X., Nicolay, K., Pelletier, D., Pouwels, P. J. W., Smith, S. A., Wheeler-Kingshott, C. A. M., Stankoff, B., Yousry, T. & Miller, D. H., 2014, In : Lancet Neurology. 13, 8, p. 807-822

Research output: Contribution to journalArticleAcademicpeer-review

Patient subgroup analyses of the treatment effect of subcutaneous interferon beta-1a on development of multiple sclerosis in the randomized controlled REFLEX study

Freedman, M. S., De Stefano, N., Barkhof, F., Polman, C. H., Comi, G., Uitdehaag, B. M. J., Casset-Semanaz, F., Hennessy, B., Lehr, L., Stubinski, B., Jack, D. L. & Kappos, L., 2014, In : Journal of Neurology. 261, 3, p. 490-499

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence of cortical superficial siderosis in a memory clinic population

Zonneveld, H. I., Goos, J. D. C., Wattjes, M. P., Prins, N. D., Scheltens, P., van der Flier, W. M., Kuijer, J. P. A., Muller, M. & Barkhof, F., 2014, In : Neurology. 82, 8, p. 698-704

Research output: Contribution to journalArticleAcademicpeer-review

Progression in disability and regional grey matter atrophy in relapsing-remitting multiple sclerosis

Hofstetter, L., Naegelin, Y., Filli, L., Kuster, P., Traud, S., Smieskova, R., Mueller-Lenke, N., Kappos, L., Gass, A., Sprenger, T., Penner, I. K., Nichols, T. E., Vrenken, H., Barkhof, F., Polman, C., Radue, E. W., Borgwardt, S. J. & Bendfeldt, K., 2014, In : Multiple Sclerosis. 20, 2, p. 202-213

Research output: Contribution to journalArticleAcademicpeer-review

Proliferative Retinopathy in Type 1 Diabetes Is Associated With Cerebral Microbleeds, Which Is Part of Generalized Microangiopathy

Woerdeman, J. P., van Duinkerken, E., Wattjes, M. P., Barkhof, F., Snoek, F. J., Moll, A. C., Klein, M., de Boer, M. P., IJzerman, R. G., Serne, E. H. & Diamant, M., 2014, In : Diabetes Care. 37, 4, p. 1165-1168

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative regional validation of the visual rating scale for posterior cortical atrophy

Möller, C., van der Flier, W. M., Versteeg, A., Benedictus, M. R., Wattjes, M. P., Koedam, E. L. G. M., Scheltens, P., Barkhof, F. & Vrenken, H., 2014, In : European Radiology. 24, 2, p. 397-404

Research output: Contribution to journalArticleAcademicpeer-review

Randomized phase I trials of the safety/tolerability of anti-LINGO-1 monoclonal antibody BIIB033

Tran, J. Q., Rana, J., Barkhof, F., Melamed, I., Gevorkyan, H., Wattjes, M. P., Jong, R., Brosofsky, K., Ray, S., Xu, L., Zhao, J., Parr, E. & Cadavid, D., 2014, In : Neurology neuroimmunology & neuroinflammation. 1, 2, e18.

Research output: Contribution to journalArticleAcademicpeer-review

Regional atrophy is associated with impairment in distinct cognitive domains in Alzheimer's disease

Smits, L. L., Tijms, B. M., Benedictus, M. R., Koedam, E. L. G. E., Koene, T., Reuling, I. E. W., Barkhof, F., Scheltens, P., Pijnenburg, Y. A. L., Wattjes, M. P. & van der Flier, W. M., 2014, In : Alzheimers & Dementia. 10, 5 Suppl, p. S299-S305

Research output: Contribution to journalArticleAcademicpeer-review

Resting-State Functional MR Imaging: A New Window to the Brain

Barkhof, F., Haller, S. & Rombouts, S. A. R. B., 2014, In : Radiology. 272, 1, p. 28-48

Research output: Contribution to journalArticleAcademicpeer-review

Sex-specific extent and severity of white matter damage in multiple sclerosis: Implications for cognitive decline

Schoonheim, M. M., Vigeveno, R. M., Lopes, F. C. R., Pouwels, P. J. W., Polman, C. H., Barkhof, F. & Geurts, J. J. G., 2014, In : Human Brain Mapping. 35, 5, p. 2348-2358

Research output: Contribution to journalArticleAcademicpeer-review

Single-subject gray matter graph properties and their relationship with cognitive impairment in early- and late-onset Alzheimer's disease

Tijms, B. M., Yeung, H. M., Sikkes, S. A. M., Moller, C., Smits, L. L., Stam, C. J., Scheltens, P., van der Flier, W. M. & Barkhof, F., 2014, In : Brain Connectivity. 4, 5, p. 337-346

Research output: Contribution to journalArticleAcademicpeer-review

Spinal cord MRI should always be performed in clinically isolated syndrome patients: Yes

Barkhof, F., 2014, In : Multiple Sclerosis. 20, 13, p. 1688-1689

Research output: Contribution to journalArticleAcademicpeer-review

Structural degree predicts functional network connectivity: A multimodal resting-state fMRI and MEG study

Tewarie, P., Hillebrand, A., van Dellen, E., Schoonheim, M. M., Barkhof, F., Polman, C. H., Beaulieu, C., Gong, G., van Dijk, B. W. & Stam, C. J., 2014, In : NeuroImage. 97, p. 296-307

Research output: Contribution to journalArticleAcademicpeer-review

The Dutch Parelsnoer Institute - Neurodegenerative diseases; methods, design and baseline results

Aalten, P., Ramakers, I. H. G. B., Biessels, G. J., de Deyn, P. P., Koek, H. L., Olde Rikkert, M. G. M., Oleksik, A. M., Richard, E., Smits, L. L., van Swieten, J. C., Teune, L. K., van der Lugt, A., Barkhof, F., Teunissen, C. E., Rozendaal, N., Verhey, F. R. J. & van der Flier, W. M., 2014, In : BMC Neurology. 14, 254.

Research output: Contribution to journalArticleAcademicpeer-review

The effect of galantamine on brain atrophy rate in subjects with mild cognitive impairment is modified by apolipoprotein E genotype: post-hoc analysis of data from a randomized controlled trial

Prins, N. D., van der Flier, W. A., Knol, D. L., Fox, N. C., Brashear, H. R., Nye, J. S., Barkhof, F. & Scheltens, P., 2014, In : Alzheimer's Research & Therapy. 6, 4, 47.

Research output: Contribution to journalArticleAcademicpeer-review

The SIENA/FSL whole brain atrophy algorithm is no more reproducible at 3 T than 1.5 T for Alzheimer's disease

Cover, K. S., van Schijndel, R. A., Popescu, V., van Dijk, B. W., Redolfi, A., Knol, D. L., Frisoni, G. B., Barkhof, F. & Vrenken, H., 2014, In : Psychiatry Research: Neuroimaging. 224, 1, p. 14-21

Research output: Contribution to journalArticleAcademicpeer-review

Validation of the Automated Method VIENA: An Accurate, Precise, and Robust Measure of Ventricular Enlargement

Vrenken, H., Vos, E. K., van der Flier, W. M., Sluimer, I. C., Cover, K. S., Knol, D. L. & Barkhof, F., 2014, In : Human Brain Mapping. 35, 4, p. 1101-1110

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression

Ascherio, A., Munger, K. L., White, R., Kochert, K., Simon, K. C., Polman, C. H., Freedman, M. S., Hartung, H. P., Miller, D. H., Montalban, X., Edan, G., Barkhof, F., Pleimes, D., Radu, E. W., Sandbrink, R., Kappos, L. & Pohl, C., 2014, In : JAMA Neurology. 71, 3, p. 306-314

Research output: Contribution to journalArticleAcademicpeer-review

What Explains Gray Matter Atrophy in Long-standing Multiple Sclerosis?

Steenwijk, M. D., Daams, M., Pouwels, P. J. W., Balk, L. J., Tewarie, P. K., Killestein, J., Uitdehaag, B. M. J., Geurts, J. J. G., Barkhof, F. & Vrenken, H., 2014, In : Radiology. 272, 3, p. 832-842

Research output: Contribution to journalArticleAcademicpeer-review

Widespread Disruption of Functional Brain Organization in Early-Onset Alzheimer's Disease

Adriaanse, S. M., Binnewijzend, M. A. A., Ossenkoppele, R., Tijms, B. M., van der Flier, W. M., Koene, T., Smits, L. L., Wink, A. M., Scheltens, P., van Berckel, B. N. M. & Barkhof, F., 2014, In : PLoS ONE. 9, 7, p. e102995 e102995.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Accelerated aging, decreased white matter integrity, and associated neuropsychological dysfunction 25 years after pediatric lymphoid malignancies

Schuitema, I., Deprez, S., van Hecke, W., Daams, M., Uyttebroeck, A., Sunaert, S., Barkhof, F., van Dulmen-den Broeder, E., van der Pal, H. J., Bos, C., Veerman, A. J. & de Sonneville, L. M., 2013, In : Journal of Clinical Oncology. 31, 27, p. 3378-3388

Research output: Contribution to journalArticleAcademicpeer-review

Accurate white matter lesion segmentation by k nearest neighbor classification with tissue type priors (kNN-TTPs)

Steenwijk, M. D., Pouwels, P. J., Daams, M., van Dalen, J. W., Caan, M. W., Richard, E., Barkhof, F. & Vrenken, H., 2013, In : NeuroImage: Clinical. 3, p. 462-469

Research output: Contribution to journalArticleAcademicpeer-review

An MRI rating scale for amyloid-related imaging abnormalities with edema or effusion

Barkhof, F., Daams, M., Scheltens, P., Brashear, H. R., Arrighi, H. M., Bechten, A. K., Morris, K., McGovern, M. & Wattjes, M. P., 2013, In : American Journal of Neuroradiology. 34, 8, p. 1550-1555

Research output: Contribution to journalArticleAcademicpeer-review

Atypical idiopathic inflammatory demyelinating lesions: prognostic implications and relation to multiple sclerosis

Wallner-Blazek, M., Rovira, A., Fillipp, M., Rocca, M. A., Miller, D. H., Schmierer, K., Frederiksen, J., Gass, A., Gama, H., Tilbery, C. P., Da Rocha, A. J., Flores, J., Barkhof, F., Seewann, A., Palace, J., Yousry, T., Montalban, X., Enzinger, C. & Fazekas, F., 2013, In : Journal of Neurology. 260, 8, p. 2016-2022

Research output: Contribution to journalArticleAcademicpeer-review

Brain atrophy and lesion load predict long term disability in multiple sclerosis

Popescu, V., Agosta, F., Hulst, H. E., Sluimer, I. C., Knol, D. L., Sormani, M. P., Enzinger, C., Ropele, S., Alonso, J., Sastre-Garriga, J., Rovira, A., Montalban, X., Bodini, B., Ciccarelli, O., Khaleeli, Z., Chard, D. T., Matthews, L., Palace, J., Giorgio, A., De Stefano, N. & 9 othersEisele, P., Gass, A., Polman, C. H., Uitdehaag, B. M. J., Messina, M. J., Comi, G., Filippi, M., Barkhof, F. & Vrenken, H., 2013, In : Journal of Neurology, Neurosurgery and Psychiatry. 84, 10, p. 1082-1091

Research output: Contribution to journalArticleAcademicpeer-review