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2013

Multicontrast MR imaging at 7T in multiple sclerosis: highest lesion detection in cortical gray matter with 3D-FLAIR

Kilsdonk, I. D., de Graaf, W. L., Lopez Soriano, A., Zwanenburg, J. J., Visser, F., Kuijer, J. P. A., Geurts, J. J. G., Pouwels, P. J. W., Polman, C. H., Castelijns, J. A., Luijten, P. R., Barkhof, F. & Wattjes, M. P., 2013, In : American Journal of Neuroradiology. 34, 4, p. 791-796

Research output: Contribution to journalArticleAcademicpeer-review

Multiple sclerosis: CCSVI deconstructed and discarded

Barkhof, F. & Wattjes, M. P., 2013, In : Nature Reviews Neurology. 9, p. 661-662

Research output: Contribution to journalArticleAcademicpeer-review

Mystery Case: Balo concentric sclerosis

Grooters, G. S., Visser, L. H., Barkhof, F., van der Knaap, M. S. & van Asseldonk, J. T., 2013, In : Neurology. 80, 7, p. E71-E72

Research output: Contribution to journalArticleAcademicpeer-review

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

Wardlaw, J. M., Smith, E. E., Biessels, G. J., Cordonnier, C., Fazekas, F., Frayne, R., Lindley, R. I., O'Brien, J. T., Barkhof, F., Benavente, O. R., Black, S. E., Brayne, C., Breteler, M., Chabriat, H., deCarli, C., de Leeuw, F. E., Doubal, F., Duering, M., Fox, N. C., Greenberg, S. & 16 others, Hachinski, V., Kilimann, I., Mok, V., van Oostenbrugge, R., Pantoni, L., Speck, O., Stephan, B. C. M., Teipel, S., Viswanathan, A., Werring, D., Chen, C., Smith, C., van Buchem, M., Norrving, B., Gorelick, P. B. & Dichgans, M., 2013, In : Lancet Neurology. 12, 8, p. 822-838

Research output: Contribution to journalArticleAcademicpeer-review

PML in a Patient Treated with Dimethyl Fumarate from a Compounding Pharmacy

van Oosten, B. W., Killestein, J., Barkhof, F., Polman, C. H. & Wattjes, M. P., 2013, In : New England Journal of Medicine. 368, 17, p. 1658-1659

Research output: Contribution to journalArticleAcademicpeer-review

Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease

Prestia, A., Caroli, A., van der Flier, W. M., Ossenkoppele, R., van Berckel, B. N. M., Barkhof, F., Teunissen, C. E., Wall, A. E., Carter, S. F., Scholl, M., Choo, I. H., Nordberg, A., Scheltens, P. & Frisoni, G. B., 2013, In : Neurology. 80, 11, p. 1048-1056

Research output: Contribution to journalArticleAcademicpeer-review

Predictors of Progression from Mild Cognitive Impairment to Dementia in the Placebo-Arm of a Clinical Trial Population

Prins, N. D., van der Flier, W. M., Brashear, H. R., Knol, D. L., van de Pol, L. A., Barkhof, F. & Scheltens, P., 2013, In : Journal of Alzheimer's Disease. 36, 1, p. 79-85

Research output: Contribution to journalArticleAcademicpeer-review

Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis

Vrenken, H., Jenkinson, M., Horsfield, M. A., Battaglini, M., van Schijndel, R. A., Rostrup, E., Geurts, J. J. G., Fisher, E., Zijdenbos, A., Ashburner, J., Miller, D. H., Filippi, M., Fazekas, F., Rovaris, M., Rovira, A., Barkhof, F. & De Stefano, N., 2013, In : Journal of Neurology. 260, 10, p. 2458-2471

Research output: Contribution to journalArticleAcademicpeer-review

Relationships Between White Matter Hyperintensities, Cerebral Amyloid Angiopathy and Dementia in a Population-based Sample of the Oldest Old

Tanskanen, M., Kalaria, R. N., Notkola, I. L., Makela, M., Polvikoski, T., Myllykangas, L., Sulkava, R., Kalimo, H., Paetau, A., Scheltens, P., Barkhof, F., van Straaten, E. C. W. & Erkinjuntti, T., 2013, In : Current Alzheimer Research. 10, 10, p. 1090-1097

Research output: Contribution to journalArticleAcademicpeer-review

Relevance of Spinal Cord Abnormalities to Clinical Disability in Multiple Sclerosis: MR Imaging Findings in a Large Cohort of Patients

Lukas, C., Sombekke, M. H., Bellenberg, B., Hahn, H. K., Popescu, V., Bendfeldt, K., Radue, E. W., Gass, A., Borgwardt, S. J., Kappos, L., Naegelin, Y., Knol, D. L., Polman, C. H., Geurts, J. J. G., Barkhof, F. & Vrenken, H., 2013, In : Radiology. 269, 2, p. 541-551

Research output: Contribution to journalArticleAcademicpeer-review

Resection Probability Maps for Quality Assessment of Glioma Surgery without Brain Location Bias

Versélewel de Witt Hamer, P. C., Hendriks, E. J., Mandonnet, E., Barkhof, F., Zwinderman, A. H. & Duffau, H., 2013, In : PLoS ONE. 8, 9, e73353.

Research output: Contribution to journalArticleAcademicpeer-review

Single-Subject Grey Matter Graphs in Alzheimer's Disease

Tijms, B. M., Moller, C., Vrenken, H., Wink, A. M., de Haan, W., van der Flier, W. M., Stam, C. J., Scheltens, P. & Barkhof, F., 2013, In : PLoS ONE. 8, 3, p. e58921 e58921.

Research output: Contribution to journalArticleAcademicpeer-review

Specific risk factors for microbleeds and white matter hyperintensities in Alzheimer's disease

Benedictus, M. R., Goos, J. D. C., Binnewijzend, M. A. A., Muller, M., Barkhof, F., Scheltens, P., Prins, N. D. & van der Flier, W. M., 2013, In : Neurobiology of Aging. 34, 11, p. 2488-2494

Research output: Contribution to journalArticleAcademicpeer-review

Spinal cord lesions in patients with clinically isolated syndrome A powerful tool in diagnosis and prognosis

Sombekke, M. H., Wattjes, M. P., Balk, L. J., Nielsen, J. M., Vrenken, H., Uitdehaag, B. M. J., Polman, C. H. & Barkhof, F., 2013, In : Neurology. 80, 1, p. 69-75

Research output: Contribution to journalArticleAcademicpeer-review

The chameleon of neuroinflammation: magnetic resonance imaging characteristics of natalizumab-associated progressive multifocal leukoencephalopathy

Wattjes, M. P., Richert, N. D., Killestein, J., de Vos, M. L., Sanchez, E., Snæbjörnsson, P., Cadavid, D. & Barkhof, F., 2013, In : Multiple Sclerosis. 19, 14, p. 1826-1840

Research output: Contribution to journalArticleAcademicpeer-review

Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers

Lehmann, M., Koedam, E. L., Barnes, J., Bartlett, J. W., Barkhof, F., Wattjes, M. P., Schott, J. M., Scheltens, P. & Fox, N. C., 2013, In : Neurobiology of Aging. 34, 1, p. 73-82

Research output: Contribution to journalArticleAcademicpeer-review

2012

Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial

Coles, A. J., Twyman, C. L., Arnold, D. L., Cohen, J. A., Confavreux, C., Fox, E. J., Hartung, H. P., Havrdova, E., Selmaj, K. W., Weiner, H. L., Miller, T., Fisher, E., Sandbrink, R., Lake, S. L., Margolin, D. H., Oyuela, P., Barkhof, F., Panzara, M. A. & Compston, D., 2012, In : Lancet. 380, 9856, p. 1829-1839

Research output: Contribution to journalArticleAcademicpeer-review

Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial

Cohen, J. A., Coles, A. J., Arnold, D. L., Confavreux, C., Fox, E. J., Hartung, H. P., Havrdova, E., Selmaj, K. W., Weiner, H. L., Fisher, E., Brinar, V. V., Giovannoni, G., Stojanovic, M., Ertik, B. I., Lake, S. L., Margolin, D. H., Barkhof, F., Panzara, M. A. & Compston, D., 2012, In : Lancet. 380, 9856, p. 1819-1828

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement

Ossenkoppele, R., Zwan, M. D., Tolboom, N., van Assema, D. M. E., Adriaanse, S. F., Kloet, R. W., Boellaard, R., Windhorst, A. D., Barkhof, F., Lammertsma, A. A., Scheltens, P., van der Flier, W. M. & van Berckel, B. N. M., 2012, In : Brain. 135, p. 2115-2125

Research output: Contribution to journalArticleAcademicpeer-review

A Randomized Trial of High-Dose Vitamin D2 in Relapsing-remitting Multiple Sclerosis

Leitner, H. H., Grimaldi, L., Barkhof, F., Beelke, M., Burton, H., Holmoy, T., Hupperts, R., Killestein, J., Rieckmann, P., Schluep, M. & Smolders, J., 2012, In : Neurology. 78, 11, p. 840-841

Research output: Contribution to journalArticleAcademicpeer-review

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Association between pathological and MRI findings in multiple sclerosis

Filippi, M. D., Rocca, M. A., Barkhof, F., Bruck, W., Chen, J. T., Comi, G., DeLuca, G., De Stefano, N., Erickson, B. J., Evangelou, N., Fazekas, F., Geurts, J. J. G., Lucchinetti, C., Miller, D. H., Pelletier, D., Popescu, B. F. G. & Lassmann, H., 2012, In : Lancet Neurology. 11, 4, p. 349-360

Research output: Contribution to journalArticleAcademicpeer-review

Brain atrophy accelerates cognitive decline in cerebral small vessel disease: The LADIS study

Jokinen, H., Lipsanen, J., Schmidt, R., Fazekas, F., Gouw, A. A., van der Flier, W. M., Barkhof, F., Madureira, S., Verdelho, A., Ferro, J. M., Wallin, A., Pantoni, L., Inzitari, D. & Erkinjuntti, T., 2012, In : Neurology. 78, 22, p. 1785-1792

Research output: Contribution to journalArticleAcademicpeer-review

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Callosal tissue loss parallels subtle decline in psychomotor speed. A longitudinal quantitative MRI study. The LADIS Study

Jokinen, H., Frederiksen, K. S., Garde, E., Skimminge, A., Siebner, H., Waldemar, G., Ylikoski, R., Madureira, S., Verdelho, A., van Straaten, E. C. W., Barkhof, F., Fazekas, F., Schmidt, R., Pantoni, L., Inzitari, D. & Erkinjuntti, T., 2012, In : Neuropsychologia. 50, 7, p. 1650-1655

Research output: Contribution to journalArticleAcademicpeer-review

Characteristics of Early MRI in Children and Adolescents with Vanishing White Matter

van der Lei, H. D. W., Steenweg, M. E., Barkhof, F., de Grauw, T., D'Hooghe, M., Morton, R., Shah, S., Wolf, N. & van der Knaap, M. S., 2012, In : Neuropediatrics. 43, 1, p. 22-26

Research output: Contribution to journalArticleAcademicpeer-review

Coil-treated Aneurysms: Decision Making Regarding Additional Treatment Based on Findings of MR Angiography and Intraarterial DSA

Schaafsma, J. D., Velthuis, B. K., van den Berg, R., Brouwer, P. A., Majoie, C. B. L. M., Barkhof, F., Eshghi, O., de Kort, G. A. P., Lo, R. T. H., Sprengers, M. E. S., van Rooij, W. J., Bot, J. C. J. & Rinkel, G. J. E., 2012, In : Radiology. 265, 3, p. 858-863

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event suggestive of multiple sclerosis (REFLEX): a phase 3 randomised controlled trial

Comi, G., De Stefano, N., Freedman, M. S., Barkhof, F., Polman, C. H., Uitdehaag, B. M. J., Casset-Semanaz, F., Hennessy, B., Moraga, M. S., Rocak, S., Stubinski, B. & Kappos, L., 2012, In : Lancet Neurology. 11, 1, p. 33-41

Research output: Contribution to journalArticleAcademicpeer-review

Diagnostic relevance of high field MRI in clinical neuroradiology: the advantages and challenges of driving a sports car

Wattjes, M. P. & Barkhof, F., 2012, In : European Radiology. 22, 11, p. 2304-2306

Research output: Contribution to journalArticleAcademicpeer-review

Diffusion tensor imaging in type 1 diabetes: decreased white matter integrity relates to cognitive functions

van Duinkerken, E., Schoonheim, M. M., IJzerman, R. G., Klein, M., Ryan, C. M., Moll, A. C., Snoek, F. J., Barkhof, F., Diamant, M. & Pouwels, P. J. W., 2012, In : Diabetologia. 55, 4, p. 1218-1220

Research output: Contribution to journalArticleAcademicpeer-review

Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia

van Straaten, E. C. W., de Haan, W., de Waal, H., Scheltens, P., van der Flier, W. M., Barkhof, F., Koene, T. & Stam, C. J., 2012, In : BMC Neuroscience. 13, p. 85 85.

Research output: Contribution to journalArticleAcademicpeer-review

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Open Access
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Effects of interferon beta-1b on cognitive performance in patients with a first event suggestive of multiple sclerosis

Penner, I. K., Stemper, B., Calabrese, P., Freedman, M. S., Polman, C. H., Edan, G., Hartung, H. P., Miller, D. H., Montalban, X., Barkhof, F., Pleimes, D., Lanius, V., Pohl, C., Kappos, L. & Sandbrink, R., 2012, In : Multiple Sclerosis. 18, 10, p. 1466-1471

Research output: Contribution to journalArticleAcademicpeer-review

EFNS task force: the use of neuroimaging in the diagnosis of dementia

Filippi, M., Agosta, F., Barkhof, F., Dubois, B., Fox, N. C., Frisoni, G. B., Jack, C. R., Johannsen, P., Miller, B. L., Nestor, P. J., Scheltens, P., Sorbi, S., Teipel, S., Thompson, P. M. & Wahlund, L. O., 2012, In : European Journal of Neurology. 19, 12, p. 1487-1501

Research output: Contribution to journalArticleAcademicpeer-review

169 Downloads (Pure)

Functional adaptive changes within the hippocampal memory system of patients with multiple sclerosis

Hulst, H. E., Schoonheim, M. M., Roosendaal, S. D., Popescu, V., Schweren, L. J. S., van der Werf, Y. D., Visser, L. H., Polman, C. H., Barkhof, F. & Geurts, J. J. G., 2012, In : Human Brain Mapping. 33, 10, p. 2268-2280

Research output: Contribution to journalArticleAcademicpeer-review

Gender-related differences in functional connectivity in multiple sclerosis

Schoonheim, M. M., Hulst, H. E., Landi, D., Ciccarelli, O., Roosendaal, S. D., Sanz-Arigita, E. J., Vrenken, H., Polman, C. H., Stam, C. J., Barkhof, F. & Geurts, J. J. G., 2012, In : Multiple Sclerosis. 18, 2, p. 164-173

Research output: Contribution to journalArticleAcademicpeer-review

Increased plasma 8,12-iso-iPF2alpha-VI levels in relapsing multiple sclerosis patients are not predictive of disease progression

Teunissen, C. E., Sombekke, M. H., van Winsen, L., Killestein, J., Barkhof, F., Polman, C. H., Dijkstra, C. D., Blankenstein, M. A. & Pratico, D., 2012, In : Multiple Sclerosis. 18, 8, p. 1092-1098

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation High-Field Magnetic Resonance Imaging

Kilsdonk, I. D., de Graaf, W. L., Barkhof, F. & Wattjes, M. P., 2012, In : Neuroimaging Clinics of North America. 22, 2, p. 135-157

Research output: Contribution to journalArticleAcademicpeer-review

Injury markers predict time to dementia in subjects with MCI and amyloid pathology

van Rossum, I. A., Vos, S. J. B., Burns, L., Knol, D. L., Scheltens, P., Soininen, H., Wahlund, L. O., Hampel, H., Tsolaki, M., Minthon, L., L'Italien, G., van der Flier, W. M., Teunissen, C. E., Blennow, K., Barkhof, F., Rueckert, D., Wolz, R., Verhey, F. & Visser, P. J., 2012, In : Neurology. 79, 17, p. 1809-1816

Research output: Contribution to journalArticleAcademicpeer-review

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Lesion detection at seven Tesla in multiple sclerosis using magnetisation prepared 3D-FLAIR and 3D-DIR

de Graaf, W. L., Zwanenburg, J. J. M., Visser, F., Wattjes, M. P., Pouwels, P. J. W., Geurts, J. J. G., Polman, C. H., Barkhof, F., Luijten, P. R. & Castelijns, J. A., 2012, In : European Radiology. 22, 1, p. 221-231

Research output: Contribution to journalArticleAcademicpeer-review

Longitudinal gray matter changes in multiple sclerosisuDifferential scanner and overall disease-related effects

Bendfeldt, K., Hofstetter, L., Kuster, P., Traud, S., Mueller-Lenke, N., Naegelin, Y., Kappos, L., Gass, A., Nichols, T. E., Barkhof, F., Vrenken, H., Roosendaal, S. D., Geurts, J. J. G., Radue, E. W. & Borgwardt, S. J., 2012, In : Human Brain Mapping. 33, 5, p. 1225-1245

Research output: Contribution to journalArticleAcademicpeer-review

Making better use of our brain MRI research data

Barkhof, F., 2012, In : European Radiology. 22, 7, p. 1395-1396

Research output: Contribution to journalArticleAcademicpeer-review

Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab

Ostrowitzki, S., Deptula, D., Thurfjell, L., Barkhof, F., Bohrmann, B., Brooks, D. J., Klunk, W. E., Ashford, E., Yoo, K., Xu, Z. X., Loetscher, H. & Santarelli, L., 2012, In : Archives of Neurology. 69, 2, p. 198-207

Research output: Contribution to journalArticleAcademicpeer-review

Memantine and Brain Atrophy in Alzheimer's Disease: A 1-Year Randomized Controlled Trial

Wilkinson, D., Fox, N. C., Barkhof, F., Phul, R., Lemming, O. & Scheltens, P., 2012, In : Journal of Alzheimer's Disease. 29, 2, p. 459-469

Research output: Contribution to journalArticleAcademicpeer-review

Microbleeds do not affect rate of cognitive decline in Alzheimer disease

van der Vlies, A. E., Goos, J. D. C., Barkhof, F., Scheltens, P. & van der Flier, W. M., 2012, In : Neurology. 79, 8, p. 763-769

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Microbleeds relate to altered amyloid-beta metabolism in Alzheimer's disease

Goos, J. D. C., Teunissen, C. E., Veerhuis, R., Verwey, N. A., Barkhof, F., Blankenstein, M. A., Scheltens, P. & van der Flier, W. M., 2012, In : Neurobiology of Aging. 33, 5, p. 1011.e1-1011.e9

Research output: Contribution to journalArticleAcademicpeer-review

Microglial activation in healthy aging

Schuitemaker, A., van der Doef, T. F., Boellaard, R., van der Flier, W. M., Yaqub, M. M., Windhorst, A. D., Barkhof, F., Jonker, C., Kloet, R. W., Lammertsma, A. A., Scheltens, P. & van Berckel, B. N. M., 2012, In : Neurobiology of Aging. 33, 6, p. 1067-1072

Research output: Contribution to journalArticleAcademicpeer-review