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Personal profile

Research interests

My research is centred around the effects of aberrant expression of normally meiosis-specific genes on DNA repair dysfunction and/or re-wiring in cancer. We are interested in understanding how cancer cells exploit idiosyncratic DNA repair pathways and functionalities that normally act in meiosis. We employ a combination of state-of-the-art genetics, cell biology and cancer biology to define how these pathways might represent currently under-explored potential avenues for biomarker development and therapeutic intervention.

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Research Output

Active transcription and Orc1 drive chromatin association of the AAA+ ATPase Pch2 during meiotic G2/prophase

Cardoso da Silva, R., Villar-Fernández, M. A. & Vader, G., 1 Jun 2020, In : PLoS Genetics. 16, 6, p. e1008905 e1008905.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Homeostatic control of meiotic G2/prophase checkpoint function by Pch2 and Hop1

Raina, V. & Vader, G., 25 Apr 2020, In : Biorxiv. 10.1101/2020.04.24.059642.

Research output: Contribution to journalArticleAcademic

Open Access

A dCas9/CRISPR-based targeting system identifies a central role for Ctf19 in kinetochore-derived suppression of meiotic recombination

Kuhl, L-M., makrantoni, V., Recknagel, S., Vaze, A., marston, A. & Vader, G., 8 Apr 2020, In : Biorxiv. 2020.04.07.030221.

Research output: Contribution to journalArticleAcademic

Open Access

The kinetochore prevents centromere-proximal crossover recombination during meiosis

Vincenten, N., Kuhl, L. M., Lam, I., Oke, A., Kerr, A. R. W., Hochwagen, A., Fung, J., Keeney, S., Vader, G. & Marston, A. L., 14 Dec 2015, In : eLife. 4, DECEMBER2015, e10850.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protection of repetitive DNA borders from self-induced meiotic instability

Vader, G., Blitzblau, H. G., Tame, M. A., Falk, J. E., Curtin, L. & Hochwagen, A., 1 Sep 2011, In : Nature. 477, 7362, p. 115-121 7 p.

Research output: Contribution to journalArticleAcademicpeer-review