Gerhard Bouma

PROF.DR., (Principal Investigator)

20082019
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Research Output 2008 2019

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2019

Adverse events related to low dose corticosteroids in autoimmune hepatitis

van den Brand, F. F., van der Veen, K. S., Lissenberg-Witte, B. I., de Boer, Y. S., van Hoek, B., Drenth, J. P. H., Verdonk, R. C., Vrolijk, J. M., van Nieuwkerk, C. M. J., Bouma, G. & the Dutch Autoimmune Hepatitis Study Group, 1 Nov 2019, In : Alimentary Pharmacology and Therapeutics. 50, 10, p. 1120-1126

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association Between Black Race and Presentation and Liver-Related Outcomes of Patients With Autoimmune Hepatitis

de Boer, Y. S., Gerussi, A., van den Brand, F. F., Wong, G-W., Halliday, N., Liberal, R., Drenth, J. P. H., Thorburn, D., Bouma, G., Dutch Autoimmune Hepatitis Study group, van Gerven, N. M., Beuers, U., van Erpecum, K. J., van Buuren, H. R., den Ouden, J. W., Brouwer, J. T., Vrolijk, J. M., Verdonk, R. C., van Hoek, B., Koek, G. H. & 13 othersGuichelaar, M. M. J., Bloemena, E., van Nieuwkerk, C. M. J., Schreuder, T. C. M. A., van der Wouden, E. J., van Meyel, J. J. M., Baak, L. C., Stadhouders, P. H. G. M., Klemt-Kropp, M., Verhagen, M. A. M. T., Bhalla, A., Kuijvenhoven, J. P. & Heneghan, M. A., 1 Jul 2019, In : Clinical Gastroenterology and Hepatology. 17, 8, p. 1616-1624.e2

Research output: Contribution to journalArticleAcademicpeer-review

CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors

Bar-Ephraim, Y. E., Koning, J. J., Burniol Ruiz, E., Konijn, T., Mourits, V. P., Lakeman, K. A., Boon, L., Bögels, M., van Maanen, J. P., den Haan, J. M. M., van Egmond, M., Bouma, G., Reijmers, R. M. & Mebius, R. E., 2019, In : Journal of Immunology. 202, 1, p. 171-182

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients

Simsek, M., Meijer, B., Ramsoekh, D., Bouma, G., van der Wouden, E-J., den Hartog, B., de Vries, A. C., Hoentjen, F., Dijkstra, G., de Boer, S. Y., Jansen, J. M., van der Meulen, A. E., Beukers, R., Brink, M. A., Steinhauser, T., Oldenburg, B., Gilissen, L. P., Naber, T. H., Verhagen, M. A., de Boer, N. K. H. & 2 othersMulder, C. J. J. & Dutch Initiative on Crohn and Colitis (ICC), 1 Feb 2019, In : Clinical Gastroenterology and Hepatology. 17, 3, p. 568-570 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Faecal scent as a novel non-invasive biomarker to discriminate between coeliac disease and refractory coeliac disease: A proof of principle study

Rouvroye, M. D., Wicaksono, A., Bosch, S., Savelkoul, E., Covington, J. A., Beaumont, H., Mulder, C. J., Bouma, G., de Meij, T. G. J. & de Boer, N. K. H., 1 Jun 2019, In : Biosensors. 9, 2, 69.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gamma-delta T lymphocytes in the diagnostic approach of coeliac disease

Nijeboer, P., van Gils, T., Reijm, M., Ooijevaar, R., Lissenberg-Witte, B. I., Bontkes, H. J., Mulder, C. J. J. & Bouma, G., 1 May 2019, In : Journal of Clinical Gastroenterology. 53, 5, p. E208-E213

Research output: Contribution to journalArticleAcademicpeer-review

Predniso(lo)ne Dosage and Chance of Remission in Patients With Autoimmune Hepatitis

Pape, S., Gevers, T. J. G., Belias, M., Mustafajev, I. F., Vrolijk, J. M., van Hoek, B., Bouma, G., van Nieuwkerk, C. M. J., Hartl, J., Schramm, C., Lohse, A. W., Taubert, R., Jaeckel, E., Manns, M. P., Papp, M., Stickel, F., Heneghan, M. A. & Drenth, J. P. H., 1 Sep 2019, In : Clinical Gastroenterology and Hepatology. 17, 10, p. 2068-2075.e2

Research output: Contribution to journalArticleAcademicpeer-review

Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study

Cellier, C., Bouma, G., van Gils, T., Khater, S., Malamut, G., Crespo, L., Collin, P., Green, P. H. R., Crowe, S. E., Tsuji, W., Butz, E., Cerf-Bensussan, N., Macintyre, E., Parnes, J. R., Leon, F., Hermine, O., Mulder, C. J., Jabri, B., Murray, J., DiMarino, A. & 22 othersKelly, C. P., Byrnes, V., Sanders, D., Lundin, K. E. A., Schumann, M., Bontkes, H., Meresse, B., Roy Ariño, G., Bhagat, G., Viiri, K., Rounioja, S., Bui, J., Perez Maseda, R., García-Hoz, C., Trinquand, A., Vlad, G., Hadjivassiliou, M., Azizi, M., Blanchard, A., Llewellyn, B., Palmer, A. & Raymond, R., 2019, In : The Lancet Gastroenterology and Hepatology. 4, 12, p. 960-970

Research output: Contribution to journalArticleAcademicpeer-review

2018

A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease

Hrdlickova, B., Mulder, C. J., Malamut, G., Meresse, B., Platteel, M., Kamatani, Y., Ricaño-Ponce, I., van Wanrooij, R. L. J., Zorro, M. M., Jan Bonder, M., Gutierrez-Achury, J., Cellier, C., Zhernakova, A., Nijeboer, P., Galan, P., Withoff, S., Lathrop, M., Bouma, G., Xavier, R. J., Jabri, B. & 3 othersBensussan, N. C., Wijmenga, C. & Kumar, V., 2018, In : European Journal of Gastroenterology and Hepatology. 30, 8, p. 828-837

Research output: Contribution to journalArticleAcademicpeer-review

Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands

van den Brand, F. F., van Nieuwkerk, C. M. J., Verwer, B. J., de Boer, Y. S., de Boer, N. K. H., Mulder, C. J. J., Bloemena, E., Bakker, C. M., Vrolijk, J. M., Drenth, J. P. H., Tan, A. C. I. T. L., Ter Borg, F., Ter Borg, M. J., van den Hazel, S. J., Inderson, A., Tushuizen, M. E. & Bouma, G., Oct 2018, In : Alimentary pharmacology & therapeutics. 48, 7, p. 761-767 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Efficacy and Safety of Budesonide, vs Mesalazine or Placebo, as Induction Therapy for Lymphocytic Colitis

BUG-1/LMC Study Group, 2018, In : Gastroenterology. 155, 6, p. 1795-1804.e3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

The International IBD Genetics Consortium, 2018, In : Nature Communications. 9, 1, 2427.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased Mortality Among Patients With vs Without Cirrhosis and Autoimmune Hepatitis

van den Brand, F. F., van der Veen, K. S., de Boer, Y. S., van Gerven, N. M., Lissenberg-Witte, B. I., Beuers, U., van Erpecum, K. J., van Buuren, H. R., den Ouden, J. W., Brouwer, J. T., Vrolijk, J. M., Verdonk, R. C., van Hoek, B., Koek, G. H., Drenth, J. P. H., Guichelaar, M. M. J., Mulder, C. J. J., Bloemena, E., van Nieuwkerk, C. M. J., Bouma, G. & 1 othersDutch Autoimmune Hepatitis Study group, 3 Oct 2018, In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticleAcademicpeer-review

Methotrexate and thioguanine rescue therapy for conventional thiopurine failing ulcerative colitis patients: A multi-center database study on tolerability and effectiveness

Meijer, B., Mulder, C. J. J., Bouma, G., Ponsioen, C. Y., van der Woude, C. J., van der Meulen, A. E., Wintjens, D. S. J., Dijkstra, G., Hoentjen, F., Oldenburg, B., van Bodegraven, A. A. & de Boer, N. K. H., 2018, In : Inflammatory Bowel Diseases. 24, 7, p. 1558-1565

Research output: Contribution to journalArticleAcademicpeer-review

Risks for lymphoma and gastrointestinal carcinoma in patients with newly diagnosed adult-onset celiac disease: Consequences for follow-up: Celiac disease, lymphoma and GI carcinoma

van Gils, T., Nijeboer, P., Overbeek, L. I., Hauptmann, M., Castelijn, D. A., Bouma, G., Mulder, C. J., van Leeuwen, F. E. & de Jong, D., Dec 2018, In : United European Gastroenterology Journal. 6, 10, p. 1485-1495 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Role of age in presentation, response to therapy and outcome of autoimmune hepatitis article

Baven-Pronk, M. A. M. C., Biewenga, M., van Silfhout, J. J., van den Berg, A. P., van Buuren, H. R., Verwer, B. J., van Nieuwkerk, C. M. J., Bouma, G. & van Hoek, B., 2018, In : CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY. 9, 6, 165.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Salivary Function and Oral Health Problems in Crohn's Disease Patients

de Vries, S. A. G., Tan, C. X. W., Bouma, G., Forouzanfar, T., Brand, H. S. & de Boer, N. K., 2018, In : Inflammatory Bowel Diseases. 24, 6, p. 1361-1367

Research output: Contribution to journalArticleAcademicpeer-review

Sex-Related Differences in Patients with Inflammatory Bowel Disease: Results of 2 Prospective Cohort Studies

Severs, M., Spekhorst, L. M., Mangen, M-J. J., Dijkstra, G., Löwenberg, M., Hoentjen, F., van der Meulen-de Jong, A. E., Pierik, M., Ponsioen, C. Y., Bouma, G., van der Woude, J. C., van der Valk, M. E., Romberg-Camps, M. J. L., Clemens, C. H. M., van de Meeberg, P., Mahmmod, N., Jansen, J., Jharap, B., Weersma, R. K., Oldenburg, B. & 2 othersFesten, E. A. M. & Fidder, H. H., 2018, In : Inflammatory Bowel Diseases. 24, 6, p. 1298-1306

Research output: Contribution to journalArticleAcademicpeer-review

The daily practice of (suspected) coeliac disease management by general practitioners: A qualitative approach

van Gils, T., Senler, T. G., van der Horst, H. E., Mulder, C. J. J., Bouma, G. & de Vries, H., 1 Dec 2018, In : The European journal of general practice. 24, 1, p. 236-242 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Transient elastography to assess liver stiffness in patients with inflammatory bowel disease

Meijer, B., van Everdingen, C. K., Ramsoekh, D., Stedman, C., Frampton, C. M. A., Mulder, C. J. J., Bouma, G., de Boer, N. K. H. & Gearry, R. B., 1 Jan 2018, In : Digestive and Liver Disease. 50, 1, p. 48-53 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

6-methylmercaptopurine-induced leukocytopenia during thiopurine therapy in inflammatory bowel disease patients

Meijer, B., Kreijne, J. E., van Moorsel, S. A. W., Derijks, L. J. J., Bouma, G., Mulder, C. J. J., Wong, D. R., van der Woude, C. J., van Bodegraven, A. A. & de Boer, N. K. H., 1 Jun 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, 6, p. 1183-1190 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes

Kooy-Winkelaar, Y. M. C., Bouwer, D., Janssen, G. M. C., Thompson, A., Brugman, M. H., Schmitz, F., de Ru, A. H., van Gils, T., Bouma, G., van Rood, J. J., van Veelen, P. A., Mearin, M. L., Mulder, C. J., Koning, F. & van Bergen, J., 7 Feb 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 6, p. E980-E989

Research output: Contribution to journalArticleAcademicpeer-review

Clinical experience and diagnostic algorithm of vulval Crohn's disease

Boxhoorn, L., Stoof, T. J., De Meij, T., Hoentjen, F., Oldenburg, B., Bouma, G., Löwenberg, M., Van Bodegraven, A. A., De Boer, N. K. H. & On behalf of the Dutch Initiative on Crohn and Colitis, 2017, In : European Journal of Gastroenterology and Hepatology. 29, 7, p. 838-843 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cohort profile: design and first results of the Dutch IBD Biobank: a prospective, nationwide biobank of patients with inflammatory bowel disease

Spekhorst, L. M., Imhann, F., Festen, E. A. M., van Bodegraven, A. A., de Boer, N. K. H., Bouma, G., Fidder, H. H., d'Haens, G., Hoentjen, F., Hommes, D. W., de Jong, D. J., Löwenberg, M., Maljaars, P. W. J., van der Meulen-de Jong, A. E., Oldenburg, B., Pierik, M. J., Ponsioen, C. Y., Stokkers, P. C., Verspaget, H. W., Visschedijk, M. C. & 4 othersvan der Woude, C. J., Dijkstra, G., Weersma, R. K. & Parelsnoer Institute (PSI) and the Dutch Initiative on Crohn and Colitis (ICC), 8 Nov 2017, In : BMJ Open. 7, 11, p. e016695

Research output: Contribution to journalArticleAcademicpeer-review

Expert clinical management of autoimmune hepatitis in the real world

Liberal, R., de Boer, Y. S., Andrade, R. J., Bouma, G., Dalekos, G. N., Floreani, A., Gleeson, D., Hirschfield, G. M., Invernizzi, P., Lenzi, M., Lohse, A. W., Macedo, G., Milkiewicz, P., Terziroli, B., van Hoek, B., Vierling, J. M., Heneghan, M., Pares, A., Montano-Loza, A. J., Granito, A. & 31 othersKremer, A. E., Floreani, A., Lohse, A. W., van Hoek, B., Terziroli, B., Schramm, C., Lammert, C., Cancado, E. L. R., Bjornsson, E., Lammert, F., Dalekos, G. N., Bouma, G., Hirschflield, G. M., Macedo, G., Hofer, H., Mackay, I., Neuberger, J., Vierling, J. M., Drenth, J. P. H., van Nieuwkerk, C. M. J., Muratori, L., Lenzi, M., Swain, M., Heneghan, M., Zeniya, M., Chazouilleres, O., Gines, P., Milkiewicz, P., Andrade, R. J., Ma, X. & the International Autoimmune Hepatitis Group (IAIHG), 1 Mar 2017, In : Alimentary Pharmacology and Therapeutics. 45, 5, p. 723-732 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gastrointestinal diseases and their oro-dental manifestations: Part 3: Coeliac disease

Van Gils, T., Brand, H. S., De Boer, N. K. H., Mulder, C. J. J. & Bouma, G., 27 Jan 2017, In : British Dental Journal. 222, 2, p. 126-129 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Optimizing Thiopurine Therapy in Inflammatory Bowel Disease among 2 Real-life Intercept Cohorts: Effect of Allopurinol Comedication?

Meijer, B., Seinen, M. L., Van Egmond, R., Bouma, G., Mulder, C. J. J., Van Bodegraven, A. A. & De Boer, N. K. H., 1 Nov 2017, In : Inflammatory Bowel Diseases. 23, 11, p. 2011-2017 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Reply

van Gils, T., Rootsaert, B., Bouma, G. & Mulder, C. J. J., Mar 2017, In : Journal of Gastrointestinal and Liver Diseases. 26, 1, p. 93

Research output: Contribution to journalArticleAcademicpeer-review

Splenic volume differentiates complicated and non-complicated celiac disease

van Gils, T., Nijeboer, P., van Waesberghe, J. H. TM., Coupé, V. M. H., Janssen, K., Zegers, J. A., Nurmohamed, S. A., Kraal, G., Jiskoot, S. C. I., Bouma, G. & Mulder, C. J. J., 1 Apr 2017, In : United European Gastroenterology Journal. 5, 3, p. 374-379 6 p.

Research output: Contribution to journalArticleProfessional

2016

Activation of neutrophils by immunoglobulin A (IgA) exacerbates pathogenesis of inflammatory bowel disease (IBD)

Bogels, M., van der Steen, L. P. E., Bouma, G. & van Egmond, M., Apr 2016, In : European Journal of Clinical Investigation. 46, p. 82-82

Research output: Contribution to journalArticleAcademicpeer-review

Actual Usage and Quality of Experimental Colitis Models in Preclinical Efficacy Testing: A Scoping Review

Zeeff, S. B., Kunne, C., Bouma, G., de Vries, R. B. & te Velde, A. A., Jun 2016, In : Inflammatory Bowel Diseases. 22, 6, p. 1296-1305 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Auto immune hepatitis

van Gerven, N. M. F., de Boer, Y. S., Mulder, C. J. J., van Nieuwkerk, C. M. J. & Bouma, G., 21 May 2016, In : World Journal of Gastroenterology. 22, 19, p. 4651-4661

Research output: Contribution to journalArticleAcademicpeer-review

Celiac Disease in The Netherlands: Demographic Data of Members of the Dutch Celiac Society

van Gils, T., Rootsaert, B., Bouma, G. & Mulder, C. J. J., Dec 2016, In : Journal of Gastrointestinal and Liver Diseases. 25, 4, p. 441-445 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

CLINICAL MANAGEMENT OF AUTOIMMUNE HEPATITIS IN THE REAL WORLD

Liberal, R., de Boer, Y., Andrade, R. J., Bouma, G., Dalekos, G. N., Floreani, A., Gleeson, D., Hirschfield, G., Invernizzi, P., Lenzi, M., Lohse, A. W., Macedo, L. G., Milkiewicz, P., Terziroli, B., van Hoek, B., Vierling, J. & Heneghan, M. A., 2016, In : Journal of Hepatology. 64, p. S652-S652

Research output: Contribution to journalArticleAcademicpeer-review

Optimize Thiopurine Therapy in Autoimmune Hepatitis

Meijer, B., Bouma, G. & de Boer, N. K. H., Jul 2016, In : Clinical Gastroenterology and Hepatology. 14, 7, p. 1062-3 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence and Characterization of Self-Reported Gluten Sensitivity in The Netherlands

van Gils, T., Nijeboer, P., IJssennagger, C. E., Sanders, D. S., Mulder, C. J. J. & Bouma, G., Nov 2016, In : Nutrients. 8, 11

Research output: Contribution to journalArticleAcademicpeer-review

The first cases of collagenous sprue successfully treated with thioguanine

van Gils, T., van de Donk, T., Bouma, G., van Delft, F., Neefjes-Borst, E. A. & Mulder, C. J. J., 2016, In : BMJ open gastroenterology. 3, 1, p. e000099

Research output: Contribution to journalArticleAcademicpeer-review

2015

Assessment of the histopathological key features in autoimmune hepatitis

de Boer, Y. S., van Nieuwkerk, C. M. J., Witte, B. I., Mulder, C. J. J., Bouma, G. & Bloemena, E., 2015, In : Histopathology. 66, 3, p. 351-362

Research output: Contribution to journalArticleAcademicpeer-review

Coeliakie en tandheelkunde

van Gils, T., de Boer, N. K. H. & Bouma, G., 2015, In : Nederlands Tijdschrift voor Tandheelkunde. 122, 9, p. 443-448

Research output: Contribution to journalArticleProfessional

Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts' Criteria

Catassi, C., Elli, L., Bonaz, B., Bouma, G., Carroccio, A., Castillejo, G., Cellier, C., Cristofori, F., de Magistris, L., Dolinsek, J., Dieterich, W., Francavilla, R., Hadjivassiliou, M., Holtmeier, W., Korner, U., Leffler, D. A., Lundin, K. E. A., Mazzarella, G., Mulder, C. J., Pellegrini, N. & 10 othersRostami, K., Sanders, D., Skodje, G. I., Schuppan, D., Ullrich, R., Volta, U., Williams, M., Zevallos, V. F., Zopf, Y. & Fasano, A., 2015, In : Nutrients. 7, 6, p. 4966-4977

Research output: Contribution to journalArticleAcademicpeer-review

Enteropathy-Associated T-Cell Lymphoma: Improving Treatment Strategies

Nijeboer, P., Malamut, G., Mulder, C. J., Cerf-Bensussan, N., Sibon, D., Bouma, G., Cellier, C., Hermine, O. & Visser, O., 2015, In : Digestive Diseases. 33, 2, p. 231-235

Research output: Contribution to journalArticleAcademicpeer-review

HLA-DRB1*03:01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1

van Gerven, N. M. F., de Boer, Y. S., Zwiers, A., Verwer, B. J., Drenth, J. P. H., van Hoek, B., van Erpecum, K. J., Beuers, U., van Buuren, H. R., den Ouden, J. W., Verdonk, R. C., Koek, G. H., Brouwer, J. T., Guichelaar, M. J., Vrolijk, J. M., Coenraad, M. J., Kraal, G., Mulder, C. J. J., van Nieuwkerk, C. M. J., Bloemena, E. & 6 othersVerspaget, H. W., Kumar, V., Zhernakova, A., Wijmenga, C., Franke, L. & Bouma, G., 2015, In : Genes and Immunity. 16, 4, p. 247-252

Research output: Contribution to journalArticleAcademicpeer-review

Intestinal epithelial cell transported TLR2 ligand stimulates Ly6C(+) monocyte differentiation in a G-CSF dependent manner

Hiemstra, I. H., Vrijland, K., Hogenboom, M. M., Bouma, G., Kraal, G. & den Haan, J. M. M., 2015, In : Immunobiology. 220, 11, p. 1255-1265

Research output: Contribution to journalArticleAcademicpeer-review

Mechanisms and management of refractory coeliac disease

van Gils, T., Nijeboer, P., van Wanrooij, R. L. J., Bouma, G. & Mulder, C. J. J., 2015, In : Nature Review Gastroenterology and Hepatology. 12, 10, p. 572-579

Research output: Contribution to journalArticleAcademicpeer-review

Microscopic Colitis

Bouma, G. & Munch, A. S., 2015, In : Digestive Diseases. 33, 2, p. 208-214

Research output: Contribution to journalArticleAcademicpeer-review