1981 …2020

Research output per year

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Research Output

2020

Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia

Hubeek, I., Broekhuizen, R., Jaramillo, A. C., Pastor-Anglada, M., Kaspers, G. J. L., Jansen, G., Cloos, J. & Peters, G. J., 1 Jan 2020, (Accepted/In press) In : Nucleosides, Nucleotides and Nucleic Acids.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

Hu, Y., Wang, B., Shen, J., Low, S. A., Putt, K. S., Niessen, H. W. M., Matteson, E. L., Murphy, L., Ruppert, C., Jansen, G., Oliver, S. J., Feng, Y., Dimitrov, D. S., Nickerson-Nutter, C. & Low, P. S., 7 Jun 2019, In : Arthritis Research and Therapy. 21, 1, 143.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach

Bruijnen, S. T. G., Chandrupatla, D. M. S. H., Giovanonni, L., Neri, D., Vugts, D. J., Huisman, M. C., Hoekstra, O. S., Musters, R. J. P., Lammertsma, A. A., van Dongen, G. A. M. S., Jansen, G., Molthoff, C. F. M. & van der Laken, C. J., 7 Jan 2019, In : Molecular Pharmaceutics. 16, 1, p. 273-281

Research output: Contribution to journalArticleAcademicpeer-review

Folate receptors and transporters: Biological role and diagnostic/therapeutic targets in cancer and other diseases

Frigerio, B., Bizzoni, C., Jansen, G., Leamon, C. P., Peters, G. J., Low, P. S., Matherly, L. H. & Figini, M., 12 Mar 2019, In : JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 38, 1, 125.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Folic acid conjugates of a bleomycin mimic for selective targeting of folate receptor positive cancer cells

Geersing, A., de Vries, R. H., Jansen, G., Rots, M. G. & Roelfes, G., 1 Aug 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 15, p. 1922-1927 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

Sciarrillo, R., Wojtuszkiewicz, A., El Hassouni, B., Funel, N., Gandellini, P., Lagerweij, T., Buonamici, S., Blijlevens, M., Zeeuw van der Laan, E. A., Zaffaroni, N., Deraco, M., Kusamura, S., Würdinger, T., Peters, G. J., Molthoff, C. F. M., Jansen, G., Kaspers, G. J. L., Cloos, J. & Giovannetti, E., Jan 2019, In : EBioMedicine. 39, p. 215-225

Research output: Contribution to journalArticleAcademicpeer-review

The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis

Chandrupatla, D. M. S. H., Molthoff, C. F. M., Lammertsma, A. A., van der Laken, C. J. & Jansen, G., 15 Feb 2019, In : Drug delivery and translational research. 9, 1, p. 366-378 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Therapeutic drug monitoring of methotrexate in disease

de Jonge, R., Muller, IB., Gosselt, HRG. & Jansen, G., 2019, In : Research Outreach. 110, p. 161-164 4 p.

Research output: Contribution to journalArticlePopular

Open Access
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2018

Aminopeptidase antibodies in mesothelioma: new wine deserves new sacks: new wine deserves new sacks

van Meerbeeck, J. P., Jansen, G., Giovannetti, E. & Peters, G. J., 2018, In : European Respiratory Journal. 51, 5, p. pii: 1800807 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Checkpoint inhibitors en reumatische complicaties

Translated title of the contribution: Checkpoint inhibitors and rheumatic complicationsVisser, K. & Jansen, G., 20 Dec 2018, In : Nederlands Tijdschrift voor Reumatologie. 21, 4, p. 35-39 5 p.

Research output: Contribution to journalArticleProfessional

Enhanced Dendritic Cell Development Through Long-Term Proteasome Inhibition

van de Ven, R., Verbrugge, S. E., Al, M., Dekker, H., Verheul, HMW., Anderl, J. L., Chan, E. T., Dijkmans, BAC., Lems, WF., Scheper, RJ., Jansen, G. & de Gruijl, TD., 18 Jan 2018, In : Journal of Molecular and Clinical Medicine. 1, 1, p. 37-46 10 p., DOI: 10.31083/j.jmcm.2018.01.005.

Research output: Contribution to journalArticleAcademicpeer-review

How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?

Jaramillo Mantilla, CA., Al Saig, F., Cloos, J., Jansen, G. & Peters, GJ., 19 Mar 2018, In : Cancer Drug Resistance. 1, p. 6-29 24 p., DOI: 10.20517/cdr.2018.02.

Research output: Contribution to journalReview articleAcademicpeer-review

Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate

Chandrupatla, D. M. S. H., Jansen, G., Mantel, E., Low, P. S., Matsuyama, T., Musters, R. P., Windhorst, A. D., Lammertsma, A. A., Molthoff, C. F. M. & van der Laken, C. J., 2018, In : Contrast media & molecular imaging. 2018, 8092781.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ontwikkeling van een LC-MS/MS methode voor de bepaling van folylpolyglutamaat synthetase (FPGS)

Muller, IB., Struys, EA., Lems, WF., Cloos, J., Jansen, G. & de Jonge, R., Oct 2018, In : Analyse. 73, 5, p. 101-103 3 p.

Research output: Contribution to journalArticleProfessional

Positioning of proteasome inhibitors in therapy of solid malignancies

Roeten, M. S. F., Cloos, J. & Jansen, G., 1 Feb 2018, In : Cancer Chemotherapy and Pharmacology. 81, 2, p. 227-243 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate

Chandrupatla, D. M. S. H., Molthoff, C. F. M., Ritsema, W. I. G. R., Vos, R., Elshof, E., Matsuyama, T., Low, P. S., Musters, R. J. P., Hammond, A., Windhorst, A. D., Lammertsma, A. A., van der Laken, C. J., Brands, R. & Jansen, G., 2018, In : Translational research : the journal of laboratory and clinical medicine. 199, p. 24-38 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide

Oerlemans, R., Berkers, C. R., Assaraf, Y. G., Scheffer, G. L., Peters, G. J., Verbrugge, S. E., Cloos, J., Slootstra, J., Meloen, R. H., Shoemaker, R. H., Dijkmans, B. A. C., Scheper, R. J., Ovaa, H. & Jansen, G., 1 Oct 2018, In : Investigational New Drugs. 36, 5, p. 797-809 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Synovial Macrophages: Potential Key Modulators of Cartilage Damage, Osteophyte Formation and Pain in Knee Osteoarthritis

Berkelaar, M. HM., Korthagen, N. M., Jansen, G. & van Spil, W. E., 3 Mar 2018, In : Journal Rheumatic Diseases and Treatment. 4, 1, p. 059 16 p., doi.org/10.23937/2469-5726/1510059.

Research output: Contribution to journalArticleAcademicpeer-review

Transporter and lysosomal mediated (Multi)drug resistance to tyrosine kinase inhibitors and potential strategies to overcome resistance

de Klerk, D. J., Honeywell, R. J., Jansen, G. & Peters, G. J., 2018, In : Cancers. 10, 12, 503.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2017

(Immuno)proteasomes as therapeutic target in acute leukemia

Cloos, J., Roeten, M. S. F., Franke, N. E., van Meerloo, J., Zweegman, S., Kaspers, G. J. L. & Jansen, G., Dec 2017, In : Cancer and Metastasis Reviews. p. 1-17 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

[18F]FLUORO-PEG-FOLATE PET: A NOVEL IMAGING TECHNIQUE TO VISUALIZE RHEUMATOID ARTHRITIS

Verweij, N., Bruijnen, S., Gent, Y., Huisman, M., Jansen, G., Molthoff, C., Chen, Q., Low, P., Windhorst, A., Lammertsma, A., Hoekstra, O., Voskuyl, A. & van der Laken, C., Jun 2017, p. 1020-1021.

Research output: Contribution to conferencePosterAcademic

Bortezomib resistance in multiple myeloma is associated with increased serine synthesis

Zaal, E. A., Wu, W., Jansen, G., Zweegman, S., Cloos, J. & Berkers, C. R., 2017, In : CANCER & METABOLISM. 5, 1, p. 7 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Drug resistance in pancreatic cancer: Impact of altered energy metabolism

Grasso, C., Jansen, G. & Giovannetti, E., 1 Jun 2017, In : Critical Reviews in Oncology/Hematology. 114, p. 139-152 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Folic Acid Impairs the Uptake of 5-Methyltetrahydrofolate in Human Umbilical Vascular Endothelial Cells

Smith, D., Hornstra, J., Rocha, M., Jansen, G., Assaraf, Y., Lasry, I., Blom, H. & Smulders, Y. M., 1 Oct 2017, In : Journal of Cardiovascular Pharmacology. 70, 4, p. 271-275 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

IN VIVO MONITORING OF ANTI-FOLATE THERAPY IN ARTHRITIC RATS USING [18F]FLUORO-PEG-FOLATE AND PET

Chandrupatla, D. M. S. H., van der Laken, C. J., Vos, R., Verlaan, M., van Kooij, R., Windhorst, A. D., Chen, Q., Low, P. S., Lammertsma, A. A., Jansen, G. & Molthoff, C. F. M., Jun 2017, p. 494-494.

Research output: Contribution to conferencePosterAcademic

In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography

Chandrupatla, D. M. S. H., Jansen, G., Vos, R., Verlaan, M., Chen, Q., Low, P. S., Windhorst, A. D., Lammertsma, A. A., van der Laken, C. J. & Molthoff, C. F. M., 31 May 2017, In : Arthritis Research and Therapy. 19, 1, 114.

Research output: Contribution to journalArticleAcademicpeer-review

Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: Clinical evidence and new pharmacological tools

Giovannetti, E., Zucali, P. A., Assaraf, Y. G., Funel, N., Gemelli, M., Stark, M., Thunnissen, E., Hou, Z., Muller, I. B., Struys, E. A., Perrino, M., Jansen, G., Matherly, L. H. & Peters, G. J., 2017, In : Annals of Oncology. 28, 11, p. 2725-2732 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

Franke, N. E., Kaspers, G. L., Assaraf, Y. G., van Meerloo, J., Niewerth, D., Kessler, F. L., Poddighe, P. J., Kole, J., Smeets, S. J., Ylstra, B., Bi, C., Chng, W. J., Horton, T. M., Menezes, R. X., Musters, R., Zweegman, S., Jansen, G. & Cloos, J., 15 Nov 2016, In : Oncotarget. 7, 46, p. 74779-74796

Research output: Contribution to journalArticleAcademicpeer-review

Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance

Wojtuszkiewicz, A., Raz, S., Stark, M., Assaraf, Y. G., Jansen, G., Peters, G. J., Sonneveld, E., Kaspers, G. J. L. & Cloos, J., 1 Apr 2016, In : International Journal of Cancer. 138, 7, p. 1645-1656

Research output: Contribution to journalArticleAcademicpeer-review

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR

Verbrugge, C., Al, M., Assaraf, Y. G., Kammerer, S., Chandrupatla, D. M. S. H., Honeywell, R. J., Musters, R. P. J., Giovannetti, E., O'Toole, T., Scheffer, G. L., Krige, D., de Gruijl, T. D., Niessen, J., Lems, W. F., Kramer, P. A., Scheper, R. J., Cloos, J., Ossenkoppele, G. J., Peters, G. J. & Jansen, G., 2 Feb 2016, In : Oncotarget. 7, 5, p. 5240-5257

Research output: Contribution to journalArticleAcademicpeer-review

Proteasome subunit expression analysis and chemosensitivity in relapsed paediatric acute leukaemia patients receiving bortezomib-containing chemotherapy

Niewerth, D., Kaspers, G. J. L., Jansen, G., van Meerloo, J., Zweegman, S., Jenkins, G., Whitlock, J. A., Hunger, S. P., Lu, X., Alonzo, T. A., de Ven, P. M. V., Horton, T. M. & Cloos, J., 6 Sep 2016, In : Journal of hematology & oncology. 9

Research output: Contribution to journalArticleAcademicpeer-review

The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia

Wojtuszkiewicz, A., Assaraf, Y. G., Hoekstra, M., Sciarrillo, R., Jansen, G., Peters, G. J., Pieters, R., Sonneveld, E., Escherich, G., Kaspers, G. J. L. & Cloos, J., Jul 2016, In : Haematologica. 101, 7, p. 291-294

Research output: Contribution to journalArticleAcademicpeer-review

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Sciarrillo, R., Wojtuszkiewicz, A., Kooi, I. E., Gómez, V. E., Boggi, U., Jansen, G., Kaspers, G-J., Cloos, J. & Giovannetti, E., 9 Dec 2016, In : Journal of Visualized Experiments. 118

Research output: Contribution to journalArticleAcademic

Abstract 4764: Transfer of regulatory protein networks via extracellular vesicles as a candidate mechanism of apoptosis-resistance in acute myeloid leukemia

Assaraf, Y. G., Zweegman, S., Cloos, J., Jansen, G., Knol, J., Schuurhuis, G. J., Jimenez, C. R., Piersma, S., Kessler, F. L., Wojtuszkiewicz, A. & Kaspers, G. L., 1 May 2015, In : Cancer Research. 74, 19 Supplement, p. 4764-4764 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Abstract LB-169: Ratios of immunoproteasome over constitutive proteasome expression are an indicator for sensitivity to bortezomib-containing reinduction chemotherapy in pediatric relapsed ALL and AML

Cloos, J., Jansen, G., Whitlock, J. A., Hunger, S. P., Meerloo, J. V., Zweegman, S., Horton, T. M., Jenkins, G., Lu, X., Kaspers, G. J. L. & Niewerth, D., 1 May 2015, In : Cancer Research. 74, 19 Supplement, p. LB-169-LB-169

Research output: Contribution to journalArticleAcademicpeer-review

ALK-negative anaplastic large cell lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2

Cillessen, S. A. G. M., Hijmernig, N. J., Moesbergen, L. M., Vos, W., Verbrugge, C. S. E., Jansen, G., Visser, O. J., Oudejans, J. J. & Meijer, C. J. L. M., 2015, In : Haematologica. 100, 9, p. E365-E368

Research output: Contribution to journalArticleAcademicpeer-review

Effect of prednisone on type I interferon signature in rheumatoid arthritis: consequences for response prediction to rituximab

de Jong, T. D., Vosslamber, S., Blits, M., Wolbink, G., Nurmohamed, M. T., van der Laken, C. J., Jansen, G., Voskuyl, A. E. & Verweij, C. L., 2015, In : Arthritis Research & Therapy. 17, 78.

Research output: Contribution to journalArticleAcademicpeer-review

Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

Wojtuszkiewicz, A. M., Peters, G. J., Ramakers-van Woerden, NL., Dubbelman, B., Escherich, G., Schmiegelow, K., Sonneveld, E., Pieters, R., van de Ven, P. M., Jansen, G., Assaraf, Y. G., Kaspers, G. J. L. & Cloos, J., 2015, In : Journal of hematology & oncology. 8, 61.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular basis of resistance to proteasome inhibitors in hematological malignancies

Niewerth, D., Jansen, G., Assaraf, Y. G., Zweegman, S., Kaspers, G. J. L. & Cloos, J., 2015, In : Drug Resistance Updates. 18, p. 18-35 18 p.

Research output: Contribution to journalArticleAcademicpeer-review