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Personal profile

Research interests

Inflammation is a host-protective response and efficient resolution of inflammation (orchestrated by specialized pro-resolving lipid mediators, SPMs) is essential to clear the threat and restore tissues into their original/functional state. However, an inadequate resolution response propagates chronic inflammation, which is a unifying component in many chronic diseases, including multiple sclerosis (MS). My main research focus is to elucidate whether and how altered inflammation-resolving mechanisms underlie MS to provide new perspectives on its pathogenesis and define novel and safe treatment opportunities. During my postdoctoral training at Harvard in Boston, on personal grants from IBRO, Nauta foundation and the Dutch MS research foundation, I discovered a unique lipid mediator signature in the cerebrospinal fluid and plasma associated with the clinical course of MS and provided first evidence for an impaired resolution of inflammation process in MS as reflected by the absence of protective lipid mediators at specific disease stages. Importantly, re-instating a proper resolution response significantly prevented neuro-inflammation and neuro-degeneration in animal models for MS. Together, these exciting findings form the basis of my current research line to reveal whether failed resolution mechanisms are at the root of MS pathogenesis and unravel underlying regulatory mechanisms to ultimately fully exploit this endogenous protection system and investigate its implementation for MS patient stratification (diagnosis, treatment efficacy) and therapy. These projects are funded by a personal Vidi (NWO) and Fellowship (Dutsch MS society) grants.Please add research interests.

Specialisation

Neuroscience and Immunology; Multiple Sclerosis, Experimental autoimmune encephalomyelitis, Resolution of inflammation; lipidomics; SPMs

Education/Academic qualification

PhD, VU University medical center

1 Mar 20043 Dec 2009

External positions

Postdoctoral fellow, Harvard Medical School

1 Jan 20161 Jan 2017

Postdoctoral fellow, Theodor Kocher Institute

1 Aug 20151 Dec 2015

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Research Output 2005 2019

Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling

Hoeksema, M. A., Laan, L. C., Postma, J. J., Cummings, R. D., de Winther, M. P. J., Dijkstra, C. D., van Die, I. & Kooij, G., Aug 2016, In : FASEB Journal. 30, 8, p. 2826-2836

Research output: Contribution to journalArticleAcademicpeer-review

Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation

Kooij, G., Kopplin, K., Blasig, R., Stuiver, M., Koning, N., Goverse, G., van der Pol, S. M. A., Hof, B. V., Gollasch, M., Drexhage, J. A. R., Reijerkerk, A., Meij, I. C., Mebius, R., Willnow, T. E., Muller, D., Blasig, I. E. & de Vries, H. E., 2014, In : Acta Neuropathologica. 128, 2, p. 267-277

Research output: Contribution to journalArticleAcademicpeer-review

Modulation of innate immunity of patients with Alzheimer’s disease by omega-3 fatty acids

Fiala, M., Kooij, G., Wagner, K., Hammock, B. & Pellegrini, M., 1 Aug 2017, In : FASEB Journal. 31, 8, p. 3229-3239 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma

Kooij, G., Kroon, J., Paul, D., Reijerkerk, A., Geerts, D., van der Pol, S. M. A., Hof, B. V. H., Drexhage, J. A., van Vliet, S. J., Hekking, L. H. P., van Buul, J. D., Pachter, J. S. & de Vries, H. E., 2014, In : Acta Neuropathologica. 127, 5, p. 699-711

Research output: Contribution to journalArticleAcademicpeer-review

Macrophage CD40-signaling drives experimental autoimmune encephalomyelitis

Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van Tiel, C. M., Reiche, M. E., den Toom, M., Beckers, L., van Roomen, C. P. A. A., de Winther, M. P. J., Kooij, G. & Lutgens, E., 1 Apr 2019, In : Journal of Pathology. 247, 4, p. 471-480 10 p.

Research output: Contribution to journalArticleAcademicpeer-review