20052019
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Research Output 2005 2019

2019

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology

Derada Troletti, C., Fontijn, R. D., Gowing, E., Charabati, M., van Het Hof, B., Didouh, I., van der Pol, S. M. A., Geerts, D., Prat, A., van Horssen, J., Kooij, G. & de Vries, H. E., 2019, In : Cell Death and Disease. 10, 2, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Macrophage CD40-signaling drives experimental autoimmune encephalomyelitis

Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van Tiel, C. M., Reiche, M. E., den Toom, M., Beckers, L., van Roomen, C. P. A. A., de Winther, M. P. J., Kooij, G. & Lutgens, E., 1 Apr 2019, In : Journal of Pathology. 247, 4, p. 471-480 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

nEUROinflammation in multiple sclerosis: from blood-brain barrier dysfunction to resolution

Derada Troletti, C., 2019

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

2018

CD40 in MS: Multiple sclerosis and the metabolic syndrome

Aarts, S. A. B. M., 2018

Research output: ThesisResearch external, graduation externalAcademic

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Seijkens, T. T. P., van Tiel, C. M., Kusters, P. J. H., Atzler, D., Soehnlein, O., Zarzycka, B., Aarts, S. A. B. M., Lameijer, M., Gijbels, M. J., Beckers, L., den Toom, M., Slütter, B., Kuiper, J., Duchene, J., Aslani, M., Megens, R. T. A., van ‘t Veer, C., Kooij, G., Schrijver, R., Hoeksema, M. A. & 16 othersBoon, L., Fay, F., Tang, J., Baxter, S., Jongejan, A., Moerland, P. D., Vriend, G., Bleijlevens, B., Fisher, E. A., Duivenvoorden, R., Gerdes, N., de Winther, M. P. J., Nicolaes, G. A., Mulder, W. J. M., Weber, C. & Lutgens, E., 2018, In : Journal of the American College of Cardiology. 71, 5, p. 527-542 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van der Pol, S. M. A., Zarzycka, B., Heijnen, P. D. A. M., Beckers, L., den Toom, M., Gijbels, M. J. J., Boon, L., Weber, C., de Vries, H. E., Nicolaes, G. A. F., Dijkstra, C. D., Kooij, G. & Lutgens, E., 12 May 2017, In : Journal of Neuroinflammation. 14, 1, 105.

Research output: Contribution to journalArticleAcademicpeer-review

Modulation of innate immunity of patients with Alzheimer’s disease by omega-3 fatty acids

Fiala, M., Kooij, G., Wagner, K., Hammock, B. & Pellegrini, M., 1 Aug 2017, In : FASEB Journal. 31, 8, p. 3229-3239 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Purinergic receptor P2Y12: a potential target for PET imaging of neuroinflammation in multiple sclerosis and EAE

Beaino, W., Janssen, B., Kooij, G., van der Pol, S., Windhorst, A. D. & de Vries, H. E., Jun 2017, In : GLIA. 65, p. E478-E479

Research output: Contribution to journalMeeting AbstractAcademic

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

Beaino, W., Janssen, B., Kooij, G., van der Pol, S. M. A., van Het Hof, B., van Horssen, J., Windhorst, A. D. & de Vries, H. E., 22 Dec 2017, In : Journal of Neuroinflammation. 14, 1, p. 259

Research output: Contribution to journalArticleAcademicpeer-review

The CD40-CD40L dyad in experimental autoimmune encephalomyelitis and multiple sclerosis

Aarts, S. A. B. M., Seijkens, T. T. P., van Dorst, K. J. F., Dijkstra, C. D., Kooij, G. & Lutgens, E., 12 Dec 2017, In : Frontiers in Immunology. 8, DEC, 1791.

Research output: Contribution to journalReview articleAcademicpeer-review

The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells

Laan, L. C., Williams, A. R., Stavenhagen, K., Giera, M., Kooij, G., Vlasakov, I., Kalay, H., Kringel, H., Nejsum, P., Thamsborg, S. M., Wuhrer, M., Dijkstra, C. D., Cummings, R. D. & Van Die, I., 1 Feb 2017, In : FASEB Journal. 31, 2, p. 719-731 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats I: Magnetic resonance imaging

van Vliet, E. A., Otte, W. M., Wadman, W. J., Aronica, E., Kooij, G., de Vries, H. E., Dijkhuizen, R. M. & Gorter, J. A., Jan 2016, In : Epilepsia. 57, 1, p. 59-69

Research output: Contribution to journalArticleAcademicpeer-review

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms

van Vliet, E. A., Otte, W. M., Wadman, W. J., Aronica, E., Kooij, G., de Vries, H. E., Dijkhuizen, R. M. & Gorter, J. A., Jan 2016, In : Epilepsia. 57, 1, p. 70-78

Research output: Contribution to journalArticleAcademicpeer-review

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke

Lopes Pinheiro, M., Kooij, G., Mizee, M. R., Kamermans, A., Enzmann, G., Lyck, R., Schwaninger, M., Engelhardt, B. & de Vries, H. E., Mar 2016, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1862, 3, p. 461-471

Research output: Contribution to journalArticleAcademicpeer-review

In Vitro and Ex Vivo Model Systems to Measure ABC Transporter Activity at the Blood-Brain Barrier

de Wit, N. M., Kooij, G. & de Vries, H. E., 2016, In : Current Pharmaceutical Design. 22, 38, p. 5768-5773

Research output: Contribution to journalArticleAcademicpeer-review

Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling

Hoeksema, M. A., Laan, L. C., Postma, J. J., Cummings, R. D., de Winther, M. P. J., Dijkstra, C. D., van Die, I. & Kooij, G., Aug 2016, In : FASEB Journal. 30, 8, p. 2826-2836

Research output: Contribution to journalArticleAcademicpeer-review

2015

GM-CSF promotes migration of human monocytes across the blood brain barrier

Vogel, D. Y. S., Kooij, G., Heijnen, P. D. A. M., Breur, M., Peferoen, L. A. N., van der Valk, P., de Vries, H. E., Amor, S. & Dijkstra, C. D., 2015, In : European Journal of Immunology. 45, 6, p. 1808-1819

Research output: Contribution to journalArticleAcademicpeer-review

In vivo MR imaging of intercellular adhesion molecule-1 expression in an animal model of multiple sclerosis

Blezer, E. L. A., Deddens, L. H., Kooij, G., Drexhage, J. A. R., van der Pol, S. M. A., Reijerkerk, A., Dijkhuizen, R. M. & de Vries, H. E., 2015, In : Contrast media & molecular imaging. 10, 2, p. 111-121

Research output: Contribution to journalArticleAcademicpeer-review

Protective effects of monomethyl fumarate at the inflamed blood-brain barrier

Lim, J. L., van der Pol, S. M. A., Di Dio, F., van het Hof, B., Kooij, G., de Vries, H. E. & van Horssen, J., 2015, In : Microvascular Research. 105, p. 61-68

Research output: Contribution to journalArticleAcademicpeer-review

Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin alpha-4-transduced outside-in signalling

Haarmann, A., Nowak, E., Deiss, A., van der Pol, S. M. A., Monoranu, C. M., Kooij, G., Muller, N., van der Valk, P., Stoll, G., de Vries, H. E., Berberich-Siebelt, F. & Buttmann, M., 2015, In : Acta Neuropathologica. 129, 5, p. 639-652

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration

van Strien, M. E., de Vries, H. E., Chrobok, N. L., Bol, J. G. J. M., Breve, J. J. P., van der Pol, S. M. P., Kooij, G., van Buul, J. D., Karpuj, M., Steinman, L., Wilhelmus, M. M., Sestito, C., Drukarch, B. & Van Dam, A-M., Nov 2015, In : Brain Behavior and Immunity. 50, p. 141-154 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis

Kooij, G., Braster, R., Koning, J. J., Laan, L. C., van Vliet, S. J., Los, T., Eveleens, A. M., van der Pol, S. M. A., Forster-Waldl, E., Boztug, K., Belot, A., Szilagyi, K., van den Berg, T. K., van Buul, J. D., van Egmond, M., de Vries, H. E., Cummings, R. D., Dijkstra, C. D. & van Die, I., 2015, In : Acta Neuropathologica Communinications. 3, 45.

Research output: Contribution to journalArticleAcademicpeer-review

2014

ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy

Carrano, A., Snkhchyan, H., Kooij, G., van der Pol, S., van Horssen, J., Veerhuis, R., Hoozemans, J. J. M., Rozemuller, A. J. M. & de Vries, H. E., 2014, In : Neurobiology of Aging. 35, 3, p. 565-575

Research output: Contribution to journalArticleAcademicpeer-review

Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists

Pryce, G., Visintin, C., Ramagopalan, S. V., Al-Izki, S., De Faveri, L. E., Nuamah, R. A., Mein, C. A., Montpetit, A., Hardcastle, A. J., Kooij, G., de Vries, H. E., Amor, S., Thomas, S. A., Ledent, C., Marsicano, G., Lutz, B., Thompson, A. J., Selwood, D. L., Giovannoni, G. & Baker, D., 2014, In : FASEB Journal. 28, 1, p. 117-130

Research output: Contribution to journalArticleAcademicpeer-review

Disease Influence on BBB Transport in Inflammatory Disorders

Schenk, G. J., Kooij, G., Reijerkerk, A. & de Vries, H. E., 2014, Drug Delivery to the Brain. Physiological Concepts, Methodologies and Approaches. New York: Springer, p. 573-589 (AAPS Advances in the Pharmaceutical Sciences Series; no. 10).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation

Kooij, G., Kopplin, K., Blasig, R., Stuiver, M., Koning, N., Goverse, G., van der Pol, S. M. A., Hof, B. V., Gollasch, M., Drexhage, J. A. R., Reijerkerk, A., Meij, I. C., Mebius, R., Willnow, T. E., Muller, D., Blasig, I. E. & de Vries, H. E., 2014, In : Acta Neuropathologica. 128, 2, p. 267-277

Research output: Contribution to journalArticleAcademicpeer-review

Multiple Sclerosis: Impact on Functioning of the Blood–Brain Barrier

Mizee, M. R., Kooij, G. & de Vries, H. E., 2014, Neuroinflammation and Neurodegeneration. New York: Springer, p. 143-160

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma

Kooij, G., Kroon, J., Paul, D., Reijerkerk, A., Geerts, D., van der Pol, S. M. A., Hof, B. V. H., Drexhage, J. A., van Vliet, S. J., Hekking, L. H. P., van Buul, J. D., Pachter, J. S. & de Vries, H. E., 2014, In : Acta Neuropathologica. 127, 5, p. 699-711

Research output: Contribution to journalArticleAcademicpeer-review

The helminth Trichuris suis suppresses TLR4-induced inflammatory responses in human macrophages

Ottow, M. K., Klaver, E. J., van der Pouw Kraan, C. T. M., Heijnen, P. D., Laan, L. C., Kringel, H., Vogel, D. Y. S., Dijkstra, C. D., Kooij, G. & van Die, I., 2014, In : Genes and Immunity. 15, 7, p. 477-486

Research output: Contribution to journalArticleAcademicpeer-review

2013

Mesenchymal stem cells are mobilized from the bone marrow during inflammation

Koning, J. J., Kooij, G., de Vries, H. E., Nolte, M. A. & Mebius, R. E., 2013, In : Frontiers in Immunology: Molecular Innate Immunity. 4, 49.

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

Reijerkerk, A., Lopez-Ramirez, M. A., van het Hof, B., Drexhage, J. A. R., Kamphuis, W. W., Kooij, G., Vos, J. B., van der Pouw Kraan, C. T. M., van Zonneveld, A. J., Horrevoets, A. J., Prat, A., Romero, I. A. & de Vries, H. E., 2013, In : Journal of Neuroscience. 33, 16, p. 6857-6863

Research output: Contribution to journalArticleAcademicpeer-review

2012

Brain endothelial barrier passage by monocytes is controlled by the endothelin system

Reijerkerk, A., Lakeman, K. A. M., Drexhage, J. A. R., van het Hof, B., van Wijck, Y., van der Pol, S. M. A., Kooij, G., Geerts, D. & de Vries, H. E., 2012, In : Journal of Neurochemistry. 121, 5, p. 730-737

Research output: Contribution to journalArticleAcademicpeer-review

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation

Gaillard, P. J., Appeldoorn, C. C., Rip, J., van Dorland, R., van der Pol, S. M. A., Kooij, G., de Vries, H. E. & Reijerkerk, A., 2012, In : Journal of Controlled Release. 164, 3, p. 364-369

Research output: Contribution to journalArticleAcademicpeer-review

Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

van Doorn, R. P., Nijland, P. G., Dekker, N., Witte, M. E., Lopes Pinheiro, M. A., van het Hof, B., Kooij, G., Reijerkerk, A., Dijkstra, C. D., van der Valk, P., van Horssen, J. & de Vries, H. E., 2012, In : Acta Neuropathologica. 124, 3, p. 397-410

Research output: Contribution to journalArticleAcademicpeer-review

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: Implications for clinical disease

de Vries, H. E., Kooij, G., Frenkel, D., Georgopoulos, S., Monsonego, A. & Janigro, D., 2012, In : Epilepsia. 53, p. 45-52

Research output: Contribution to journalArticleAcademicpeer-review

Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation

Kuijk, L. M., Klaver, E. J., Kooij, G., van der Pol, S. M. A., Heijnen, P., Bruijns, S. C. M., Kringel, H., Pinelli, E., Kraal, G., de Vries, H. E., Dijkstra, C. D., Bouma, G. & van Die, I. M., 2012, In : Molecular Immunology. 51, 2, p. 210-218

Research output: Contribution to journalArticleAcademicpeer-review

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

van Doorn, R. P., Lopes Pinheiro, M. A., Kooij, G., Lakeman, K., van het Hof, B., van der Pol, S. M. A., Geerts, D., van Horssen, J., van der Valk, P., van der Kam, E., Ronken, E., Reijerkerk, A. & de Vries, H. E., 2012, In : Journal of Neuroinflammation. 9, p. 133 133.

Research output: Contribution to journalArticleAcademicpeer-review

37 Downloads (Pure)

The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive Lipids

Kooij, G., van Horssen, J., Bandaru, V. V. R., Haughey, N. J. & de Vries, H. E., 2012, In : Frontiers in Pharmacology. 3, 74.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2011

Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis

Kooij, G., Mizee, M. R., van Horssen, J., Reijerkerk, A., Witte, M. E., Drexhage, J. A. R., van der Pol, SM., Van Het Hof, B., Scheffer, G. L., Scheper, R. J., Dijkstra, C. D., van der Valk, P. & de Vries, H. E., 2011, In : Brain. 134, p. 555-570

Research output: Contribution to journalArticleAcademicpeer-review

2010

The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier

Reijerkerk, A., Kooij, G., van der Pol, S. M. A., Leyen, T. A., Lakeman, K., Van Het Hof, B., Vivien, D. & de Vries, H. E., 2010, In : Journal of Neurochemistry. 113, 2, p. 447-453

Research output: Contribution to journalArticleAcademicpeer-review

T lymphocytes impair P-glycoprotein function during neuroinflammation

Kooij, G., van Horssen, J., de Lange, E. C. M., Reijerkerk, A., van der Pol, S. M. A., Hof, B. V., Drexhage, J. A. R., Vennegoor, A., Killestein, J., Scheffer, G. L., Oerlemans, R., Scheper, R. J., van der Valk, P., Dijkstra, C. D. & de Vries, H. E., 2010, In : Journal of Autoimmunity. 34, 4, p. 416-425

Research output: Contribution to journalArticleAcademicpeer-review

2009
43 Downloads (Pure)

Blood-brain barrier alterations in multiple sclerosis

Kooij, G., 2009, S.I.: s.n..

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Immunoglobulin A: Fc alpha RI Interactions Induce Neutrophil Migration Through Release of Leukotriene B4

van der Steen, L. P. E., Tuk, C. W., Bakema, J. E., Kooij, G., Reijerkerk, A., Vidarsson, G., Bouma, G., Kraal, G., de Vries, H. E., Beelen, R. H. J. & van Egmond, M., 2009, In : Gastroenterology. 137, 6, p. 2018-2029

Research output: Contribution to journalArticleAcademicpeer-review

36 Downloads (Pure)

P-Glycoprotein Acts as an Immunomodulator during Neuroinflammation

Kooij, G., Backer, R., Koning, J. J., Reijerkerk, A., van Horssen, J., van der Pol, S. M. A., Drexhage, J., Schinkel, A., Dijkstra, C. D., den Haan, J. M. M., Geijtenbeek, T. B. H. & de Vries, H. E., 2009, In : PLoS ONE. 4, 12, p. e8212 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2008

Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE

Dijkstra, S., Kooij, G., Verbeek, R., van der Pol, S. M. A., Amor, S., Geisert, E. E. J., Dijkstra, C. D., van Noort, J. M. & de Vries, H. E., 2008, In : Neurobiology of Disease. 31, 3, p. 413-421

Research output: Contribution to journalArticleAcademicpeer-review

Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier

Reijerkerk, A., Kooij, G., van der Pol, SM., Leyen, T., van het Hof, B., Couraud, P. O., Vivien, D., Dijkstra, C. D. & de Vries, H. E., 2008, In : Journal of Immunology. 181, 5, p. 3567-3574

Research output: Contribution to journalArticleAcademicpeer-review

2007

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

Schreibelt, G., Kooij, G., Reijerkerk, A., van Doorn, R., Gringhuis, S. I., van der Pol, S., Weksler, B. B., Romero, I. A., Couraud, P-O., Piontek, J., Blasig, I. E., Dijkstra, C. D., Ronken, E. & de Vries, H. E., Nov 2007, In : FASEB Journal. 21, 13, p. 3666-76 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2006

Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells

Reijerkerk, A., Kooij, G., van der Pol, S. M. A., Khazen, S., Dijkstra, C. D. & de Vries, H. E., Dec 2006, In : FASEB Journal. 20, 14, p. 2550-2 3 p.

Research output: Contribution to journalArticleAcademicpeer-review