Guus de Waard

MSC.

20152020

Research output per year

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Research Output

Downstream Influence of Coronary Stenoses on Microcirculatory Remodeling: A Histopathology Study

de Waard, G. A., Hollander, M. R., Ruiter, D., ten Bokkel Huinink, T., Meer, R., van der Hoeven, N. W., Meinster, E., Beliën, J. A. M., Niessen, H. W. & van Royen, N., 2020, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 40, 1, p. 230-238 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Platelet Inhibition, Endothelial Function, and Clinical Outcome in Patients Presenting With ST-Segment-Elevation Myocardial Infarction Randomized to Ticagrelor Versus Prasugrel Maintenance Therapy: Long-Term Follow-Up of the REDUCE-MVI Trial

van der Hoeven, N. W., Janssens, G. N., Everaars, H., Nap, A., Lemkes, J. S., de Waard, G. A., van de Ven, P. M., van Rossum, A. C., Escaned, J., Mejia-Renteria, H., Ten Cate, T. J. F., Piek, J. J., von Birgelen, C., Valgimigli, M., Diletti, R., Riksen, N. P., Van Mieghem, N. M., Nijveldt, R., van Leeuwen, M. A. H. & van Royen, N., 3 Mar 2020, In : Journal of the American Heart Association. 9, 5, p. e014411

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Artificial Intelligence for Aortic Pressure Waveform Analysis During Coronary Angiography: Machine Learning for Patient Safety

Howard, J. P., Cook, C. M., van de Hoef, T. P., Meuwissen, M., de Waard, G. A., van Lavieren, M. A., Echavarria-Pinto, M., Danad, I., Piek, J. J., Götberg, M., Al-Lamee, R. K., Sen, S., Nijjer, S. S., Seligman, H., van Royen, N., Knaapen, P., Escaned, J., Francis, D. P., Petraco, R. & Davies, J. E., 28 Oct 2019, In : JACC: Cardiovascular Interventions. 12, 20, p. 2093-2101

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive physiological evaluation of epicardial and microvascular coronary domains using vascular conductance and zero flow pressure

van der Hoeven, N. W., de Waard, G. A., Quirós, A., De Hoyos, A., Broyd, C., Nijjer, S. S., van de Hoef, T. P., Petraco, R., Driessen, R. S., Mejía-Rentería, H., Kikuta, Y., Echavarría Pinto, M., van de Ven, P. M., Meuwissen, M., Knaapen, P., Piek, J. J., Davies, J. E., van Royen, N. & Escaned, J., 8 Feb 2019, In : EuroIntervention. 14, 15, p. e1593-e1600

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Determining the Predominant Lesion in Patients With Severe Aortic Stenosis and Coronary Stenoses: A Multicenter Study Using Intracoronary Pressure and Flow

Ahmad, Y., Vendrik, J., Eftekhari, A., Howard, J. P., Cook, C., Rajkumar, C., Malik, I., Mikhail, G., Ruparelia, N., Hadjiloizou, N., Nijjer, S., Al-Lamee, R., Petraco, R., Warisawa, T., Wijntjens, G. W. M., Koch, K. T., van de Hoef, T., de Waard, G., Echavarria-Pinto, M., Frame, A. & 20 others, Sutaria, N., Kanaganayagam, G., Ariff, B., Anderson, J., Chukwuemeka, A., Fertleman, M., Koul, S., Iglesias, J. F., Francis, D., Mayet, J., Serruys, P., Davies, J., Escaned, J., van Royen, N., Götberg, M., Juhl Terkelsen, C., Høj Christiansen, E., Piek, J. J., Baan, J. & Sen, S., 2019, In : Circulation-cardiovascular interventions. 12, 12, p. e008263

Research output: Contribution to journalArticleAcademicpeer-review

Diastolic-systolic velocity ratio to detect coronary stenoses under physiological resting conditions: A mechanistic study

de Waard, G. A., Broyd, C. J., Cook, C. M., van der Hoeven, N. W., Petraco, R., Nijjer, S. S., van de Hoef, T. P., Echavarria-Pinto, M., Meuwissen, M., Sen, S., Knaapen, P., Escaned, J., Piek, J. J., van Royen, N. & Davies, J. E., 1 Mar 2019, In : Open Heart. 6, 1, e000968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of Microvascular Injury in Revascularized Patients With ST-Segment-Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel: The REDUCE-MVI Trial

van Leeuwen, M. A. H., van der Hoeven, N. W., Janssens, G. N., Everaars, H., Nap, A., Lemkes, J. S., de Waard, G. A., van de Ven, P. M., van Rossum, A. C., ten Cate, T. J. F., Piek, J. J., von Birgelen, C., Escaned, J., Valgimigli, M., Diletti, R., Riksen, N. P., van Mieghem, N. M., Nijveldt, R. & van Royen, N., 2019, In : Circulation. 139, 5, p. 636-646

Research output: Contribution to journalArticleAcademicpeer-review

Interindividual Variations in the Adenosine-Induced Hemodynamics During Fractional Flow Reserve Evaluation: Implications for the Use of Quantitative Flow Ratio in Assessing Intermediate Coronary Stenoses

Mejía-Rentería, H., Lauri, F. M., Lee, J. M., McInerney, A., van der Hoeven, N. W., de Waard, G. A., Fernández-Ortiz, A., Macaya, C., Knaapen, P., van Royen, N., Koo, B-K. & Escaned, J., 20 Aug 2019, In : Journal of the American Heart Association. 8, 16, p. e012906 e012906.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Temporal Changes in Coronary Hyperemic and Resting Hemodynamic Indices in Nonculprit Vessels of Patients With ST-Segment Elevation Myocardial Infarction

van der Hoeven, N. W., Janssens, G. N., de Waard, G. A., Everaars, H., Broyd, C. J., Beijnink, C. W. H., van de Ven, P. M., Nijveldt, R., Cook, C. M., Petraco, R., Ten Cate, T., von Birgelen, C., Escaned, J., Davies, J. E., van Leeuwen, M. A. H. & van Royen, N., 1 Aug 2019, In : JAMA cardiology. 4, 8, p. 736-744 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The heart of the matter: Exploring the interaction between the coronary artery and the downstream microcirculation

de Waard, G. A., 2019, 368 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University Amsterdam

Open Access
2018

Coronary autoregulation and assessment of stenosis severity without pharmacological vasodilation

de Waard, G. A., Cook, C. M., van Royen, N. & Davies, J. E., 1 Jan 2018, In : European Heart Journal. 39, 46, p. 4062-4071 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Doppler Versus Thermodilution-Derived Coronary Microvascular Resistance to Predict Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction or Stable Angina Pectoris

Williams, R. P., de Waard, G. A., De Silva, K., Lumley, M., Asrress, K., Arri, S., Ellis, H., Mir, A., Clapp, B., Chiribiri, A., Plein, S., Teunissen, P. F., Hollander, M. R., Marber, M., Redwood, S., van Royen, N. & Perera, D., 2 Jan 2018, In : American Journal of Cardiology. 121, 1, p. 1-8

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hyperaemic microvascular resistance predicts clinical outcome and microvascular injury after myocardial infarction

de Waard, G. A., Fahrni, G., de Wit, D., Kitabata, H., Williams, R., Patel, N., Teunissen, P. F., van de Ven, P. M., Umman, S., Knaapen, P., Perera, D., Akasaka, T., Sezer, M., Kharbanda, R. K. & van Royen, N., 1 Jan 2018, In : Heart. 104, 2, p. 127-134 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Influence of Microcirculatory Dysfunction on Angiography-Based Functional Assessment of Coronary Stenoses

Mejía-Rentería, H., Lee, J. M., Lauri, F., van der Hoeven, N. W., de Waard, G. A., Macaya, F., Pérez-Vizcayno, M. J., Gonzalo, N., Jiménez-Quevedo, P., Nombela-Franco, L., Salinas, P., Núñez-Gil, I., del Trigo, M., Goto, S., Lee, H. J., Liontou, C., Fernández-Ortiz, A., Macaya, C., van Royen, N., Koo, B-K. & 1 others, Escaned, J., 2018, In : JACC: Cardiovascular Interventions. 11, 8, p. 741-753

Research output: Contribution to journalArticleAcademicpeer-review

2017

Assessment of the non-culprit lesion in patients with STEMI: a comparison between FFR and iFR

van der Hoeven, N., Janssens, G., de Waard, G., Everaars, H., Beijnink, C., Nijveldt, R., Cook, C., Davies, J. & van Royen, N., 31 Oct 2017, In : Journal of the American College of Cardiology. 70, 18, p. B90-B91

Research output: Contribution to journalMeeting AbstractAcademic

Diastolic-systolic velocity ratio to detect coronary stenoses

de Waard, G., Cook, C., Petraco, R., Nijjer, S., van de Hoef, T., Echavarria Pinto, M., Sen, S., Meuwissen, M., Knaapen, P., Escaned, J., Piek, J., van Royen, N. & Davies, J., 31 Oct 2017, In : Journal of the American College of Cardiology. 70, 18, p. B170-B170

Research output: Contribution to journalMeeting AbstractAcademic

Discordance in Stenosis Classification by Pressure Only Indices of Stenosis Severity is Related to Differences in Coronary Flow Reserve: - The DISCORD Study

Cook, C. M., Jeremias, A., Ahmad, Y., Shun-Shin, M., Petraco, R., Nijjer, S., de Waard, G., Sen, S., Van de Hoef, T., Echavarria-Pinto, M., van Lavieren, M., Al-Lamee, R., Kikuta, Y., Shiono, Y., Buch, A., Meuwissen, M., Danad, I., Knaapen, P., Maeharah, A., Koo, B-K. & 4 others, Mintz, G. S., Piek, J., Van Royen, N. & Davies, J., 13 Feb 2017, In : JACC Cardiovascular Interventions. 10, 3, p. S27-S27

Research output: Contribution to journalMeeting AbstractAcademic

Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance in Angiographically Intermediate Coronary Stenoses An Analysis Using Doppler-Derived Coronary Flow Measurements

Cook, C. M., Jeremias, A., Petraco, R., Sen, S., Nijjer, S., Shun-Shin, M. J., Ahmad, Y., de Waard, G., van de Hoef, T., Echavarria-Pinto, M., van Lavieren, M., Al Lamee, R., Kikuta, Y., Shiono, Y., Buch, A., Meuwissen, M., Danad, I., Knaapen, P., Maehara, A., Koo, B-K. & 8 others, Mintz, G. S., Escaned, J., Stone, G. W., Francis, D. P., Mayet, J., Piek, J. J., van Royen, N. & Davies, J. E., 26 Dec 2017, In : JACC Cardiovascular Interventions. 10, 24, p. 2514-2524

Research output: Contribution to journalArticleAcademicpeer-review

Hemodynamic changes after percutaneous coronary interventions of stenoses with discordant fractional flow reserve and coronary flow reserve

Wijntjens, G., Kikuta, Y., van de Hoef, T., Petraco, R., Nijjer, S., de Waard, G., Sen, S., Pinto, M. E., Stegehuis, V., Mejia-Renteria, H., Meuwissen, M., Danad, I., Knaapen, P., Escaned, J., Davies, J., Van Royen, N. & Piek, J., 31 Oct 2017, In : Journal of the American College of Cardiology. 70, 18, p. B138-B139

Research output: Contribution to journalMeeting AbstractAcademic

Implementation of computational fluid dynamics increases the diagnostic performance of angiography-derived indices of stenosis severity

Mejia-Renteria, H., Lauri, F., Lee, J. M., van der Hoeven, N., de Waard, G., de Hoyos, A., Macaya, F., Ryan, N., Gonzalo, N., Jimenez-Quevedo, P., Franco, L. N., Nunez-Gil, I., Salinas, P., Del Trigo, M., Perez-Vizcayno, M., Fernandez-Ortiz, A., Macaya, C., Koo, B-K., van Royen, N. & Escaned, J., 31 Oct 2017, In : Journal of the American College of Cardiology. 70, 18, p. B74-B75

Research output: Contribution to journalMeeting AbstractAcademic

Influence of microcirculatory resistance on the assessment of coronary stenosis severity with Quantitative Flow Ratio (QFR): Results of an international multicentre study

Mejia-Renteria, H., Lauri, F., Lee, J. M., van der Hoeven, N., de Waard, G., de Hoyos, A., Macaya, F., Ryan, N., Gonzalo, N., Jimenez-Quevedo, P., Nombela Franco, L., Nunez-Gil, I., Salinas, P., Del Trigo, M., Perez-Vizcayno, M., Fernandez-Ortiz, A., Macaya, C., Koo, B-K., van Royen, N. & Escaned, J., 31 Oct 2017, In : Journal of the American College of Cardiology. 70, 18, p. B30-B31

Research output: Contribution to journalMeeting AbstractAcademic

Instantaneous wave-free ratio to guide coronary revascularisation: Physiological framework, validation and differences from fractional flow reserve

De Waard, G. A., Di Mario, C., Lerman, A., Serruys, P. W. & Van Royen, N., 1 Jul 2017, In : EuroIntervention. 13, 4, p. 450-458 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Integral Hemodynamic Assessment of the Coronary Circulation using Seperate Epicardial and Microvascular Conductance

van der Hoeven, N., de Waard, G. A., Quiros, A., de Hoyos, A., Broyd, C., Nijjer, S., van de Hoef, T. P., Petraco, R., Driessen, R., Mejia-Renteria, H., van de Ven, P. M., Meuwissen, M., Knaapen, P., Piek, J. J., Davies, J. E., van Royen, N. & Escaned, J., 14 Nov 2017, In : Circulation. 136

Research output: Contribution to journalMeeting AbstractAcademic

Interrogation of Non-culprit Stenoses in Patients With St-segment Elevation Myocardial Infarction: A Comparison Between Ffr and Ifr

van der Hoeven, N. W., Janssens, G. N., de Waard, G. A., Everaars, H., Beijnink, C. W. H., van de Ven, P. M., Nijveldt, R., Diletti, R., Cook, C. M., Davies, J. E., van Leeuwen, M. A. H. & van Royen, N., 14 Nov 2017, In : Circulation. 136

Research output: Contribution to journalMeeting AbstractAcademic

Novel method to assess both the epicardial and microvascular domain using vascular conductance obtained from intracoronary pressure and flow velocity

van der Hoeven, N., de Waard, G., Quiros, A., de Hoyos, A., Nijjer, S., de Hoef, T. V., Petraco, R., Driessen, R., Mejia-Renteria, H., Meuwissen, M., Knaapen, P., Piek, J., Davies, J., van Royen, N. & Escaned, J., 31 Oct 2017, In : Journal of the American College of Cardiology. 70, 18, p. B154-B154

Research output: Contribution to journalMeeting AbstractAcademic

Statins; the panacea of cardiovascular disease

de Waard, G. A. & van Royen, N., 1 Apr 2017, In : Netherlands Heart Journal. 25, 4, p. 229-230 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Why does Exercise in Cold Air Increase Susceptibility to Myocardial Ischaemia?

Williams, R., de Waard, G., Arri, S., Patterson, T., Ellis, H., Briceno, N., Chiribiri, A., Clapp, B., van Royen, N., Perera, D., Marber, M. & Redwood, S., 31 Oct 2017, In : Journal of the American College of Cardiology. 70, 18, p. B14-B14

Research output: Contribution to journalArticleAcademicpeer-review

2016

Ballonpulmonalisangioplastiek voor chronische trombo-embolische pulmonale hypertensie

Translated title of the contribution: Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertensionde Waard, G. A., Melenhorst, M. C. A. M., van Leeuwen, M. A. H., Bogaard, H. J., Lely, R. J. & van Royen, N., 2016, In : Nederlands Tijdschrift voor Geneeskunde. 160, p. A9807

Research output: Contribution to journalArticleProfessional

Changes in Coronary Blood Flow After Acute Myocardial Infarction Insights From a Patient Study and an Experimental Porcine Model

de Waard, G. A., Hollander, M. R., Teunissen, P. F. A., Jansen, M. F., Eerenberg, E. S., Beek, A. M., Marques, K. M., van de Ven, P. M., Garrelds, I. M., Danser, A. H. J., Duncker, D. J. & van Royen, N., 28 Mar 2016, In : JACC Cardiovascular Interventions. 9, 6, p. 602-613

Research output: Contribution to journalArticleAcademicpeer-review

Coronary pressure and flow relationships in humans: phasic analysis of normal and pathological vessels and the implications for stenosis assessment: a report from the Iberian-Dutch-English (IDEAL) collaborators

Nijjer, S. S., de Waard, G. A., Sen, S., van de Hoef, T. P., Petraco, R., Echavarria-Pinto, M., van Lavieren, M. A., Meuwissen, M., Danad, I., Knaapen, P., Escaned, J., Piek, J. J., Davies, J. E. & van Royen, N., 7 Jul 2016, In : European Heart Journal. 37, 26, p. 2069-2080

Research output: Contribution to journalArticleAcademicpeer-review

Correction: Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., Van Nieuw Amerongen, G. P., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 2016, In : PLoS ONE. 11, 11, p. e0166809

Research output: Contribution to journalArticleAcademicpeer-review

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., van Nieuw Amerongen, G., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 15 Nov 2016, In : PLoS ONE. 11, 11, e0157233.

Research output: Contribution to journalArticleAcademicpeer-review

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., Van Nieuw-Amerongen, G. P., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 2016, In : PLoS ONE. 11, 7, p. e0157233

Research output: Contribution to journalArticleAcademicpeer-review

Fluoroscopy Assisted Scoring of Myocardial Hypoperfusion (FLASH) ratio as a novel predictor of mortality after primary PCI in STEMI patients

Biesbroek, P. S., Roos, S. T., van Hout, M., van der Gragt, J., Teunissen, P. F. A., de Waard, G. A., Knaapen, P., Kamp, O. & van Royen, N., 1 Jan 2016, In : International Journal of Cardiology. 202, p. 639-645

Research output: Contribution to journalArticleAcademicpeer-review

Invasive minimal Microvascular Resistance Is a New Index to Assess Microcirculatory Function Independent of Obstructive Coronary Artery Disease

de Waard, G. A., Nijjer, S. S., van Lavieren, M. A., van der Hoeven, N. W., Petraco, R., van de Hoef, T. P., Echavarria-Pinto, M., Sen, S., van de Ven, P. M., Knaapen, P., Escaned, J., Piek, J. J., Davies, J. E. & van Royen, N., Dec 2016, In : Journal of American Heart Association. 5, 12

Research output: Contribution to journalArticleAcademicpeer-review

Kinetics of coagulation in ST-elevation myocardial infarction following successful primary percutaneous coronary intervention

Teunissen, P. F. A., Tijssen, R., van Montfoort, M. L., Robbers, L. F. H. J., de Waard, G. A., van de Ven, P. M., Beek, A. M., Knaapen, P., Meijers, J. C. M. & van Royen, N., Jan 2016, In : Thrombosis Research. 137, p. 64-71

Research output: Contribution to journalArticleAcademicpeer-review

2015

Coronary vasomotor function in infarcted and remote myocardium after primary percutaneous coronary intervention

Teunissen, P. F. A., Timmer, S. A. J., Danad, I., de Waard, G. A., van de Ven, P. M., Raijmakers, P. G., Lammertsma, A. A., van Rossum, A. C., van Royen, N. & Knaapen, P., 2015, In : Heart. 101, 19, p. 1577-1583

Research output: Contribution to journalArticleAcademicpeer-review

Intramyocardial haemorrhage after acute myocardial infarction

Betgem, R. P., de Waard, G. A., Nijveldt, R., Beek, A. M., Escaned, J. & van Royen, N., 2015, In : Nature Reviews Cardiology. 12, 3, p. 156-167

Research output: Contribution to journalArticleAcademicpeer-review

T2 versus T2*: competitive or complementary sequences?

Betgem, R. P., de Waard, G. A., Nijveldt, R., Beek, A. M., Escaned, J. & van Royen, N., 2015, In : Nature Reviews Cardiology. 12, 4, p. 198-198

Research output: Contribution to journalArticleAcademicpeer-review